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Subnucleosome preference of human chromatin remodeller SMARCAD1.
Hu P, Sun J, Sun H, Chen K, Sia Y, Xia X, Xi Q, Chen Z. Hu P, et al. Nature. 2025 Aug;644(8077):818-826. doi: 10.1038/s41586-025-09100-0. Epub 2025 Jun 4. Nature. 2025. PMID: 40468067
Cryo-electron microscopy structures of SMARCAD1 bound to the nucleosome and hexasome provide mechanistic insights into the substrate selectivity. SMARCAD1 binds to the hexasome through multiple family-specific elements that are essential for the functions in vitro a …
Cryo-electron microscopy structures of SMARCAD1 bound to the nucleosome and hexasome provide mechanistic insights into the substrate …
Chromatin remodeling and mismatch repair: Access and excision.
Goellner EM. Goellner EM. DNA Repair (Amst). 2020 Jan;85:102733. doi: 10.1016/j.dnarep.2019.102733. Epub 2019 Oct 17. DNA Repair (Amst). 2020. PMID: 31698199 Free PMC article. Review.
Recent Xenopus and Saccharomyces cerevisiae studies describe a physical interaction between Msh2 and chromatin-remodeling ATPase Fun30/SMARCAD1, with potential mechanistic roles for SMARCAD1 in moving histones for both mispair access and excision tract elongation. . …
Recent Xenopus and Saccharomyces cerevisiae studies describe a physical interaction between Msh2 and chromatin-remodeling ATPase Fun30/SM …
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange.
Aboulache BL, Hoitsma NM, Luger K. Aboulache BL, et al. J Biol Chem. 2024 Dec;300(12):107893. doi: 10.1016/j.jbc.2024.107893. Epub 2024 Oct 17. J Biol Chem. 2024. PMID: 39424143 Free PMC article.
We have shown previously that phosphorylated SMARCAD1 exhibits reduced binding to nucleosomes. However, it is unknown how phosphorylation affects SMARCAD1's ability to perform its various enzymatic activities. Here we use mutational analysis, activity assays, and ma …
We have shown previously that phosphorylated SMARCAD1 exhibits reduced binding to nucleosomes. However, it is unknown how phosphoryla …
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.
Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, Dubois K, Wiegant WW, Thierry A, Burma S, van Attikum H, Llorente B. Costelloe T, et al. Nature. 2012 Sep 27;489(7417):581-4. doi: 10.1038/nature11353. Epub 2012 Sep 9. Nature. 2012. PMID: 22960744 Free PMC article.
The loss of SMARCAD1 impairs end resection and recombinational DNA repair, and renders cells hypersensitive to DNA damage resulting from camptothecin or poly(ADP-ribose) polymerase inhibitor treatments. These findings unveil an evolutionarily conserved role for the Fun30 a …
The loss of SMARCAD1 impairs end resection and recombinational DNA repair, and renders cells hypersensitive to DNA damage resulting f …
Antler-derived microRNA PC-5p-1090 inhibits HCC cell proliferation, migration, and invasion by targeting MARCKS, SMARCAD1, and SOX9.
Wu J, Yang F, Zhao M, Xiao H, Chen Y, Liu X, Zheng D. Wu J, et al. Funct Integr Genomics. 2023 May 11;23(2):156. doi: 10.1007/s10142-023-01089-x. Funct Integr Genomics. 2023. PMID: 37165199
Moreover, mechanistic investigations revealed that miR-PC-1090 promoted the degradation of MARCKS and SMARCAD1 mRNAs and hindered the translation of SOX9 mRNA by recognizing their 3' untranslated regions. Subsequent loss-of-function and rescue experiments confirmed the inv …
Moreover, mechanistic investigations revealed that miR-PC-1090 promoted the degradation of MARCKS and SMARCAD1 mRNAs and hindered the …
SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/beta-catenin-Mediated EMT.
Liu F, Xia Z, Zhang M, Ding J, Feng Y, Wu J, Dong Y, Gao W, Han Z, Liu Y, Yao Y, Li D. Liu F, et al. Int J Biol Sci. 2019 Jan 1;15(3):636-646. doi: 10.7150/ijbs.29562. eCollection 2019. Int J Biol Sci. 2019. PMID: 30745850 Free PMC article.
With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechanistically, we first demonstrate that SMARCAD1 induces EMT via activating Wnt/beta-catenin signaling pathway in pancreatic cancer. Our …
With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechan …
SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
Al Kubaisy E, Arafat K, De Wever O, Hassan AH, Attoub S. Al Kubaisy E, et al. Expert Opin Ther Targets. 2016 Sep;20(9):1035-43. doi: 10.1080/14728222.2016.1195059. Epub 2016 Jun 13. Expert Opin Ther Targets. 2016. PMID: 27232533
RESEARCH DESIGN AND METHODS: Using two different designs of shRNA targeting SMARCAD1, we investigated the impact of SMARCAD1 knockdown on the migration, invasion, and metastasis potential of the breast cancer cells MDA-MB-231 and T47D. ...CONCLUSIONS: These results …
RESEARCH DESIGN AND METHODS: Using two different designs of shRNA targeting SMARCAD1, we investigated the impact of SMARCAD1 k …
(1)H, (13)C and (15)N resonance assignments for the tandem CUE domains from chromatin remodeler SMARCAD1.
Biasutto AJ, West PM, Mancini EJ, Redfield C. Biasutto AJ, et al. Biomol NMR Assign. 2019 Oct;13(2):261-265. doi: 10.1007/s12104-019-09888-9. Epub 2019 Mar 27. Biomol NMR Assign. 2019. PMID: 30919308 Free PMC article.
SMARCAD1 is conserved from yeast to humans and has reported roles in the maintenance of heterochromatin following replication and in double-strand break repair. ...These assignments provide the starting point for detailed investigations of the structure and interactions of …
SMARCAD1 is conserved from yeast to humans and has reported roles in the maintenance of heterochromatin following replication and in …
The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS.
Okazaki N, Ikeda S, Ohara R, Shimada K, Yanagawa T, Nagase T, Ohara O, Koga H. Okazaki N, et al. J Mol Biol. 2008 Oct 3;382(2):257-65. doi: 10.1016/j.jmb.2008.07.031. Epub 2008 Jul 17. J Mol Biol. 2008. PMID: 18675275
The SMARCAD1/KIAA1122 protein is structurally classified into the SWI2/SNF2 superfamily of DNA-dependent ATPases that are catalytic subunits of chromatin-remodeling complexes. ...From these findings, we propose a novel model for gene regulation via the SMARCAD1/KIAA …
The SMARCAD1/KIAA1122 protein is structurally classified into the SWI2/SNF2 superfamily of DNA-dependent ATPases that are catalytic s …
Mutations in SMARCAD1 cause autosomal dominant adermatoglyphia and perturb the expression of epidermal differentiation-associated genes.
Nousbeck J, Sarig O, Magal L, Warshauer E, Burger B, Itin P, Sprecher E. Nousbeck J, et al. Br J Dermatol. 2014 Dec;171(6):1521-4. doi: 10.1111/bjd.13176. Epub 2014 Oct 26. Br J Dermatol. 2014. PMID: 24909267
RESULTS: We identified three novel heterozygous mutations in SMARCAD1 (c.378 + 2T > C, c.378 + 5G > C and c.378 + 1G > A) in a total of six patients. Surprisingly, all four ADG-causing mutations identified to date disrupt a single conserved donor splice site adjac …
RESULTS: We identified three novel heterozygous mutations in SMARCAD1 (c.378 + 2T > C, c.378 + 5G > C and c.378 + 1G > A) in …
45 results