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2016 7
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SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
Yan W, Xie C, Sun S, Zheng Q, Wang J, Wang Z, Man CH, Wang H, Yang Y, Wang T, Shi L, Zhang S, Huang C, Xu S, Wang YP. Yan W, et al. EMBO J. 2024 Jun;43(12):2337-2367. doi: 10.1038/s44318-024-00101-9. Epub 2024 Apr 22. EMBO J. 2024. PMID: 38649537 Free PMC article.
Here, we report that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlates with ETC genes across various TCGA cancer transcriptomes. Mechanistically, SUCLG1 restricts succinyl-CoA levels to suppress …
Here, we report that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlat …
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z. Tong Y, et al. Mol Cell. 2021 Jun 3;81(11):2303-2316.e8. doi: 10.1016/j.molcel.2021.04.002. Epub 2021 May 14. Mol Cell. 2021. PMID: 33991485 Free article.
Upon oxidative stress, the succinyl-coenzyme A (CoA) synthetase ADP-forming subunit beta (SUCLA2) phosphorylated by p38 mitogen-activated protein kinase (MAPK) at S79 dissociates from GLS, resulting in enhanced GLS K311 succinylation, oligomerization, and activity. ...
Upon oxidative stress, the succinyl-coenzyme A (CoA) synthetase ADP-forming subunit beta (SUCLA2) phosphorylated by p38 mitogen-activ …
Leigh Syndrome: A Study of 209 Patients at the Beijing Children's Hospital.
Stenton SL, Zou Y, Cheng H, Liu Z, Wang J, Shen D, Jin H, Ding C, Tang X, Sun S, Han H, Ma Y, Zhang W, Jin R, Wang H, Sun D, Lv JL, Prokisch H, Fang F. Stenton SL, et al. Ann Neurol. 2022 Apr;91(4):466-482. doi: 10.1002/ana.26313. Epub 2022 Mar 6. Ann Neurol. 2022. PMID: 35094435
Discriminating neuroimaging and/or clinical features were identified for MT-ATP6 (m.9176T>C), MT-ND5, PDHA1, SUCLG1, and SURF1. Poorest survival was associated with MT-ND5, MT-ATP6 (m.8993T>C and m.9176T>C), SURF1, and ALDH5A1 ( 50% 3 year's survival), in contrast …
Discriminating neuroimaging and/or clinical features were identified for MT-ATP6 (m.9176T>C), MT-ND5, PDHA1, SUCLG1, and SURF1. Po …
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK.
Peng C, Jiang H, Jing L, Yang W, Guan X, Wang H, Yu S, Cao Y, Wang M, Ma H, Lv Z, Gu H, Xia C, Guo X, Sun B, Wang A, Xie C, Wu W, Lu L, Song J, Lei S, Wu R, Zang Y, Tang E, Li J. Peng C, et al. Nat Commun. 2025 Feb 18;16(1):1738. doi: 10.1038/s41467-025-57044-w. Nat Commun. 2025. PMID: 39966410 Free PMC article.
Here we show that in ATM glutaminolysis is the fundamental metabolic flux providing energy and substrate, bridging with AMP-activated protein kinase (AMPK) activity, succinate-induced interleukin-1beta (IL-1beta) production, and obesity. Abrogation of AMPKalpha in myeloid …
Here we show that in ATM glutaminolysis is the fundamental metabolic flux providing energy and substrate, bridging with AMP-activated protei …
Ketogenic β-hydroxybutyrate regulates β-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice.
Han W, Zhang B, Zhao W, Zhao W, He J, Qiu X, Zhang L, Wang X, Wang Y, Lu H, Zhang Y, Xie Y, Geng Y, Zhao W, Huang Q, Zhang YW, Wang Z. Han W, et al. Aging Cell. 2025 Jan;24(1):e14368. doi: 10.1111/acel.14368. Epub 2024 Oct 16. Aging Cell. 2025. PMID: 39411885 Free PMC article.
We identified a series of tricarboxylic acid (TCA) cycle-associated enzymes including citrate synthase (CS) and succinate-CoA ligase subunit alpha (SUCLG1), whose Kbhb modifications were decreased in APP/PS1 mice at pathological stages. Sodium beta-hyd …
We identified a series of tricarboxylic acid (TCA) cycle-associated enzymes including citrate synthase (CS) and succinate-CoA …
SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia.
Gao M, Shi M, Ding H, Xu L, Zhao N, Wang L, Huang S, Jiang H, Bourova-Flin E, Mi J, Khochbin S, Iuso D, Zhu X. Gao M, et al. Cell Rep. 2025 Aug 26;44(8):116147. doi: 10.1016/j.celrep.2025.116147. Epub 2025 Aug 12. Cell Rep. 2025. PMID: 40811057 Free article.
Here, we report that a global increase in protein/histone succinylation is associated with mitochondrial tricarboxylic acid cycle defects in acute myeloid leukemia (AML). Depletion of the succinyl-coenzyme A (CoA) synthetase alpha subunit SUCLG1 causes protein/histo …
Here, we report that a global increase in protein/histone succinylation is associated with mitochondrial tricarboxylic acid cycle defects in …
Tartryl-CoA inhibits succinyl-CoA synthetase.
Huang J, Fraser ME. Huang J, et al. Acta Crystallogr F Struct Biol Commun. 2020 Jul 1;76(Pt 7):302-308. doi: 10.1107/S2053230X20008201. Epub 2020 Jul 1. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32627745 Free PMC article.
Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. ...The purified protein crystallized from a solution containing tartrate, CoA and magnesium chloride, and a crystal diffracted to 1.52 A resolution …
Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. ...The purifie …
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E. Gut P, et al. Nat Commun. 2020 Nov 23;11(1):5927. doi: 10.1038/s41467-020-19743-4. Nat Commun. 2020. PMID: 33230181 Free PMC article.
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism. Here, we show that succinyl-CoA accumulates in …
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase …
SUCLG1 mutations and mitochondrial encephalomyopathy: a case study and review of the literature.
Molaei Ramsheh S, Erfanian Omidvar M, Tabasinezhad M, Alipoor B, Salmani TA, Ghaedi H. Molaei Ramsheh S, et al. Mol Biol Rep. 2020 Dec;47(12):9699-9714. doi: 10.1007/s11033-020-05999-y. Epub 2020 Nov 23. Mol Biol Rep. 2020. PMID: 33230783
Also, a systematic review was performed to explore the involvement of SUCLG1 mutations in published mitochondrial encephalomyopathies cases. Genotyping was performed by implementing whole-exome sequencing. ...We identified a novel, homozygote missense variant chr2: 8467679 …
Also, a systematic review was performed to explore the involvement of SUCLG1 mutations in published mitochondrial encephalomyopathies …
Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis.
Boese AC, Kang J, Hwang JS, Kim J, Eun K, Malin CM, Magliocca KR, Pan C, Jin L, Kang S. Boese AC, et al. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2217332120. doi: 10.1073/pnas.2217332120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37253003 Free PMC article.
Through a customized mitochondrion RNAi screen, we identified succinyl-CoA ligase ADP-forming subunit beta (SUCLA2) as a critical anoikis resistance and metastasis driver in human cancers. ...
Through a customized mitochondrion RNAi screen, we identified succinyl-CoA ligase ADP-forming subunit beta (SUCLA2) as a criti …
84 results