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Year Number of Results
2019 10
2020 24
2021 25
2022 12
2023 15
2024 2

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80 results

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Page 1
Clinical Features and Genetic Analysis of Taiwanese Primary Immunodeficiency Patients with Prolonged Diarrhea and Monogenetic Inflammatory Bowel Disease.
Lee WI, Chen CC, Chen SH, Lai WT, Jaing TH, Ou LS, Liang CJ, Kang CC, Huang JL. Lee WI, et al. J Clin Immunol. 2023 Aug;43(6):1455-1467. doi: 10.1007/s10875-023-01503-w. Epub 2023 May 19. J Clin Immunol. 2023. PMID: 37202577
In the mono-IBD group, seventeen patients with mutant TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2), LRBA (1), TTC37 (3), IL10RA (1), STAT1 (1), ZAP70 (1), PIK3CD (1), and PIK3R1 (1) genes failed to respond to aggressive treatments. ...
In the mono-IBD group, seventeen patients with mutant TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2), LRBA (1), TTC37 (3), IL10RA (1), STAT1 (1), …
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.
Dahlvang JD, Dick JK, Sangala JA, Kennedy PR, Pomeroy EJ, Snyder KM, Moushon JM, Thefaine CE, Wu J, Hamilton SE, Felices M, Miller JS, Walcheck B, Webber BR, Moriarity BS, Hart GT. Dahlvang JD, et al. J Immunol. 2023 Apr 15;210(8):1108-1122. doi: 10.4049/jimmunol.2200488. J Immunol. 2023. PMID: 36881874 Free PMC article.
We ablated genes that encode molecules in the ADCC pathway, such as FcRgamma, CD3zeta, SYK, SHP-1, ZAP70, and the transcription factor PLZF, and tested subsequent ADCC and cytokine production. ...Importantly, SYK kinase ablation significantly enhanced cytotoxicity, cytokin …
We ablated genes that encode molecules in the ADCC pathway, such as FcRgamma, CD3zeta, SYK, SHP-1, ZAP70, and the transcription facto …
The role of competing mechanisms on Lck regulation.
Bozso SJ, Kang JJH, Nagendran J. Bozso SJ, et al. Immunol Res. 2020 Oct;68(5):289-295. doi: 10.1007/s12026-020-09148-2. Epub 2020 Aug 14. Immunol Res. 2020. PMID: 32794043 Review.
A systematic analysis of immune genes and overall survival in cancer patients.
Wang Q, Li P, Wu W. Wang Q, et al. BMC Cancer. 2019 Dec 16;19(1):1225. doi: 10.1186/s12885-019-6414-6. BMC Cancer. 2019. PMID: 31842801 Free PMC article.
Eleven out of the 48 PIGs were found to participate in the T cell receptor (TCR) signaling pathway according to the STRING database. Among these genes, ZAP70, CD3E, CD3G, CD3D, and CD247 were part of the TCR 'signal-triggering module'; (3) High expression of the PIGs invol …
Eleven out of the 48 PIGs were found to participate in the T cell receptor (TCR) signaling pathway according to the STRING database. Among t …
Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.
Quinn LM, Haldenby S, Antzcak P, Fowler A, Bullock K, Kenny J, Gilbert T, Andrews T, Diaz-Nieto R, Fenwick S, Jones R, Costello-Goldring E, Poston G, Greenhalf W, Palmer D, Malik H, Goldring C. Quinn LM, et al. Sci Rep. 2023 Apr 24;13(1):6681. doi: 10.1038/s41598-023-33096-0. Sci Rep. 2023. PMID: 37095160 Free PMC article.
Mutation-enriched pathways were primarily immunological, including innate Dectin-2 (FDR 0.001) and adaptive T-cell receptor pathways including PD-1 (FDR 0.007), CD4 phosphorylation (FDR 0.009) and ZAP70 translocation (FDR 0.009), with overlapping HLA genes. We observed can …
Mutation-enriched pathways were primarily immunological, including innate Dectin-2 (FDR 0.001) and adaptive T-cell receptor pathways includi …
Biomarker prediction in autism spectrum disorder using a network-based approach.
Rastegari M, Salehi N, Zare-Mirakabad F. Rastegari M, et al. BMC Med Genomics. 2023 Jan 23;16(1):12. doi: 10.1186/s12920-023-01439-5. BMC Med Genomics. 2023. PMID: 36691005 Free PMC article.
RESULTS: In the first step of the framework, the FA_gene algorithm finds a set of important genes; TP53, TNF, MAPK3, ACTB, TLR7, LCK, RAC2, EEF2, CAT, ZAP70, CD19, RPLP0, CDKN1A, CCL2, CDK4, CCL5, CTSD, CD4, RACK1, CD74; using co-expression and protein-protein interaction …
RESULTS: In the first step of the framework, the FA_gene algorithm finds a set of important genes; TP53, TNF, MAPK3, ACTB, TLR7, LCK, RAC2, …
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus.
Yang ML, Lam TT, Kanyo J, Kang I, Zhou ZS, Clarke SG, Mamula MJ. Yang ML, et al. Autoimmunity. 2023 Dec;56(1):2282945. doi: 10.1080/08916934.2023.2282945. Epub 2023 Nov 23. Autoimmunity. 2023. PMID: 37994408 Free article.
Herein, we demonstrate that isoAsp modifications arise within the ZAP70 protein tyrosine kinase upon T-cell antigen receptor (TCR) engagement. ...Our studies reveal a phenotypic role of isoAsp modification and phosphorylation of ZAP70 in lupus T cell autoimmunity an …
Herein, we demonstrate that isoAsp modifications arise within the ZAP70 protein tyrosine kinase upon T-cell antigen receptor (TCR) en …
Examination of clonal evolution in chronic lymphocytic leukemia.
Koczkodaj D, Popek-Marciniec S, Zmorzyński S, Wąsik-Szczepanek E, Filip AA. Koczkodaj D, et al. Med Oncol. 2019 Aug 2;36(9):79. doi: 10.1007/s12032-019-1300-2. Med Oncol. 2019. PMID: 31375939
., the expression of ZAP-70 kinase, CD38 antigen, and the mutation statuses of IGVH and NOTCH1 genes. Classic prognostic factors, i.e., categorized ZAP70 and CD38 expressions as well as mutations in IGVH and NOTCH1 genes did not influence the course of clonal evolution in …
., the expression of ZAP-70 kinase, CD38 antigen, and the mutation statuses of IGVH and NOTCH1 genes. Classic prognostic factors, i.e., cate …
Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia.
Jelloul FZ, Yang R, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda W, Jain N, Thompson P, Luthra R, Medeiros LJ, Patel KP. Jelloul FZ, et al. Leuk Res. 2022 May;116:106827. doi: 10.1016/j.leukres.2022.106827. Epub 2022 Mar 21. Leuk Res. 2022. PMID: 35430388 Free PMC article.
NOTCH1 mutations were more commonly seen in patients with unmutated IGHV, ZAP70 positivity and CD38 positivity. Mixed NOTCH1 mutations were also more commonly seen in patients with unmutated IGHV and ZAP70. ...
NOTCH1 mutations were more commonly seen in patients with unmutated IGHV, ZAP70 positivity and CD38 positivity. Mixed NOTCH1 mutation …
80 results