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Year Number of Results
2016 6
2017 22
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89 results

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Page 1
Development of SGLT1 and SGLT2 inhibitors.
Rieg T, Vallon V. Rieg T, et al. Diabetologia. 2018 Oct;61(10):2079-2086. doi: 10.1007/s00125-018-4654-7. Epub 2018 Aug 22. Diabetologia. 2018. PMID: 30132033 Free PMC article. Review.
Sodium-glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and SGLT2 (encoded by SGLT2, also known as SLC5A2) are important mediators of epithelial glucose transport. While SGLT1 accounts for most of the dietary glucose uptake in the …
Sodium-glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and SGLT2 (encoded by SGLT2, also known as …
SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q. Lv Y, et al. Cardiovasc Diabetol. 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. Cardiovasc Diabetol. 2024. PMID: 38715111 Free PMC article.
Accordingly, we used Mendelian Randomization (MR) to examine the role of circulating metabolites in mediating SGLT2 and SGLT1 inhibition in CSVD. METHODS: Genetic instruments for SGLT1/2 inhibition were identified as genetic variants, which were both associated with …
Accordingly, we used Mendelian Randomization (MR) to examine the role of circulating metabolites in mediating SGLT2 and SGLT1 inhibit …
SLC5A1 Variants in Turkish Patients with Congenital Glucose-Galactose Malabsorption.
Hoşnut FÖ, Janecke AR, Şahin G, Vogel GF, Lafcı NG, Bichler P, Müller T, Huber LA, Valovka T, Aksu AÜ. Hoşnut FÖ, et al. Genes (Basel). 2023 Jun 27;14(7):1359. doi: 10.3390/genes14071359. Genes (Basel). 2023. PMID: 37510265 Free PMC article.
Congenital glucose-galactose malabsorption is a rare autosomal recessive disorder caused by mutations in SLC5A1 encoding the apical sodium/glucose cotransporter SGLT1. We present clinical and molecular data from eleven affected individuals with congenital glucose-ga …
Congenital glucose-galactose malabsorption is a rare autosomal recessive disorder caused by mutations in SLC5A1 encoding the apical s …
Genetic polymorphism in Leishmania infantum isolates from human and animals determined by nagt PCR-RFLP.
El Hamouchi A, El Kacem S, Ejghal R, Lemrani M. El Hamouchi A, et al. Infect Dis Poverty. 2018 Jun 14;7(1):54. doi: 10.1186/s40249-018-0439-y. Infect Dis Poverty. 2018. PMID: 29898776 Free PMC article.
METHODS: The intraspecific genetic variability of 40 Moroccan L. infantum MON-1 strains isolated from patients with VL (n = 31) and CL (n = 2) and from dogs (n = 7) was evaluated by PCR-RFLP of nagt, a single-copy gene encoding N-acetylglucosamine-1-phosphate transferase. …
METHODS: The intraspecific genetic variability of 40 Moroccan L. infantum MON-1 strains isolated from patients with VL (n = 31) and CL (n = …
Genetic determinants of circulating GIP and GLP-1 concentrations.
Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson-Laakso E, Asplund O, Sonestedt E, Prasad RB, Laurila E, Orho-Melander M, Melander O, Tuomi T, Holst JJ, Nilsson PM, Wierup N, Groop L, Ahlqvist E. Almgren P, et al. JCI Insight. 2017 Nov 2;2(21):e93306. doi: 10.1172/jci.insight.93306. JCI Insight. 2017. PMID: 29093273 Free PMC article.
We identified 6 genome-wide significant functional loci associated with plasma incretin concentrations in or near the SLC5A1 (encoding SGLT1), GIPR, ABO, GLP2R, F13A1, and HOXD1 genes and studied the effect of these variants on mRNA expression in pancreatic islet an …
We identified 6 genome-wide significant functional loci associated with plasma incretin concentrations in or near the SLC5A1 (encodin …
Hypertension genetics past, present and future applications.
Olczak KJ, Taylor-Bateman V, Nicholls HL, Traylor M, Cabrera CP, Munroe PB. Olczak KJ, et al. J Intern Med. 2021 Dec;290(6):1130-1152. doi: 10.1111/joim.13352. Epub 2021 Jul 8. J Intern Med. 2021. PMID: 34166551 Free article. Review.
Drug re-purposing opportunities, including SLC5A1 and canagliflozin (a type-2 diabetes drug), are also being identified. In this review, we present key studies from the past, highlight current avenues of research and look to the future focusing on gene discovery, epigeneti …
Drug re-purposing opportunities, including SLC5A1 and canagliflozin (a type-2 diabetes drug), are also being identified. In this revi …
Single-cell transcriptomics of human organoid-derived enteroendocrine cell populations from the small intestine.
Smith CA, Lu VB, Bany Bakar R, Miedzybrodzka E, Davison A, Goldspink D, Reimann F, Gribble FM. Smith CA, et al. J Physiol. 2025 Dec;603(24):7751-7763. doi: 10.1113/JP287463. Epub 2024 Dec 5. J Physiol. 2025. PMID: 39639676 Free PMC article.
Bile acid receptor GPBAR1 was most highly expressed in L-cells (producing glucagon-like peptide 1 and peptide YY), long-chain fatty acid receptor FFAR1 was highest in I-cells (cholecystokinin), K-cells (glucose-dependent insulinotropic polypeptide) and L-cells, short-chain fatty …
Bile acid receptor GPBAR1 was most highly expressed in L-cells (producing glucagon-like peptide 1 and peptide YY), long-chain fatty acid rec …
Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk.
Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD. Seidelmann SB, et al. J Am Coll Cardiol. 2018 Oct 9;72(15):1763-1773. doi: 10.1016/j.jacc.2018.07.061. J Am Coll Cardiol. 2018. PMID: 30286918 Free PMC article.
BACKGROUND: Loss-of-function mutations in the SGLT1 (sodium/glucose co-transporter-1) gene result in a rare glucose/galactose malabsorption disorder and neonatal death if untreated. ...CONCLUSIONS: Functionally damaging missense variants in SGLT1 protect from diet-i …
BACKGROUND: Loss-of-function mutations in the SGLT1 (sodium/glucose co-transporter-1) gene result in a rare glucose/galactose malabso …
Assessment of nuclear and mitochondrial genes in precise identification and analysis of genetic polymorphisms for the evaluation of Leishmania parasites.
Fotouhi-Ardakani R, Dabiri S, Ajdari S, Alimohammadian MH, AlaeeNovin E, Taleshi N, Parvizi P. Fotouhi-Ardakani R, et al. Infect Genet Evol. 2016 Dec;46:33-41. doi: 10.1016/j.meegid.2016.10.011. Epub 2016 Oct 17. Infect Genet Evol. 2016. PMID: 27765638
The genetic variation of Leishmania species (L. major, L. tropica, L. tarentolae, L. mexicana, L. infantum) were analyzed and compared using mitochondrial (COII and Cyt b) and nuclear (nagt, ITS-rDNA and HSP70) genes. The role of each enzymatic (COII, Cyt b and nagt …
The genetic variation of Leishmania species (L. major, L. tropica, L. tarentolae, L. mexicana, L. infantum) were analyzed and compared using …
Identification and phylogenic analysis of Leishmania species among patients and reservoir hosts based on N-acetylglucosamine-1-phosphate transferase gene in Central Iran.
Farrokhi-Karibozorg M, Hajjaran H, Ghayour-Najafabadi Z, Hejazi SH, Ataei-Pirkooh A, Mohebali M. Farrokhi-Karibozorg M, et al. Ann Parasitol. 2022;68(3):461-471. doi: 10.17420/ap6803.452. Ann Parasitol. 2022. PMID: 36502673
In total, 85 parasitologically positive samples were subjected to the PCR-RFLP method based on the nagt gene for identification of Leishmania species, also 11 samples were subjected to sequencing and phylogenetic analysis. For all positive samples, a 1450-1460 bp band of t …
In total, 85 parasitologically positive samples were subjected to the PCR-RFLP method based on the nagt gene for identification of Le …
89 results