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Dieckol induces vasodilation via endothelial-smooth muscle crosstalk in co-culture and in vivo zebrafish models.
Jeong S, Lu YA, Lee S, Kim JI, Jeon YJ, Hyun J, Ryu B. Jeong S, et al. Chem Biol Interact. 2026 Jan 5;423:111815. doi: 10.1016/j.cbi.2025.111815. Epub 2025 Nov 15. Chem Biol Interact. 2026. PMID: 41248784 Free article.
Dieckol (DK), a phlorotannin isolated from Ecklonia cava, has been suggested to exert vasodilatory effects through endothelial signaling. ...Moreover, DK counteracted phenylephrine-induced vasoconstriction in zebrafish by reinforcing vascular in …
Dieckol (DK), a phlorotannin isolated from Ecklonia cava, has been suggested to exert vasodilatory effects through endo …
Molecular insights into the anticancer properties of dieckol: a comprehensive review.
Pandi A, Sen N, Kalappan VM, Chandrashekar N, Perumal MK. Pandi A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2026 Feb;399(3):3303-3319. doi: 10.1007/s00210-025-04674-y. Epub 2025 Oct 22. Naunyn Schmiedebergs Arch Pharmacol. 2026. PMID: 41125915 Review.
Increasing attention is being directed toward the potential of natural compounds as promising candidates in the search for effective cancer treatments. Dieckol, a marine-derived phlorotannin isolated from the brown algae Ecklonia cava, has garnered attention for its …
Increasing attention is being directed toward the potential of natural compounds as promising candidates in the search for effective cancer …
Dieckol ameliorates inflammatory response via inhibition of CHI3L1 expression in collagen-induced arthritis rats.
Wang W, Li H. Wang W, et al. Allergol Immunopathol (Madr). 2025 May 1;53(3):88-97. doi: 10.15586/aei.v53i3.1308. eCollection 2025. Allergol Immunopathol (Madr). 2025. PMID: 40342118
BACKGROUND: Dieckol (DEK), the main phlorotannin of brown algal, has been regarded as a powerful anti-inflammatory agent in various diseases. ...RESULTS: DEK treatment significantly ameliorates paw swelling, inflammatory cell infiltration, chondrocyte apoptosis and vasc …
BACKGROUND: Dieckol (DEK), the main phlorotannin of brown algal, has been regarded as a powerful anti-inflammatory agent in various d …
2,7-Phloroglucinol-6,6'-bieckol from Ecklonia cava ameliorates nanoplastics-induced premature endothelial senescence and dysfunction.
Sim HH, Shiwakoti S, Lee JH, Lee IY, Ok Y, Lim HK, Ko JY, Oak MH. Sim HH, et al. Sci Total Environ. 2024 Nov 1;949:175007. doi: 10.1016/j.scitotenv.2024.175007. Epub 2024 Jul 23. Sci Total Environ. 2024. PMID: 39053557
This study investigates the efficacy of Ecklonia cava extract (ECE) in preventing NPs-induced premature vascular senescence and dysfunction. ...Moreover, PHB also improved NPs-induced vascular dysfunction by upregulating endothelial nitric oxide synthase (eNO …
This study investigates the efficacy of Ecklonia cava extract (ECE) in preventing NPs-induced premature vascular senescence an …
Anti-obesity effects of a standardized ethanol extract of Eisenia bicyclis by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice.
Yoon YS, Chung KS, Lee SY, Heo SW, Kim YR, Lee JK, Kim H, Park S, Shin YK, Lee KT. Yoon YS, et al. Food Funct. 2024 Jun 17;15(12):6424-6437. doi: 10.1039/d4fo00759j. Food Funct. 2024. PMID: 38771619
Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, tumor growth, and non-alcoholic fatty liver disease. We investigated the anti-obesity effect of a 30% ethanol extract of Eisenia b …
Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, …
Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines.
Coelho M, Pacheco R. Coelho M, et al. Life (Basel). 2023 Jun 5;13(6):1325. doi: 10.3390/life13061325. Life (Basel). 2023. PMID: 37374108 Free PMC article.
The drugs currently available for hypercholesterolemia control have several side effects, so it is necessary to develop new effective and safer therapies. Seaweeds serve as sources of several bioactive compounds with claimed beneficial effects. Eisenia bicyclis …
The drugs currently available for hypercholesterolemia control have several side effects, so it is necessary to develop new effective …
Nanoformulation of Seaweed Eisenia bicyclis in Albumin Nanoparticles Targeting Cardiovascular Diseases: In Vitro and In Vivo Evaluation.
Pinto S, Gaspar MM, Ascensão L, Faísca P, Reis CP, Pacheco R. Pinto S, et al. Mar Drugs. 2022 Sep 27;20(10):608. doi: 10.3390/md20100608. Mar Drugs. 2022. PMID: 36286431 Free PMC article.
This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles (BSA NPs) loaded with an extract of Eisenia bicyclis and to validate its beneficial health effects, particularly targeting hypercholesterolemia and CVD prevention. Small …
This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles (BSA NPs) loaded with an extract of Eisenia …
Edible algae (Ecklonia cava) bioprocessed with mycelia of shiitake (Lentinula edodes) mushrooms in liquid culture and its isolated fractions protect mice against allergic asthma.
Lee KH, Jang YJ, Hwang WS, Kwon KS, Lee WY, Kim J, Kim SP, Friedman M. Lee KH, et al. BMC Complement Med Ther. 2022 Sep 17;22(1):242. doi: 10.1186/s12906-022-03705-y. BMC Complement Med Ther. 2022. PMID: 36115955 Free PMC article.
BACKGROUND: Ecklonia cava is an edible marine brown alga harvested from the ocean that is widely consumed in Asian countries as a health-promoting medicinal food The objective of the present study is to evaluate the anti-asthma mechanism of a new functional food produced b …
BACKGROUND: Ecklonia cava is an edible marine brown alga harvested from the ocean that is widely consumed in Asian countries as a hea …
Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1alpha and SOD2.
Byun KA, Oh S, Yang JY, Lee SY, Son KH, Byun K. Byun KA, et al. Biomed Pharmacother. 2022 Sep;153:113283. doi: 10.1016/j.biopha.2022.113283. Epub 2022 Jun 16. Biomed Pharmacother. 2022. PMID: 35717781 Free article.
Vascular calcification (VC) is induced by a decrease in sirtuin 3 (SIRT3) and superoxide dismutase (SOD)2 and increases mitochondrial reactive oxygen species (mtROS), eventually leading to mitochondrial dysfunction and phenotype alterations in vascular smooth muscle …
Vascular calcification (VC) is induced by a decrease in sirtuin 3 (SIRT3) and superoxide dismutase (SOD)2 and increases mitochondrial …
Pharmacological actions of dieckol on modulation of platelet functions and thrombus formation via integrin alpha(IIb)beta(3) and cAMP signaling.
Irfan M, Kwon TH, Kwon HW, Rhee MH. Irfan M, et al. Pharmacol Res. 2022 Mar;177:106088. doi: 10.1016/j.phrs.2022.106088. Epub 2022 Jan 14. Pharmacol Res. 2022. PMID: 35038555
BACKGROUND AND PURPOSE: Dieckol is a phlorotannin that can be found in seaweeds, particularly in Eisenia bicyclis (brown algae) and is known to have anti-oxidant, anti-inflammatory, and anti-microbial properties. It also possesses anti-thrombotic and p …
BACKGROUND AND PURPOSE: Dieckol is a phlorotannin that can be found in seaweeds, particularly in Eisenia bicyclis (brow …
54 results