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Page 1
Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex.
Yuan X, Yan L, Chen Q, Zhu S, Zhou X, Zeng LH, Liu M, He X, Huang J, Lu W, Zhang L, Yan H, Wang F. Yuan X, et al. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2405177121. doi: 10.1073/pnas.2405177121. Epub 2024 Aug 7. Proc Natl Acad Sci U S A. 2024. PMID: 39110738 Free PMC article.
Surprisingly, Sororin, which contains a conserved FGF motif and functions as a master antagonist of Wapl in S-phase and G2-phase, does not bind the Scc1-SA2 interface. Moreover, Sgo1, the major protector of Cohesin at mitotic centromeres, can only compete with the FGF moti …
Surprisingly, Sororin, which contains a conserved FGF motif and functions as a master antagonist of Wapl in S-phase and G2-phase, does not b …
Structural basis of centromeric cohesion protection.
García-Nieto A, Patel A, Li Y, Oldenkamp R, Feletto L, Graham JJ, Willems L, Muir KW, Panne D, Rowland BD. García-Nieto A, et al. Nat Struct Mol Biol. 2023 Jun;30(6):853-859. doi: 10.1038/s41594-023-00968-y. Epub 2023 Apr 20. Nat Struct Mol Biol. 2023. PMID: 37081319 Free PMC article.
Here we present the X-ray crystal structure of a segment of human SGO1 bound to a conserved surface of the cohesin complex. SGO1 binds to a composite interface formed by the SA2 and SCC1(RAD21) subunits of cohesin. SGO1 shares this binding interface with CTCF …
Here we present the X-ray crystal structure of a segment of human SGO1 bound to a conserved surface of the cohesin complex. SGO1 …
Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis.
Wu F, Akbar H, Wang C, Yuan X, Dou Z, Mullen M, Niu L, Zhang L, Zang J, Wang Z, Yao X, Song X, Liu X. Wu F, et al. J Mol Cell Biol. 2024 Apr 4;15(10):mjad061. doi: 10.1093/jmcb/mjad061. J Mol Cell Biol. 2024. PMID: 37777834 Free PMC article.
However, it remains uncertain whether other centromeric proteins play a role in regulating the localization and function of Sgo1 during mitosis. Here, we show that CENP-A interacts with Sgo1 and determines the localization of Sgo1 to the centromere during mit …
However, it remains uncertain whether other centromeric proteins play a role in regulating the localization and function of Sgo1 duri …
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin.
Hellmuth S, Stemmann O. Hellmuth S, et al. EMBO J. 2024 Nov;43(21):5237-5259. doi: 10.1038/s44318-024-00228-9. Epub 2024 Sep 13. EMBO J. 2024. PMID: 39271794 Free PMC article.
In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects pericentromeric cohesion by dephosphorylation of cohesin and its associated Wapl antagonist sororin. However, Sgo1-PP2A relocates to inner …
In mitotic prophase cohesin is removed from chromosome arms in a Wapl- and phosphorylation-dependent manner. Sgo1-PP2A protects peric …
Molecular mechanism of condensin I activation by KIF4A.
Cutts EE, Tetiker D, Kim E, Aragon L. Cutts EE, et al. EMBO J. 2025 Feb;44(3):682-704. doi: 10.1038/s44318-024-00340-w. Epub 2024 Dec 17. EMBO J. 2025. PMID: 39690239 Free PMC article.
We identify similar SLiMs in the known yeast condensin interactors, Sgo1 and Lrs4, which bind yeast condensin subunit, Ycg1, the equivalent HAWK to NCAPG. ...
We identify similar SLiMs in the known yeast condensin interactors, Sgo1 and Lrs4, which bind yeast condensin subunit, Ycg1, the equi …
Shugoshin 1 expression in various cancers: a potential target for therapy.
Ankathatti Narayanaswamy I, Kattepur AK, Raju K, Perumal V, Ramalingam R, Raavi V. Ankathatti Narayanaswamy I, et al. Clin Transl Oncol. 2025 May;27(5):1953-1966. doi: 10.1007/s12094-024-03749-1. Epub 2024 Oct 30. Clin Transl Oncol. 2025. PMID: 39476301 Review.
Furthermore, targeting SGO1 with siRNA/shRNA reduced the expression of SGO1 and proliferation, and induced apoptosis of cancer cells. Overall, the SGO1 expression levels were significantly higher in various cancers, and targeting SGO1 with siRNA and sh …
Furthermore, targeting SGO1 with siRNA/shRNA reduced the expression of SGO1 and proliferation, and induced apoptosis of cancer …
Prognosis and biological function of SGOL1 in clear cell renal cell carcinoma: a multiomics analysis.
Yang Z, Jiang Y, Wang L, Yu B, Cai H, Fan J, Zhang M. Yang Z, et al. BMC Med Genomics. 2024 Feb 21;17(1):60. doi: 10.1186/s12920-024-01825-7. BMC Med Genomics. 2024. PMID: 38383432 Free PMC article.
Aberrant SGOL1 expression was reported to be closely correlated with the malignant progression of various tumors. ...In addition, we identified a potential SNHG17/PVT1/ZMIZ1-AS1-miR-23b-3p-SGOL1 axis correlated with ccRCC carcinogenesis and progression. Finally, we …
Aberrant SGOL1 expression was reported to be closely correlated with the malignant progression of various tumors. ...In addition, we …
The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
Reed R, Park K, Waddell B, Timbers TA, Li C, Baxi K, Giacomin RM, Leroux MR, Carvalho CE. Reed R, et al. Sci Rep. 2023 Jun 9;13(1):9410. doi: 10.1038/s41598-023-36430-8. Sci Rep. 2023. PMID: 37296204 Free PMC article.
The conserved Shugoshin (SGO) protein family is essential for mediating proper chromosome segregation from yeast to humans but has also been implicated in diverse roles outside of the nucleus. ...In Caenorhabditis elegans, a species with holocentric chromosomes, SGO …
The conserved Shugoshin (SGO) protein family is essential for mediating proper chromosome segregation from yeast to humans but has al …
Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma.
Cakiroglu E, Eris S, Oz O, Karakülah G, Senturk S. Cakiroglu E, et al. Cell Death Dis. 2025 Apr 3;16(1):241. doi: 10.1038/s41419-025-07587-z. Cell Death Dis. 2025. PMID: 40180891 Free PMC article.
Mechanistically, BUB1 is indispensable for the proper localization of essential mitotic regulators MAD1, MAD2, and Shugoshin (SGO1), thereby ensuring the functionality of the spindle assembly checkpoint (SAC). Furthermore, BUB1 ablation leads to cytokinesis failure and mul …
Mechanistically, BUB1 is indispensable for the proper localization of essential mitotic regulators MAD1, MAD2, and Shugoshin (SGO1), …
19 results