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Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling.
Chu X, Zhou Y, Zhang S, Liu S, Li G, Xin Y. Chu X, et al. Lipids Health Dis. 2022 Dec 19;21(1):140. doi: 10.1186/s12944-022-01730-x. Lipids Health Dis. 2022. PMID: 36529726 Free PMC article.
Male C57BL/6 mice were randomized and provided with control chow as the control, or high fat diet (HFD) to induce nonalcoholic fatty liver disease (NAFLD). ...CONCLUSIONS: These findings indicated that CLP treatment alleviated the gain in body weigh …
Male C57BL/6 mice were randomized and provided with control chow as the control, or high fat diet (HFD) to induce nonalcoholic …
Partial replacement of soybean meal with Chlorella vulgaris in broiler diets influences performance and improves breast meat quality and fatty acid composition.
Boskovic Cabrol M, Martins JC, Malhão LP, Alves SP, Bessa RJB, Almeida AM, Raymundo A, Lordelo M. Boskovic Cabrol M, et al. Poult Sci. 2022 Aug;101(8):101955. doi: 10.1016/j.psj.2022.101955. Epub 2022 May 9. Poult Sci. 2022. PMID: 35709682 Free PMC article.

Compared to the control group, birds supplemented with C. vulgaris (15% and 20%) had lower body weight, weight gain, and feed intake (P < 0.0001), whereas no differences were observed between the control and CV10% groups (P > 0.05). ...A 2

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Compared to the control group, birds supplemented with C. vulgaris (15% and 20%) had lower body weight, weight g …
High-intensity interval training with or without chlorella vulgaris supplementation in obese and overweight women: effects on mitochondrial biogenesis, performance and body composition.
Sanayei M, Hajizadeh-Sharafabad F, Amirsasan R, Barzegar A. Sanayei M, et al. Br J Nutr. 2022 Jul 28;128(2):200-210. doi: 10.1017/S0007114521003287. Epub 2021 Aug 26. Br J Nutr. 2022. PMID: 34433510 Clinical Trial.
This study aimed to determine the effects of CV and/or HIIT on mitochondrial biogenesis, performance and body composition among overweight/obese women. There was a significant reduction in the fat mass (FM) of the CV + HIIT group, as compared wi …
This study aimed to determine the effects of CV and/or HIIT on mitochondrial biogenesis, performance and body composition among ov …
Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial.
Sanayei M, Izadi A, Hajizadeh-Sharafabad F, Amirsasan R, Kaviani M, Barzegar A. Sanayei M, et al. J Diabetes Metab Disord. 2021 May 31;20(1):781-792. doi: 10.1007/s40200-021-00816-0. eCollection 2021 Jun. J Diabetes Metab Disord. 2021. PMID: 34178863 Free PMC article.
This investigation aimed to evaluate the effects of CV and/or HIIT on anthropometric parameters and cardiometabolic risk factors among overweight or obese women. METHODS: Present randomized double-blind clinical trial, included 46 women w …
This investigation aimed to evaluate the effects of CV and/or HIIT on anthropometric parameters and cardiometabolic risk factors among ov …
Influence of dietary Chlorella vulgaris and carbohydrate-active enzymes on growth performance, meat quality and lipid composition of broiler chickens.
Alfaia CM, Pestana JM, Rodrigues M, Coelho D, Aires MJ, Ribeiro DM, Major VT, Martins CF, Santos H, Lopes PA, Lemos JPC, Fontes CMGA, Lordelo MM, Prates JAM. Alfaia CM, et al. Poult Sci. 2021 Feb;100(2):926-937. doi: 10.1016/j.psj.2020.11.034. Epub 2020 Nov 28. Poult Sci. 2021. PMID: 33518146 Free PMC article.
Body weight gain and feed conversion rate of broilers were not affected by C. vulgaris but digesta viscosity increased more than 2-fold (P < 0.001) relative to the control. In addition, neither cooking loss, shear force, juiciness, flavor nor …
Body weight gain and feed conversion rate of broilers were not affected by C. vulgaris but digesta viscosity inc …
Ameliorative effects of dietary Chlorella vulgaris and β-glucan against diazinon-induced toxicity in Nile tilapia (Oreochromis niloticus).
Abdelhamid FM, Elshopakey GE, Aziza AE. Abdelhamid FM, et al. Fish Shellfish Immunol. 2020 Jan;96:213-222. doi: 10.1016/j.fsi.2019.12.009. Epub 2019 Dec 9. Fish Shellfish Immunol. 2020. PMID: 31821844
The results also revealed that fish in DZN-CV group had the highest survival rate, final body weight (FBW) and body weight gain (BWG). On the other hand, feed conversion ratio (FCR), specific growth rate (SGR), and protein efficien …
The results also revealed that fish in DZN-CV group had the highest survival rate, final body weight (FBW) and body …
Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea.
Haidari F, Homayouni F, Helli B, Haghighizadeh MH, Farahmandpour F. Haidari F, et al. Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:185-189. doi: 10.1016/j.ejogrb.2018.08.578. Epub 2018 Aug 27. Eur J Obstet Gynecol Reprod Biol. 2018. PMID: 30205315 Clinical Trial.
OBJECTIVE: Primary dysmenorrhea is one of the most commonly reported disorders for women that have unfavorable effects on patient's quality of life. Based on the evidences that suggest the anti-inflammatory and analgesic properties of chlorella, this double-blind …
OBJECTIVE: Primary dysmenorrhea is one of the most commonly reported disorders for women that have unfavorable effects on patient's q …
The effect of Chlorella pyrenoidosa supplementation on immune responses to 2 days of intensified training.
Chidley C, Davison G. Chidley C, et al. Eur J Nutr. 2018 Oct;57(7):2529-2536. doi: 10.1007/s00394-017-1525-9. Epub 2017 Aug 19. Eur J Nutr. 2018. PMID: 28825174 Free PMC article.
METHODS: Twenty-six subjects (age 29.1 8.7 years; VO(2max) 53.7 11.7 ml kg min(-1)) provided resting saliva samples for determination of sIgA, at baseline (week-0) and following 4, 5, and 6 weeks (weeks-4, -5, -6) of daily supplementation with 6 g/day Chlorella (n = 13) or …
METHODS: Twenty-six subjects (age 29.1 8.7 years; VO(2max) 53.7 11.7 ml kg min(-1)) provided resting saliva samples for determination of sIg …
Effect of Chlorella Ingestion on Oxidative Stress and Fatigue Symptoms in Healthy Men.
Okada H, Yoshida N, Kakuma T, Toyomasu K. Okada H, et al. Kurume Med J. 2018 Jul 10;64(4):83-90. doi: 10.2739/kurumemedj.MS644001. Epub 2018 May 21. Kurume Med J. 2018. PMID: 29780062 Free article. Clinical Trial.
METHOD: We conducted a double-blind, parallel-arm controlled study. Twenty-seven healthy male volunteers (mean age, 35.410.4 years) were randomly divided into the chlorella and placebo groups, and received chlorella (6 g/day) and lactose as placebo …
METHOD: We conducted a double-blind, parallel-arm controlled study. Twenty-seven healthy male volunteers (mean age, 35.410.4 years) w …
Influences of Chlorella vulgaris dietary supplementation on growth performance, hematology, immune response and disease resistance in Oreochromis niloticus exposed to sub-lethal concentrations of penoxsulam herbicide.
Galal AAA, Reda RM, Abdel-Rahman Mohamed A. Galal AAA, et al. Fish Shellfish Immunol. 2018 Jun;77:445-456. doi: 10.1016/j.fsi.2018.04.011. Epub 2018 Apr 4. Fish Shellfish Immunol. 2018. PMID: 29626668
Therefore, the current study was undertaken to highlight the effects of penoxsulam exposure on O. niloticus and to evaluate the advantages of Chlorella vulgaris (CV) dietary supplementation against the induced effects. ...Sub-acute penoxsulam exposure significantly …
Therefore, the current study was undertaken to highlight the effects of penoxsulam exposure on O. niloticus and to evaluate the advantages o …
Effects of protein sources on growth, immunity and antioxidant capacity of juvenile pearl oyster Pinctada fucata martensii.
Yang C, Hao R, Deng Y, Liao Y, Wang Q, Sun R, Jiao Y, Du X. Yang C, et al. Fish Shellfish Immunol. 2017 Aug;67:411-418. doi: 10.1016/j.fsi.2017.06.037. Epub 2017 Jun 15. Fish Shellfish Immunol. 2017. PMID: 28624469
In this study, we formulated five diets, namely, P1, P2, P3, P4 and P5, with Chlorella sp. powder, Spirulina platensis powder, yeast powder, soybean meal and corn gluten, respectively, as major protein sources. ...Significantly higher expression levels of SOD, GPx, CAT, he …
In this study, we formulated five diets, namely, P1, P2, P3, P4 and P5, with Chlorella sp. powder, Spirulina platensis powder, yeast …
Effects of dietary supplementation with freshwater microalgae on growth performance, nutrient digestibility and gut health in weaned piglets.
Furbeyre H, van Milgen J, Mener T, Gloaguen M, Labussière E. Furbeyre H, et al. Animal. 2017 Feb;11(2):183-192. doi: 10.1017/S1751731116001543. Epub 2016 Jul 25. Animal. 2017. PMID: 27452961 Free article. Clinical Trial.
Dietary supplementation with microalgae as an alternative to antibiotic use was studied in two trials (72 piglets with initial BW=9.11.1 kg in trial 1 and 24 piglets with initial BW=9.10.9 kg in trial 2). ...In trial 1, 94% of the pigs had diarrhoea in …
Dietary supplementation with microalgae as an alternative to antibiotic use was studied in two trials (72 piglets with initial BW=9.1 …
A dietary cholesterol challenge study to assess Chlorella supplementation in maintaining healthy lipid levels in adults: a double-blinded, randomized, placebo-controlled study.
Kim S, Kim J, Lim Y, Kim YJ, Kim JY, Kwon O. Kim S, et al. Nutr J. 2016 May 13;15(1):54. doi: 10.1186/s12937-016-0174-9. Nutr J. 2016. PMID: 27177615 Free PMC article. Clinical Trial.
This study aimed to conduct a pioneering investigation to clarify this issue in healthy subjects by adopting a dietary cholesterol challenge, which has not been used previously in similar studies of Chlorella in hypercholesterolemia. METHODS: In this double blind, …
This study aimed to conduct a pioneering investigation to clarify this issue in healthy subjects by adopting a dietary cholesterol challenge …
Isolation of a novel lutein-protein complex from Chlorella vulgaris and its functional properties.
Cai X, Huang Q, Wang S. Cai X, et al. Food Funct. 2015 Jun;6(6):1893-9. doi: 10.1039/c4fo01096e. Food Funct. 2015. PMID: 25945783
A novel kind of lutein-protein complex (LPC) was extracted from heterotrophic Chlorella vulgaris through aqueous extraction. The purification procedure contained solubilization of thylakoid proteins by a zwitterionic detergent CHAPS, anion exchange chromatography an …
A novel kind of lutein-protein complex (LPC) was extracted from heterotrophic Chlorella vulgaris through aqueous extraction. T …
Domestication of the green alga Chlorella sorokiniana: reduction of antenna size improves light-use efficiency in a photobioreactor.
Cazzaniga S, Dall'Osto L, Szaub J, Scibilia L, Ballottari M, Purton S, Bassi R. Cazzaniga S, et al. Biotechnol Biofuels. 2014 Oct 21;7(1):157. doi: 10.1186/s13068-014-0157-z. eCollection 2014. Biotechnol Biofuels. 2014. PMID: 25352913 Free PMC article.
Such domestication strategies include decreasing the absorption cross section in order to enhance light penetration, increasing the size of metabolic sinks per chlorophyll and minimizing feedback energy dissipation. RESULTS: In this work we applied random mut …
Such domestication strategies include decreasing the absorption cross section in order to enhance light penetration, increasing the size of …
Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides.
Szabo NJ, Matulka RA, Chan T. Szabo NJ, et al. Food Chem Toxicol. 2013 Sep;59:34-45. doi: 10.1016/j.fct.2013.05.035. Epub 2013 Jun 1. Food Chem Toxicol. 2013. PMID: 23733102
Whole Algalin Protein (WAP) from dried milled Chlorella protothecoides was evaluated for dietary safety in a 13-week feeding trial in rodents with genotoxic potential evaluated using in vitro and in vivo assays and the likelihood of food allergy potential evaluated …
Whole Algalin Protein (WAP) from dried milled Chlorella protothecoides was evaluated for dietary safety in a 13-week feeding trial …
Investigation of the effects of Chlorella vulgaris supplementation on the modulation of oxidative stress in apparently healthy smokers.
Panahi Y, Mostafazadeh B, Abrishami A, Saadat A, Beiraghdar F, Tavana S, Pishgoo B, Parvin S, Sahebkar A. Panahi Y, et al. Clin Lab. 2013;59(5-6):579-87. doi: 10.7754/clin.lab.2012.120110. Clin Lab. 2013. PMID: 23865357 Clinical Trial.
The present study evaluated the effect of supplementation with Chlorella vulgaris, a nutrient and bioactive green microalgae with proven antioxidant capacity, on the burden of oxidative stress in Iranian smokers. ...Hence, C. vulgaris might prevent the dis …
The present study evaluated the effect of supplementation with Chlorella vulgaris, a nutrient and bioactive green microalgae w …
Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants.
Otsuki T, Shimizu K, Iemitsu M, Kono I. Otsuki T, et al. Nutr J. 2012 Dec 11;11:103. doi: 10.1186/1475-2891-11-103. Nutr J. 2012. PMID: 23227811 Free PMC article. Clinical Trial.
Here, we investigated whether intake of this chlorella-derived supplement attenuated the reduced salivary SIgA secretion rate during a kendo training camp. METHODS: Ten female kendo athletes participated in inter-university 6-day spring and 4-day summer camps …
Here, we investigated whether intake of this chlorella-derived supplement attenuated the reduced salivary SIgA secretion ra …
Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial.
Panahi Y, Ghamarchehreh ME, Beiraghdar F, Zare R, Jalalian HR, Sahebkar A. Panahi Y, et al. Hepatogastroenterology. 2012 Oct;59(119):2099-2103. doi: 10.5754/hge10860. Hepatogastroenterology. 2012. PMID: 23234816 Clinical Trial.
BACKGROUND/AIMS: To investigate the advantage of Chlorella vulgaris supplementation as an adjunctive therapy in patients with non-alcoholic fatty liver disease (NAFLD). ...Weight, body mass index (BMI), homeostasis model ass …
BACKGROUND/AIMS: To investigate the advantage of Chlorella vulgaris supplementation as an adjunctive therapy in patients with …
Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase.
Ryabinina OP, Minko IG, Lasarev MR, McCullough AK, Lloyd RS. Ryabinina OP, et al. DNA Repair (Amst). 2011 Oct 10;10(10):1014-22. doi: 10.1016/j.dnarep.2011.07.015. Epub 2011 Sep 1. DNA Repair (Amst). 2011. PMID: 21889915 Free PMC article.
Based on the co-crystal structures of bacteriophage T4-pdg and homology modeling of a related enzyme from Paramecium bursaria Chlorella virus-1, the structure-function basis for the processive incision activity for both enzymes was investigated using site-directed mutagene …
Based on the co-crystal structures of bacteriophage T4-pdg and homology modeling of a related enzyme from Paramecium bursaria Chlorella …
Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study.
Otsuki T, Shimizu K, Iemitsu M, Kono I. Otsuki T, et al. Nutr J. 2011 Sep 9;10:91. doi: 10.1186/1475-2891-10-91. Nutr J. 2011. PMID: 21906314 Free PMC article. Clinical Trial.
The purpose of this study was to investigate whether chlorella ingestion increases the salivary secretory immunoglobulin A (SIgA) secretion in humans using a blind, randomized, crossover study design. ...Although the SIgA secretion rate was not affecte …
The purpose of this study was to investigate whether chlorella ingestion increases the salivary secretory immunoglobulin A (SIgA) sec …
Enhancement of lutein production in Chlorella sorokiniana (Chorophyta) by improvement of culture conditions and random mutagenesis.
Cordero BF, Obraztsova I, Couso I, Leon R, Vargas MA, Rodriguez H. Cordero BF, et al. Mar Drugs. 2011;9(9):1607-1624. doi: 10.3390/md9091607. Epub 2011 Sep 20. Mar Drugs. 2011. PMID: 22131961 Free PMC article.
Chlorella sorokiniana has been selected for lutein production, after a screening of thirteen species of microalgae, since it showed both a high content in this carotenoid and a high growth rate. The effects of several nutritional and environmental factors on cell gr …
Chlorella sorokiniana has been selected for lutein production, after a screening of thirteen species of microalgae, since it showed b …
Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction.
Bedirli A, Kerem M, Ofluoglu E, Salman B, Katircioglu H, Bedirli N, Yilmazer D, Alper M, Pasaoglu H. Bedirli A, et al. Clin Nutr. 2009 Dec;28(6):674-8. doi: 10.1016/j.clnu.2009.06.001. Epub 2009 Jul 8. Clin Nutr. 2009. PMID: 19589628
Main outcome measures were endotoxin concentrations in plasma, evidence of bacterial translocation (BT) in mesenteric lymph nodes (MLNs) and liver, oxidative stress, and histology. RESULTS: Compared to the group I, a significant increase in contamined MLNs, liver, and sple …
Main outcome measures were endotoxin concentrations in plasma, evidence of bacterial translocation (BT) in mesenteric lymph nodes (ML …
Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study.
Shimada M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi T. Shimada M, et al. Clin Exp Hypertens. 2009 Jun;31(4):342-54. doi: 10.1080/10641960902977908. Clin Exp Hypertens. 2009. PMID: 19811362 Clinical Trial.
The anti-hypertensive effect of GABA-rich Chlorella was studied after oral administration for 12 weeks in the subjects with high-normal blood pressure and borderline hypertension in the placebo-controlled, double-blind manner in order to investigate if …
The anti-hypertensive effect of GABA-rich Chlorella was studied after oral administration for 12 weeks in the subjects with hi …
Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.
Mizoguchi T, Takehara I, Masuzawa T, Saito T, Naoki Y. Mizoguchi T, et al. J Med Food. 2008 Sep;11(3):395-404. doi: 10.1089/jmf.2006.0180. J Med Food. 2008. PMID: 18800884 Clinical Trial.
We conducted blood biochemical tests and analyzed gene expression profile in whole blood cells in the peripheral blood before and after Chlorella intake. We confirmed that in both groups, Chlorella intake resulted in noticeable reductions in body …
We conducted blood biochemical tests and analyzed gene expression profile in whole blood cells in the peripheral blood before and after C …
Transfer and trapping of excitation energy in photosystem II as studied by chlorophyll alpha 2 fluorescence quenching by dinitrobenzene and carotenoid triplet. The matrix model.
Sonneveld A, Rademaker H, Duysens LN. Sonneveld A, et al. Biochim Biophys Acta. 1980 Dec 3;593(2):272-89. doi: 10.1016/0005-2728(80)90065-1. Biochim Biophys Acta. 1980. PMID: 6786339
The fluorescence yield as a function of the concentration of a quencher is described for three models for the energy transfer between the units, and the matrix model. If it is assumed that the rate constant of quenching by dinitrobenzene is high and thus the number …
The fluorescence yield as a function of the concentration of a quencher is described for three models for the energy transfer between …
Time course and quantum efficiency of photosynthesis in Chlorella.
BRACKETT FS, OLSON RA, CRICKARD RG. BRACKETT FS, et al. J Gen Physiol. 1953 Mar;36(4):563-79. doi: 10.1085/jgp.36.4.563. J Gen Physiol. 1953. PMID: 13035069 Free PMC article.
Dark adaptation under aerobic conditions produces an initial photosynthetic rate of nearly zero. The immediate rise to steady state is somewhat logarithmic in character and may require over 3 minutes. 5. In intermittent light (of periods from 1 to 6 minutes) the induction …
Dark adaptation under aerobic conditions produces an initial photosynthetic rate of nearly zero. The immediate rise to steady state i …