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Page 1
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N. Davis K, et al. Semin Diagn Pathol. 2023 May;40(3):202-215. doi: 10.1053/j.semdp.2023.04.003. Epub 2023 Apr 9. Semin Diagn Pathol. 2023. PMID: 37120350 Review.
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between the ICC and WHO 5th edition publications, compiles key features of each entity, and provides a diagnostic algorithmic approach. ...The establ …
This increased diagnostic and therapeutic complexity can be overwhelming, and this review compares nomenclature differences between t …
Transcription factor abnormalities in B-ALL leukemogenesis and treatment.
Yin H, Wang J, Tan Y, Jiang M, Zhang H, Meng G. Yin H, et al. Trends Cancer. 2023 Oct;9(10):855-870. doi: 10.1016/j.trecan.2023.06.004. Epub 2023 Jul 3. Trends Cancer. 2023. PMID: 37407363 Review.
In B cell acute lymphoblastic leukemia (B-ALL) TF abnormalities occur at high frequency and are often recognized as the major driving factor in carcinogenesis. We provide an in-depth review of molecular mechanisms of six major TF rearrangements in B-ALL, including DUX4-rea …
In B cell acute lymphoblastic leukemia (B-ALL) TF abnormalities occur at high frequency and are often recognized as the major driving factor …
Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review).
Organista-Nava J, Gómez-Gómez Y, Illades-Aguiar B, Leyva-Vázquez MA. Organista-Nava J, et al. Oncol Rep. 2016 Sep;36(3):1226-32. doi: 10.3892/or.2016.4948. Epub 2016 Jul 19. Oncol Rep. 2016. PMID: 27431573 Review.
We reviewed the roles of miRNA here with emphasis on their function in human leukemia and the mechanisms of the TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins on miRNAs expression in acute lymphoblastic leukemia....
We reviewed the roles of miRNA here with emphasis on their function in human leukemia and the mechanisms of the TEL/AML1, BCR/ABL, MLL/AF4 a …
A (1;19) translocation involving TCF3-PBX1 fusion within the context of a hyperdiploid karyotype in adult B-ALL: a case report and review of the literature.
Tirado CA, Shabsovich D, Yeh L, Pullarkat ST, Yang L, Kallen M, Rao N. Tirado CA, et al. Biomark Res. 2015 Feb 18;3:4. doi: 10.1186/s40364-015-0029-0. eCollection 2015. Biomark Res. 2015. PMID: 25729575 Free PMC article.
Fluorescence in situ hybridization (FISH) on previously G-banded metaphases using the LSI TCF3/PBX1 Dual Color, Dual Fusion Translocation Probe confirmed the presence of the TCF3-PBX1 gene fusion. ...This case is one of only a few cases with both hyper …
Fluorescence in situ hybridization (FISH) on previously G-banded metaphases using the LSI TCF3/PBX1 Dual Color, Dual Fusion Tr …
BCR-ABL1-like acute lymphoblastic leukaemia: From bench to bedside.
Boer JM, den Boer ML. Boer JM, et al. Eur J Cancer. 2017 Sep;82:203-218. doi: 10.1016/j.ejca.2017.06.012. Epub 2017 Jul 12. Eur J Cancer. 2017. PMID: 28709134 Review.
These so-called BCR-ABL1-like fusions are mutually exclusive with the sentinel translocations in BCP-ALL (BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and KMT2A (MLL) rearrangements) and have the promising prospect to be sensitive to tyrosine kinase inhibitors similar to BCR-AB …
These so-called BCR-ABL1-like fusions are mutually exclusive with the sentinel translocations in BCP-ALL (BCR-ABL1, ETV6-RUNX1, TCF3- …
Excellent outcome of acute lymphoblastic leukaemia with TCF3-PBX1 rearrangement in Hong Kong.
Lin A, Cheng FWT, Chiang AKS, Luk CW, Li RCH, Ling ASC, Cheuk DKL, Chang KO, Ku D, Lee V, Ha SY, Li CK. Lin A, et al. Pediatr Blood Cancer. 2018 Dec;65(12):e27346. doi: 10.1002/pbc.27346. Epub 2018 Jul 26. Pediatr Blood Cancer. 2018. PMID: 30051646
OBJECTIVE: The aim of this study was to review clinical outcomes and prognosis of paediatric patients with acute lymphoblastic leukaemia (ALL) with TCF3-PBX1 rearrangement. ...Compared with 239 intermediate risk patients without TCF3-PBX1 rearra …
OBJECTIVE: The aim of this study was to review clinical outcomes and prognosis of paediatric patients with acute lymphoblastic leukae …
Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling: A case report and literature review.
He GQ, Guo X, Jiang MY, Xu RR, Dai YL, Luo L, Gao J. He GQ, et al. Medicine (Baltimore). 2021 Feb 26;100(8):e24802. doi: 10.1097/MD.0000000000024802. Medicine (Baltimore). 2021. PMID: 33663097 Free PMC article.
DIAGNOSES: The child was eventually diagnosed as having precursor B cell ALL with central nervous system involved, with TCF3-PBX1 fusion gene and additional chromosomal aberrations, based on examinations of the bone marrow and brain magnetic resonance imaging. ...Ou …
DIAGNOSES: The child was eventually diagnosed as having precursor B cell ALL with central nervous system involved, with TCF3-PBX1 …
Insights into the prenatal origin of childhood acute lymphoblastic leukemia.
Hein D, Borkhardt A, Fischer U. Hein D, et al. Cancer Metastasis Rev. 2020 Mar;39(1):161-171. doi: 10.1007/s10555-019-09841-1. Cancer Metastasis Rev. 2020. PMID: 31902036 Free PMC article. Review.
Many of these aberrations originate in utero and the cells transform in early childhood through acquired secondary mutations. In this review, we will discuss the most common prenatal lesions that can lead to childhood ALL, with a special emphasis on the most common translo …
Many of these aberrations originate in utero and the cells transform in early childhood through acquired secondary mutations. In this rev …
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M. Buchner M, et al. Curr Opin Hematol. 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. Curr Opin Hematol. 2014. PMID: 24811161 Free PMC article. Review.
PURPOSE OF REVIEW: Normal B cells that have failed to productively rearrange immunoglobulin V region genes encoding a functional B-cell receptor (BCR) are destined to die. ...RECENT FINDINGS: Although the dependency on pre-BCR signaling in pre-B acute lymphoblastic leukemi …
PURPOSE OF REVIEW: Normal B cells that have failed to productively rearrange immunoglobulin V region genes encoding a functional B-ce …
Commonly Assessed Markers in Childhood BCP-ALL Diagnostic Panels and Their Association with Genetic Aberrations and Outcome Prediction.
Kulis J, Sędek Ł, Słota Ł, Perkowski B, Szczepański T. Kulis J, et al. Genes (Basel). 2022 Jul 31;13(8):1374. doi: 10.3390/genes13081374. Genes (Basel). 2022. PMID: 36011285 Free PMC article. Review.
These aberrations include: ETV6::RUNX1 fusion gene, Philadelphia chromosome (BCR::ABL1 fusion gene), rearrangements of the KMT2A, TCF3::PBX1 fusion gene and changes in chromosome number (hyperdiploidy and hypodiploidy). ...Some genetic features of leukemic cells (bl …
These aberrations include: ETV6::RUNX1 fusion gene, Philadelphia chromosome (BCR::ABL1 fusion gene), rearrangements of the KMT2A, TCF3 …
15 results