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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1969 1
1974 1
1976 1
1977 1
1979 2
1980 4
1983 2
1984 1
1985 3
1986 4
1987 2
1988 3
1989 2
1990 5
1991 7
1992 6
1993 3
1994 2
1995 6
1996 9
1997 9
1998 12
1999 12
2000 14
2001 15
2002 31
2003 41
2004 65
2005 80
2006 159
2007 169
2008 254
2009 373
2010 424
2011 604
2012 835
2013 1169
2014 1688
2015 2144
2016 2698
2017 3346
2018 4216
2019 5601
2020 6627
2021 7057
2022 6684
2023 6884
2024 11234
2025 15121
2026 9048

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77,263 results

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Page 1
Interaction between drugs and the gut microbiome.
Weersma RK, Zhernakova A, Fu J. Weersma RK, et al. Gut. 2020 Aug;69(8):1510-1519. doi: 10.1136/gutjnl-2019-320204. Epub 2020 May 14. Gut. 2020. PMID: 32409589 Free PMC article. Review.
The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome composition can be influenced by drugs, but, vice versa, the gut microbiome can also influence an individual's response to a …
The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome …
Mechanisms and consequences of intestinal dysbiosis.
Weiss GA, Hennet T. Weiss GA, et al. Cell Mol Life Sci. 2017 Aug;74(16):2959-2977. doi: 10.1007/s00018-017-2509-x. Epub 2017 Mar 28. Cell Mol Life Sci. 2017. PMID: 28352996 Free PMC article. Review.
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota itself. Natural variations in the gut microbiota can deteriorate to …
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the …
Mapping human microbiome drug metabolism by gut bacteria and their genes.
Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, Goodman AL. Zimmermann M, et al. Nature. 2019 Jun;570(7762):462-467. doi: 10.1038/s41586-019-1291-3. Epub 2019 Jun 3. Nature. 2019. PMID: 31158845 Free PMC article.
We combined high-throughput genetic analyses with mass spectrometry to systematically identify microbial gene products that metabolize drugs. These microbiome-encoded enzymes can directly and substantially affect intestinal and systemic drug metabolism in mic …
We combined high-throughput genetic analyses with mass spectrometry to systematically identify microbial gene products that metabolize dr …
Chemical transformation of xenobiotics by the human gut microbiota.
Koppel N, Maini Rekdal V, Balskus EP. Koppel N, et al. Science. 2017 Jun 23;356(6344):eaag2770. doi: 10.1126/science.aag2770. Science. 2017. PMID: 28642381 Free PMC article. Review.
The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of dietary components, industrial chemicals, and pharmaceuticals into metabolites with altered activities, toxicities, and lifetimes within the bod …
The human gut microbiota makes key contributions to the metabolism of ingested compounds (xenobiotics), transforming hundreds of diet …
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism.
Huang F, Zheng X, Ma X, Jiang R, Zhou W, Zhou S, Zhang Y, Lei S, Wang S, Kuang J, Han X, Wei M, You Y, Li M, Li Y, Liang D, Liu J, Chen T, Yan C, Wei R, Rajani C, Shen C, Xie G, Bian Z, Li H, Zhao A, Jia W. Huang F, et al. Nat Commun. 2019 Oct 31;10(1):4971. doi: 10.1038/s41467-019-12896-x. Nat Commun. 2019. PMID: 31672964 Free PMC article.
Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. ...Our results shed light into the mechanisms behind the cholesterol- and lipid-lowering effects of Pu …
Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated wit …
Pueraria lobata-derived exosome-like nanovesicles alleviate rheumatoid arthritis via targeting Ruminococcus gnavus phenylethylamine production.
Han B, Jiang Y, Liu H, Zhang F, Xu Y, Li Z, Zheng S, Ma F, Shi H, Jia X, Chen J, Tan L, Fan H, Lv S, Gao L, Zhao X, Zhou HW, Li J, Hong M. Han B, et al. Gut. 2026 May 12;75(6):1123-1135. doi: 10.1136/gutjnl-2025-336451. Gut. 2026. PMID: 41475979
As key roles mediating interkingdom crosstalk among plants, microbiomes and mammals, plant-derived exosome-like nanoparticles (ELNs) could use lipids and microRNA components to precisely modulate gene expression of gut microbiota, showing potential as a dietary inte …
As key roles mediating interkingdom crosstalk among plants, microbiomes and mammals, plant-derived exosome-like nanoparticles (ELNs) …
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome.
Javdan B, Lopez JG, Chankhamjon P, Lee YJ, Hull R, Wu Q, Wang X, Chatterjee S, Donia MS. Javdan B, et al. Cell. 2020 Jun 25;181(7):1661-1679.e22. doi: 10.1016/j.cell.2020.05.001. Epub 2020 Jun 10. Cell. 2020. PMID: 32526207 Free PMC article.
Here, we develop a quantitative experimental framework for mapping the ability of the human gut microbiome to metabolize small molecule drugs: Microbiome-Derived Metabolism (MDM)-Screen. ...Our framework identifies novel drug-microbiome interact …
Here, we develop a quantitative experimental framework for mapping the ability of the human gut microbiome to metabolize small molecu …
Pharmacomicrobiomics.
Gronich N, Geva-Zatorsky N, Herren R, Kelly L, Cohen Z, Zhou H, Chen YC, Shah K, Robinson-Catala TA, Frisby G, Karnes JH, Shoda L. Gronich N, et al. Clin Pharmacol Ther. 2025 Dec;118(6):1366-1377. doi: 10.1002/cpt.70066. Epub 2025 Sep 28. Clin Pharmacol Ther. 2025. PMID: 41017122 Free PMC article. Review.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug-metabolizing enzymes, …
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, …
Pharmacokinetic and pharmacodynamic alterations in older people: what we know so far.
Mangoni AA, Woodman RJ, Jarmuzewska EA. Mangoni AA, et al. Expert Opin Drug Metab Toxicol. 2025 Jul;21(7):811-829. doi: 10.1080/17425255.2025.2503848. Epub 2025 May 11. Expert Opin Drug Metab Toxicol. 2025. PMID: 40338211 Review.
Complex therapeutic decisions may increase the risk of inappropriate polypharmacy, drug-drug, and drug-disease interactions in the context of age-associated pharmacokinetic and pharmacodynamic alterations, with consequent drug accumulation and toxicity …
Complex therapeutic decisions may increase the risk of inappropriate polypharmacy, drug-drug, and drug-disease interact …
Xiaoyaosan improves depression-like behaviours in mice with post-stroke depression by modulating gut microbiota and microbial metabolism and regulating P2X7R/NLRP3 inflammasome.
Chen YY, Lu YT, Wang YD, Ding NN, Huang ZX, Hu JB, Tong JX, Zhang YR, Deng LJ, Luo X, Hao WZ, Chen JX. Chen YY, et al. Phytomedicine. 2025 Sep;145:157078. doi: 10.1016/j.phymed.2025.157078. Epub 2025 Jul 13. Phytomedicine. 2025. PMID: 40684490
In addition, by performing faecal microbiota transplantation (FMT) on PSD mice with faecal bacteria treated with XYS, the authors further clarified the relationship between intestinal flora disorder, the onset of PSD, and the intervention effect of XYS. ...XYS inhib …
In addition, by performing faecal microbiota transplantation (FMT) on PSD mice with faecal bacteria treated with XYS, the auth …
77,263 results
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