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2021 11
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114 results

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Page 1
Aicardi-Goutières syndrome: A monogenic type I interferonopathy.
Liu A, Ying S. Liu A, et al. Scand J Immunol. 2023 Oct;98(4):e13314. doi: 10.1111/sji.13314. Epub 2023 Jul 29. Scand J Immunol. 2023. PMID: 37515439 Free article. Review.
AGS may be caused by mutations in any one of nine genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, IFIH1, LSM11 and RNU7-1) that result in accumulation of self-nucleic acids in the cytoplasm or aberrant sensing of self-nucleic acids. ...
AGS may be caused by mutations in any one of nine genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, IFIH1, LSM11 and RNU7-1) …
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC. Maxwell MB, et al. Cell. 2024 Jun 20;187(13):3390-3408.e19. doi: 10.1016/j.cell.2024.04.025. Epub 2024 May 15. Cell. 2024. PMID: 38754421 Free PMC article.
Overexpression of the R-loop resolving enzyme, RNASEH2B, or cytosolic DNase, TREX1, in ARID1A-deficient cells prevented cytosolic ssDNA accumulation and ARID1A-IFN gene upregulation. ...
Overexpression of the R-loop resolving enzyme, RNASEH2B, or cytosolic DNase, TREX1, in ARID1A-deficient cells prevented cytosolic ssD …
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage.
Li L, Ye Q, Ma J, Wang Z, Liu T, Lei Y, Lu M, Kang J, Xiang H, Li B, Xu S, Wang K, Chen Y, Chen J, Ma B, Huang W, Cai M, Wu N, Li Y, An J, Jiang C, Ye R, Liu J, Lin SH, Gao Y, Ma J, Li L. Li L, et al. Cancer Cell. 2026 Feb 9;44(2):306-320.e7. doi: 10.1016/j.ccell.2025.12.013. Epub 2026 Jan 8. Cancer Cell. 2026. PMID: 41512867 Free article.
Mechanistically, the cytosolic DNA exonuclease TREX1 is degraded by the E3 ubiquitin ligase SPOP but is reversely stabilized by the deubiquitinase USP7. Cancer-associated SPOP mutations or USP7 overexpression elevate TREX1 levels, promoting cytosolic DNA degradation …
Mechanistically, the cytosolic DNA exonuclease TREX1 is degraded by the E3 ubiquitin ligase SPOP but is reversely stabilized by the d …
Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination.
Karasu ME, Toufektchan E, Chen Y, Albertelli A, Cullot G, Maciejowski J, Corn JE. Karasu ME, et al. Nat Biotechnol. 2025 Jul;43(7):1168-1176. doi: 10.1038/s41587-024-02356-3. Epub 2024 Aug 12. Nat Biotechnol. 2025. PMID: 39134754 Free PMC article.
TREX1 expression serves as a biomarker for CRISPR-Cas9-mediated HDR in that the high TREX1 expression present in many different cell types (such as U2OS, Jurkat, MDA-MB-231 and primary T cells as well as hematopoietic stem and progenitor cells) predicts poor HDR. He …
TREX1 expression serves as a biomarker for CRISPR-Cas9-mediated HDR in that the high TREX1 expression present in many differen …
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.
Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G, Manel N, Chavrier P, Piel M. Nader GPF, et al. Cell. 2021 Sep 30;184(20):5230-5246.e22. doi: 10.1016/j.cell.2021.08.035. Epub 2021 Sep 21. Cell. 2021. PMID: 34551315 Free article.
We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1 …
We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture …
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.
Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D, Zheng Y, Gao C. Zhang X, et al. Cell Rep. 2024 Jun 25;43(6):114248. doi: 10.1016/j.celrep.2024.114248. Epub 2024 May 24. Cell Rep. 2024. PMID: 38795350 Free article.
A USP8 inhibitor ameliorates pathological inflammation in Trex1(-/-) mice. Systemic lupus erythematosus (SLE) databases indicate a positive correlation between USP8 expression and SLE. ...
A USP8 inhibitor ameliorates pathological inflammation in Trex1(-/-) mice. Systemic lupus erythematosus (SLE) databases indicate a po …
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity.
Xu Y, Zhou Z, Chen W, Du F, Huang S, Qi J, Zeng Y, Su H, Wang J, Xiao C, Zhao X, Liu X, Feng Y, Li CY, Wang F, Liu Z, Zhang Y, Peng Z, Bu Z, Fu YX, Li Z, Wang D, Han C. Xu Y, et al. J Exp Med. 2025 Dec 1;222(12):e20250265. doi: 10.1084/jem.20250265. Epub 2025 Oct 7. J Exp Med. 2025. PMID: 41055714
Furthermore, Trex1 inhibition specifically reduced MSI-H/dMMR tumors growth in vivo, highlighting its clinical potential. Together, we identify the cGAS-STING-TREX1 loop as a key immune escape mechanism in MSI-H/dMMR cancers, suggesting TREX1 inhibition could …
Furthermore, Trex1 inhibition specifically reduced MSI-H/dMMR tumors growth in vivo, highlighting its clinical potential. Together, w …
Activation and regulation of cGAS-STING signaling in cancer cells.
Shim A, Chen Y, Maciejowski J. Shim A, et al. Mol Cell. 2025 Oct 16;85(20):3807-3822. doi: 10.1016/j.molcel.2025.08.030. Mol Cell. 2025. PMID: 41106370 Review.
We also highlight how key regulators, such as the exonuclease TREX1, may be co-opted to shield genomically unstable cancer cells from immune surveillance. ...
We also highlight how key regulators, such as the exonuclease TREX1, may be co-opted to shield genomically unstable cancer cells from …
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling.
Técher H, Gopaul D, Heuzé J, Bouzalmad N, Leray B, Vernet A, Mettling C, Moreaux J, Pasero P, Lin YL. Técher H, et al. Nat Commun. 2024 Jun 26;15(1):5423. doi: 10.1038/s41467-024-49740-w. Nat Commun. 2024. PMID: 38926338 Free PMC article.
Overexpression of the cytosolic nuclease TREX1 also prevented OIS. Conversely, overexpression of a dominant negative mutant of TREX1 or treatment with IFN-beta was sufficient to induce RS and DNA damage, independent of RAS(V12) induction. These data suggest that the …
Overexpression of the cytosolic nuclease TREX1 also prevented OIS. Conversely, overexpression of a dominant negative mutant of TRE …
Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair.
Zhang W, Qin X, Li G, Zhou X, Li H, Wu D, Song Y, Zhao K, Wang K, Feng X, Tan L, Wang B, Sun X, Wen Z, Yang C. Zhang W, et al. Nat Commun. 2024 Jul 9;15(1):5736. doi: 10.1038/s41467-024-50045-1. Nat Commun. 2024. PMID: 38982049 Free PMC article.
Mechanically, exercise promotes cytosolic DNA sensing-mediated inflammatory activation in senescent nucleus pulposus (NP) cells (the master cell population for IVD homeostasis maintenance), which accelerates IVDD. TREX1 serves as a crucial nuclease, and disassembly of TRAM …
Mechanically, exercise promotes cytosolic DNA sensing-mediated inflammatory activation in senescent nucleus pulposus (NP) cells (the master …
114 results