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Host-pathogen interactions involved in erythrocyte invasion by Francisella tularensis.
Schreiber RM, D'Cunha L, Hall M, DeBastiani A, Schmitt DM, Cantlay S, Horzempa J. Schreiber RM, et al. Front Cell Infect Microbiol. 2025 Sep 23;15:1664733. doi: 10.3389/fcimb.2025.1664733. eCollection 2025. Front Cell Infect Microbiol. 2025. PMID: 41064638 Free PMC article.
Here, we identified that the F. tularensis Glycine Cleavage Protein T, GcvT, interacts with the cytoplasmic domain of Band 3. A mutational analysis confirmed GcvT is required for RBC invasion by F. tularensis validating the finding that GcvT interacts …
Here, we identified that the F. tularensis Glycine Cleavage Protein T, GcvT, interacts with the cytoplasmic doma …
AMT inhibits the progression of non-small cell lung cancer by suppressing the PI3K/AKT/GSK-3β/β-catenin pathway via H3K27me3 regulation.
Gao Y, E G, Feng L, Gan P, Huang S, Tang Z, Liang Q, Wang Y, Gao Y, Zhang E. Gao Y, et al. Eur J Pharmacol. 2026 Jan 12;1011:178460. doi: 10.1016/j.ejphar.2025.178460. Epub 2025 Dec 5. Eur J Pharmacol. 2026. PMID: 41354296
The mRNA and protein expression of aminomethyltransferase (AMT), an enzyme of the glycine cleavage system, is decreased in human non-small cell lung cancer (NSCLC) and is associated with poor prognosis. ...
The mRNA and protein expression of aminomethyltransferase (AMT), an enzyme of the glycine cleavage system, is decreased …
Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching.
Perry RN, Albarracin D, Aherrahrou R, Civelek M. Perry RN, et al. Circ Genom Precis Med. 2023 Aug;16(4):372-381. doi: 10.1161/CIRCGEN.122.003781. Epub 2023 Jun 30. Circ Genom Precis Med. 2023. PMID: 37387208 Free PMC article.
CONCLUSIONS: Our work suggests that dysregulation of vascular smooth muscle cell metabolism participates in phenotypic transitioning, which may contribute to disease progression, and suggests that AMT (aminomethyltransferase) and MPI (mannose phosphate isomerase) may play …
CONCLUSIONS: Our work suggests that dysregulation of vascular smooth muscle cell metabolism participates in phenotypic transitioning, which …
Homozygosity for disease-causing variants in AMT and GLDC in a patient with severe nonketotic hyperglycinemia.
Drackley A, Peter M, Rathbun P, Ing A, Prada CE, Yap KL. Drackley A, et al. Am J Med Genet A. 2024 Aug;194(8):e63622. doi: 10.1002/ajmg.a.63622. Epub 2024 Apr 4. Am J Med Genet A. 2024. PMID: 38572626
Three genes encoding components of the glycine cleavage enzyme system-GLDC, AMT, and GCSH-are independently associated with NKH. ...Our patient demonstrates a novel combination of two homozygous disease-causing variants impacting the glycine cleavage p …
Three genes encoding components of the glycine cleavage enzyme system-GLDC, AMT, and GCSH-are independently associated with NK …