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2024 1
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Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation.
Mei Z, Yilamu K, Ni W, Shen P, Pan N, Chen H, Su Y, Guo L, Sun Q, Li Z, Huang D, Fang X, Fan S, Zhang H, Shen S. Mei Z, et al. Nat Commun. 2025 May 27;16(1):4892. doi: 10.1038/s41467-025-60037-4. Nat Commun. 2025. PMID: 40425566 Free PMC article.
Mechanistically, elevated FAO reduces AMPK activity, impairs SOX9 phosphorylation, and ultimately promotes its ubiquitination-mediated degradation. ...
Mechanistically, elevated FAO reduces AMPK activity, impairs SOX9 phosphorylation, and ultimately promotes its ubiquitination-mediate …
Dissecting the Spatial and Single-Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer.
Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G, Yan X, Wang Y, Zhang M. Zhang G, et al. Adv Sci (Weinh). 2025 May;12(18):e2413019. doi: 10.1002/advs.202413019. Epub 2025 Feb 14. Adv Sci (Weinh). 2025. PMID: 39950944 Free PMC article.
Notably, it is uncovered that amphiregulin (AREG) derived from iCAFs promotes tumor stemness by upregulating the expression of SOX9 in tumor cells, and contributes to drug resistance via the AREG-ERBB2 axis. This study provides valuable insight into the characteristics of …
Notably, it is uncovered that amphiregulin (AREG) derived from iCAFs promotes tumor stemness by upregulating the expression of SOX9 i …
USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer.
Han F, Qi G, Li R, Peng J, Yan S, Yuan C, Kong B, Ma H. Han F, et al. Cell Death Dis. 2025 Apr 16;16(1):305. doi: 10.1038/s41419-025-07647-4. Cell Death Dis. 2025. PMID: 40240356 Free PMC article.
Our study demonstrated that elevated expression of SRY-box 9 (SOX9) contributes to olaparib resistance in ovarian cancer. Mechanistically, the deubiquitinating enzyme USP28 was identified as a novel interacting partner of SOX9. ...Additionally, USP28 promoted olapar …
Our study demonstrated that elevated expression of SRY-box 9 (SOX9) contributes to olaparib resistance in ovarian cancer. Mechanistic …
SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 induction.
Feng Y, Zhu N, Bedi K, Li J, Perera C, Green M, Assarzadegan N, Zhai Y, Liu Q, Baladandayuthapani V, Spence JR, Cho KR, Fearon ER. Feng Y, et al. J Clin Invest. 2025 Apr 3;135(11):e184115. doi: 10.1172/JCI184115. eCollection 2025 Jun 2. J Clin Invest. 2025. PMID: 40179020 Free PMC article.
In an independent mouse CRC model with combined Apc, Kras, and Trp53 defects, Sox9 inactivation promoted SOX2 induction and distant metastases. About 20% of 171 human CRCs showed loss of SOX9 protein expression, which correlated with higher tumor grade. ...SOX9 …
In an independent mouse CRC model with combined Apc, Kras, and Trp53 defects, Sox9 inactivation promoted SOX2 induction and distant m …
The evolution of hominin bipedalism in two steps.
Senevirathne G, Fernandopulle SC, Richard D, Baumgart SL, Christensen AL, Fabbri M, Höppner J, Jüppner H, Li P, Bothe V, Fröbisch N, Simcock I, Arthurs OJ, Calder A, Freilich N, Nowlan NC, Glass IA, Craft A, Capellini TD. Senevirathne G, et al. Nature. 2025 Sep;645(8082):952-963. doi: 10.1038/s41586-025-09399-9. Epub 2025 Aug 27. Nature. 2025. PMID: 40866708 Free PMC article.
Underlying these two shifts are regulatory changes in an integrated chondrocyte-perichondral-osteoblast pathway, involving complex hierarchical interactions between SOX9-ZNF521-PTH1R and RUNX2-FOXP1/2. These innovations facilitated further growth of the human pelvis and th …
Underlying these two shifts are regulatory changes in an integrated chondrocyte-perichondral-osteoblast pathway, involving complex hierarchi …
CDK1 drives SOX9-mediated chemotherapeutic resistance in gastric cancer.
Al-Mathkour M, Chen Z, Poveda J, Cao L, McDonald OG, Peng D, Soutto M, Chen Z, Lu H, Guo Y, Kumar S, Zaika A, Giordano S, Zhu S, El-Rifai W. Al-Mathkour M, et al. J Exp Clin Cancer Res. 2025 Oct 8;44(1):284. doi: 10.1186/s13046-025-03523-3. J Exp Clin Cancer Res. 2025. PMID: 41063222 Free PMC article.
Mechanistically, CDK1 regulates SOX9 through a miR-145-dependent epigenetic axis: CDK1-mediated phosphorylation and activation of DNMT1 to drive methylation-dependent silencing of miR-145, thereby relieving miR-145's repression of SOX9. Strikingly, both CDK1 and …
Mechanistically, CDK1 regulates SOX9 through a miR-145-dependent epigenetic axis: CDK1-mediated phosphorylation and activation of DNM …
Molecular Mechanisms Regulating Epithelial Mesenchymal Transition (EMT) to Promote Cancer Progression.
Ghafoor S, Garcia E, Jay DJ, Persad S. Ghafoor S, et al. Int J Mol Sci. 2025 May 3;26(9):4364. doi: 10.3390/ijms26094364. Int J Mol Sci. 2025. PMID: 40362600 Free PMC article. Review.
This reprogramming is initiated and controlled by various signaling pathways and governed by several key transcription factors, including Snail 1, Snail 2 (Slug), TWIST 1, TWIST2, ZEB1, ZEB2, PRRX1, GOOSECOID, E47, FOXC2, SOX4, SOX9, HAND1, and HAND2. The intracellular sig …
This reprogramming is initiated and controlled by various signaling pathways and governed by several key transcription factors, including Sn …
FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development.
Danti L, Lundin K, Nedeczey-Ruzsák P, Tuuri T, Tapanainen JS. Danti L, et al. Reprod Biol Endocrinol. 2025 Mar 18;23(1):44. doi: 10.1186/s12958-025-01377-0. Reprod Biol Endocrinol. 2025. PMID: 40102860 Free PMC article.
RESULTS: Our results demonstrate that FOXL2 downregulates coelomic epithelial markers GATA4 and LHX9, female gonadal markers RSPO1 and WNT4, and male gonadal markers SOX9, NR0B1 and DHH. The differentially expressed genes were mostly associated with Kyoto encyclopaedia of …
RESULTS: Our results demonstrate that FOXL2 downregulates coelomic epithelial markers GATA4 and LHX9, female gonadal markers RSPO1 and WNT4, …
Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.
Broadaway KA, Sun Q, Edmiston SN, Currin KW, Vadlamudi S, Miller-Fleming TW, Shi Y, Fajgenbaum K, Melendez-Gonzalez M, Bui H, Blum FR, Westerkam L, Shams R, Mallela T, Levitt B, Lin L, Hao H, Memili A, Straub P, Zhou W, Harris KM, Martin A, Cox NJ, Liu Z, Thomas NE, Li Y, Mohlke KL, Sayed CJ. Broadaway KA, et al. Br J Dermatol. 2025 Oct 17;193(5):948-958. doi: 10.1093/bjd/ljaf277. Br J Dermatol. 2025. PMID: 40650879 Free PMC article.
To identify functional noncoding variants, we performed transcriptional reporter assays for signals near KLF5 and SOX9. RESULTS: We identified 11 significant HS signals across 7 loci: 4 corresponded to previously reported associations, 4 represented novel signals within kn …
To identify functional noncoding variants, we performed transcriptional reporter assays for signals near KLF5 and SOX9. RESULTS: We i …
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y. Liu X, et al. Oncogene. 2025 Aug;44(29):2474-2489. doi: 10.1038/s41388-025-03426-9. Epub 2025 Apr 30. Oncogene. 2025. PMID: 40307507
In terms of mechanism, SETD5 as H3K36me3 facilitates the m6A modification of METTL14 and the recruitment of YTHDF1 and mediates PKM2 nuclear translocation and phosphorylation of p-PKM2 Tyr105, regulating GPX4 mediated ferroptosis resistance and SOX9 mediated stemness in NS …
In terms of mechanism, SETD5 as H3K36me3 facilitates the m6A modification of METTL14 and the recruitment of YTHDF1 and mediates PKM2 nuclear …
80 results