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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1988 1
1989 2
1990 5
1991 3
1992 9
1993 5
1994 3
1995 7
1996 9
1997 6
1998 9
1999 8
2000 6
2001 12
2002 16
2003 7
2004 10
2005 19
2006 13
2007 18
2008 18
2009 16
2010 18
2011 18
2012 29
2013 20
2014 17
2015 23
2016 26
2017 15
2018 17
2019 19
2020 16
2021 18
2022 10
2023 5
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2025 12
2026 7

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434 results

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Page 1
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration.
Verma M, Lizama BN, Chu CT. Verma M, et al. Transl Neurodegener. 2022 Jan 25;11(1):3. doi: 10.1186/s40035-021-00278-7. Transl Neurodegener. 2022. PMID: 35078537 Free PMC article. Review.
However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death following acute brain injuries such as stroke and trauma. While excitotoxic cell death has also been implicated in some neurodegenerative disease models, th …
However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death following acute brain injuries …
Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration.
Arnold FJ, Putka AF, Raychaudhuri U, Hsu S, Bedlack RS, Bennett CL, La Spada AR. Arnold FJ, et al. Int J Mol Sci. 2024 May 21;25(11):5587. doi: 10.3390/ijms25115587. Int J Mol Sci. 2024. PMID: 38891774 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder. While there are five FDA-approved drugs for treating this disease, each has only modest benefits. ...By identifying key targets in the excitotoxicity cascade, we emphasize the importance o …
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder. While there are five FDA-approved drugs for treating th …
Alternative excitotoxic hypotheses.
Albin RL, Greenamyre JT. Albin RL, et al. Neurology. 1992 Apr;42(4):733-8. doi: 10.1212/wnl.42.4.733. Neurology. 1992. PMID: 1314341 Review.
While there is strong evidence supporting the role of excitotoxicity in acute processes such as hypoxia/ischemia and hypoglycemia, the role of excitotoxicity in chronic neurologic disease is not firmly established. To account for the inter- and intraregional variations in …
While there is strong evidence supporting the role of excitotoxicity in acute processes such as hypoxia/ischemia and hypoglycemia, the role …
Excitotoxicity and neurodegenerative diseases.
Ikonomidou C, Turski L. Ikonomidou C, et al. Curr Opin Neurol. 1995 Dec;8(6):487-97. doi: 10.1097/00019052-199512000-00017. Curr Opin Neurol. 1995. PMID: 8845937 Review.
Glutamate is an excitatory neurotransmitter in the mammalian central nervous system and a neurotoxin (excitotoxin) that has the potential to destroy neurones by activation of ionotropic receptors. In contrast to the well documented role of glutamate in the pathogenesis of …
Glutamate is an excitatory neurotransmitter in the mammalian central nervous system and a neurotoxin (excitotoxin) that has the potential to …
Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target.
Bogaert E, d'Ydewalle C, Van Den Bosch L. Bogaert E, et al. CNS Neurol Disord Drug Targets. 2010 Jul;9(3):297-304. doi: 10.2174/187152710791292576. CNS Neurol Disord Drug Targets. 2010. PMID: 20406181 Review.
In this review, we give an overview of the contribution of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis (ALS). The selective motor neuron death that is the hallmark of this neurodegenerative disease seems to be related to a number of in …
In this review, we give an overview of the contribution of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis (ALS). The se …
Apoptosis, excitotoxicity, and neuropathology.
Leist M, Nicotera P. Leist M, et al. Exp Cell Res. 1998 Mar 15;239(2):183-201. doi: 10.1006/excr.1997.4026. Exp Cell Res. 1998. PMID: 9521837 Review.
While a high rate of cell loss is tolerated and even required to model the developing nervous system, an increased rate of cell death in the adult nervous system underlies neurodegenerative disease. Evolutionarily conserved mechanisms involving proteases, Bcl-2-rela …
While a high rate of cell loss is tolerated and even required to model the developing nervous system, an increased rate of cell death in the …
Excitotoxicity as a Target Against Neurodegenerative Processes.
Binvignat O, Olloquequi J. Binvignat O, et al. Curr Pharm Des. 2020;26(12):1251-1262. doi: 10.2174/1381612826666200113162641. Curr Pharm Des. 2020. PMID: 31931694 Review.
Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury and death of neurons due to excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role. ...Despi …
Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury a …
Excitotoxicity and amyotrophic lateral sclerosis.
Van Damme P, Dewil M, Robberecht W, Van Den Bosch L. Van Damme P, et al. Neurodegener Dis. 2005;2(3-4):147-59. doi: 10.1159/000089620. Neurodegener Dis. 2005. PMID: 16909020 Review.
Since its description by Charcot more than 130 years ago, the pathogenesis of selective motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains unsolved. Over the years, many pathogenic mechanisms have been proposed. ...In this review, we will give …
Since its description by Charcot more than 130 years ago, the pathogenesis of selective motor neuron degeneration in amyotroph …
Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms.
Khan S, Bano N, Ahamad S, John U, Dar NJ, Bhat SA. Khan S, et al. Aging Dis. 2024 Aug 1;16(5):2504-2543. doi: 10.14336/AD.2024.0125-1. Aging Dis. 2024. PMID: 39122453 Free PMC article. Review.
This review centers on elucidating the role(s) of excitotoxicity, oxytosis/ferroptosis and neurodegeneration within the context of mitochondrial bioenergetics, biogenesis, mitophagy and oxidative stress and explores their intricate interplay in the pathogenesis of neuro …
This review centers on elucidating the role(s) of excitotoxicity, oxytosis/ferroptosis and neurodegeneration within the context of mi …
Excitotoxin-mediated neuron death in youth and old age.
Olney JW. Olney JW. Prog Brain Res. 1990;86:37-51. doi: 10.1016/s0079-6123(08)63165-9. Prog Brain Res. 1990. PMID: 1982368 Review.
I have briefly described several classes of anti-excitotoxic agents which are currently under study for their ability to protect neurons against excitotoxin-mediated neuronal degeneration. There is growing interest in the possibility that such agents, especia …
I have briefly described several classes of anti-excitotoxic agents which are currently under study for their ability to protect neurons …
434 results