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Integrated transcriptomics and machine learning reveal REN as a dual regulator of tumor stemness and NK cell evasion in Wilms tumor progression.
Cao Q, Li J, Zou Y, Xu C, Tang H, Chen M. Cao Q, et al. Front Immunol. 2025 Jun 4;16:1612987. doi: 10.3389/fimmu.2025.1612987. eCollection 2025. Front Immunol. 2025. PMID: 40534868 Free PMC article.
Additionally, molecular docking simulations and in vitro functional assays were performed to validate the role of key regulators in tumor stemness and immune evasion, as well as to explore potential therapeutic strategies targeting these molecular drivers. RESULTS: Renin …
Additionally, molecular docking simulations and in vitro functional assays were performed to validate the role of key regulators in tumor st …
Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis.
Peterson TE, Lima JAC, Shah SJ, Bluemke DA, Bertoni AG, Liu Y, Ngo D, Varadarajan V, Mychaleckyj JC, Johnson CW, Psaty BM, Clish CB, Taylor KD, Durda P, Tracy RP, Gerszten RE, Rich SS, Rotter JI, Post WS, Pankow JS. Peterson TE, et al. ESC Heart Fail. 2025 Feb;12(1):239-249. doi: 10.1002/ehf2.15073. Epub 2024 Sep 12. ESC Heart Fail. 2025. PMID: 39263947 Free PMC article.

Following adjustment for renal function and traditional CVD risk factors, plasma levels of 3 proteins were associated with LV mass index at both time points with the same directionality (FDR < 0.05): leptin (LEP), renin (REN), and cathepsin-D (CTSD); 20 with LV e

…
Following adjustment for renal function and traditional CVD risk factors, plasma levels of 3 proteins were associated with LV mass index at …
The Angiotensin-converting Enzyme Insertion/Deletion Polymorphism as a Common Risk Factor for Major Pregnancy Complications.
Gintoni I, Adamopoulou M, Yapijakis C. Gintoni I, et al. In Vivo. 2021 Jan-Feb;35(1):95-103. doi: 10.21873/invivo.12236. In Vivo. 2021. PMID: 33402454 Free PMC article. Review.
A key functional polymorphism of the ACE gene is the insertion/deletion (I/D) polymorphism, which affects gene expression and product levels, and can therefore lead to high blood pressure and/or reduced fibrinolytic activity. ...This review discusses how the ACE I/D …
A key functional polymorphism of the ACE gene is the insertion/deletion (I/D) polymorphism, which affects gene expression and …
Leader peptide or pro-segment mutants of renin are misrouted to mitochondria in autosomal dominant tubulointerstitial kidney disease.
Schaeffer C, De Fusco M, Pasqualetto E, Scolari C, Izzi C, Scolari F, Rampoldi L. Schaeffer C, et al. Dis Model Mech. 2023 Jun 1;16(6):dmm049963. doi: 10.1242/dmm.049963. Epub 2023 Jun 7. Dis Model Mech. 2023. PMID: 37283036 Free PMC article.
Autosomal dominant tubulointerstitial kidney disease (ADTKD), a rare genetic disorder characterised by progressive chronic kidney disease, is caused by mutations in different genes, including REN, encoding renin. Renin is a secreted protease composed o …
Autosomal dominant tubulointerstitial kidney disease (ADTKD), a rare genetic disorder characterised by progressive chronic kidney disease, i …
Vitamin D decreases silencer methylation to downregulate renin gene expression.
Govender D, Damjanovic L, Gaza CA, Meyer V. Govender D, et al. Gene. 2021 Jun 20;786:145623. doi: 10.1016/j.gene.2021.145623. Epub 2021 Mar 31. Gene. 2021. PMID: 33798678
Renin, encoded by REN, is an essential enzyme in the renin-angiotensin aldosterone system (RAAS) which is responsible for the maintenance of blood pressure homeostasis. ...We hypothesized that in addition to these, differential DNA methylation is linked to …
Renin, encoded by REN, is an essential enzyme in the renin-angiotensin aldosterone system (RAAS) which is responsible f …
Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer.
Mehranfard D, Perez G, Rodriguez A, Ladna JM, Neagra CT, Goldstein B, Carroll T, Tran A, Trivedi M, Speth RC. Mehranfard D, et al. J Renin Angiotensin Aldosterone Syst. 2021 Jul 5;2021:9987115. doi: 10.1155/2021/9987115. eCollection 2021. J Renin Angiotensin Aldosterone Syst. 2021. PMID: 34285715 Free PMC article.
MATERIALS AND METHODS: Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically. ...Expr …
MATERIALS AND METHODS: Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip array …
Identification of key genes and validation of key gene aquaporin 1 on Wilms' tumor metastasis.
Liu H, Jin C, Yang X, Xia N, Guo C, Dong Q. Liu H, et al. PeerJ. 2023 Oct 26;11:e16025. doi: 10.7717/peerj.16025. eCollection 2023. PeerJ. 2023. PMID: 37904849 Free PMC article.
METHODS: Differentially expressed genes (DEGs) were generated from WT gene expression data sets from the Gene Expression Omnibus (GEO) database. ...Finally, top five key genes were identified using CytoHubba, including Renin (REN), nephro …
METHODS: Differentially expressed genes (DEGs) were generated from WT gene expression data sets from the Gene Expressio …
Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.
Takeda Y, Itaya-Hironaka A, Yamauchi A, Makino M, Sakuramoto-Tsuchida S, Ota H, Kawaguchi R, Takasawa S. Takeda Y, et al. Int J Mol Sci. 2021 Sep 19;22(18):10127. doi: 10.3390/ijms221810127. Int J Mol Sci. 2021. PMID: 34576290 Free PMC article.
We exposed human HEK293 and mouse As4.1 renal cells to experimental IH or normoxia for 24 h and then measured the mRNA levels using a real-time reverse transcription polymerase chain reaction. The mRNA levels of Renin (Ren) and Cd38 were significantly increased by I …
We exposed human HEK293 and mouse As4.1 renal cells to experimental IH or normoxia for 24 h and then measured the mRNA levels using a real-t …
Upregulation of the Renin-Angiotensin System Is Associated with Patient Survival and the Tumour Microenvironment in Glioblastoma.
Lozinski M, Lumbers ER, Bowden NA, Martin JH, Fay MF, Pringle KG, Tooney PA. Lozinski M, et al. Cells. 2024 Apr 5;13(7):634. doi: 10.3390/cells13070634. Cells. 2024. PMID: 38607073 Free PMC article.
We studied the expression of RAS-related genes (ATP6AP2, AGTR1, AGTR2, ACE, AGT, and REN) in The Cancer Genome Atlas (TCGA) glioblastoma cohort, their relationship to patient survival, and association with tumour microenvironment pathways. The expression of RAS g …
We studied the expression of RAS-related genes (ATP6AP2, AGTR1, AGTR2, ACE, AGT, and REN) in The Cancer Genome Atlas (TCGA) gl …
Renin-Angiotensin System Single Nucleotide Polymorphisms Are Associated with Bladder Cancer Risk.
Samara M, Papathanassiou M, Farmakioti I, Anagnostou M, Satra M, Mitrakas L, Anastasiou D, Chasiotis G, Christopoulos A, Anagnostou A, Christodoulou A, Daponte A, Ioannou M, Koukoulis G, Tzortzis V, Vlachostergios PJ. Samara M, et al. Curr Oncol. 2021 Nov 15;28(6):4702-4708. doi: 10.3390/curroncol28060396. Curr Oncol. 2021. PMID: 34898568 Free PMC article.
The renin-angiotensin system (RAS), besides being a major regulator of blood pressure, is also involved in tumor angiogenesis. ...In conclusion, these results support the clinical utility of RAS gene SNPs AT2R rs11091046, REN rs12750834, and ANG rs699 in the …
The renin-angiotensin system (RAS), besides being a major regulator of blood pressure, is also involved in tumor angiogenesis. ...In …
39 results