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Global Glaucoma Prevalence: Burden and Projection to 2060.
Wang Z, Xue CC, Li Y, Wu Y, Pan Z, Li F, Cheung CY, Ohno-Matsui K, Friedman DS, Garway-Heath D, Zangwill LM, Chauhan BC, Burgoyne CF, Tham YC, Zhang C, Jonas JB, Cheng CY, Wong TY, Wang YX. Wang Z, et al. Am J Ophthalmol. 2025 Dec 18:S0002-9394(25)00665-8. doi: 10.1016/j.ajo.2025.12.013. Online ahead of print. Am J Ophthalmol. 2025. PMID: 41421762 Free article. Review.
Accurate prevalence and burden estimates, accounting for both demographic and refractive trends, are essential to guide global eye health policy, resource allocation, and preventive strategies. METHODS: A systematic review and meta-analysis (PROSPERO: CRD42024520990) of 77 …
Accurate prevalence and burden estimates, accounting for both demographic and refractive trends, are essential to guide global eye health po …
AI-Driven Early Detection of Diabetic Glaucoma and Emerging Horizons in Bionic Eye Technology.
Tiwari G, Wal A, Suryavanshi RS, Shukla R, Khan M, Chaurasia BK. Tiwari G, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2025 Dec 1;41:e20250031. doi: 10.62958/j.cjap.2025.031. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2025. PMID: 41320280 Free article. Review.
With its rising global incidence, there is a critical need for early and reliable methods of detection to prevent severe complications. OBJECTIVE: This study highlights the growing role of artificial intelligence (AI), especially deep learning technologies, in identifying …
With its rising global incidence, there is a critical need for early and reliable methods of detection to prevent severe complication …
Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management.
Xie M, Huang Z, Ma K, Deng Y, Tang J. Xie M, et al. J Ophthalmol. 2025 Nov 14;2025:8826306. doi: 10.1155/joph/8826306. eCollection 2025. J Ophthalmol. 2025. PMID: 41283188 Free PMC article. Review.
Understanding associations between these biomechanical changes and glaucoma development can elucidate disease mechanisms, enabling more effective treatment strategies and preventive measures. This review explores the latest research developments on corneal biomechanical ch …
Understanding associations between these biomechanical changes and glaucoma development can elucidate disease mechanisms, enabling more effe …
Nicotinamide and Pyruvate as Potential Therapeutic Interventions for Metabolic Dysfunction in Primary Open-Angle Glaucoma-A Narrative Review.
Schanzer N, Harris A, Kanwar K, Mortensen R, Verticchio Vercellin A, Oddone F, Carnevale C, Wood K, Siesky B. Schanzer N, et al. J Clin Med. 2025 Nov 10;14(22):7954. doi: 10.3390/jcm14227954. J Clin Med. 2025. PMID: 41302990 Free PMC article. Review.
Pilot works suggest their consumption may help prevent retinal ganglion cell deterioration under elevated intraocular pressure (IOP) and oxidative stress. ...
Pilot works suggest their consumption may help prevent retinal ganglion cell deterioration under elevated intraocular pressure (IOP) …
Risk factors for glaucoma in nanophthalmos - a systematic review and meta-analysis.
Rajendrababu S, Berendschot TTJM, Senthilkumar VA, Niranjana B, Rao M, Maghalakshmi U, Iswarya M, Kumaragurupari T, Jerrome S, Webers CAB. Rajendrababu S, et al. BMC Ophthalmol. 2025 Nov 4;25(1):617. doi: 10.1186/s12886-025-04447-4. BMC Ophthalmol. 2025. PMID: 41188801 Free PMC article.
These findings emphasize the need for early biometric screening, vigilant monitoring, and individualized anatomy-based management strategies to prevent irreversible vision loss among nanophthalmic patients. TRIAL REGISTRATION: International prospective register of systemat …
These findings emphasize the need for early biometric screening, vigilant monitoring, and individualized anatomy-based management strategies …
Controversies, consensuses, and guidelines for acute primary angle closure attack (APACA) by the Asia-Pacific Glaucoma Society (APGS) and the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO).
Chan PP, Zhang X, Aung T, Chew PTK, Congdon N, Dada T, Fang SK, He M, Kim CY, Lai JSM, Lee JWY, Liang Y, Lingam V, Liu CY, Rojanapongpun P, Sun X, Tang X, Tham CCY. Chan PP, et al. Asia Pac J Ophthalmol (Phila). 2025 Nov-Dec;14(6):100223. doi: 10.1016/j.apjo.2025.100223. Epub 2025 Jul 2. Asia Pac J Ophthalmol (Phila). 2025. PMID: 40615047 Free article. Review.
Earlier phacoemulsification is effective in preventing further retinal ganglion cell loss and disease progression after APACA and is worth considering, provided adequate facilities and expertise are available. ...
Earlier phacoemulsification is effective in preventing further retinal ganglion cell loss and disease progression after APACA and is …
Diet, Exercise, and Lifestyle in Glaucoma: Current Evidence and Future Perspectives.
Hanyuda A, Tsuda S, Himori N, Sato K, Takahashi N, Nakazawa T. Hanyuda A, et al. Nutrients. 2025 Oct 27;17(21):3369. doi: 10.3390/nu17213369. Nutrients. 2025. PMID: 41228444 Free PMC article. Review.
Flavonoids (anthocyanins and flavanols), carotenoids (lutein/zeaxanthin), and B vitamins have strong biological rationale for glaucoma prevention but have limited support from long-term, large population-based studies. The effect of polyunsaturated fats on glaucoma remains …
Flavonoids (anthocyanins and flavanols), carotenoids (lutein/zeaxanthin), and B vitamins have strong biological rationale for glaucoma pr …
Portable devices for the diagnosis of glaucoma: a scoping review.
Garba F, Kyari F, Burton MJ, Adler SH, Khan Z, Bello M, Evans J, Gordon I, Hu VH, Nolan W. Garba F, et al. BMJ Open. 2025 Oct 21;15(10):e105681. doi: 10.1136/bmjopen-2025-105681. BMJ Open. 2025. PMID: 41125271 Free PMC article.
Early detection and continuous monitoring are essential to preventing vision loss, yet traditional diagnostic tools remain largely inaccessible in low-resource settings. ...
Early detection and continuous monitoring are essential to preventing vision loss, yet traditional diagnostic tools remain largely in …
Research progress of Mendelian randomization analysis for glaucoma etiology.
Wang JM, Song YW, Su JJ, Fu LC, Gong D, Guo P, Yang WH. Wang JM, et al. Int J Ophthalmol. 2025 Jul 18;18(7):1383-1397. doi: 10.18240/ijo.2025.07.23. eCollection 2025. Int J Ophthalmol. 2025. PMID: 40688780 Free PMC article. Review.
It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strategies against glaucoma. Recent MR research has delved into diverse potential glaucoma risk factors, including behavioral habits, metabolic pr …
It facilitates the identification of potential risk factors, laying the groundwork for developing preventative and therapeutic strate …
Feasibility analysis of Sinomenine alleviating fibrosis of filtering bleb after glaucoma filtering surgery: a mini review.
Xun X, Liu X, Zhou P, Wu C, Peng Q. Xun X, et al. Front Med (Lausanne). 2025 Jul 8;12:1607500. doi: 10.3389/fmed.2025.1607500. eCollection 2025. Front Med (Lausanne). 2025. PMID: 40697912 Free PMC article. Review.
The antimetabolite drugs 5-fluorouracil (5-FU) and mitomycin C (MMC) are effective in preventing filtering bleb fibrosis, but their non-specific cytotoxic effects necessitate the development of targeted therapeutic alternatives. ...
The antimetabolite drugs 5-fluorouracil (5-FU) and mitomycin C (MMC) are effective in preventing filtering bleb fibrosis, but their n …
Understanding Glaucoma: Why it Remains a Leading Cause of Blindness Worldwide.
Qi T, Liu H, Frühn L, Löw K, Cursiefen C, Prokosch V. Qi T, et al. Klin Monbl Augenheilkd. 2025 Jul;242(7):712-717. doi: 10.1055/a-2617-1575. Epub 2025 Jul 24. Klin Monbl Augenheilkd. 2025. PMID: 40719087 Free PMC article. Review.
Vision loss caused by glaucoma is irreversible but largely preventable, highlighting the importance of early detection and treatment. Diagnosis presents significant challenges, particularly due to the asymptomatic nature of the disease and age-related risk factors. ...
Vision loss caused by glaucoma is irreversible but largely preventable, highlighting the importance of early detection and treatment. …
Potential benefits of vitamin A and its derivatives in glaucoma.
Zhang X, Yang H, Zhou X, Xu J, Chen J, Liao L, Wu P, Duan X. Zhang X, et al. Eur J Med Res. 2025 Jul 1;30(1):527. doi: 10.1186/s40001-025-02780-4. Eur J Med Res. 2025. PMID: 40597446 Free PMC article. Review.
If increasing total dietary VA intake is successful as an effective prevention strategy, this would be a promising approach for primary prevention of glaucoma. ...Additionally, studies have also shown that VA and its derivatives could also play a role in preventi …
If increasing total dietary VA intake is successful as an effective prevention strategy, this would be a promising approach for prima …
Incidence of Glaucoma in Type 2 Diabetes Patients Treated With GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis.
Asif M, Asif A, Rahman UA, Farooqi HA, Fatima O, Ali W, Jafar U, Jaber MH. Asif M, et al. Endocrinol Diabetes Metab. 2025 Jul;8(4):e70059. doi: 10.1002/edm2.70059. Endocrinol Diabetes Metab. 2025. PMID: 40509955 Free PMC article.
These results advocate for further clinical studies to confirm GLP-1RAs' protective ocular effects, potentially influencing future treatment guidelines and preventive care strategies for glaucoma patients....
These results advocate for further clinical studies to confirm GLP-1RAs' protective ocular effects, potentially influencing future treatment …
Direct and indirect healthcare costs of ocular diseases in Italy: a literature review on glaucoma, diabetic retinopathy, and macular degeneration.
Pennisi F, Gentile L, Borlini S, Gianfredi V, Signorelli C. Pennisi F, et al. Ann Ig. 2025 Jul-Aug;37(4):532-555. doi: 10.7416/ai.2025.2676. Epub 2025 Jan 15. Ann Ig. 2025. PMID: 39811964 Free article.
CONCLUSIONS: This study highlights the substantial economic burden ocular diseases place on the Italian healthcare system. Early intervention and preventive strategies could reduce the long-term costs of managing diabetic retinopathy and age-related macular degeneration. . …
CONCLUSIONS: This study highlights the substantial economic burden ocular diseases place on the Italian healthcare system. Early interventio …
Should We Fear Wipe-Out in Glaucoma Surgery?
Zeppieri M, Cannizzaro L, Gagliano G, Cappellani F, Rapisarda L, Spinello A, Longo A, Russo A, Avitabile A. Zeppieri M, et al. Diagnostics (Basel). 2025 Jun 20;15(13):1571. doi: 10.3390/diagnostics15131571. Diagnostics (Basel). 2025. PMID: 40647570 Free PMC article. Review.
Modern MIGS and refined trabeculectomy techniques exhibit notably lower wipe-out risks compared to historical data. The literature emphasizes preventive management, including careful patient selection, incremental intraocular pressure reduction, and minimally invasive anes …
Modern MIGS and refined trabeculectomy techniques exhibit notably lower wipe-out risks compared to historical data. The literature emphasize …
Melatonin in Glaucoma: Integrative Mechanisms of Intraocular Pressure Control and Neuroprotection.
Hou X, Pan Y. Hou X, et al. Biomedicines. 2025 May 16;13(5):1213. doi: 10.3390/biomedicines13051213. Biomedicines. 2025. PMID: 40427040 Free PMC article. Review.
Moreover, it protects RGCs by mitigating oxidative stress, preventing mitochondrial dysfunction, and inhibiting apoptotic and inflammatory cascades. ...
Moreover, it protects RGCs by mitigating oxidative stress, preventing mitochondrial dysfunction, and inhibiting apoptotic and inflamm …
Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma.
Rajakrishna N, Lim ST, Wang X, Wong TT. Rajakrishna N, et al. Front Cell Dev Biol. 2025 Apr 30;13:1586240. doi: 10.3389/fcell.2025.1586240. eCollection 2025. Front Cell Dev Biol. 2025. PMID: 40371387 Free PMC article. Review.
Given the irreversibility of RGC death, neuroprotection of RGCs is a promising avenue of glaucoma prevention and treatment. The caspase family of proteins are integral members of the apoptotic death cascade. ...
Given the irreversibility of RGC death, neuroprotection of RGCs is a promising avenue of glaucoma prevention and treatment. The caspa …
Acute Angle-Closure Glaucoma as an Ocular Complication of Dengue Fever: A Comprehensive Review.
Al-Essa A. Al-Essa A. Cureus. 2025 Apr 11;17(4):e82119. doi: 10.7759/cureus.82119. eCollection 2025 Apr. Cureus. 2025. PMID: 40357076 Free PMC article. Review.
The review emphasizes the importance of long-term monitoring to assess ocular outcomes and prevent relapse. While AACG occurrence in dengue patients is rare, healthcare providers in endemic areas must stay alert for ocular symptoms in dengue patients presenting with vision …
The review emphasizes the importance of long-term monitoring to assess ocular outcomes and prevent relapse. While AACG occurrence in …
Changes in the Protein Composition of the Aqueous Humor in Patients with Glaucoma: An Update Review.
Kiełbus M, Kuźmiuk D, Skrzyniarz AM, Zynkowska A, Dolar-Szczasny J, Chorągiewicz T, Rejdak R. Kiełbus M, et al. Int J Mol Sci. 2025 Mar 28;26(7):3129. doi: 10.3390/ijms26073129. Int J Mol Sci. 2025. PMID: 40243897 Free PMC article. Review.
We hope that our review will contribute to the improvement of current diagnostic methods in this illness and, through a better understanding of the changes occurring during the progression of the disease, will enable the development of more effective preventive and therape …
We hope that our review will contribute to the improvement of current diagnostic methods in this illness and, through a better understanding …
Interventional glaucoma: Rethinking glaucoma treatment paradigms in the Asian context.
Teo AWJ, Angmo D, Wong TTL, Nongpiur ME. Teo AWJ, et al. Indian J Ophthalmol. 2025 Mar 1;73(Suppl 2):S207-S213. doi: 10.4103/IJO.IJO_517_24. Epub 2025 Feb 21. Indian J Ophthalmol. 2025. PMID: 39982081 Free PMC article. Review.
By administering them earlier, these interventions can modulate the course of the disease and prevent significant visual loss, thereby reducing or delaying the need for subsequent filtering surgeries. ...
By administering them earlier, these interventions can modulate the course of the disease and prevent significant visual loss, thereb …
Current perspectives in tackling glaucoma blindness.
Bhartiya S, Ichhpujani P, Wadhwani M. Bhartiya S, et al. Indian J Ophthalmol. 2025 Mar 1;73(Suppl 2):S189-S196. doi: 10.4103/IJO.IJO_3280_23. Epub 2025 Feb 21. Indian J Ophthalmol. 2025. PMID: 39982079 Free PMC article. Review.
The advent of personalized medicine, genetic profiling, and innovative biomarkers for identifying susceptible individuals and tailoring treatment strategies may help prevent blindness and improve patient outcomes. Evaluation of the impact of lifestyle modifications and hol …
The advent of personalized medicine, genetic profiling, and innovative biomarkers for identifying susceptible individuals and tailoring trea …
Glaucoma animal models in rabbits: State of the art and perspectives-A review.
Hu R, Wu K, Shi J, Yu J, Yao XL. Hu R, et al. Animal Model Exp Med. 2025 Mar;8(3):429-440. doi: 10.1002/ame2.12565. Epub 2025 Feb 6. Animal Model Exp Med. 2025. PMID: 39913189 Free PMC article. Review.
Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma. Rabbit eyeballs possess similar vascularity and aqueous humor outflow pathways to those of humans. ...
Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effect …
Central Corneal Thickness and Glaucoma Risk: The Importance of Corneal Pachymetry in Screening Adults Over 50 and Glaucoma Suspects.
Agbato D, Rickford K, Laroche D. Agbato D, et al. Clin Ophthalmol. 2025 Feb 15;19:563-570. doi: 10.2147/OPTH.S498422. eCollection 2025. Clin Ophthalmol. 2025. PMID: 39974660 Free PMC article. Review.
Glaucoma is a leading cause of preventable blindness, yet nearly half of those affected are unaware of their diagnosis. ...
Glaucoma is a leading cause of preventable blindness, yet nearly half of those affected are unaware of their diagnosis. ...
Ocular hyperemia associated with topical glaucoma medication: understanding and differentiating clinical appearance and underlying mechanisms.
Holló G. Holló G. Expert Opin Drug Saf. 2025 Feb;24(2):145-156. doi: 10.1080/14740338.2024.2436062. Epub 2024 Dec 9. Expert Opin Drug Saf. 2025. PMID: 39648794 Free article. Review.
These medications are essential to preserve vision and prevent worsening of glaucoma. They may have side effects, however. The most common is a reddening of the ocular surface, known as ocular hyperemia. ...
These medications are essential to preserve vision and prevent worsening of glaucoma. They may have side effects, however. The most c …
Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies.
Zhang F, Li T, Wan J, Wang L, Guo W, Hu Y, Wang H, Bian W. Zhang F, et al. Front Pharmacol. 2025 Jan 15;15:1521188. doi: 10.3389/fphar.2024.1521188. eCollection 2024. Front Pharmacol. 2025. PMID: 39881870 Free PMC article.
INTRODUCTION: Resveratrol, a polyphenolic compound commonly found in natural plants and fruits, exhibits potential in preventing optic nerve damage in glaucoma, as indicated by several animal studies. However, there is presently a dearth of relevant evidence available for …
INTRODUCTION: Resveratrol, a polyphenolic compound commonly found in natural plants and fruits, exhibits potential in preventing opti …
Role of Endocannabinoids in Glaucoma: A Review.
Warjri GB, Gowtham L, Venkatraman V, Velpandian T, Dada T, Angmo D. Warjri GB, et al. J Curr Glaucoma Pract. 2025 Jan-Mar;19(1):28-37. doi: 10.5005/jp-journals-10078-1467. Epub 2025 Mar 24. J Curr Glaucoma Pract. 2025. PMID: 40417140 Free PMC article. Review.
CLINICAL SIGNIFICANCE: We still do not have drugs for the prevention of retinal ganglion cell loss and for neuroprotection in glaucoma. Drugs that target cannabinoid receptors can revolutionize glaucoma management owing to their IOP-lowering action and neuroprotective effe …
CLINICAL SIGNIFICANCE: We still do not have drugs for the prevention of retinal ganglion cell loss and for neuroprotection in glaucom …
Gene therapy for glaucoma: Targeting key mechanisms.
Henderson J, O'Callaghan J, Campbell M. Henderson J, et al. Vision Res. 2024 Dec;225:108502. doi: 10.1016/j.visres.2024.108502. Epub 2024 Oct 18. Vision Res. 2024. PMID: 39423611 Free PMC article. Review.
Thus, there is a critical need for better strategies to prevent irreversible vision loss in glaucoma. Gene therapy holds significant promise in this regard, offering potential long-term solutions by targeting the disease's underlying causes at a molecular level. ...Neuropr …
Thus, there is a critical need for better strategies to prevent irreversible vision loss in glaucoma. Gene therapy holds significant …
Global incidence and risk factors for glaucoma: A systematic review and meta-analysis of prospective studies.
Shan S, Wu J, Cao J, Feng Y, Zhou J, Luo Z, Song P, Rudan I; Global Health Epidemiology Research Group (GHERG). Shan S, et al. J Glob Health. 2024 Nov 8;14:04252. doi: 10.7189/jogh.14.04252. J Glob Health. 2024. PMID: 39513294 Free PMC article.
Further research is needed to understand which risk factors drive glaucoma incidence in different socioeconomic strata for tailored health policy on preventing glaucoma. REGISTRATION: This study is registered with PROSPERO (number CRD42023434203)....
Further research is needed to understand which risk factors drive glaucoma incidence in different socioeconomic strata for tailored health p …
Glaucoma and dietary links: insights from high-salt intake, the Mediterranean diet, and specific nutrients.
Yang Y, Zhou H, Hong Z. Yang Y, et al. Front Nutr. 2024 Oct 24;11:1461748. doi: 10.3389/fnut.2024.1461748. eCollection 2024. Front Nutr. 2024. PMID: 39512517 Free PMC article. Review.
In recent years, dietary habits, as a controllable lifestyle factor, have received increasing attention in the prevention and treatment of glaucoma. The purpose of this review was to investigate the effects of dietary factors on glaucoma, with a particular emphasis on two …
In recent years, dietary habits, as a controllable lifestyle factor, have received increasing attention in the prevention and treatme …
Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma.
Cheng Y, Chen X, Zhu G, Li N, Sun Y, Luo S, Liu Y, Lu X. Cheng Y, et al. Planta Med. 2024 Oct;90(13):992-1004. doi: 10.1055/a-2409-2999. Epub 2024 Sep 20. Planta Med. 2024. PMID: 39303747 Free article. Review.
Therefore, protecting the optic nerve and inhibiting the apoptosis of retinal ganglion cells are the current hot topic for prevention and treatment of glaucoma. Recently, Erigeron breviscapus, originating from Yunnan province in China, has been shown to be a promising herb …
Therefore, protecting the optic nerve and inhibiting the apoptosis of retinal ganglion cells are the current hot topic for prevention …
Impact of Environmental Factors on Glaucoma Progression: A Systematic Review.
Almarzouki N. Almarzouki N. Clin Ophthalmol. 2024 Sep 30;18:2705-2720. doi: 10.2147/OPTH.S484855. eCollection 2024. Clin Ophthalmol. 2024. PMID: 39372224 Free PMC article. Review.
Environmental factors hold promise as potential targets for glaucoma prevention and management strategies. Future research should focus on well-designed studies to investigate causal relationships and biological mechanisms....
Environmental factors hold promise as potential targets for glaucoma prevention and management strategies. Future research should foc …
Big data for imaging assessment in glaucoma.
da Costa DR, Medeiros FA. da Costa DR, et al. Taiwan J Ophthalmol. 2024 Sep 13;14(3):299-318. doi: 10.4103/tjo.TJO-D-24-00079. eCollection 2024 Jul-Sep. Taiwan J Ophthalmol. 2024. PMID: 39430345 Free PMC article. Review.
Early detection and reliable monitoring are crucial to prevent vision loss. With the rapid development of computational technologies, artificial intelligence (AI) and deep learning (DL) algorithms are emerging as potential tools for screening, diagnosing, and monitoring gl …
Early detection and reliable monitoring are crucial to prevent vision loss. With the rapid development of computational technologies, …
Review: Neuroprotective Nanocarriers in Glaucoma.
Pei K, Georgi M, Hill D, Lam CFJ, Wei W, Cordeiro MF. Pei K, et al. Pharmaceuticals (Basel). 2024 Sep 10;17(9):1190. doi: 10.3390/ph17091190. Pharmaceuticals (Basel). 2024. PMID: 39338350 Free PMC article. Review.
Therefore, the research focus has shifted to therapeutic targets aimed at preventing or delaying RGC death and optic nerve degeneration to slow or halt disease progression. ...
Therefore, the research focus has shifted to therapeutic targets aimed at preventing or delaying RGC death and optic nerve degenerati …
Glaucoma: Current and New Therapeutic Approaches.
Lee HP, Tsung TH, Tsai YC, Chen YH, Lu DW. Lee HP, et al. Biomedicines. 2024 Sep 3;12(9):2000. doi: 10.3390/biomedicines12092000. Biomedicines. 2024. PMID: 39335514 Free PMC article. Review.
Lately, there has been an increasing focus on neuroprotective therapies for glaucoma because of the limited effectiveness of standard methods in reducing IOP and preventing ongoing vision deterioration in certain glaucoma patients. Various drug-based techniques with neurop …
Lately, there has been an increasing focus on neuroprotective therapies for glaucoma because of the limited effectiveness of standard method …
NAD+ and Niacin Supplementation as Possible Treatments for Glaucoma and Age-Related Macular Degeneration: A Narrative Review.
Gemae MR, Bassi MD, Wang P, Chin EK, Almeida DRP. Gemae MR, et al. Nutrients. 2024 Aug 21;16(16):2795. doi: 10.3390/nu16162795. Nutrients. 2024. PMID: 39203931 Free PMC article. Review.
Large-scale population-based studies indicate an inverse correlation between niacin intake and glaucoma prevalence, suggesting a preventative role. Randomized controlled trials assessing niacin supplementation showed significant improvements in visual field sensitivity and …
Large-scale population-based studies indicate an inverse correlation between niacin intake and glaucoma prevalence, suggesting a preventa …
Integrating Genetics in Glaucoma Screening.
Mackey DA, Bigirimana D, Staffieri SE. Mackey DA, et al. J Glaucoma. 2024 Aug 1;33(Suppl 1):S49-S53. doi: 10.1097/IJG.0000000000002425. Epub 2024 Aug 19. J Glaucoma. 2024. PMID: 39149951 Free PMC article. Review.
Ensuring genetic research is equitable to prevent glaucoma blindness worldwide is crucial. PURPOSE: To review the progress in glaucoma genetics over the past 25 years, including the identification of genes with varying contributions to the disease and the development of po …
Ensuring genetic research is equitable to prevent glaucoma blindness worldwide is crucial. PURPOSE: To review the progress in glaucom …
Polygenic Risk Scores Driving Clinical Change in Glaucoma.
Kolovos A, Hassall MM, Siggs OM, Souzeau E, Craig JE. Kolovos A, et al. Annu Rev Genomics Hum Genet. 2024 Aug;25(1):287-308. doi: 10.1146/annurev-genom-121222-105817. Epub 2024 Aug 6. Annu Rev Genomics Hum Genet. 2024. PMID: 38599222 Free article. Review.
Glaucoma is a clinically heterogeneous disease and the world's leading cause of irreversible blindness. Therapeutic intervention can prevent blindness but relies on early diagnosis, and current clinical risk factors are limited in their ability to predict who will develop …
Glaucoma is a clinically heterogeneous disease and the world's leading cause of irreversible blindness. Therapeutic intervention can prev …
A Comprehensive Review of Recent Advances in Minimally Invasive Glaucoma Surgery: Current Trends and Future Directions.
Dhawale KK, Tidake P. Dhawale KK, et al. Cureus. 2024 Jul 24;16(7):e65236. doi: 10.7759/cureus.65236. eCollection 2024 Jul. Cureus. 2024. PMID: 39184647 Free PMC article. Review.
Glaucoma, a leading cause of blindness globally, necessitates effective management strategies to prevent irreversible vision loss. Traditional glaucoma surgeries, while effective, are associated with significant risks and complications. ...
Glaucoma, a leading cause of blindness globally, necessitates effective management strategies to prevent irreversible vision loss. Tr …
Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study.
King AJ, Hudson J, Azuara-Blanco A, Burr J, Kernohan A, Homer T, Shabaninejad H, Sparrow JM, Garway-Heath D, Barton K, Norrie J, Davidson T, Vale L, MacLennan G; TAGS Study Group∗. King AJ, et al. Ophthalmology. 2024 Jul;131(7):759-770. doi: 10.1016/j.ophtha.2024.01.007. Epub 2024 Jan 9. Ophthalmology. 2024. PMID: 38199528 Free PMC article. Clinical Trial.
CONCLUSIONS: At 5 years, the Treatment of Advanced Glaucoma Study demonstrated that primary trabeculectomy surgery is more effective in lowering IOP and preventing disease progression than primary medical treatment in patients with advanced disease and has a similar safety …
CONCLUSIONS: At 5 years, the Treatment of Advanced Glaucoma Study demonstrated that primary trabeculectomy surgery is more effective in lowe …
Unveiling Novel Structural Biomarkers for the Diagnosis of Glaucoma.
Tsai YC, Lee HP, Tsung TH, Chen YH, Lu DW. Tsai YC, et al. Biomedicines. 2024 May 29;12(6):1211. doi: 10.3390/biomedicines12061211. Biomedicines. 2024. PMID: 38927418 Free PMC article. Review.
Early detection is crucial for effective management and prevention of vision loss. This study presents a collection of novel structural biomarkers in glaucoma diagnosis. ...
Early detection is crucial for effective management and prevention of vision loss. This study presents a collection of novel structur …
The Application of Rho Kinase Inhibitors in the Management of Glaucoma.
Liu LC, Chen YH, Lu DW. Liu LC, et al. Int J Mol Sci. 2024 May 21;25(11):5576. doi: 10.3390/ijms25115576. Int J Mol Sci. 2024. PMID: 38891764 Free PMC article. Review.
This review aims to discuss the mechanism of ROCK inhibitors in reducing IOP, providing neuroprotection, and preventing fibrosis. We also highlight recent studies and clinical trials evaluating the efficacy and safety of ROCK inhibitors, compare them with other clinical an …
This review aims to discuss the mechanism of ROCK inhibitors in reducing IOP, providing neuroprotection, and preventing fibrosis. We …
Microbial Dynamics in Ophthalmic Health: Exploring the Interplay between Human Microbiota and Glaucoma Pathogenesis.
Hernández-Zulueta J, Bolaños-Chang AJ, Santa Cruz-Pavlovich FJ, Valero Rodríguez AD, Lizárraga Madrigal A, Del Rio-Murillo XI, Navarro-Partida J, Gonzalez-De la Rosa A. Hernández-Zulueta J, et al. Medicina (Kaunas). 2024 Apr 3;60(4):592. doi: 10.3390/medicina60040592. Medicina (Kaunas). 2024. PMID: 38674238 Free PMC article. Review.
In this sense, it has been shown that a healthy ocular microbiota acts as a barrier against the entry of pathogens, contributing to the prevention of infections. In recent years, a relationship has been suggested between microbiota dysbiosis and the development of neurodeg …
In this sense, it has been shown that a healthy ocular microbiota acts as a barrier against the entry of pathogens, contributing to the p …
Molecular pathways in experimental glaucoma models.
Bugara K, Pacwa A, Smedowski A. Bugara K, et al. Front Neurosci. 2024 Mar 18;18:1363170. doi: 10.3389/fnins.2024.1363170. eCollection 2024. Front Neurosci. 2024. PMID: 38562304 Free PMC article. Review.
Although much research has been done to better understand the molecular mechanisms underlying this disease, there is still much to be learned to develop effective treatments and prevent vision loss in those affected by glaucoma....
Although much research has been done to better understand the molecular mechanisms underlying this disease, there is still much to be learne …
Adherence and factors influencing adherence to glaucoma medications among adult glaucoma patients in Ethiopia: A systematic review and meta-analysis.
Abore KW, Fole EB, Abebe MT, Tekle NF, Tilahun RB, Chinkey FD, Abera MT. Abore KW, et al. PLoS One. 2024 Mar 13;19(3):e0293047. doi: 10.1371/journal.pone.0293047. eCollection 2024. PLoS One. 2024. PMID: 38478513 Free PMC article.
Adherence to ocular hypotensive medications is vital to prevent optic nerve damage and its consequences. This study was conducted to systematically summarize the magnitude of glaucoma medication adherence and factors influencing adherence to glaucoma medications among adul …
Adherence to ocular hypotensive medications is vital to prevent optic nerve damage and its consequences. This study was conducted to …
Knowledge about glaucoma among adults in Africa: a systematic review.
Yimam W, Anbesaw T, Seid M, Kumar P, Wolie H. Yimam W, et al. BMC Ophthalmol. 2024 Feb 14;24(1):69. doi: 10.1186/s12886-024-03333-9. BMC Ophthalmol. 2024. PMID: 38355482 Free PMC article.
If left untreated, glaucoma can cause blindness and permanent vision loss if it is not addressed promptly. Good knowledge is essential for preventing glaucoma's irreversible blindness and ocular damage. However, no systematic review has been done to report the pooled perce …
If left untreated, glaucoma can cause blindness and permanent vision loss if it is not addressed promptly. Good knowledge is essential for …
Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics.
Shean R, Yu N, Guntipally S, Nguyen V, He X, Duan S, Gokoffski K, Zhu Y, Xu B. Shean R, et al. Bioengineering (Basel). 2024 Jan 30;11(2):138. doi: 10.3390/bioengineering11020138. Bioengineering (Basel). 2024. PMID: 38391624 Free PMC article. Review.
Glaucoma is a leading cause of irreversible blindness, and early detection and treatment are crucial for preventing vision loss. This review aims to provide an overview of current diagnostic and treatment standards, recent medical and technological advances, and current ch …
Glaucoma is a leading cause of irreversible blindness, and early detection and treatment are crucial for preventing vision loss. This …
Glial cells as a promising therapeutic target of glaucoma: beyond the IOP.
Shinozaki Y, Namekata K, Guo X, Harada T. Shinozaki Y, et al. Front Ophthalmol (Lausanne). 2024 Jan 8;3:1310226. doi: 10.3389/fopht.2023.1310226. eCollection 2023. Front Ophthalmol (Lausanne). 2024. PMID: 38983026 Free PMC article. Review.
Because glaucoma is a complex, multifactorial disease influenced by various factors that contribute to its onset and progression, it is imperative that we consider factors beyond IOP to effectively prevent or slow down the disease's advancement. In the realm of CNS neurode …
Because glaucoma is a complex, multifactorial disease influenced by various factors that contribute to its onset and progression, it is impe …
The progress of assessment methods and treatments of neovascular glaucoma secondary to central retinal vein occlusion.
Qu S, Zou Y, Yang L, Wu H. Qu S, et al. Front Med (Lausanne). 2024 Jan 8;10:1280776. doi: 10.3389/fmed.2023.1280776. eCollection 2023. Front Med (Lausanne). 2024. PMID: 38259837 Free PMC article. Review.
Meanwhile, although pan-retinal photocoagulation is a standard treatment to prevent the onset of neovascular glaucoma, its actual efficacy and the timing of intervention remain highly controversial. ...This article details the debate on the above issues and explores ideas …
Meanwhile, although pan-retinal photocoagulation is a standard treatment to prevent the onset of neovascular glaucoma, its actual eff …
Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma.
Masson EAY, Serrano J, Leger-Charnay E, Acar N. Masson EAY, et al. Front Ophthalmol (Lausanne). 2024 Jan 3;3:1303649. doi: 10.3389/fopht.2023.1303649. eCollection 2023. Front Ophthalmol (Lausanne). 2024. PMID: 38983043 Free PMC article. Review.
This represents an understudied but attractive topic to better understand glaucoma and conceive novel preventive or curative strategies. The present review describes the current knowledge on i) sterol metabolism in retinal glial cells, ii) the potential role of cholesterol …
This represents an understudied but attractive topic to better understand glaucoma and conceive novel preventive or curative strategi …
Molecular aspects of optic nerve autophagy in glaucoma.
Kitaoka Y, Sase K. Kitaoka Y, et al. Mol Aspects Med. 2023 Dec;94:101217. doi: 10.1016/j.mam.2023.101217. Epub 2023 Oct 14. Mol Aspects Med. 2023. PMID: 37839231 Free article. Review.
This concept is an attractive approach to the prevention of further retinal ganglion cell death. In this review, we describe the factors affecting autophagy, including nicotinamide riboside, p38, ULK, AMPK, ROCK, and SIRT1, in the optic nerve and propose potential methods …
This concept is an attractive approach to the prevention of further retinal ganglion cell death. In this review, we describe the fact …
Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy.
Wang J, Wang H, Dang Y. Wang J, et al. Ophthalmol Ther. 2023 Dec;12(6):2943-2957. doi: 10.1007/s40123-023-00820-y. Epub 2023 Oct 14. Ophthalmol Ther. 2023. PMID: 37837578 Free PMC article. Review.
Reduction of intraocular pressure (IOP) is the only known modifiable risk factor for preventing and treating glaucoma. Rho kinase (ROCK) inhibitors are a new class of glaucoma drugs with a novel mechanism of action and good safety profile. ...
Reduction of intraocular pressure (IOP) is the only known modifiable risk factor for preventing and treating glaucoma. Rho kinase (RO …
Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors.
Stuart KV, Pasquale LR, Kang JH, Foster PJ, Khawaja AP. Stuart KV, et al. Mol Aspects Med. 2023 Oct;93:101203. doi: 10.1016/j.mam.2023.101203. Epub 2023 Jul 8. Mol Aspects Med. 2023. PMID: 37423164 Free PMC article. Review.
Importantly, the ability to modify the risk associated with a particular genetic makeup promises to lead to personalised recommendations for glaucoma prevention, as well as novel treatment approaches in years to come. Here we provide an overview of genetic and environmenta …
Importantly, the ability to modify the risk associated with a particular genetic makeup promises to lead to personalised recommendations for …
Adherence and Persistence to Medical Therapy in Glaucoma: An Overview.
Quaranta L, Novella A, Tettamanti M, Pasina L, Weinreb RN, Nobili A. Quaranta L, et al. Ophthalmol Ther. 2023 Oct;12(5):2227-2240. doi: 10.1007/s40123-023-00730-z. Epub 2023 Jun 14. Ophthalmol Ther. 2023. PMID: 37311908 Free PMC article. Review.
The education of patients about glaucoma and the potential consequences of insufficient adherence and persistence seems fundamental to maximize the probability of treatment success and therefore prevent visual disability to avoid unnecessary healthcare costs....
The education of patients about glaucoma and the potential consequences of insufficient adherence and persistence seems fundamental to maxim …
Clinical risk stratification in glaucoma.
Poostchi A, Kastner A, Konstantakopoulou E, Gazzard G, Jayaram H. Poostchi A, et al. Eye (Lond). 2023 Oct;37(15):3121-3127. doi: 10.1038/s41433-023-02480-5. Epub 2023 Mar 14. Eye (Lond). 2023. PMID: 36918628 Free PMC article. Review.
Glaucoma is the leading cause of preventable sight loss in the United Kingdom and the provision of timely glaucoma care has been highlighted as a significant challenge in recent years. ...
Glaucoma is the leading cause of preventable sight loss in the United Kingdom and the provision of timely glaucoma care has been high …
Efficacy of citicoline as a supplement in glaucoma patients: A systematic review.
Prinz J, Prokosch V, Liu H, Walter P, Fuest M, Migliorini F. Prinz J, et al. PLoS One. 2023 Sep 28;18(9):e0291836. doi: 10.1371/journal.pone.0291836. eCollection 2023. PLoS One. 2023. PMID: 37768938 Free PMC article.
Thus, alternative treatment strategies to prevent glaucoma progression are an unmet need. Citicoline has demonstrated neuroprotective properties in central neurodegenerative diseases. ...
Thus, alternative treatment strategies to prevent glaucoma progression are an unmet need. Citicoline has demonstrated neuroprotective …
Fourteen-Year Outcome of Angle-Closure Prevention with Laser Iridotomy in the Zhongshan Angle-Closure Prevention Study: Extended Follow-up of a Randomized Controlled Trial.
Yuan Y, Wang W, Xiong R, Zhang J, Li C, Yang S, Friedman DS, Foster PJ, He M. Yuan Y, et al. Ophthalmology. 2023 Aug;130(8):786-794. doi: 10.1016/j.ophtha.2023.03.024. Epub 2023 Apr 6. Ophthalmology. 2023. PMID: 37030454 Free article. Clinical Trial.
DESIGN: Extended follow-up of the Zhongshan Angle-Closure Prevention Study. PARTICIPANTS: Eight hundred eighty-nine Chinese patients 50 to 70 years of age with bilateral PACS. ...
DESIGN: Extended follow-up of the Zhongshan Angle-Closure Prevention Study. PARTICIPANTS: Eight hundred eighty-nine Chinese patients …
Exploring the Relationship between Anti-VEGF Therapy and Glaucoma: Implications for Management Strategies.
Daka Q, Špegel N, Atanasovska Velkovska M, Steblovnik T, Kolko M, Neziri B, Cvenkel B. Daka Q, et al. J Clin Med. 2023 Jul 14;12(14):4674. doi: 10.3390/jcm12144674. J Clin Med. 2023. PMID: 37510790 Free PMC article. Review.
Strategies are needed to identify patients at risk in a timely manner and to prevent sustained elevation of IOP....
Strategies are needed to identify patients at risk in a timely manner and to prevent sustained elevation of IOP....
Sustained release ocular drug delivery systems for glaucoma therapy.
Al-Qaysi ZK, Beadham IG, Schwikkard SL, Bear JC, Al-Kinani AA, Alany RG. Al-Qaysi ZK, et al. Expert Opin Drug Deliv. 2023 Jul-Dec;20(7):905-919. doi: 10.1080/17425247.2023.2219053. Epub 2023 Jun 12. Expert Opin Drug Deliv. 2023. PMID: 37249548 Free article. Review.
Patient adherence to conventional eye drops remains a major obstacle in preventing glaucoma progression. Additional problems emerge from inadequate patient education as well as local and systemic side effects associated with adminstering ocular hypotensive drugs. ...Sustai …
Patient adherence to conventional eye drops remains a major obstacle in preventing glaucoma progression. Additional problems emerge f …
Effect of yoga on intra-ocular pressure in patients with glaucoma: A systematic review and meta-analysis.
Chetry D, Singh J, Chhetri A, Katiyar VK, Singh DS. Chetry D, et al. Indian J Ophthalmol. 2023 May;71(5):1757-1765. doi: 10.4103/ijo.IJO_2054_22. Indian J Ophthalmol. 2023. PMID: 37203026 Free PMC article.
Treatment of glaucoma focuses on lowering intra-ocular pressure to prevent progression of visual field defects, which is the only proven method for treating this disease. Yoga practices are believed to lower intra-ocular pressure in the eyes and prevent further dama …
Treatment of glaucoma focuses on lowering intra-ocular pressure to prevent progression of visual field defects, which is the only pro …
Is fat the future for saving sight? Bioactive lipids and their impact on glaucoma.
Kolko M, Mouhammad ZA, Cvenkel B. Kolko M, et al. Pharmacol Ther. 2023 May;245:108412. doi: 10.1016/j.pharmthera.2023.108412. Epub 2023 Apr 8. Pharmacol Ther. 2023. PMID: 37037408 Free article. Review.
In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of glaucoma by asking the question "is fat the future for saving sight"....
In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of …
The Mediterranean Diet and Age-Related Eye Diseases: A Systematic Review.
Wu Y, Xie Y, Yuan Y, Xiong R, Hu Y, Ning K, Ha J, Wang W, Han X, He M. Wu Y, et al. Nutrients. 2023 Apr 23;15(9):2043. doi: 10.3390/nu15092043. Nutrients. 2023. PMID: 37432187 Free PMC article.
The Mediterranean diet (MD) is a healthy diet pattern that can prevent chronic age-related diseases, especially age-related eye diseases (AREDs) including cataract, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR) and dry eye syndrome (DES). ...
The Mediterranean diet (MD) is a healthy diet pattern that can prevent chronic age-related diseases, especially age-related eye disea …
Glaucoma and Systemic Disease.
Hsu E, Desai M. Hsu E, et al. Life (Basel). 2023 Apr 15;13(4):1018. doi: 10.3390/life13041018. Life (Basel). 2023. PMID: 37109547 Free PMC article. Review.
The goal of our discussion of systemic conditions including their commonality, mechanisms, treatments, and associations with developing glaucoma is to emphasize the importance of ocular examinations and follow-up with the multidisciplinary teams involved in the care of each patie …
The goal of our discussion of systemic conditions including their commonality, mechanisms, treatments, and associations with developing glau …
Anti-vascular endothelial growth factor for neovascular glaucoma.
Rittiphairoj T, Roberti G, Michelessi M. Rittiphairoj T, et al. Cochrane Database Syst Rev. 2023 Apr 3;4(4):CD007920. doi: 10.1002/14651858.CD007920.pub4. Cochrane Database Syst Rev. 2023. PMID: 37010901 Free PMC article.
It is caused by the formation of abnormal new blood vessels, which prevent normal drainage of aqueous from the anterior segment of the eye. Anti-vascular endothelial growth factor (anti-VEGF) medications are specific inhibitors of the primary mediators of neovascularizatio …
It is caused by the formation of abnormal new blood vessels, which prevent normal drainage of aqueous from the anterior segment of th …
Device-modified trabeculectomy for glaucoma.
Park J, Rittiphairoj T, Wang X, E JY, Bicket AK. Park J, et al. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD010472. doi: 10.1002/14651858.CD010472.pub3. Cochrane Database Syst Rev. 2023. PMID: 36912740 Free PMC article.
Treatment for glaucoma aims to reduce intraocular pressure (IOP) to slow or prevent further vision loss. IOP can be lowered with medications, laser, or incisional surgery. ...PreserFlo MicroShunt may be inferior to standard trabeculectomy in lowering IOP. However, PreserFl …
Treatment for glaucoma aims to reduce intraocular pressure (IOP) to slow or prevent further vision loss. IOP can be lowered with medi …
Subconjunctival filtration in evolution: current evidence on MicroShunt implantation for treating patients with glaucoma.
Ahmed IIK, Sadruddin O, Panarelli JF. Ahmed IIK, et al. Eye Vis (Lond). 2023 Mar 2;10(1):10. doi: 10.1186/s40662-022-00322-1. Eye Vis (Lond). 2023. PMID: 36859515 Free PMC article. Review.
MAIN TEXT: The MicroShunt is an 8.5-mm tube made of an inert polymer with no endplate, an internal diameter of 70 mum, and fins intended to prevent peritubular flow and anchor the device within the sclera to prevent proximal migration into the eye. ...
MAIN TEXT: The MicroShunt is an 8.5-mm tube made of an inert polymer with no endplate, an internal diameter of 70 mum, and fins intended to …
Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery.
Shao CG, Sinha NR, Mohan RR, Webel AD. Shao CG, et al. Biomedicines. 2023 Feb 21;11(3):657. doi: 10.3390/biomedicines11030657. Biomedicines. 2023. PMID: 36979636 Free PMC article. Review.
Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy is needed to prevent progressive tissue remodeling and formation of a fibrotic scar, subsequently increasing surgical success and re …
Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy …
A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice.
Ramji S, Nagi G, Ansari AS, Kailani O. Ramji S, et al. Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261(2):477-501. doi: 10.1007/s00417-022-05785-5. Epub 2022 Aug 8. Graefes Arch Clin Exp Ophthalmol. 2023. PMID: 35939118 Free PMC article.
Treatment aims to reduce IOP in order to prevent optic nerve damage. A systematic review was completed synthesising results from randomised control trials (RCTs) comparing interventions for the management of NVG and their efficacy and safety. ...
Treatment aims to reduce IOP in order to prevent optic nerve damage. A systematic review was completed synthesising results from rand …
Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target.
Loo JH, Wang Z, Chong RS. Loo JH, et al. Front Med (Lausanne). 2023 Jan 24;10:1087123. doi: 10.3389/fmed.2023.1087123. eCollection 2023. Front Med (Lausanne). 2023. PMID: 36760400 Free PMC article. Review.
Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascular diseases. Endothelial nitric oxide synthase and endothelin-1 are key vasoactive molecules expressed in retinal blood vessels that function …
Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascula …