LBX1 alters polyamine pathway in adolescent idiopathic scoliosis - a new therapeutic target to mitigate curve progression.
Zhang Z, Wang Y, Hu Z, Tian W, Li M, Tang Z, Chang L, Tang HH, Tang G, Li J, Wu Z, Xu H, Chui EC, Liu Z, Lau AY, Lam TP, Mok DK, Chen H, Qiu Y, Cheng JC, Zhu Z, Lee WY.
Zhang Z, et al.
J Orthop Translat. 2026 Feb 25;57:101063. doi: 10.1016/j.jot.2026.101063. eCollection 2026 Mar.
J Orthop Translat. 2026.
PMID: 41993097
Free PMC article.
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common three-dimensional (3D) spinal deformity occurring during puberty, with girls at a higher risk of curve progression to the surgical threshold. ...Importantly, daily spermidine supplementation significantly …
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common three-dimensional (3D) spinal deformity occurring during puberty …