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2020 15
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Page 1
Identification of important genes related to anoikis in acute myocardial infarction.
Song P, Yakufujiang Y, Zhou J, Gu S, Wang W, Huo Z. Song P, et al. J Cell Mol Med. 2024 Apr;28(8):e18264. doi: 10.1111/jcmm.18264. J Cell Mol Med. 2024. PMID: 38526027 Free PMC article.
PPI network analysis was also conducted, and 10 hub genes, such as IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN were identified. IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were …
PPI network analysis was also conducted, and 10 hub genes, such as IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN were …
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus.
Yang ML, Lam TT, Kanyo J, Kang I, Zhou ZS, Clarke SG, Mamula MJ. Yang ML, et al. Autoimmunity. 2023 Dec;56(1):2282945. doi: 10.1080/08916934.2023.2282945. Epub 2023 Nov 23. Autoimmunity. 2023. PMID: 37994408 Free PMC article.
PIMT deficiency leads to T cell hyper-proliferation and hyper-phosphorylation through ZAP70 signaling. We demonstrate that inducing the overexpression of PIMT can correct the hyper-responsive phenotype in lupus T cells. Our studies reveal a phenotypic role of isoAsp modifi …
PIMT deficiency leads to T cell hyper-proliferation and hyper-phosphorylation through ZAP70 signaling. We demonstrate that inducing t …
A Novel Homozygous RHOH Variant Associated with T Cell Dysfunction and Recurrent Opportunistic Infections.
Zhou J, Qian M, Jiang N, Wu J, Feng X, Yu M, Min Q, Xu H, Yang Y, Yang Q, Zhou F, Shao L, Zhu H, Yang Y, Wang JY, Ruan Q, Zhang W. Zhou J, et al. J Clin Immunol. 2024 May 22;44(6):131. doi: 10.1007/s10875-024-01735-4. J Clin Immunol. 2024. PMID: 38775840
Furthermore, the C82Y variant showed reduced RHOH protein expression and impaired interaction with the TCR signaling molecule ZAP70. Together, these data suggest that the newly identified autosomal-recessive RHOH variant is associated with T cell dysfunction and recurrent …
Furthermore, the C82Y variant showed reduced RHOH protein expression and impaired interaction with the TCR signaling molecule ZAP70. …
Clinical Features and Genetic Analysis of Taiwanese Primary Immunodeficiency Patients with Prolonged Diarrhea and Monogenetic Inflammatory Bowel Disease.
Lee WI, Chen CC, Chen SH, Lai WT, Jaing TH, Ou LS, Liang CJ, Kang CC, Huang JL. Lee WI, et al. J Clin Immunol. 2023 Aug;43(6):1455-1467. doi: 10.1007/s10875-023-01503-w. Epub 2023 May 19. J Clin Immunol. 2023. PMID: 37202577
In the mono-IBD group, seventeen patients with mutant TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2), LRBA (1), TTC37 (3), IL10RA (1), STAT1 (1), ZAP70 (1), PIK3CD (1), and PIK3R1 (1) genes failed to respond to aggressive treatments. ...
In the mono-IBD group, seventeen patients with mutant TTC7A (2), FOXP3 (2), NEMO (2), XIAP (2), LRBA (1), TTC37 (3), IL10RA (1), STAT1 (1), …
Biomarker prediction in autism spectrum disorder using a network-based approach.
Rastegari M, Salehi N, Zare-Mirakabad F. Rastegari M, et al. BMC Med Genomics. 2023 Jan 23;16(1):12. doi: 10.1186/s12920-023-01439-5. BMC Med Genomics. 2023. PMID: 36691005 Free PMC article.
RESULTS: In the first step of the framework, the FA_gene algorithm finds a set of important genes; TP53, TNF, MAPK3, ACTB, TLR7, LCK, RAC2, EEF2, CAT, ZAP70, CD19, RPLP0, CDKN1A, CCL2, CDK4, CCL5, CTSD, CD4, RACK1, CD74; using co-expression and protein-protein interaction …
RESULTS: In the first step of the framework, the FA_gene algorithm finds a set of important genes; TP53, TNF, MAPK3, ACTB, TLR7, LCK, RAC2, …
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants.
Aykut A, Durmaz A, Karaca N, Gulez N, Genel F, Celmeli F, Cogurlu MT, Akcan M, Cicek D, Cipe FE, Kiykim A, Yıldıran A, Unluhizarci K, Kilic SS, Aksu G, Ardeniz O, Kutukculer N. Aykut A, et al. Immunol Res. 2024 Aug;72(4):714-726. doi: 10.1007/s12026-024-09477-6. Epub 2024 Apr 22. Immunol Res. 2024. PMID: 38644452 Free PMC article.
According to the latest report from the International Union of Immunological Societies (IUIS), PIRDs arise from mutations in various genes including LYST, RAB27A, AP3B1, AP3D1, PRF1, UNC13D, STX11, STXBP2, FAAP24, SLC7A7, RASGRP1, CD70, CTPS1, RLTPR, ITK, MAGT1, PRKCD, TNFRSF9, S …
According to the latest report from the International Union of Immunological Societies (IUIS), PIRDs arise from mutations in various genes i …
Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients.
Guaraldi F, Morandi L, Zoli M, Mazzatenta D, Righi A, Evangelisti S, Ambrosi F, Tonon C, Giannini C, Lloyd RV, Asioli S. Guaraldi F, et al. Clin Endocrinol (Oxf). 2022 Dec;97(6):763-772. doi: 10.1111/cen.14827. Epub 2022 Oct 7. Clin Endocrinol (Oxf). 2022. PMID: 36161330 Free PMC article.
AIP (N = 6) was the most frequently mutated gene, followed by NOTCH (4), and TP53 (3). Hypermethylation of PARP15, LINC00599, ZAP70 was more common in aggressive than non-aggressive PAs/PITNETs (p < .05). Lower levels of methylation of AIP, GNAS and PDCD1 were detec …
AIP (N = 6) was the most frequently mutated gene, followed by NOTCH (4), and TP53 (3). Hypermethylation of PARP15, LINC00599, ZAP70 w …
Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma.
Zhu Y, Jin X, Liu J, Yang W. Zhu Y, et al. Biochem Genet. 2025 Jun;63(3):2470-2488. doi: 10.1007/s10528-024-10831-4. Epub 2024 May 27. Biochem Genet. 2025. PMID: 38802691
MR analysis revealed a significant association only between zeta chain of T-cell receptor-associated protein kinase 70 (ZAP70) and FL risk, with no significance observed for the other top genes. GSEA and immune cell analysis suggested that ZAP70 may be involved in t …
MR analysis revealed a significant association only between zeta chain of T-cell receptor-associated protein kinase 70 (ZAP70) and FL …
Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia.
Jelloul FZ, Yang R, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda W, Jain N, Thompson P, Luthra R, Medeiros LJ, Patel KP. Jelloul FZ, et al. Leuk Res. 2022 May;116:106827. doi: 10.1016/j.leukres.2022.106827. Epub 2022 Mar 21. Leuk Res. 2022. PMID: 35430388 Free PMC article.
NOTCH1 mutations were more commonly seen in patients with unmutated IGHV, ZAP70 positivity and CD38 positivity. Mixed NOTCH1 mutations were also more commonly seen in patients with unmutated IGHV and ZAP70. ...
NOTCH1 mutations were more commonly seen in patients with unmutated IGHV, ZAP70 positivity and CD38 positivity. Mixed NOTCH1 mutation …
80 results