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EFFECT OF GENOTYPE AND AGE ON A DEFINED MICROBIOTA IN GNOTOBIOTIC SCID PIGLETS.
Widmer KM, Rahic-Seggerman F, Forster A, Ahrens-Kress A, Sauer M, Mooyottu S, Vinithakumari A, Dunkerson-Kurzhumov A, Sponseller B, Kiupel M, Schmitz-Esser S, Tuggle CK. Widmer KM, et al. Among authors: tuggle ck. bioRxiv [Preprint]. 2024 Sep 7:2024.09.03.611011. doi: 10.1101/2024.09.03.611011. bioRxiv. 2024. PMID: 39282343 Free PMC article. Preprint.
Severe combined immunodeficient (SCID) individuals lack functional T and B lymphocytes, leading to a deficient adaptive immune system. ...The hypothesis was that an increase in complexity of microbiota inoculum will allow for more stability in the composition of the gut mi …
Severe combined immunodeficient (SCID) individuals lack functional T and B lymphocytes, leading to a deficient adaptive immune system …
CD3ε+ Cells in Pigs With Severe Combined Immunodeficiency Due to Defects in ARTEMIS.
Boettcher AN, Cino-Ozuna AG, Solanki Y, Wiarda JE, Putz E, Owens JL, Crane SA, Ahrens AP, Loving CL, Cunnick JE, Rowland RRR, Charley SE, Dekkers JCM, Tuggle CK. Boettcher AN, et al. Among authors: tuggle ck. Front Immunol. 2020 Mar 31;11:510. doi: 10.3389/fimmu.2020.00510. eCollection 2020. Front Immunol. 2020. PMID: 32296428 Free PMC article.
Hypomorphic activity in the products from these genes can function in the development of T and B cells and is referred to as a leaky phenotype in patients and animals diagnosed with SCID. We previously described two natural, single nucleotide variants in ARTEMIS (DCLR1EC) …
Hypomorphic activity in the products from these genes can function in the development of T and B cells and is referred to as a leaky phenoty …
Novel Engraftment and T Cell Differentiation of Human Hematopoietic Cells in ART(-/-)IL2RG(-/Y) SCID Pigs.
Boettcher AN, Li Y, Ahrens AP, Kiupel M, Byrne KA, Loving CL, Cino-Ozuna AG, Wiarda JE, Adur M, Schultz B, Swanson JJ, Snella EM, Ho CS, Charley SE, Kiefer ZE, Cunnick JE, Putz EJ, Dell'Anna G, Jens J, Sathe S, Goldman F, Westin ER, Dekkers JCM, Ross JW, Tuggle CK. Boettcher AN, et al. Among authors: tuggle ck. Front Immunol. 2020 Feb 6;11:100. doi: 10.3389/fimmu.2020.00100. eCollection 2020. Front Immunol. 2020. PMID: 32117254 Free PMC article.
Next, we performed in utero injections of cultured human CD34(+) selected cord blood cells into the fetal ART(-/-)IL2RG(-/Y) SCID pigs. At birth, human CD45(+) CD3epsilon(+) cells were detected in cord and peripheral blood of in utero injected SCID piglets. ...Taken …
Next, we performed in utero injections of cultured human CD34(+) selected cord blood cells into the fetal ART(-/-)IL2RG(-/Y) SCID pig …
Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection.
Rajao DS, Loving CL, Waide EH, Gauger PC, Dekkers JC, Tuggle CK, Vincent AL. Rajao DS, et al. Among authors: tuggle ck. J Innate Immun. 2017;9(2):193-202. doi: 10.1159/000451007. Epub 2016 Dec 17. J Innate Immun. 2017. PMID: 27988511 Free PMC article.
SCID pigs challenged with H1N1pdm09 showed milder lung pathology compared to the non-SCID heterozygous carrier pigs. Viral titers in the lungs and nasal swabs of challenged SCID pigs were significantly higher than in carrier pigs 7 days postinfection, despite …
SCID pigs challenged with H1N1pdm09 showed milder lung pathology compared to the non-SCID heterozygous carrier pigs. Viral tit …
Infectivity of GII.4 human norovirus does not differ between T-B-NK(+) severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.
Annamalai T, Lu Z, Jung K, Langel SN, Tuggle CK, Dekkers JCM, Waide EH, Kandasamy S, Saif LJ. Annamalai T, et al. Among authors: tuggle ck. Virus Res. 2019 Jul 2;267:21-25. doi: 10.1016/j.virusres.2019.05.002. Epub 2019 May 2. Virus Res. 2019. PMID: 31054932 Free PMC article.
Forty SCID and non-SCID pigs were randomly grouped: 1) SCID+HuNoV (n = 12); 2) non-SCID+HuNoV (n = 14); 3) SCID mock-inoculated (n = 6); and 4) non-SCID mock-inoculated (n = 8). ...Unlike the increased infectivity of HuNoV observed previo …
Forty SCID and non-SCID pigs were randomly grouped: 1) SCID+HuNoV (n = 12); 2) non-SCID+HuNoV (n = 14); 3) SC …
SCID pigs: An emerging large animal NK model.
Powell EJ, Cunnick JE, Tuggle CK. Powell EJ, et al. Among authors: tuggle ck. J Rare Dis Res Treat. 2017;2(3):1-6. Epub 2017 Apr 18. J Rare Dis Res Treat. 2017. PMID: 29152615 Free PMC article.
Severe Combined ImmunoDeficiency (SCID) is defined as the lack or impairment of an adaptive immune system. Although SCID phenotypes are characteristically absent of T and B cells, many such SCID cellular profiles include the presence of NK cells. ...This revi …
Severe Combined ImmunoDeficiency (SCID) is defined as the lack or impairment of an adaptive immune system. Although SCID pheno …
Not All SCID Pigs Are Created Equally: Two Independent Mutations in the Artemis Gene Cause SCID in Pigs.
Waide EH, Dekkers JC, Ross JW, Rowland RR, Wyatt CR, Ewen CL, Evans AB, Thekkoot DM, Boddicker NJ, Serão NV, Ellinwood NM, Tuggle CK. Waide EH, et al. Among authors: tuggle ck. J Immunol. 2015 Oct 1;195(7):3171-9. doi: 10.4049/jimmunol.1501132. Epub 2015 Aug 28. J Immunol. 2015. PMID: 26320255 Free PMC article.
Piglets from a line of Yorkshire pigs at Iowa State University were shown to be affected by T(-)B(-)NK(+) SCID, representing, to our knowledge, the first example of naturally occurring SCID in pigs. In this study, we present evidence for two spontaneous mutations as …
Piglets from a line of Yorkshire pigs at Iowa State University were shown to be affected by T(-)B(-)NK(+) SCID, representing, to our …
Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research.
Boettcher AN, Loving CL, Cunnick JE, Tuggle CK. Boettcher AN, et al. Among authors: tuggle ck. Front Oncol. 2018 Nov 30;8:559. doi: 10.3389/fonc.2018.00559. eCollection 2018. Front Oncol. 2018. PMID: 30560086 Free PMC article.
Biocontainment facilities and positive pressure isolators are developed to limit pathogen exposure and prolong the life of SCID pigs. Raising SCID pigs in such facilities allows for completion of long-term studies such as xenotransplantation of human cells. ...We th …
Biocontainment facilities and positive pressure isolators are developed to limit pathogen exposure and prolong the life of SCID pigs. …
Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs.
Boettcher AN, Cunnick JE, Powell EJ, Egner TK, Charley SE, Loving CL, Tuggle CK. Boettcher AN, et al. Among authors: tuggle ck. Xenotransplantation. 2019 Mar;26(2):e12466. doi: 10.1111/xen.12466. Epub 2018 Oct 12. Xenotransplantation. 2019. PMID: 30311702 Free PMC article.
The development of a humanized SCID pig through xenotransplantation of human hematopoietic stem cells (HSCs) would be a further demonstration of the value of such a large animal SCID model. ...Therefore, we investigated whether porcine SIRPA binds human CD47 in the …
The development of a humanized SCID pig through xenotransplantation of human hematopoietic stem cells (HSCs) would be a further demon …
Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs.
Boettcher AN, Kiupel M, Adur MK, Cocco E, Santin AD, Bellone S, Charley SE, Blanco-Fernandez B, Risinger JI, Ross JW, Tuggle CK, Shapiro EM. Boettcher AN, et al. Among authors: tuggle ck. Front Oncol. 2019 Jan 22;9:9. doi: 10.3389/fonc.2019.00009. eCollection 2019. Front Oncol. 2019. PMID: 30723704 Free PMC article.
Tumors developed in ear tissue of three SCID pigs, while two SCID pigs developed tumors in neck tissue; no tumors were detected in non-SCID control pigs. ...Confirmation that OSPC-ARK1 cells form carcinomas in SCID pigs substantiates further developmen …
Tumors developed in ear tissue of three SCID pigs, while two SCID pigs developed tumors in neck tissue; no tumors were detecte …
15 results