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PharmVar GeneFocus: SLCO1B1.
Ramsey LB, Gong L, Lee SB, Wagner JB, Zhou X, Sangkuhl K, Adams SM, Straka RJ, Empey PE, Boone EC, Klein TE, Niemi M, Gaedigk A. Ramsey LB, et al. Clin Pharmacol Ther. 2023 Apr;113(4):782-793. doi: 10.1002/cpt.2705. Epub 2022 Jul 27. Clin Pharmacol Ther. 2023. PMID: 35797228 Free PMC article. Review.
Genetic variation within the SLCO1B1 gene locus impacts drug transport, which can lead to altered pharmacokinetic profiles of several commonly prescribed drugs. ...The PharmVar-developed SLCO1B1 nomenclature has been incorporated by the Clinical Pharmacogenetics Imp …
Genetic variation within the SLCO1B1 gene locus impacts drug transport, which can lead to altered pharmacokinetic profiles of several …
Risk factors associated with high-dose methotrexate induced toxicities.
Li W, Mo J, Yang Z, Zhao Z, Mei S. Li W, et al. Expert Opin Drug Metab Toxicol. 2024 Apr;20(4):263-274. doi: 10.1080/17425255.2024.2332366. Epub 2024 Mar 19. Expert Opin Drug Metab Toxicol. 2024. PMID: 38501267
Factors such as MTX exposure, drug interactions, demographics, serum albumin, urine pH, serum calcium, and genetic polymorphisms affecting MTX transport (e.g. SLCO1B1), intracellular folate metabolism (MTHFR), cell development (ARID5B), metabolic pathways (UGT1A1, PNPLA3), …
Factors such as MTX exposure, drug interactions, demographics, serum albumin, urine pH, serum calcium, and genetic polymorphisms affecting M …
SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.
Cheng YY, Chang KC, Chen PL, Yeung CY, Liou BY, Chen HL. Cheng YY, et al. J Formos Med Assoc. 2023 Jul;122(7):648-652. doi: 10.1016/j.jfma.2023.03.003. Epub 2023 Mar 23. J Formos Med Assoc. 2023. PMID: 36964102 Free article.
We report five Taiwanese pediatric and adult patients aged 5-32 years presenting with conjugated hyperbilirubinemia, and were found to have genetic variants of SLCO1B1 and SLCO1B3. Two also had history of prolonged neonatal jaundice. Genetic analysis using panel-based next …
We report five Taiwanese pediatric and adult patients aged 5-32 years presenting with conjugated hyperbilirubinemia, and were found to have …
Associations between SLCO1B1, APOE and CYP2C9 and lipid-lowering efficacy and pharmacokinetics of fluvastatin: a meta-analysis.
Zhang ZH, Yue Sun LC, Gu HY, Jiang C, Yi ZM. Zhang ZH, et al. Pharmacogenomics. 2023 Jun;24(8):475-484. doi: 10.2217/pgs-2023-0004. Epub 2023 Jun 15. Pharmacogenomics. 2023. PMID: 37318060
Objective: This meta-analysis was designed to investigate the associations between SLCO1B1, APOE and CYP2C9 and the lipid-lowering effects and pharmacokinetics of fluvastatin. ...Results: SLCO1B1 521T>C was associated with lower total cholesterol and low-density …
Objective: This meta-analysis was designed to investigate the associations between SLCO1B1, APOE and CYP2C9 and the lipid-lowering ef …
Associations between four polymorphisms of the SLCO1B1 and effectiveness of the statins: a meta-analysis.
Nguyen HH, Nguyen CTT, Mai TNP, Huong PT. Nguyen HH, et al. Pharmacogenet Genomics. 2023 Jun 1;33(4):65-78. doi: 10.1097/FPC.0000000000000490. Epub 2023 Mar 6. Pharmacogenet Genomics. 2023. PMID: 37098851
This study was conducted to assess the association of variants of the solute carrier anion transporter family 1B1 (SLCO1B1) gene, which encodes a transporter involving the hepatic clearance of the statins and their therapeutic efficacy. ...There was no heterogeneity and pu …
This study was conducted to assess the association of variants of the solute carrier anion transporter family 1B1 (SLCO1B1) gene, whi …
Association between SLCO1B1 genetic polymorphisms and bleeding risk in patients treated with edoxaban.
Han JM, Jang EJ, Yee J, Song TJ, Kim DH, Park J, Gwak HS. Han JM, et al. Sci Rep. 2023 Sep 25;13(1):15967. doi: 10.1038/s41598-023-43179-7. Sci Rep. 2023. PMID: 37749323 Free PMC article.
Since SLCO1B1 encodes the uptake transporter OATP1B1, which can influence the pharmacokinetic and pharmacodynamic profiles of edoxaban, polymorphisms in SLCO1B1 may affect the edoxaban response. This study aimed to investigate the association between SLCO1B1
Since SLCO1B1 encodes the uptake transporter OATP1B1, which can influence the pharmacokinetic and pharmacodynamic profiles of edoxaba …
SLCO1B1 variants and the risk of antituberculosis drug-induced hepatotoxicity: a systematic review and meta-analysis.
Zhu M, Chen X, Hao Z, He Y, Han B, Tang S. Zhu M, et al. Pharmacogenomics. 2023 Dec;24(18):931-942. doi: 10.2217/pgs-2023-0168. Epub 2023 Nov 29. Pharmacogenomics. 2023. PMID: 38019119 Review.
Aims: To evaluate the association between SLCO1B1 gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxicity (ATDH). ...Among four SNPs reported in two or more studies, the final results indicated that SNP rs4149014 was significantly associated w …
Aims: To evaluate the association between SLCO1B1 gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxici …
SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients.
Türkmen D, Bowden J, Masoli JAH, Melzer D, Pilling LC. Türkmen D, et al. Int J Mol Sci. 2024 Apr 17;25(8):4426. doi: 10.3390/ijms25084426. Int J Mol Sci. 2024. PMID: 38674010 Free PMC article.
We studied 51 predicted gain/loss-of-function variants affecting OATP1B1. Both SLCO1B1*5 alone and the SLCO1B1*15 haplotype increased LDL during treatment (beta*5 = 0.08 mmol/L, p = 6 10(-8); beta*15 = 0.03 mmol/L, p = 3 10(-4)), as did the likelihood of discontinui …
We studied 51 predicted gain/loss-of-function variants affecting OATP1B1. Both SLCO1B1*5 alone and the SLCO1B1*15 haplotype in …
Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors.
Fontana RJ, Li YJ, Chen V, Kleiner D, Stolz A, Odin J, Vuppalanchi R, Gu J, Dara L, Barnhart H; Drug-Induced Liver Injury Network. Fontana RJ, et al. Hepatol Commun. 2024 Aug 26;8(9):e0518. doi: 10.1097/HC9.0000000000000518. eCollection 2024 Sep 1. Hepatol Commun. 2024. PMID: 39185906 Free PMC article.
The HLA alleles associated with autoimmune hepatitis were not over-represented, but 2 host immune response genes (EDIL3 and SAMA5A) and 3 other genes (GABRP, SMAD3, and SLCO1B1) were associated with ILICI (OR: 2.08-2.4, p<0.01). CONCLUSIONS: ILICI typically arises withi …
The HLA alleles associated with autoimmune hepatitis were not over-represented, but 2 host immune response genes (EDIL3 and SAMA5A) and 3 ot …
Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1.
de With M, van Doorn L, Kloet E, van Veggel A, Matic M, de Neijs MJ, Oomen-de Hoop E, van Meerten E, van Schaik RHN, Mathijssen RHJ, Bins S. de With M, et al. Clin Pharmacokinet. 2023 Nov;62(11):1589-1597. doi: 10.1007/s40262-023-01279-7. Epub 2023 Sep 16. Clin Pharmacokinet. 2023. PMID: 37715926 Free PMC article.
METHODS: Patients who provided written informed consent at the Erasmus Medical Center Cancer Institute to the Code Geno study (local protocol: MEC02-1002) or the IRI28-study (NTR-6612) were enrolled in the study and were genotyped for 15 SNPs in the genes CES1, CES2, SLCO1B1
METHODS: Patients who provided written informed consent at the Erasmus Medical Center Cancer Institute to the Code Geno study (local protoco …
63 results