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Patients' and clinicians' perceptions of oral anticoagulants in atrial fibrillation: a systematic narrative review and meta-analysis.
Osasu YM, Cooper R, Mitchell C. Osasu YM, et al. BMC Fam Pract. 2021 Dec 22;22(1):254. doi: 10.1186/s12875-021-01590-x. BMC Fam Pract. 2021. PMID: 34937557 Free PMC article.
Historically, warfarin was the anticoagulant of choice for stroke prevention in patients with AF but lately patients are being switched or started on direct oral anticoagulants (DOACs). ...
Historically, warfarin was the anticoagulant of choice for stroke prevention in patients with AF but lately patients are being switch …
Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials.
Woodhouse LJ, Montgomery AA, Mant J, Davis BR, Algra A, Mas JL, Staessen JA, Thijs L, Tonkin A, Kirby A, Pocock SJ, Chalmers J, Hankey GJ, Spence JD, Sandercock P, Diener HC, Uchiyama S, Sprigg N, Bath PM. Woodhouse LJ, et al. BMC Med Res Methodol. 2021 Oct 17;21(1):218. doi: 10.1186/s12874-021-01388-6. BMC Med Res Methodol. 2021. PMID: 34657596 Free PMC article.
BACKGROUND: Vascular prevention trials typically use dichotomous event outcomes although this may be inefficient statistically and gives no indication of event severity. ...We suggest a potential role for using ordinal outcomes in vascular prevention trials....
BACKGROUND: Vascular prevention trials typically use dichotomous event outcomes although this may be inefficient statistically and gi …
At the Intersection of Gut Microbiome and Stroke: A Systematic Review of the Literature.
Sharma V, Sharma V, Shahjouei S, Li J, Chaudhary D, Khan A, Wolk DM, Zand R, Abedi V. Sharma V, et al. Front Neurol. 2021 Sep 24;12:729399. doi: 10.3389/fneur.2021.729399. eCollection 2021. Front Neurol. 2021. PMID: 34630304 Free PMC article.
Our analysis revealed that restoration of a healthy gut, through targeted TMAO-reducing therapies, could provide alternative secondary prevention for at-risk patients. Discussion: Biochemical interactions between the gut microbiome and inflammation, resulting in metabolic …
Our analysis revealed that restoration of a healthy gut, through targeted TMAO-reducing therapies, could provide alternative secondary pr
Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis.
Mac Grory B, Nossek E, Reznik ME, Schrag M, Jayaraman M, McTaggart R, de Havenon A, Yaghi S, Feng W, Furie K, Boyanpally A. Mac Grory B, et al. PLoS One. 2021 Sep 17;16(9):e0257697. doi: 10.1371/journal.pone.0257697. eCollection 2021. PLoS One. 2021. PMID: 34534252 Free PMC article.
DISCUSSION: Carotid webs are more common in young patients with cryptogenic stroke than in other stroke subtypes. Future studies concerning the diagnosis and secondary prevention of stroke associated with carotid web should focus on this population....
DISCUSSION: Carotid webs are more common in young patients with cryptogenic stroke than in other stroke subtypes. Future studies concerning …
Quality of stroke guidelines in low- and middle-income countries: a systematic review.
Yaria J, Gil A, Makanjuola A, Oguntoye R, Miranda JJ, Lazo-Porras M, Zhang P, Tao X, Ahlgren JÁ, Bernabe-Ortiz A, Moscoso-Porras M, Malaga G, Svyato I, Osundina M, Gianella C, Bello O, Lawal A, Temitope A, Adebayo O, Lakkhanaloet M, Brainin M, Johnson W, Thrift AG, Phromjai J, Mueller-Stierlin AS, Perone SA, Varghese C, Feigin V, Owolabi MO; Stroke Experts Collaboration Group. Yaria J, et al. Bull World Health Organ. 2021 Sep 1;99(9):640-652E. doi: 10.2471/BLT.21.285845. Epub 2021 Jun 29. Bull World Health Organ. 2021. PMID: 34475601 Free PMC article. Review.
We reviewed each included guideline for coverage of four key components of stroke services (surveillance, prevention, acute care and rehabilitation). We also assessed compliance with the eight Institute of Medicine standards for clinical practice guidelines, the ease of im …
We reviewed each included guideline for coverage of four key components of stroke services (surveillance, prevention, acute care and …
Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.
Betancur DFA, Tarragó MDGL, Torres ILDS, Fregni F, Caumo W. Betancur DFA, et al. Front Neurol. 2021 Aug 18;12:678198. doi: 10.3389/fneur.2021.678198. eCollection 2021. Front Neurol. 2021. PMID: 34484097 Free PMC article.
The main limitations in the interpretation of the results were the heterogeneity in parameter measurements, unknown cortical excitability measures as potential prognostic markers, the lack of a control group without pain, and the absence of consistent and validated diagnosis crit …
The main limitations in the interpretation of the results were the heterogeneity in parameter measurements, unknown cortical excitability me …
Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis.
Del Giovane C, Boncoraglio GB, Bertù L, Banzi R, Tramacere I. Del Giovane C, et al. BMC Neurol. 2021 Aug 16;21(1):319. doi: 10.1186/s12883-021-02341-2. BMC Neurol. 2021. PMID: 34399713 Free PMC article.
BACKGROUND: Antiplatelet drugs may prevent recurrent ischemic events after ischemic stroke but their relative effectiveness and harms still need to be clarified. ...Randomized controlled trials (RCTs) assessing antiplatelet drugs for secondary stroke prevention were …
BACKGROUND: Antiplatelet drugs may prevent recurrent ischemic events after ischemic stroke but their relative effectiveness and harms …
Clinical follow-up of left atrial appendage occlusion in patients with atrial fibrillation ineligible of oral anticoagulation treatment-a systematic review and meta-analysis.
Labori F, Bonander C, Persson J, Svensson M. Labori F, et al. J Interv Card Electrophysiol. 2021 Aug;61(2):215-225. doi: 10.1007/s10840-021-00953-9. Epub 2021 Feb 13. J Interv Card Electrophysiol. 2021. PMID: 33580847 Free PMC article. Review.
PURPOSE: The recommended stroke prevention for patients with atrial fibrillation (AF) and increased risk of ischemic stroke is oral anticoagulation (OAC). ...This implies a risk reduction of 74.7% with LAAO compared to predicated risk with no stroke prevention. CONC …
PURPOSE: The recommended stroke prevention for patients with atrial fibrillation (AF) and increased risk of ischemic stroke is oral a …
The effect of PCSK9 inhibitors on brain stroke prevention: A systematic review and meta-analysis.
Qin J, Liu L, Su XD, Wang BB, Fu BS, Cui JZ, Liu XY. Qin J, et al. Nutr Metab Cardiovasc Dis. 2021 Jul 22;31(8):2234-2243. doi: 10.1016/j.numecd.2021.03.026. Epub 2021 Apr 20. Nutr Metab Cardiovasc Dis. 2021. PMID: 34052073 Free article.
The present meta-analysis aimed to evaluate the effects of PCSK9 inhibitors on brain stroke prevention. METHODS AND RESULTS: We searched PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov for research published until December 30, 2020, to find randomi …
The present meta-analysis aimed to evaluate the effects of PCSK9 inhibitors on brain stroke prevention. METHODS AND RESULTS: We searc …
Economic Burden of Stroke Disease: A Systematic Review.
Rochmah TN, Rahmawati IT, Dahlui M, Budiarto W, Bilqis N. Rochmah TN, et al. Int J Environ Res Public Health. 2021 Jul 15;18(14):7552. doi: 10.3390/ijerph18147552. Int J Environ Res Public Health. 2021. PMID: 34299999 Free PMC article. Review.
The high economic burden to manage stroke justifies the promotion and preventive efforts by the policymakers and motivates the practice of healthy lifestyles by the people....
The high economic burden to manage stroke justifies the promotion and preventive efforts by the policymakers and motivates the practi …
Stroke prevention in patients with arterial hypertension: Recommendations of the Spanish Society of Neurology's Stroke Study Group.
Rodríguez-Yañez M, Gómez-Choco M, López-Cancio E, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, García-Pastor A, Gomis M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Roquer J, Segura T, Serena J, Vivancos-Mora J, Fuentes B; ad hoc committee of the Spanish Society of Neurology's Study Group for Cerebrovascular Diseases. Rodríguez-Yañez M, et al. Neurologia (Engl Ed). 2021 Jul-Aug;36(6):462-471. doi: 10.1016/j.nrleng.2020.04.023. Epub 2021 Apr 23. Neurologia (Engl Ed). 2021. PMID: 34238528 Free article.
OBJECTIVE: To update the recommendations of the Spanish Society of Neurology on primary and secondary stroke prevention in patients with arterial hypertension. DEVELOPMENT: We proposed several questions to identify practical issues for the management of blood pressure (BP) …
OBJECTIVE: To update the recommendations of the Spanish Society of Neurology on primary and secondary stroke prevention in patients w …
Benefits and Risks of Dual Versus Single Antiplatelet Therapy for Secondary Stroke Prevention: A Systematic Review for the 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack.
Brown DL, Levine DA, Albright K, Kapral MK, Leung LY, Reeves MJ, Sico J, Strong B, Whiteley WN; American Heart Association Stroke Council. Brown DL, et al. Stroke. 2021 Jul;52(7):e468-e479. doi: 10.1161/STR.0000000000000377. Epub 2021 May 24. Stroke. 2021. PMID: 34024115 Free article.
The American Heart Association/American Stroke Association convened an evidence review committee to perform a systematic review and meta-analysis of the benefits and risks of DAPT compared with SAPT for secondary ischemic stroke prevention. METHODS: The Medline, Embase, an …
The American Heart Association/American Stroke Association convened an evidence review committee to perform a systematic review and meta-ana …
Shared Decision Making Tools for People Facing Stroke Prevention Strategies in Atrial Fibrillation: A Systematic Review and Environmental Scan.
Torres Roldan VD, Brand-McCarthy SR, Ponce OJ, Belluzzo T, Urtecho M, Espinoza Suarez NR, Toloza FJK, Thota AD, Organick PW, Barrera F, Liu-Sanchez C, Jaladi S, Prokop L, Ozanne EM, Fagerlin A, Hargraves IG, Noseworthy PA, Montori VM, Brito JP. Torres Roldan VD, et al. Med Decis Making. 2021 Jul;41(5):540-549. doi: 10.1177/0272989X211005655. Epub 2021 Apr 24. Med Decis Making. 2021. PMID: 33896270 Free PMC article.
OBJECTIVE: Shared decision making (SDM) tools can help implement guideline recommendations for patients with atrial fibrillation (AF) considering stroke prevention strategies. We sought to characterize all available SDM tools for this purpose and examine their quality and …
OBJECTIVE: Shared decision making (SDM) tools can help implement guideline recommendations for patients with atrial fibrillation (AF) consid …
Outcomes of COVID-19 Complications and their Possibilities as Potential Triggers of Stroke.
Patel U, Malik P, Mehta D, Rajput P, Shrivastava M, Naveed M, Urhoghide E, Martin M, Somi S, Jaiswal R, Patel A, Israni A, Singh J, Kichloo A, Shah S, Lunagariya A. Patel U, et al. J Stroke Cerebrovasc Dis. 2021 Jul;30(7):105805. doi: 10.1016/j.jstrokecerebrovasdis.2021.105805. Epub 2021 Apr 8. J Stroke Cerebrovasc Dis. 2021. PMID: 33892314 Free PMC article.
Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke and mitigate adverse outcomes....
Patients with stroke were having history of these complications. Long term monitoring is required in such patients to prevent stroke …
A systematic review and meta-analysis of early diagnosis and treatment of hypertensive stroke under calcium channel blockers.
Feng A, Wang W, Du C, He M. Feng A, et al. Ann Palliat Med. 2021 Jun;10(6):6715-6725. doi: 10.21037/apm-21-1272. Ann Palliat Med. 2021. PMID: 34237974 Free article.
However, the effective rate of clinical treatment did not increase hugely (MD =1.70, 95% CI: 0.50-5.83, Z=0.85, P=0.40), and systolic blood pressure did not drop sharply (MD =-1.24, 95% CI: -2.85-0.37, Z=1.51, P=0.13). DISCUSSION: CCB treatment of stroke effectively prevented
However, the effective rate of clinical treatment did not increase hugely (MD =1.70, 95% CI: 0.50-5.83, Z=0.85, P=0.40), and systolic blood …
Risk factors for early-onset seizures after stroke: A systematicreview and meta-analysis of 18 observational studies.
Ma S, Fan X, Zhao X, Wang K, Wang H, Yang Y. Ma S, et al. Brain Behav. 2021 Jun;11(6):e02142. doi: 10.1002/brb3.2142. Epub 2021 May 4. Brain Behav. 2021. PMID: 33942550 Free PMC article.
OBJECTIVES: To systematically evaluate the risk factors of early-onset seizures after stroke, in order to better provide evidence-based results for early detection, identification, targeted prevention, and treatment of this disease. METHODS: PubMed, EMBASE, The Cochrane Li …
OBJECTIVES: To systematically evaluate the risk factors of early-onset seizures after stroke, in order to better provide evidence-based resu …
Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials.
Bhatia K, Jain V, Aggarwal D, Vaduganathan M, Arora S, Hussain Z, Uberoi G, Tafur A, Zhang C, Ricciardi M, Qamar A. Bhatia K, et al. Stroke. 2021 Jun;52(6):e217-e223. doi: 10.1161/STROKEAHA.120.033033. Epub 2021 Apr 27. Stroke. 2021. PMID: 33902301 Free article.
BACKGROUND AND PURPOSE: Antiplatelet therapy is key for preventing thrombotic events after transient ischemic attack or ischemic stroke. Although the role of aspirin is well established, there is emerging evidence for the role of short-term dual antiplatelet therapy (DAPT) …
BACKGROUND AND PURPOSE: Antiplatelet therapy is key for preventing thrombotic events after transient ischemic attack or ischemic stro …
Reperfusion strategies in stroke due to isolated cervical internal carotid artery occlusion: systematic review and treatment comparison.
Romoli M, Mosconi MG, Pierini P, Alberti A, Venti M, Caso V, Vidale S, Lotti EM, Longoni M, Calabresi P, Tsivgoulis G, Paciaroni M. Romoli M, et al. Neurol Sci. 2021 Jun;42(6):2301-2308. doi: 10.1007/s10072-020-04735-5. Epub 2020 Oct 10. Neurol Sci. 2021. PMID: 33037515 Free PMC article.
CONCLUSIONS: Our systematic review highlights that, in acute ischemic stroke associated with isolated cervical ICA occlusion, bridging (IVT + EVT) might lead to higher rate of functional independence at follow-up, without increasing mortality. The low quality of available studies …
CONCLUSIONS: Our systematic review highlights that, in acute ischemic stroke associated with isolated cervical ICA occlusion, bridging (IVT …
Protocols Used by Occupational Therapists on Shoulder Pain after Stroke: Systematic Review and Meta-Analysis.
Souza IG, Souza RF, Barbosa FDS, Scipioni KRDDS, Aidar FJ, Zanona AF. Souza IG, et al. Occup Ther Int. 2021 May 3;2021:8811721. doi: 10.1155/2021/8811721. eCollection 2021. Occup Ther Int. 2021. PMID: 34025305 Free PMC article.
INTRODUCTION: Shoulder pain as a consequence after a stroke has multifactorial causes and can prevent the functional return of the upper limb. In addition, the effectiveness of clinical protocols applied by occupational therapists remains uncertain. ...
INTRODUCTION: Shoulder pain as a consequence after a stroke has multifactorial causes and can prevent the functional return of the up …
Burden of Stroke in India During 1960 to 2018: A Systematic Review and Meta-Analysis of Community Based Surveys.
Khurana S, Gourie-Devi M, Sharma S, Kushwaha S. Khurana S, et al. Neurol India. 2021 May-Jun;69(3):547-559. doi: 10.4103/0028-3886.317240. Neurol India. 2021. PMID: 34169841 Free article. Review.
Increase in the global burden of stroke in developed and developing countries has been alarming. To galvanize the efforts towards the prevention and treatment, there is a need for robust data on the burden of stroke. ...
Increase in the global burden of stroke in developed and developing countries has been alarming. To galvanize the efforts towards the pre
Prevalence, predictors and prognosis of incidental intracranial aneurysms in patients with suspected TIA and minor stroke: a population-based study and systematic review.
Hurford R, Taveira I, Kuker W, Rothwell PM; Oxford Vascular Study Phenotyped Cohort. Hurford R, et al. J Neurol Neurosurg Psychiatry. 2021 May;92(5):542-548. doi: 10.1136/jnnp-2020-324418. Epub 2020 Nov 4. J Neurol Neurosurg Psychiatry. 2021. PMID: 33148817 Free PMC article.
The frequency of UIA might be higher due to shared risk factors, but rupture risk might be reduced by intensive secondary prevention. We determined the prevalence and prognosis of UIA in patients with suspected TIA/minor stroke. ...
The frequency of UIA might be higher due to shared risk factors, but rupture risk might be reduced by intensive secondary prevention. …
Long noncoding RNA as a biomarker for the prognosis of ischemic stroke: A protocol for meta-analysis and bioinformatics analysis.
Fu J, Yu Q, Xiao J, Li S. Fu J, et al. Medicine (Baltimore). 2021 Apr 30;100(17):e25596. doi: 10.1097/MD.0000000000025596. Medicine (Baltimore). 2021. PMID: 33907110 Free PMC article.
At present, the molecular mechanism of ischemic stroke is still unclear, and there lacks early diagnostic markers. Therefore, there is an urgent need to find effective preventive measures, active diagnostic methods and rapid treatment measures. ...
At present, the molecular mechanism of ischemic stroke is still unclear, and there lacks early diagnostic markers. Therefore, there is an ur …
Ticagrelor vs Clopidogrel in addition to Aspirin in minor ischemic stroke/ transient ischemic attack-Protocol for a systematic review and network meta-analysis.
Zitikyte G, Roy DC, Dhaliwal S, Lun R, Hutton B, Shorr R, Dowlatshahi D. Zitikyte G, et al. PLoS One. 2021 Apr 28;16(4):e0250553. doi: 10.1371/journal.pone.0250553. eCollection 2021. PLoS One. 2021. PMID: 33909676 Free PMC article.
This systematic review and network meta-analysis (NMA) will examine the efficacy of these two different antiplatelet regimens in preventing recurrent stroke and mortality up to 30 days. METHODS AND ANALYSIS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled …
This systematic review and network meta-analysis (NMA) will examine the efficacy of these two different antiplatelet regimens in preventi
Glycated Hemoglobin as a Marker for Predicting Outcomes of Patients With Stroke (Ischemic and Hemorrhagic): A Systematic Review and Meta-Analysis.
Bao Y, Gu D. Bao Y, et al. Front Neurol. 2021 Mar 31;12:642899. doi: 10.3389/fneur.2021.642899. eCollection 2021. Front Neurol. 2021. PMID: 33868148 Free PMC article.
Conclusions: The findings indicate that glycated hemoglobin (HbA1c) could serve as a useful marker to predict the outcomes in patients with stroke and aid in the implementation of adequate preventive management strategies at the earliest....
Conclusions: The findings indicate that glycated hemoglobin (HbA1c) could serve as a useful marker to predict the outcomes in patients with …
Stroke Rehabilitation for Falls and Risk of Falls in Southeast Asia: A Scoping Review With Stakeholders' Consultation.
Ahmad Ainuddin H, Romli MH, Hamid TA, Salim MSF, Mackenzie L. Ahmad Ainuddin H, et al. Front Public Health. 2021 Mar 3;9:611793. doi: 10.3389/fpubh.2021.611793. eCollection 2021. Front Public Health. 2021. PMID: 33748063 Free PMC article.
., speech therapists, psychologists) or disciplines interested in falls. Conclusions: Falls prevention among stroke survivors has received a lack of attention and is perceived as an indirect goal in stroke rehabilitation in Southeast Asia. More innovative research adopted …
., speech therapists, psychologists) or disciplines interested in falls. Conclusions: Falls prevention among stroke survivors has rec …
Screening for Asymptomatic Carotid Artery Stenosis in the General Population: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Guirguis-Blake JM, Webber EM, Coppola EL. Guirguis-Blake JM, et al. JAMA. 2021 Feb 2;325(5):487-489. doi: 10.1001/jama.2020.20364. JAMA. 2021. PMID: 33528528 Free PMC article.
This systematic review to support the 2021 US Preventive Services Task Force Reaffirmation Recommendation Statement on screening for carotid artery stenosis summarizes published evidence on the benefits and harms of screening and treatment of asymptomatic carotid artery st …
This systematic review to support the 2021 US Preventive Services Task Force Reaffirmation Recommendation Statement on screening for …
The efficacy and safety of edoxaban versus warfarin in preventing clinical events in atrial fibrillation: A systematic review and meta-analysis.
Liang X, Xie W, Lin Z, Liu M. Liang X, et al. Anatol J Cardiol. 2021 Feb;25(2):77-88. doi: 10.14744/AnatolJCardiol.2020.18049. Anatol J Cardiol. 2021. PMID: 33583814 Free PMC article.
This study evaluates the efficacy and safety of edoxaban versus warfarin in preventing clinical events in patients with AF through a meta-analysis of randomized controlled trials (RCTs). ...
This study evaluates the efficacy and safety of edoxaban versus warfarin in preventing clinical events in patients with AF through a …
Fish consumption, long-chain omega-3 fatty acids intake and risk of stroke: An updated systematic review and meta-analysis.
Chen C, Huang H, Dai QQ, Ren J, Cai HH, Hu WJ, Zhang XJ, Zhong WT, Li XY. Chen C, et al. Asia Pac J Clin Nutr. 2021;30(1):140-152. doi: 10.6133/apjcn.202103_30(1).0017. Asia Pac J Clin Nutr. 2021. PMID: 33787050 Free article.
CONCLUSIONS: Both fish consumption and LC omega3-PUFAs intake were negatively associated with the risk of stroke, especially in women, which suggest that increased intake of fishery products and LC omega3-PUFAs may benefit primary prevention of stroke....
CONCLUSIONS: Both fish consumption and LC omega3-PUFAs intake were negatively associated with the risk of stroke, especially in women, which …
Quality of Stroke Patient Information Applied in Randomized Controlled Trials-Literature Review.
Alegiani AC, Rahn AC, Steckelberg A, Thomalla G, Heesen C, Köpke S. Alegiani AC, et al. Front Neurol. 2020 Dec 7;11:526515. doi: 10.3389/fneur.2020.526515. eCollection 2020. Front Neurol. 2020. PMID: 33365010 Free PMC article.
Background: Strokes have a huge impact on patients' quality of life. Although there are potentially effective secondary preventions and treatment options for stroke patients, adherence is mostly low. ...
Background: Strokes have a huge impact on patients' quality of life. Although there are potentially effective secondary preventions a …
The use of shoulder orthoses post-stroke: effects on balance and gait. A systematic review.
VAN Bladel A, Cambier D, Lefeber N, Oostra K. VAN Bladel A, et al. Eur J Phys Rehabil Med. 2020 Dec;56(6):695-705. doi: 10.23736/S1973-9087.20.06332-7. Epub 2020 Jun 16. Eur J Phys Rehabil Med. 2020. PMID: 32539311 Free article.
INTRODUCTION: Since there is no clear conclusion concerning the use of arm slings in the prevention or reduction of shoulder subluxation or shoulder pain in stroke patients, it seems important to explore other potentially beneficial effects. ...
INTRODUCTION: Since there is no clear conclusion concerning the use of arm slings in the prevention or reduction of shoulder subluxat …
Meta-Analysis of Dyslipidemia Management for the Prevention of Ischemic Stroke Recurrence in China.
Chen KN, He L, Zhong LM, Ran YQ, Liu Y. Chen KN, et al. Front Neurol. 2020 Nov 19;11:483570. doi: 10.3389/fneur.2020.483570. eCollection 2020. Front Neurol. 2020. PMID: 33329292 Free PMC article.
Background: The benefit of blood cholesterol reduction for secondary prevention of ischemic stroke remains undetermined in Chinese patients. ...The overall beneficial effect of statin therapy was confirmed to prevent ischemic stroke with an OR of 0.51 (95% CI: 0.36- …
Background: The benefit of blood cholesterol reduction for secondary prevention of ischemic stroke remains undetermined in Chinese pa …
The Role of DNA Methylation in Ischemic Stroke: A Systematic Review.
Zeng M, Zhen J, Zheng X, Qiu H, Xu X, Wu J, Lin Z, Hu J. Zeng M, et al. Front Neurol. 2020 Oct 27;11:566124. doi: 10.3389/fneur.2020.566124. eCollection 2020. Front Neurol. 2020. PMID: 33193003 Free PMC article.
Conclusion: DNA methylation might be associated with ischemic stroke and play a role in several pathological pathways. It is potentially a promising biomarker for stroke prevention, diagnosis and treatment, but the current evidence is limited by sample size and cross-secti …
Conclusion: DNA methylation might be associated with ischemic stroke and play a role in several pathological pathways. It is potentially a p …
Electromechanical-assisted training for walking after stroke.
Mehrholz J, Thomas S, Kugler J, Pohl M, Elsner B. Mehrholz J, et al. Cochrane Database Syst Rev. 2020 Oct 22;10(10):CD006185. doi: 10.1002/14651858.CD006185.pub5. Cochrane Database Syst Rev. 2020. PMID: 33091160 Free PMC article.
AUTHORS' CONCLUSIONS: People who receive electromechanical-assisted gait training in combination with physiotherapy after stroke are more likely to achieve independent walking than people who receive gait training without these devices. We concluded that eight patients need to be …
AUTHORS' CONCLUSIONS: People who receive electromechanical-assisted gait training in combination with physiotherapy after stroke are more li …
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A. Bala MM, et al. Cochrane Database Syst Rev. 2020 Oct 12;10(10):CD012169. doi: 10.1002/14651858.CD012169.pub3. Cochrane Database Syst Rev. 2020. PMID: 33045766 Free PMC article.
OBJECTIVES: To assess the effects of antiplatelet (AP) or anticoagulant agents, or both, for the secondary prevention of recurrent thrombosis, particularly ischemic stroke, in people with APS. ...SELECTION CRITERIA: We included randomized controlled trials (RCTs) that eval …
OBJECTIVES: To assess the effects of antiplatelet (AP) or anticoagulant agents, or both, for the secondary prevention of recurrent th …
Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic.
Fatima N, Saqqur M, Qamar F, Shaukat S, Shuaib A. Fatima N, et al. Neurol Sci. 2020 Oct;41(10):2675-2679. doi: 10.1007/s10072-020-04637-6. Epub 2020 Aug 6. Neurol Sci. 2020. PMID: 32761396 Free PMC article.
Exploring the neurological manifestation in terms of stroke among patients with COVID-19 is a step towards better understanding of the virus, preventing further spread, and treating the patients affected by this pandemic....
Exploring the neurological manifestation in terms of stroke among patients with COVID-19 is a step towards better understanding of the virus …
Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review.
Mazzucco S, Li L, Rothwell PM. Mazzucco S, et al. JAMA Neurol. 2020 Oct 1;77(10):1279-1287. doi: 10.1001/jamaneurol.2020.1948. JAMA Neurol. 2020. PMID: 32628255 Free PMC article.
IMPORTANCE: Patent foramen ovale (PFO) closure may prevent recurrent stroke after cryptogenic transient ischemic attack (TIA) or stroke (TIA/stroke) in patients aged 60 years or younger. ...
IMPORTANCE: Patent foramen ovale (PFO) closure may prevent recurrent stroke after cryptogenic transient ischemic attack (TIA) or stro …
Effect and efficacy of lifestyle interventions as secondary prevention.
Liljehult J, Christensen T, Molsted S, Overgaard D, Mesot Liljehult M, Møller T. Liljehult J, et al. Acta Neurol Scand. 2020 Oct;142(4):299-313. doi: 10.1111/ane.13308. Epub 2020 Jul 15. Acta Neurol Scand. 2020. PMID: 32620044 Free PMC article.
INTRODUCTION: Improvements in health behaviour are often recommended as part of secondary prevention in patients with stroke and transient ischaemic attack. However, there is a lack of knowledge as to how this is applied in clinical practice. ...
INTRODUCTION: Improvements in health behaviour are often recommended as part of secondary prevention in patients with stroke and tran …
Factors Associated with Risk of Stroke-Associated Pneumonia in Patients with Dysphagia: A Systematic Review.
Eltringham SA, Kilner K, Gee M, Sage K, Bray BD, Smith CJ, Pownall S. Eltringham SA, et al. Dysphagia. 2020 Oct;35(5):735-744. doi: 10.1007/s00455-019-10061-6. Epub 2019 Sep 6. Dysphagia. 2020. PMID: 31493069 Free PMC article. Review.
There is insufficient evidence to justify screening for aerobic Gram-negative bacteria. Prophylactic antibiotics did not prevent SAP and proton pump inhibitors may increase risk. Treatment with metoclopramide may reduce SAP risk. ...
There is insufficient evidence to justify screening for aerobic Gram-negative bacteria. Prophylactic antibiotics did not prevent SAP …
Carotid endarterectomy for symptomatic carotid stenosis.
Rerkasem A, Orrapin S, Howard DP, Rerkasem K. Rerkasem A, et al. Cochrane Database Syst Rev. 2020 Sep 12;9(9):CD001081. doi: 10.1002/14651858.CD001081.pub4. Cochrane Database Syst Rev. 2020. PMID: 32918282 Free PMC article.
Systemic lupus erythematosus; stroke and myocardial infarction risk: a systematic review and meta-analysis.
Yazdany J, Pooley N, Langham J, Nicholson L, Langham S, Embleton N, Wang X, Desta B, Barut V, Hammond E. Yazdany J, et al. RMD Open. 2020 Sep;6(2):e001247. doi: 10.1136/rmdopen-2020-001247. RMD Open. 2020. PMID: 32900883 Free PMC article.
Future research on the interaction between known SLE-specific modifiable risk factors and risk of stroke and MI to support development of prevention and treatment strategies are needed. PROSPERO REGISTRATION NUMBER: CRD42018098690....
Future research on the interaction between known SLE-specific modifiable risk factors and risk of stroke and MI to support development of …
Multiple versus fewer antiplatelet agents for preventing early recurrence after ischaemic stroke or transient ischaemic attack.
Naqvi IA, Kamal AK, Rehman H. Naqvi IA, et al. Cochrane Database Syst Rev. 2020 Aug 17;8(8):CD009716. doi: 10.1002/14651858.CD009716.pub2. Cochrane Database Syst Rev. 2020. PMID: 32813275 Free PMC article.
Antiplatelet agents are considered to be the cornerstone for secondary prevention of stroke, but the role of using multiple antiplatelet agents early after stroke or transient ischaemic attack (TIA) to improve outcomes has not been established. OBJECTIVES: To determine the …
Antiplatelet agents are considered to be the cornerstone for secondary prevention of stroke, but the role of using multiple antiplate …
Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis.
McHutchison C, Blair GW, Appleton JP, Chappell FM, Doubal F, Bath PM, Wardlaw JM. McHutchison C, et al. Stroke. 2020 Aug;51(8):2374-2385. doi: 10.1161/STROKEAHA.120.029454. Epub 2020 Jul 10. Stroke. 2020. PMID: 32646330 Free PMC article.
BACKGROUND AND PURPOSE: Cilostazol, a phosphodiesterase 3' inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilizes endothelium, aids myelin repair and astrocyte-neuron energy tra …
BACKGROUND AND PURPOSE: Cilostazol, a phosphodiesterase 3' inhibitor, is used in Asia-Pacific countries for stroke prevention, but ra …
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Estcourt LJ, Kohli R, Hopewell S, Trivella M, Wang WC. Estcourt LJ, et al. Cochrane Database Syst Rev. 2020 Jul 27;7(7):CD003146. doi: 10.1002/14651858.CD003146.pub4. Cochrane Database Syst Rev. 2020. PMID: 32716555 Free PMC article.
Two trials compared the drug hydroxyurea (hydroxycarbamide) and phlebotomy to long-term transfusions and iron chelation therapy: one in primary prevention (children); and one in secondary prevention (children and adolescents). ...In secondary prevention of st …
Two trials compared the drug hydroxyurea (hydroxycarbamide) and phlebotomy to long-term transfusions and iron chelation therapy: one in prim …
Cerebrolysin for acute ischaemic stroke.
Ziganshina LE, Abakumova T, Hoyle CH. Ziganshina LE, et al. Cochrane Database Syst Rev. 2020 Jul 14;7(7):CD007026. doi: 10.1002/14651858.CD007026.pub6. Cochrane Database Syst Rev. 2020. PMID: 32662068 Free PMC article.
AUTHORS' CONCLUSIONS: Moderate-quality evidence indicates that Cerebrolysin probably has little or no beneficial effect on preventing all-cause death in acute ischaemic stroke, or on the total number of people with serious adverse events. ...
AUTHORS' CONCLUSIONS: Moderate-quality evidence indicates that Cerebrolysin probably has little or no beneficial effect on preventing
The role of non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A PRISMA-compliant article.
Liu X, Huang M, Ye C, Zeng J, Zeng C, Ma J. Liu X, et al. Medicine (Baltimore). 2020 Jul 2;99(27):e21025. doi: 10.1097/MD.0000000000021025. Medicine (Baltimore). 2020. PMID: 32629725 Free PMC article.
BACKGROUND: Given the huge burden of atrial fibrillation (AF) and AF-related stroke in Asia, stroke prevention represents an urgent issue in this region. We herein performed a network meta-analysis to examine the role of non-vitamin K antagonist oral anticoagulants (NOACs) …
BACKGROUND: Given the huge burden of atrial fibrillation (AF) and AF-related stroke in Asia, stroke prevention represents an urgent i …
Anti-inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack.
Coveney S, McCabe JJ, Murphy S, O'Donnell M, Kelly PJ. Coveney S, et al. Cochrane Database Syst Rev. 2020 May 11;5(5):CD012825. doi: 10.1002/14651858.CD012825.pub2. Cochrane Database Syst Rev. 2020. PMID: 32392374 Free PMC article.
SELECTION CRITERIA: We considered randomised controlled trials (RCTs) and cluster-randomised controlled trials that evaluated anti-inflammatory medications for prevention of major cardiovascular events following ischaemic stroke or TIA. ...AUTHORS' CONCLUSIONS: There is cu …
SELECTION CRITERIA: We considered randomised controlled trials (RCTs) and cluster-randomised controlled trials that evaluated anti-inflammat …
Pharmacological, psychological and non-invasive brain stimulation interventions for preventing depression after stroke.
Allida S, Cox KL, Hsieh CF, House A, Hackett ML. Allida S, et al. Cochrane Database Syst Rev. 2020 May 11;5(5):CD003689. doi: 10.1002/14651858.CD003689.pub4. Cochrane Database Syst Rev. 2020. PMID: 32390167 Free PMC article.
There were no trials of non-invasive brain stimulation compared with sham stimulation or usual care, a combination of pharmacological intervention and one of various forms of psychological therapy with placebo and psychological therapy, or a combination of non-invasive brain stim …
There were no trials of non-invasive brain stimulation compared with sham stimulation or usual care, a combination of pharmacological interv …
Clinicians' views and experiences of prescribing oral anticoagulants for stroke prevention in atrial fibrillation: A qualitative meta-synthesis.
Pritchett RV, Clarke JL, Jolly K, Clarkesmith D, Bem D, Turner GM, Thomas GN, Lane DA. Pritchett RV, et al. PLoS One. 2020 May 7;15(5):e0232484. doi: 10.1371/journal.pone.0232484. eCollection 2020. PLoS One. 2020. PMID: 32379847 Free PMC article.
This meta-synthesis explored clinicians' beliefs and experiences regarding OAC prescription to AF patients, highlighting barriers to stroke prevention and informing future clinician-focused interventions. METHODS AND RESULTS: A qualitative meta-synthesis exploring clinicia …
This meta-synthesis explored clinicians' beliefs and experiences regarding OAC prescription to AF patients, highlighting barriers to stroke …
Acute stroke care during the COVID-19 pandemic. Ictus Madrid Program recommendations.
Rodríguez-Pardo J, Fuentes B, Alonso de Leciñana M, Campollo J, Calleja Castaño P, Carneado Ruiz J, Egido Herrero J, García Leal R, Gil Núñez A, Gómez Cerezo JF, Martín Martínez A, Masjuán Vallejo J, Palomino Aguado B, Riera López N, Simón de Las Heras R, Vivancos Mora J, Díez Tejedor E; en nombre del Grupo Multidisciplinar del Plan Ictus Madrid. Rodríguez-Pardo J, et al. Neurologia (Engl Ed). 2020 May;35(4):258-263. doi: 10.1016/j.nrl.2020.04.008. Epub 2020 Apr 24. Neurologia (Engl Ed). 2020. PMID: 32364127 Free PMC article. English, Spanish.
RESULTS: These recommendations address 5 main objectives: 1) coordination of action protocols to ensure access to hospital care for stroke patients; 2) recognition of potentially COVID-19-positive stroke patients; 3) organisation of patient management to prevent SARS-CoV-2 …
RESULTS: These recommendations address 5 main objectives: 1) coordination of action protocols to ensure access to hospital care for stroke p …
Meta-analysis of the efficacy and safety of non-vitamin K antagonist oral anticoagulants with warfarin in Latin American patients with atrial fibrillation.
Su Z, Zhang H, He W, Ma J, Zeng J, Jiang X. Su Z, et al. Medicine (Baltimore). 2020 May;99(18):e19542. doi: 10.1097/MD.0000000000019542. Medicine (Baltimore). 2020. PMID: 32358343 Free PMC article.
BACKGROUND: Data of non-vitamin K antagonist oral anticoagulants (NOACs) in current management of atrial fibrillation (AF) are predominantly derived from North American and European regions. However, the effects of NOACs for stroke prevention in Latin America remain unclea …
BACKGROUND: Data of non-vitamin K antagonist oral anticoagulants (NOACs) in current management of atrial fibrillation (AF) are predominantly …
Etiologic Workup in Cases of Cryptogenic Stroke: A Systematic Review of International Clinical Practice Guidelines.
McMahon NE, Bangee M, Benedetto V, Bray EP, Georgiou RF, Gibson JME, Lane DA, Al-Khalidi AH, Chatterjee K, Chauhan U, Clegg AJ, Lightbody CE, Lip GYH, Sekhar A, Watkins CL. McMahon NE, et al. Stroke. 2020 May;51(5):1419-1427. doi: 10.1161/STROKEAHA.119.027123. Epub 2020 Apr 13. Stroke. 2020. PMID: 32279620 Free PMC article.
Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. ...Results- We retrieved …
Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, i …
Effect of chronic stretching interventions on the mechanical properties of muscles in patients with stroke: A systematic review.
Lecharte T, Gross R, Nordez A, Le Sant G. Lecharte T, et al. Ann Phys Rehabil Med. 2020 May;63(3):222-229. doi: 10.1016/j.rehab.2019.12.003. Epub 2020 Jan 22. Ann Phys Rehabil Med. 2020. PMID: 31981838 Free article.
RESULTS: Eight randomized clinical trials (total of 290 participants) met the inclusion criteria, with highly variable sample characteristics (at risk/existing contractures), program objectives (prevent/treat contractures) and duration (from 4 to 52 weeks) and volume of st …
RESULTS: Eight randomized clinical trials (total of 290 participants) met the inclusion criteria, with highly variable sample characteristic …
Interventions for preventing silent cerebral infarcts in people with sickle cell disease.
Estcourt LJ, Kimber C, Hopewell S, Trivella M, Doree C, Abboud MR. Estcourt LJ, et al. Cochrane Database Syst Rev. 2020 Apr 6;4(4):CD012389. doi: 10.1002/14651858.CD012389.pub3. Cochrane Database Syst Rev. 2020. PMID: 32250453 Free PMC article.
The vast majority of participants had the haemoglobin (Hb)SS form of SCD. One trial focused on preventing silent cerebral infarcts or stroke; three trials were for primary stroke prevention and one trial dealt with secondary stroke prevention. ...Two trials c …
The vast majority of participants had the haemoglobin (Hb)SS form of SCD. One trial focused on preventing silent cerebral infarcts or …
Physical fitness training for stroke patients.
Saunders DH, Sanderson M, Hayes S, Johnson L, Kramer S, Carter DD, Jarvis H, Brazzelli M, Mead GE. Saunders DH, et al. Cochrane Database Syst Rev. 2020 Mar 20;3(3):CD003316. doi: 10.1002/14651858.CD003316.pub7. Cochrane Database Syst Rev. 2020. PMID: 32196635 Free PMC article.
There was no evidence of any serious adverse events. Lack of data prevents conclusions about effects of training on mood, quality of life, and cognition. ...
There was no evidence of any serious adverse events. Lack of data prevents conclusions about effects of training on mood, quality of …
Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis.
Zhao B, Zeng L, Zhao J, Wu Q, Dong Y, Zou F, Gan L, Wei Y, Zhang W. Zhao B, et al. BMJ Open. 2020 Mar 19;10(3):e032240. doi: 10.1136/bmjopen-2019-032240. BMJ Open. 2020. PMID: 32198298 Free PMC article.
Feasible magnesium-rich dietary patterns may be highly beneficial for specific populations and could be highlighted in the primary T2D and total stroke prevention strategies disseminated to the public. PROSPERO REGISTRATION NUMBER: CRD42018092690....
Feasible magnesium-rich dietary patterns may be highly beneficial for specific populations and could be highlighted in the primary T2D and t …
Impact of direct oral anticoagulant off-label doses on clinical outcomes of atrial fibrillation patients: A systematic review.
Santos J, António N, Rocha M, Fortuna A. Santos J, et al. Br J Clin Pharmacol. 2020 Mar;86(3):533-547. doi: 10.1111/bcp.14127. Epub 2020 Feb 5. Br J Clin Pharmacol. 2020. PMID: 31631392 Free PMC article. Review.
RESULTS: Data from 75 studies showed that most of the patients treated with DOACs for stroke prevention in atrial fibrillation received doses in accordance to the guidelines. ...
RESULTS: Data from 75 studies showed that most of the patients treated with DOACs for stroke prevention in atrial fibrillation receiv …
Systematic review on left atrial appendage closure with the LAmbre device in patients with non-valvular atrial fibrillation.
Ali M, Rigopoulos AG, Mammadov M, Torky A, Auer A, Matiakis M, Abate E, Bakogiannis C, Tzikas S, Bigalke B, Sedding D, Noutsias M. Ali M, et al. BMC Cardiovasc Disord. 2020 Feb 12;20(1):78. doi: 10.1186/s12872-020-01349-9. BMC Cardiovasc Disord. 2020. PMID: 32050904 Free PMC article.
BACKGROUND: Percutaneous closure (LAAC) of the left atrial appendage (LAA) is an efficacious preventive procedure for patients with non-valvular atrial fibrillation (NVAF) and considerable bleeding risk. ...CONCLUSIONS: This systematic review on the LAmbre LAA-occluder inc …
BACKGROUND: Percutaneous closure (LAAC) of the left atrial appendage (LAA) is an efficacious preventive procedure for patients with n …
Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications: A Systematic Review and Network Meta-analysis.
Wei J, Galaviz KI, Kowalski AJ, Magee MJ, Haw JS, Narayan KMV, Ali MK. Wei J, et al. JAMA Netw Open. 2020 Feb 5;3(2):e1921618. doi: 10.1001/jamanetworkopen.2019.21618. JAMA Netw Open. 2020. PMID: 32083689 Free PMC article.
IMPORTANCE: Antihypertension medications have been associated with prevention of cardiovascular events, although less is known about the comparative effectiveness of different medication classes. ...
IMPORTANCE: Antihypertension medications have been associated with prevention of cardiovascular events, although less is known about …
The effect of rehabilitation interventions on physical function and immobility-related complications in severe stroke: a systematic review.
McGlinchey MP, James J, McKevitt C, Douiri A, Sackley C. McGlinchey MP, et al. BMJ Open. 2020 Feb 5;10(2):e033642. doi: 10.1136/bmjopen-2019-033642. BMJ Open. 2020. PMID: 32029489 Free PMC article.
Two reviewers screened search results, selected studies using predefined selection criteria, extracted data and assessed risk of bias for selected studies using piloted proformas. Marked heterogeneity prevented meta-analysis and a descriptive review was performed. The Grad …
Two reviewers screened search results, selected studies using predefined selection criteria, extracted data and assessed risk of bias for se …
Selective serotonin reuptake inhibitors for functional independence and depression prevention in early stage of post-stroke: A meta-analysis.
Zhou S, Liu S, Liu X, Zhuang W. Zhou S, et al. Medicine (Baltimore). 2020 Feb;99(6):e19062. doi: 10.1097/MD.0000000000019062. Medicine (Baltimore). 2020. PMID: 32028426 Free PMC article.
BACKGROUND: The efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) for functional independence and depression prevention in early stage of post-stroke (within 1 month after stroke onset) are still unclear. ...CONCLUSIONS: Our meta-analysis revealed that …
BACKGROUND: The efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) for functional independence and depression prevent