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Knowledge about glaucoma among adults in Africa: a systematic review.
Yimam W, Anbesaw T, Seid M, Kumar P, Wolie H. Yimam W, et al. BMC Ophthalmol. 2024 Feb 14;24(1):69. doi: 10.1186/s12886-024-03333-9. BMC Ophthalmol. 2024. PMID: 38355482 Free PMC article.
If left untreated, glaucoma can cause blindness and permanent vision loss if it is not addressed promptly. Good knowledge is essential for preventing glaucoma's irreversible blindness and ocular damage. However, no systematic review has been done to report the pooled perce …
If left untreated, glaucoma can cause blindness and permanent vision loss if it is not addressed promptly. Good knowledge is essential for …
Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics.
Shean R, Yu N, Guntipally S, Nguyen V, He X, Duan S, Gokoffski K, Zhu Y, Xu B. Shean R, et al. Bioengineering (Basel). 2024 Jan 30;11(2):138. doi: 10.3390/bioengineering11020138. Bioengineering (Basel). 2024. PMID: 38391624 Free PMC article. Review.
Glaucoma is a leading cause of irreversible blindness, and early detection and treatment are crucial for preventing vision loss. This review aims to provide an overview of current diagnostic and treatment standards, recent medical and technological advances, and current ch …
Glaucoma is a leading cause of irreversible blindness, and early detection and treatment are crucial for preventing vision loss. This …
The progress of assessment methods and treatments of neovascular glaucoma secondary to central retinal vein occlusion.
Qu S, Zou Y, Yang L, Wu H. Qu S, et al. Front Med (Lausanne). 2024 Jan 8;10:1280776. doi: 10.3389/fmed.2023.1280776. eCollection 2023. Front Med (Lausanne). 2024. PMID: 38259837 Free PMC article. Review.
Meanwhile, although pan-retinal photocoagulation is a standard treatment to prevent the onset of neovascular glaucoma, its actual efficacy and the timing of intervention remain highly controversial. ...This article details the debate on the above issues and explores ideas …
Meanwhile, although pan-retinal photocoagulation is a standard treatment to prevent the onset of neovascular glaucoma, its actual eff …
Molecular aspects of optic nerve autophagy in glaucoma.
Kitaoka Y, Sase K. Kitaoka Y, et al. Mol Aspects Med. 2023 Dec;94:101217. doi: 10.1016/j.mam.2023.101217. Epub 2023 Oct 14. Mol Aspects Med. 2023. PMID: 37839231 Free article. Review.
Several molecular candidates are involved in autophagy enhancement, leading to axonal protection. This concept is an attractive approach to the prevention of further retinal ganglion cell death. In this review, we describe the factors affecting autophagy, including nicotin …
Several molecular candidates are involved in autophagy enhancement, leading to axonal protection. This concept is an attractive approach to …
Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy.
Wang J, Wang H, Dang Y. Wang J, et al. Ophthalmol Ther. 2023 Dec;12(6):2943-2957. doi: 10.1007/s40123-023-00820-y. Epub 2023 Oct 14. Ophthalmol Ther. 2023. PMID: 37837578 Free PMC article. Review.
Reduction of intraocular pressure (IOP) is the only known modifiable risk factor for preventing and treating glaucoma. Rho kinase (ROCK) inhibitors are a new class of glaucoma drugs with a novel mechanism of action and good safety profile. ...
Reduction of intraocular pressure (IOP) is the only known modifiable risk factor for preventing and treating glaucoma. Rho kinase (RO …
Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors.
Stuart KV, Pasquale LR, Kang JH, Foster PJ, Khawaja AP. Stuart KV, et al. Mol Aspects Med. 2023 Oct;93:101203. doi: 10.1016/j.mam.2023.101203. Epub 2023 Jul 8. Mol Aspects Med. 2023. PMID: 37423164 Free PMC article. Review.
Importantly, the ability to modify the risk associated with a particular genetic makeup promises to lead to personalised recommendations for glaucoma prevention, as well as novel treatment approaches in years to come. ...
Importantly, the ability to modify the risk associated with a particular genetic makeup promises to lead to personalised recommendations for …
Adherence and Persistence to Medical Therapy in Glaucoma: An Overview.
Quaranta L, Novella A, Tettamanti M, Pasina L, Weinreb RN, Nobili A. Quaranta L, et al. Ophthalmol Ther. 2023 Oct;12(5):2227-2240. doi: 10.1007/s40123-023-00730-z. Epub 2023 Jun 14. Ophthalmol Ther. 2023. PMID: 37311908 Free PMC article. Review.
The education of patients about glaucoma and the potential consequences of insufficient adherence and persistence seems fundamental to maximize the probability of treatment success and therefore prevent visual disability to avoid unnecessary healthcare costs....
The education of patients about glaucoma and the potential consequences of insufficient adherence and persistence seems fundamental to maxim …
Clinical risk stratification in glaucoma.
Poostchi A, Kastner A, Konstantakopoulou E, Gazzard G, Jayaram H. Poostchi A, et al. Eye (Lond). 2023 Oct;37(15):3121-3127. doi: 10.1038/s41433-023-02480-5. Epub 2023 Mar 14. Eye (Lond). 2023. PMID: 36918628 Free PMC article. Review.
Glaucoma is the leading cause of preventable sight loss in the United Kingdom and the provision of timely glaucoma care has been highlighted as a significant challenge in recent years. ...
Glaucoma is the leading cause of preventable sight loss in the United Kingdom and the provision of timely glaucoma care has been high …
Efficacy of citicoline as a supplement in glaucoma patients: A systematic review.
Prinz J, Prokosch V, Liu H, Walter P, Fuest M, Migliorini F. Prinz J, et al. PLoS One. 2023 Sep 28;18(9):e0291836. doi: 10.1371/journal.pone.0291836. eCollection 2023. PLoS One. 2023. PMID: 37768938 Free PMC article.
Elevated intraocular pressure (IOP) is the only modifiable risk factor, however, many patients progress despite excellent IOP control. Thus, alternative treatment strategies to prevent glaucoma progression are an unmet need. Citicoline has demonstrated neuroprotective prop …
Elevated intraocular pressure (IOP) is the only modifiable risk factor, however, many patients progress despite excellent IOP control. Thus, …
Fourteen-Year Outcome of Angle-Closure Prevention with Laser Iridotomy in the Zhongshan Angle-Closure Prevention Study: Extended Follow-up of a Randomized Controlled Trial.
Yuan Y, Wang W, Xiong R, Zhang J, Li C, Yang S, Friedman DS, Foster PJ, He M. Yuan Y, et al. Ophthalmology. 2023 Aug;130(8):786-794. doi: 10.1016/j.ophtha.2023.03.024. Epub 2023 Apr 6. Ophthalmology. 2023. PMID: 37030454 Free article. Clinical Trial.
DESIGN: Extended follow-up of the Zhongshan Angle-Closure Prevention Study. PARTICIPANTS: Eight hundred eighty-nine Chinese patients 50 to 70 years of age with bilateral PACS. ...
DESIGN: Extended follow-up of the Zhongshan Angle-Closure Prevention Study. PARTICIPANTS: Eight hundred eighty-nine Chinese patients …
Exploring the Relationship between Anti-VEGF Therapy and Glaucoma: Implications for Management Strategies.
Daka Q, Špegel N, Atanasovska Velkovska M, Steblovnik T, Kolko M, Neziri B, Cvenkel B. Daka Q, et al. J Clin Med. 2023 Jul 14;12(14):4674. doi: 10.3390/jcm12144674. J Clin Med. 2023. PMID: 37510790 Free PMC article. Review.
Strategies are needed to identify patients at risk in a timely manner and to prevent sustained elevation of IOP....
Strategies are needed to identify patients at risk in a timely manner and to prevent sustained elevation of IOP....
Effect of yoga on intra-ocular pressure in patients with glaucoma: A systematic review and meta-analysis.
Chetry D, Singh J, Chhetri A, Katiyar VK, Singh DS. Chetry D, et al. Indian J Ophthalmol. 2023 May;71(5):1757-1765. doi: 10.4103/ijo.IJO_2054_22. Indian J Ophthalmol. 2023. PMID: 37203026 Free PMC article. Review.
Treatment of glaucoma focuses on lowering intra-ocular pressure to prevent progression of visual field defects, which is the only proven method for treating this disease. Yoga practices are believed to lower intra-ocular pressure in the eyes and prevent further dama …
Treatment of glaucoma focuses on lowering intra-ocular pressure to prevent progression of visual field defects, which is the only pro …
Is fat the future for saving sight? Bioactive lipids and their impact on glaucoma.
Kolko M, Mouhammad ZA, Cvenkel B. Kolko M, et al. Pharmacol Ther. 2023 May;245:108412. doi: 10.1016/j.pharmthera.2023.108412. Epub 2023 Apr 8. Pharmacol Ther. 2023. PMID: 37037408 Free article. Review.
In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of glaucoma by asking the question "is fat the future for saving sight"....
In this review, we aim to shed light on the potential of bioactive lipids for the prevention, diagnosis, prognosis, and treatment of …
The Mediterranean Diet and Age-Related Eye Diseases: A Systematic Review.
Wu Y, Xie Y, Yuan Y, Xiong R, Hu Y, Ning K, Ha J, Wang W, Han X, He M. Wu Y, et al. Nutrients. 2023 Apr 23;15(9):2043. doi: 10.3390/nu15092043. Nutrients. 2023. PMID: 37432187 Free PMC article. Review.
The Mediterranean diet (MD) is a healthy diet pattern that can prevent chronic age-related diseases, especially age-related eye diseases (AREDs) including cataract, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR) and dry eye syndrome (DES). ...
The Mediterranean diet (MD) is a healthy diet pattern that can prevent chronic age-related diseases, especially age-related eye disea …
Glaucoma and Systemic Disease.
Hsu E, Desai M. Hsu E, et al. Life (Basel). 2023 Apr 15;13(4):1018. doi: 10.3390/life13041018. Life (Basel). 2023. PMID: 37109547 Free PMC article. Review.
The goal of our discussion of systemic conditions including their commonality, mechanisms, treatments, and associations with developing glaucoma is to emphasize the importance of ocular examinations and follow-up with the multidisciplinary teams involved in the care of each patie …
The goal of our discussion of systemic conditions including their commonality, mechanisms, treatments, and associations with developing glau …
Subconjunctival filtration in evolution: current evidence on MicroShunt implantation for treating patients with glaucoma.
Ahmed IIK, Sadruddin O, Panarelli JF. Ahmed IIK, et al. Eye Vis (Lond). 2023 Mar 2;10(1):10. doi: 10.1186/s40662-022-00322-1. Eye Vis (Lond). 2023. PMID: 36859515 Free PMC article. Review.
MAIN TEXT: The MicroShunt is an 8.5-mm tube made of an inert polymer with no endplate, an internal diameter of 70 mum, and fins intended to prevent peritubular flow and anchor the device within the sclera to prevent proximal migration into the eye. ...
MAIN TEXT: The MicroShunt is an 8.5-mm tube made of an inert polymer with no endplate, an internal diameter of 70 mum, and fins intended to …
Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery.
Shao CG, Sinha NR, Mohan RR, Webel AD. Shao CG, et al. Biomedicines. 2023 Feb 21;11(3):657. doi: 10.3390/biomedicines11030657. Biomedicines. 2023. PMID: 36979636 Free PMC article. Review.
Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy is needed to prevent progressive tissue remodeling and formation of a fibrotic scar, subsequently increasing surgical success and re …
Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy …
A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice.
Ramji S, Nagi G, Ansari AS, Kailani O. Ramji S, et al. Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261(2):477-501. doi: 10.1007/s00417-022-05785-5. Epub 2022 Aug 8. Graefes Arch Clin Exp Ophthalmol. 2023. PMID: 35939118 Free PMC article.
This results in progressive optic neuropathy and loss of visual acuity. Treatment aims to reduce IOP in order to prevent optic nerve damage. A systematic review was completed synthesising results from randomised control trials (RCTs) comparing interventions for the managem …
This results in progressive optic neuropathy and loss of visual acuity. Treatment aims to reduce IOP in order to prevent optic nerve …
Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target.
Loo JH, Wang Z, Chong RS. Loo JH, et al. Front Med (Lausanne). 2023 Jan 24;10:1087123. doi: 10.3389/fmed.2023.1087123. eCollection 2023. Front Med (Lausanne). 2023. PMID: 36760400 Free PMC article. Review.
Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascular diseases. Endothelial nitric oxide synthase and endothelin-1 are key vasoactive molecules expressed in retinal blood vessels that function …
Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascula …
Automatic detection of glaucoma via fundus imaging and artificial intelligence: A review.
Coan LJ, Williams BM, Krishna Adithya V, Upadhyaya S, Alkafri A, Czanner S, Venkatesh R, Willoughby CE, Kavitha S, Czanner G. Coan LJ, et al. Surv Ophthalmol. 2023 Jan-Feb;68(1):17-41. doi: 10.1016/j.survophthal.2022.08.005. Epub 2022 Aug 17. Surv Ophthalmol. 2023. PMID: 35985360 Free article. Review.
Early detection is crucial, allowing timely intervention that can prevent further visual field loss. To detect glaucoma an examination of the optic nerve head via fundus imaging can be performed, at the center of which is the assessment of the optic cup and disc boundaries …
Early detection is crucial, allowing timely intervention that can prevent further visual field loss. To detect glaucoma an examinatio …
A Review of Neovascular Glaucoma: Etiology, Pathogenesis, Diagnosis, and Treatment.
Urbonavičiūtė D, Buteikienė D, Janulevičienė I. Urbonavičiūtė D, et al. Medicina (Kaunas). 2022 Dec 18;58(12):1870. doi: 10.3390/medicina58121870. Medicina (Kaunas). 2022. PMID: 36557072 Free PMC article. Review.
It is an urgent ophthalmic condition; early diagnosis and treatment are necessary to preserve vision and prevent eye loss. The management of NVG requires the cooperation of retinal and glaucoma specialists. The treatment of NVG includes both control of the underlying disea …
It is an urgent ophthalmic condition; early diagnosis and treatment are necessary to preserve vision and prevent eye loss. The manage …
Combined use of coenzyme Q10 and citicoline: A new possibility for patients with glaucoma.
Martucci A, Mancino R, Cesareo M, Pinazo-Duran MD, Nucci C. Martucci A, et al. Front Med (Lausanne). 2022 Dec 15;9:1020993. doi: 10.3389/fmed.2022.1020993. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36590976 Free PMC article. Review.
New evidence strongly suggests brain involvement in all aspects of this disease. This hypothesis and the need to prevent glaucomatous progression led to a growing interest in the pharmacological research of new neuroprotective, non-IOP-lowering, agents. The aim of this pap …
New evidence strongly suggests brain involvement in all aspects of this disease. This hypothesis and the need to prevent glaucomatous …
Autophagy in glaucoma pathogenesis: Therapeutic potential and future perspectives.
Li M, Gao ZL, Zhang QP, Luo AX, Xu WY, Duan TQ, Wen XP, Zhang RQ, Zeng R, Huang JF. Li M, et al. Front Cell Dev Biol. 2022 Dec 14;10:1068213. doi: 10.3389/fcell.2022.1068213. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36589756 Free PMC article. Review.
Here, we provide a systematic review of the mechanisms and targets of interventions related to autophagy in glaucoma and discuss the outlook of emerging ideas, techniques, and multidisciplinary combinations to provide a new basis for further research and the prevention of …
Here, we provide a systematic review of the mechanisms and targets of interventions related to autophagy in glaucoma and discuss the outlook …
Updates on the Diagnosis and Management of Glaucoma.
Wagner IV, Stewart MW, Dorairaj SK. Wagner IV, et al. Mayo Clin Proc Innov Qual Outcomes. 2022 Nov 16;6(6):618-635. doi: 10.1016/j.mayocpiqo.2022.09.007. eCollection 2022 Dec. Mayo Clin Proc Innov Qual Outcomes. 2022. PMID: 36405987 Free PMC article. Review.
Chronic glaucoma occurs most commonly; thus, regular eye examinations should be performed in at-risk patients to prevent the insidious loss of vision that can develop before diagnosis. ...
Chronic glaucoma occurs most commonly; thus, regular eye examinations should be performed in at-risk patients to prevent the insidiou …
Minimally Invasive Glaucoma Surgery: Safety of Individual Devices.
Rowson AC, Hogarty DT, Maher D, Liu L. Rowson AC, et al. J Clin Med. 2022 Nov 18;11(22):6833. doi: 10.3390/jcm11226833. J Clin Med. 2022. PMID: 36431310 Free PMC article. Review.
In the last few decades, significant advances have been made in the field of minimally invasive glaucoma surgery (MIGS) devices, which aim to defer or prevent trabeculectomy via less arduous surgical techniques in certain types of glaucoma. ...
In the last few decades, significant advances have been made in the field of minimally invasive glaucoma surgery (MIGS) devices, which aim t …
Uveitic glaucoma in children: a systematic review on surgical outcomes.
van Meerwijk CLLI, Jansonius NM, Los LI. van Meerwijk CLLI, et al. J Ophthalmic Inflamm Infect. 2022 Nov 7;12(1):35. doi: 10.1186/s12348-022-00313-2. J Ophthalmic Inflamm Infect. 2022. PMID: 36344704 Free PMC article. Review.
CONCLUSIONS: The described surgical interventions are able to prevent blindness by lowering a medically uncontrolled IOP to an acceptable level. ...
CONCLUSIONS: The described surgical interventions are able to prevent blindness by lowering a medically uncontrolled IOP to an accept …
Dietary supplements in retinal diseases, glaucoma, and other ocular conditions.
Medori MC, Naureen Z, Dhuli K, Placidi G, Falsini B, Bertelli M. Medori MC, et al. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E189-E199. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2760. eCollection 2022 Jun. J Prev Med Hyg. 2022. PMID: 36479474 Free PMC article. Review.
Given the costly treatments that are currently available for the most common and threatening eye diseases (such as cataract, dry eye disorder, or diabetic retinopathy), curing these diseases or preventing refractive errors by taking nutraceuticals and natural compounds tha …
Given the costly treatments that are currently available for the most common and threatening eye diseases (such as cataract, dry eye disorde …
A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion.
Jabbehdari S, Yazdanpanah G, Cantor LB, Hajrasouliha AR. Jabbehdari S, et al. Ann Transl Med. 2022 Oct;10(19):1072. doi: 10.21037/atm-22-2730. Ann Transl Med. 2022. PMID: 36330401 Free PMC article. Review.
CONCLUSIONS: Determining potential patient responses to treatment and considering therapeutic options are challenging among patients with RVO and glaucoma. However, IOP lowering managements in preventing IOP spikes in patients with preexisting glaucoma and early treatment …
CONCLUSIONS: Determining potential patient responses to treatment and considering therapeutic options are challenging among patients with RV …
Influences of Glaucoma on the Structure and Function of Synapses in the Visual System.
Van Hook MJ. Van Hook MJ. Antioxid Redox Signal. 2022 Oct;37(10-12):842-861. doi: 10.1089/ars.2021.0253. Epub 2022 Apr 18. Antioxid Redox Signal. 2022. PMID: 35044228 Free PMC article. Review.
Future work will be able to capitalize on these findings to better design diagnostic and therapeutic approaches to detect disease and prevent vision loss. Antioxid. Redox Signal. 37, 842-861....
Future work will be able to capitalize on these findings to better design diagnostic and therapeutic approaches to detect disease and pre
New strategies for neuro protection in glaucoma.
Xuejiao Y, Junwei Y. Xuejiao Y, et al. Front Cell Dev Biol. 2022 Sep 15;10:983195. doi: 10.3389/fcell.2022.983195. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36187483 Free PMC article. Review.
The main risk factor for glaucoma onset and development is high intraocular pressure (IOP), however traditional IOP-lowering therapies are often not sufficient to prevent degeneration of RGCs and the vision loss may progress, indicating the need for complementary neuroprot …
The main risk factor for glaucoma onset and development is high intraocular pressure (IOP), however traditional IOP-lowering therapies are o …
Rho Kinase Inhibitors as a Neuroprotective Pharmacological Intervention for the Treatment of Glaucoma.
Thomas NM, Nagrale P. Thomas NM, et al. Cureus. 2022 Aug 26;14(8):e28445. doi: 10.7759/cureus.28445. eCollection 2022 Aug. Cureus. 2022. PMID: 36176819 Free PMC article. Review.
Glaucoma is a leading cause of irreversible blindness, and its prevalence has led to research into treatment modalities for glaucoma to prevent the progression of the disease. The primary treatment for glaucoma that has been extensively used is ocular hypotensives to reduc …
Glaucoma is a leading cause of irreversible blindness, and its prevalence has led to research into treatment modalities for glaucoma to p
Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma.
Strickland RG, Garner MA, Gross AK, Girkin CA. Strickland RG, et al. Int J Mol Sci. 2022 Jul 22;23(15):8068. doi: 10.3390/ijms23158068. Int J Mol Sci. 2022. PMID: 35897642 Free PMC article. Review.
The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. There are three major classes of cells in the human optic nerve head (ONH): lamina cribrosa (LC) cells, glial cells, and scleral fibroblasts …
The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. …
Role of pilocarpine use following laser peripheral iridotomy in eyes with refractory acute angle closure glaucoma: A case report and literature review.
Yen CY, Chen CC, Tseng PC. Yen CY, et al. Medicine (Baltimore). 2022 Jul 8;101(27):e29245. doi: 10.1097/MD.0000000000029245. Medicine (Baltimore). 2022. PMID: 35801778 Free PMC article. Review.
Laser peripheral iridotomy (LPI) could minimize pupillary block and prevent ACG from an acute attack. However, recurrent increase in intraocular pressure (IOP) may still occur despite successful LPI. ...
Laser peripheral iridotomy (LPI) could minimize pupillary block and prevent ACG from an acute attack. However, recurrent increase in …
A novel viewpoint in glaucoma therapeutics: enriched environment.
González Fleitas MF, Dorfman D, Rosenstein RE. González Fleitas MF, et al. Neural Regen Res. 2022 Jul;17(7):1431-1439. doi: 10.4103/1673-5374.330594. Neural Regen Res. 2022. PMID: 34916414 Free PMC article. Review.
Besides pharmacological treatments, environmental conditions have been shown to prevent neurodegeneration in the central nervous system. In this review, we discuss current concepts on key pathogenic mechanisms involved in glaucoma, the effect of enriched environment on the …
Besides pharmacological treatments, environmental conditions have been shown to prevent neurodegeneration in the central nervous syst …
Juvenile-onset open-angle glaucoma - A clinical and genetic update.
Selvan H, Gupta S, Wiggs JL, Gupta V. Selvan H, et al. Surv Ophthalmol. 2022 Jul-Aug;67(4):1099-1117. doi: 10.1016/j.survophthal.2021.09.001. Epub 2021 Sep 16. Surv Ophthalmol. 2022. PMID: 34536459 Free PMC article. Review.
Early diagnosis, prompt management, and life-long monitoring play an important role in preventing disease progression. Gene-based therapies currently under investigation offer future hope....
Early diagnosis, prompt management, and life-long monitoring play an important role in preventing disease progression. Gene-based the …
Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension.
Clement Freiberg J, von Spreckelsen A, Kolko M, Azuara-Blanco A, Virgili G. Clement Freiberg J, et al. Cochrane Database Syst Rev. 2022 Jun 10;6(6):CD013817. doi: 10.1002/14651858.CD013817.pub2. Cochrane Database Syst Rev. 2022. PMID: 35686679 Free PMC article. Review.
The etiology of POAG is unknown, but current treatments aim to reduce intraocular pressure (IOP), thus preventing the onset and progression of the disease. Compared with traditional antiglaucomatous treatments, rho kinase inhibitors (ROKi) have a different pharmacodynamic. …
The etiology of POAG is unknown, but current treatments aim to reduce intraocular pressure (IOP), thus preventing the onset and progr …
Newer advances in medical management of glaucoma.
Mohan N, Chakrabarti A, Nazm N, Mehta R, Edward DP. Mohan N, et al. Indian J Ophthalmol. 2022 Jun;70(6):1920-1930. doi: 10.4103/ijo.IJO_2239_21. Indian J Ophthalmol. 2022. PMID: 35647957 Free PMC article. Review.
While the disease pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk factor identified to prevent glaucomatous vision loss. Medical management remains the first-line of treatment in most adult glaucomas and the evolution of medical …
While the disease pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk factor identified to preven
Screening for Glaucoma in Adults: A Systematic Review for the U.S. Preventive Services Task Force.
Chou R, Selph S, Blazina I, Bougatsos C, Jungbauer R, Fu R, Grusing S, Jonas D, Tehrani S. Chou R, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 May. Report No.: 21-05286-EF-1. Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 May. Report No.: 21-05286-EF-1. PMID: 35679438 Free Books & Documents. Review.
BACKGROUND: In 2013, the United States Preventive Services Task Force (USPSTF) concluded that the evidence was insufficient to assess the balance of benefits and harms of screening for primary open angle glaucoma in adults (I Statement). ...
BACKGROUND: In 2013, the United States Preventive Services Task Force (USPSTF) concluded that the evidence was insufficient to assess …
Emerging Evidence of Noncoding RNAs in Bleb Scarring after Glaucoma Filtration Surgery.
Yu S, Tam ALC, Campbell R, Renwick N. Yu S, et al. Cells. 2022 Apr 12;11(8):1301. doi: 10.3390/cells11081301. Cells. 2022. PMID: 35455980 Free PMC article. Review.
CONCLUSIONS: Noncoding RNAs including miRNAs and lncRNAs are emerging and promising therapeutic targets in the prevention of post-glaucoma filtration surgery fibrosis....
CONCLUSIONS: Noncoding RNAs including miRNAs and lncRNAs are emerging and promising therapeutic targets in the prevention of post-gla …
From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma.
da Silva CN, Nunes KP, Dourado LFN, Vieira TO, Mariano XM, Cunha Junior ADS, de Lima ME. da Silva CN, et al. Front Mol Biosci. 2022 Apr 11;9:831823. doi: 10.3389/fmolb.2022.831823. eCollection 2022. Front Mol Biosci. 2022. PMID: 35480885 Free PMC article. Review.
Furthermore, considering that PnPP-19 increases NO availability in the corpus cavernosum, this peptide was also tested in a model of induced intraocular hypertension, characterized by low NO levels, and it showed promising results by decreasing the intraocular pressure which p
Furthermore, considering that PnPP-19 increases NO availability in the corpus cavernosum, this peptide was also tested in a model of induced …
The Role of Axonal Transport in Glaucoma.
Dias MS, Luo X, Ribas VT, Petrs-Silva H, Koch JC. Dias MS, et al. Int J Mol Sci. 2022 Apr 1;23(7):3935. doi: 10.3390/ijms23073935. Int J Mol Sci. 2022. PMID: 35409291 Free PMC article. Review.
Thus, a better understanding of the role of axonal transport in glaucoma is not only pivotal to decipher disease mechanisms but could also enable early therapies that might prevent irreversible neuronal damage at an early time point. In this review we present the current e …
Thus, a better understanding of the role of axonal transport in glaucoma is not only pivotal to decipher disease mechanisms but could also e …
Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review.
Młynarczyk M, Falkowska M, Micun Z, Obuchowska I, Kochanowicz J, Socha K, Konopińska J. Młynarczyk M, et al. Nutrients. 2022 Mar 29;14(7):1421. doi: 10.3390/nu14071421. Nutrients. 2022. PMID: 35406033 Free PMC article. Review.
It is an insidious disease with a multifactorial pathogenesis. Despite progress in treatment methods, prevention and lifestyle modifications may be useful in slowing the progression of this disease. ...
It is an insidious disease with a multifactorial pathogenesis. Despite progress in treatment methods, prevention and lifestyle modifi …
Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans.
Mendoza M, Shotbolt M, Faiq MA, Parra C, Chan KC. Mendoza M, et al. Biology (Basel). 2022 Mar 16;11(3):454. doi: 10.3390/biology11030454. Biology (Basel). 2022. PMID: 35336827 Free PMC article. Review.
A growing body of dMRI research indicates that this modality holds promise in characterizing early glaucomatous changes in the visual system, determining the disease severity, and identifying potential neurotherapeutic targets, offering more options to slow glaucoma progression a …
A growing body of dMRI research indicates that this modality holds promise in characterizing early glaucomatous changes in the visual system …
Restoring the oxidative balance in age-related diseases - An approach in glaucoma.
Cáceres-Vélez PR, Hui F, Hercus J, Bui B, Jusuf PR. Cáceres-Vélez PR, et al. Ageing Res Rev. 2022 Mar;75:101572. doi: 10.1016/j.arr.2022.101572. Epub 2022 Jan 20. Ageing Res Rev. 2022. PMID: 35065274 Free article. Review.
We consider therapeutic approaches used to counteract oxidative stress in glaucoma, including untapped treatment options such as novel plant-derived antioxidant compounds that can reduce oxidative stress and prevent neuronal loss. We summarize the current pre-clinical mode …
We consider therapeutic approaches used to counteract oxidative stress in glaucoma, including untapped treatment options such as novel plant …
Population screening for glaucoma in UK: current recommendations and future directions.
Hamid S, Desai P, Hysi P, Burr JM, Khawaja AP. Hamid S, et al. Eye (Lond). 2022 Mar;36(3):504-509. doi: 10.1038/s41433-021-01687-8. Epub 2021 Aug 3. Eye (Lond). 2022. PMID: 34345031 Free PMC article. Review.
Effective population screening for glaucoma would enable earlier diagnosis and prevention of irreversible vision loss. The UK National Screening Committee (NSC) recently published a review that examined the viability, effectiveness and appropriateness of a population-based …
Effective population screening for glaucoma would enable earlier diagnosis and prevention of irreversible vision loss. The UK Nationa …
PreserFlo() MicroShunt: An Overview of This Minimally Invasive Device for Open-Angle Glaucoma.
Gambini G, Carlà MM, Giannuzzi F, Caporossi T, De Vico U, Savastano A, Baldascino A, Rizzo C, Kilian R, Caporossi A, Rizzo S. Gambini G, et al. Vision (Basel). 2022 Feb 9;6(1):12. doi: 10.3390/vision6010012. Vision (Basel). 2022. PMID: 35225971 Free PMC article. Review.
The PreserFlo() MicroShunt (previously InnFocus MicroShunt) is an 8.5 mm glaucoma drainage device manufactured from poly(styrene-block-isobutylene-block-styrene) (SIBS), an extremely biocompatible and bioinert material. The lumen is narrow enough to prevent hypotony, but b …
The PreserFlo() MicroShunt (previously InnFocus MicroShunt) is an 8.5 mm glaucoma drainage device manufactured from poly(styrene-block-isobu …
Neuroprotection in glaucoma.
Vishwaraj CR, Kavitha S, Venkatesh R, Shukla AG, Chandran P, Tripathi S. Vishwaraj CR, et al. Indian J Ophthalmol. 2022 Feb;70(2):380-385. doi: 10.4103/ijo.IJO_1158_21. Indian J Ophthalmol. 2022. PMID: 35086201 Free PMC article. Review.
Neuroprotective therapies in glaucoma may play a role in preventing ischemia and oxidative damage that results in apoptosis of retinal ganglion cells and optic nerve damage. ...
Neuroprotective therapies in glaucoma may play a role in preventing ischemia and oxidative damage that results in apoptosis of retina …
The Role of NAD(+) and Nicotinamide (Vitamin B3) in Glaucoma: A Literature Review.
Pietris J. Pietris J. J Nutr Sci Vitaminol (Tokyo). 2022;68(3):151-154. doi: 10.3177/jnsv.68.151. J Nutr Sci Vitaminol (Tokyo). 2022. PMID: 35768245 Free article. Review.
This review aims to analyse the currently available literature to determine whether there is evidence of an association between nicotinamide adenine dinucleotide (NAD(+)) and glaucomatous optic neuropathy, and whether nicotinamide has the potential to prevent or reverse th …
This review aims to analyse the currently available literature to determine whether there is evidence of an association between nicotinamide …
Conventional glaucoma implants and the new MIGS devices: a comprehensive review of current options and future directions.
Pereira ICF, van de Wijdeven R, Wyss HM, Beckers HJM, den Toonder JMJ. Pereira ICF, et al. Eye (Lond). 2021 Dec;35(12):3202-3221. doi: 10.1038/s41433-021-01595-x. Epub 2021 Jun 14. Eye (Lond). 2021. PMID: 34127842 Free PMC article. Review.
Glaucoma is a progressive optic neuropathy that is the second leading cause of preventable blindness worldwide, after cataract formation. A rise in the intraocular pressure (IOP) is considered to be a major risk factor for glaucoma and is associated with an abnormal increa …
Glaucoma is a progressive optic neuropathy that is the second leading cause of preventable blindness worldwide, after cataract format …
Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT.
King AJ, Fernie G, Hudson J, Kernohan A, Azuara-Blanco A, Burr J, Homer T, Shabaninejad H, Sparrow JM, Garway-Heath D, Barton K, Norrie J, McDonald A, Vale L, MacLennan G. King AJ, et al. Health Technol Assess. 2021 Nov;25(72):1-158. doi: 10.3310/hta25720. Health Technol Assess. 2021. PMID: 34854808 Free article. Clinical Trial.
Patients with severe vision loss at diagnosis are the most at risk of blindness in their lifetime. Lowering pressure in the eye is the only way to prevent further vision loss. Two treatments to lower pressure are commonly used: using eye drops or having an operation known …
Patients with severe vision loss at diagnosis are the most at risk of blindness in their lifetime. Lowering pressure in the eye is the only …
Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma.
Dziedziak J, Kasarełło K, Cudnoch-Jędrzejewska A. Dziedziak J, et al. Antioxidants (Basel). 2021 Oct 30;10(11):1743. doi: 10.3390/antiox10111743. Antioxidants (Basel). 2021. PMID: 34829613 Free PMC article. Review.
For AMD, carotenoids and omega-3 fatty acids were also proved to be sufficient in preventing neurodegeneration. For glaucoma, coenzyme Q10 and alpha-lipoic acid showed efficacy for decreasing retinal ganglion cell loss and inhibiting the accompanying destructive processes. …
For AMD, carotenoids and omega-3 fatty acids were also proved to be sufficient in preventing neurodegeneration. For glaucoma, coenzym …
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D. Dumbrăveanu L, et al. Rom J Ophthalmol. 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. Rom J Ophthalmol. 2021. PMID: 35087972 Free PMC article. Review.
Managing the NVG we should aim to: 1) reduce ocular ischemia and treat its underlying cause, 2) reduce elevated IOP, once installed and 3) control the inflammatory process. Anyway, the best treatment is prevention, so we must be very attentive at patients with risk factors …
Managing the NVG we should aim to: 1) reduce ocular ischemia and treat its underlying cause, 2) reduce elevated IOP, once installed and 3) c …
Multiplex protein analysis for the study of glaucoma.
Tezel G. Tezel G. Expert Rev Proteomics. 2021 Oct;18(10):911-924. doi: 10.1080/14789450.2021.1996232. Epub 2021 Oct 29. Expert Rev Proteomics. 2021. PMID: 34672220 Free PMC article. Review.
INTRODUCTION: Glaucoma, a leading cause of irreversible blindness in the world, is a chronic neurodegenerative disease of multifactorial origin. Extensive research is ongoing to better understand, prevent, and treat progressive degeneration of retinal ganglion cells in gla …
INTRODUCTION: Glaucoma, a leading cause of irreversible blindness in the world, is a chronic neurodegenerative disease of multifactorial ori …
What Do We Really Know about the Effectiveness of Glaucoma Interventions?: An Overview of Systematic Reviews.
Qureshi R, Azuara-Blanco A, Michelessi M, Virgili G, Barbosa Breda J, Cutolo CA, Pazos M, Katsanos A, Garhöfer G, Kolko M, Prokosch-Willing V, Al Rajhi AA, Lum F, Musch D, Gedde S, Li T. Qureshi R, et al. Ophthalmol Glaucoma. 2021 Sep-Oct;4(5):454-462. doi: 10.1016/j.ogla.2021.01.007. Epub 2021 Feb 9. Ophthalmol Glaucoma. 2021. PMID: 33571689 Free PMC article. Review.
These reviews found high-certainty evidence about a few topics: reducing IOP helps to prevent glaucoma and its progression, prostaglandin analogs are the most effective medical treatment for lowering IOP, laser trabeculoplasty is as effective as medical treatment as a firs …
These reviews found high-certainty evidence about a few topics: reducing IOP helps to prevent glaucoma and its progression, prostagla …
Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma.
Theventhiran AB, Kim G, Yao W. Theventhiran AB, et al. Cochrane Database Syst Rev. 2021 Aug 26;8(8):CD009380. doi: 10.1002/14651858.CD009380.pub3. Cochrane Database Syst Rev. 2021. PMID: 34437715 Free PMC article. Review.
BACKGROUND: Glaucoma is one of the leading largely preventable causes of blindness in the world. It is usually addressed first medically with topical intraocular pressure-lowering drops or by laser trabeculoplasty. ...
BACKGROUND: Glaucoma is one of the leading largely preventable causes of blindness in the world. It is usually addressed first medica …
Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma.
Mallick S, Sharma M, Kumar A, Du Y. Mallick S, et al. Biomolecules. 2021 Aug 24;11(9):1258. doi: 10.3390/biom11091258. Biomolecules. 2021. PMID: 34572471 Free PMC article. Review.
Even in normal pressure glaucoma patients, a reduction of IOP is currently the only effective way to prevent blindness, by either increasing aqueous humor outflow or decreasing aqueous humor production. ...
Even in normal pressure glaucoma patients, a reduction of IOP is currently the only effective way to prevent blindness, by either inc …
Anatomic Changes and Predictors of Angle Widening after Laser Peripheral Iridotomy: The Zhongshan Angle Closure Prevention Trial.
Xu BY, Friedman DS, Foster PJ, Jiang Y, Pardeshi AA, Jiang Y, Munoz B, Aung T, He M. Xu BY, et al. Ophthalmology. 2021 Aug;128(8):1161-1168. doi: 10.1016/j.ophtha.2021.01.021. Epub 2021 Jan 23. Ophthalmology. 2021. PMID: 33497730 Free PMC article. Clinical Trial.
PARTICIPANTS: Primary angle-closure suspects (PACSs) 50 to 70 years of age. METHODS: Participants of the Zhongshan Angle Closure Prevention (ZAP) Trial underwent gonioscopy and AS-OCT imaging at baseline and 2 weeks after LPI. ...
PARTICIPANTS: Primary angle-closure suspects (PACSs) 50 to 70 years of age. METHODS: Participants of the Zhongshan Angle Closure Preventi
Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature.
Ciobanu AM, Dionisie V, Neagu C, Bolog OM, Riga S, Popa-Velea O. Ciobanu AM, et al. J Clin Med. 2021 Jun 30;10(13):2947. doi: 10.3390/jcm10132947. J Clin Med. 2021. PMID: 34209089 Free PMC article. Review.
Clinicians should be aware of the possible psychotropic drug induced glaucoma and monitor at risk patients closely in order to prevent this condition. Irrespective of the psychopharmacological regimen taken into consideration, the glaucoma patient should be under the stric …
Clinicians should be aware of the possible psychotropic drug induced glaucoma and monitor at risk patients closely in order to prevent
Management of glaucoma in pregnancy - balancing safety with efficacy.
Kumari R, Saha BC, Onkar A, Ambasta A, Kumari A. Kumari R, et al. Ther Adv Ophthalmol. 2021 Jun 28;13:25158414211022876. doi: 10.1177/25158414211022876. eCollection 2021 Jan-Dec. Ther Adv Ophthalmol. 2021. PMID: 34263134 Free PMC article. Review.
The challenge is not only controlling the intraocular pressure and preventing glaucoma progression in the mother, but also having to deal with her mental stress and anxiety regarding the safety of her child. ...
The challenge is not only controlling the intraocular pressure and preventing glaucoma progression in the mother, but also having to …
The Interaction Between Microglia and Macroglia in Glaucoma.
Zhao X, Sun R, Luo X, Wang F, Sun X. Zhao X, et al. Front Neurosci. 2021 May 28;15:610788. doi: 10.3389/fnins.2021.610788. eCollection 2021. Front Neurosci. 2021. PMID: 34121982 Free PMC article. Review.
Notably, research results have indicated that intricate interactions between microglia and macroglia might provide potential therapeutic targets for the prevention and treatment of glaucoma. In this review, we examine the specific roles of microglia and macroglia in open-a …
Notably, research results have indicated that intricate interactions between microglia and macroglia might provide potential therapeutic tar …
The best thickness of cornea graft from SMILE surgery as patch graft in glaucoma drainage implant surgery.
Wang Y, Liu J, Huang W, Xu Y, Cheng M, Shen Z. Wang Y, et al. Medicine (Baltimore). 2021 May 21;100(20):e25828. doi: 10.1097/MD.0000000000025828. Medicine (Baltimore). 2021. PMID: 34011047 Free PMC article. Clinical Trial.
CONCLUSIONS: The corneal graft acquired from SMILE surgery can effectively prevent drainage tube exposure and give patients a better cosmetic appearance. ...
CONCLUSIONS: The corneal graft acquired from SMILE surgery can effectively prevent drainage tube exposure and give patients a better …
Influence of Trace Elements on Neurodegenerative Diseases of The Eye-The Glaucoma Model.
Kamińska A, Romano GL, Rejdak R, Zweifel S, Fiedorowicz M, Rejdak M, Bajka A, Amato R, Bucolo C, Avitabile T, Drago F, Toro MD. Kamińska A, et al. Int J Mol Sci. 2021 Apr 21;22(9):4323. doi: 10.3390/ijms22094323. Int J Mol Sci. 2021. PMID: 33919241 Free PMC article. Review.
In this review, we aimed to summarize the current evidence on the role of trace elements in the pathogenesis and prevention of glaucomatous diseases. Special attention is also paid to the genetic background associated with glaucoma-related abnormalities of physiological pr …
In this review, we aimed to summarize the current evidence on the role of trace elements in the pathogenesis and prevention of glauco …
What Is New in Glaucoma: From Treatment to Biological Perspectives.
Nuzzi R, Marolo P, Nuzzi A. Nuzzi R, et al. J Ophthalmol. 2021 Apr 14;2021:5013529. doi: 10.1155/2021/5013529. eCollection 2021. J Ophthalmol. 2021. PMID: 33936807 Free PMC article. Review.
Research has made many efforts to improve disease control and especially to anticipate both early diagnosis and treatment of advanced stages of glaucoma. In terms of prevention, networking between professionals and nonprofessionals is an important goal to disseminate infor …
Research has made many efforts to improve disease control and especially to anticipate both early diagnosis and treatment of advanced stages …
Ultrasound biomicroscopy in glaucoma assessment.
Potop V, Coviltir V, Schmitzer S, Dragosloveanu CDM, Ionescu CI, Burcel MG, Corbu MC, Dăscălescu DMC. Potop V, et al. Rom J Ophthalmol. 2021 Apr-Jun;65(2):114-119. doi: 10.22336/rjo.2021.24. Rom J Ophthalmol. 2021. PMID: 34179574 Free PMC article. Review.
Knowing the type of glaucoma is vital, especially regarding an individualized treatment, since each patient is unique and needs to be treated accordingly, in order to prevent glaucomatous optic neuropathy and visual field loss. Abbreviations: AC = anterior chamber, ICE = i …
Knowing the type of glaucoma is vital, especially regarding an individualized treatment, since each patient is unique and needs to be treate …
Detection of glaucoma using retinal fundus images: A comprehensive review.
Shabbir A, Rasheed A, Shehraz H, Saleem A, Zafar B, Sajid M, Ali N, Dar SH, Shehryar T. Shabbir A, et al. Math Biosci Eng. 2021 Mar 2;18(3):2033-2076. doi: 10.3934/mbe.2021106. Math Biosci Eng. 2021. PMID: 33892536 Free article. Review.
There are no symptoms of glaucoma at earlier stages and if the disease remains unrectified then it can lead to complete blindness. The early diagnosis of glaucoma can prevent permanent loss of vision. Manual examination of human eye is a possible solution however it is dep …
There are no symptoms of glaucoma at earlier stages and if the disease remains unrectified then it can lead to complete blindness. The early …
Looking into the future: Gene and cell therapies for glaucoma.
Komáromy AM, Koehl KL, Park SA. Komáromy AM, et al. Vet Ophthalmol. 2021 Mar;24 Suppl 1(Suppl 1):16-33. doi: 10.1111/vop.12858. Epub 2021 Jan 7. Vet Ophthalmol. 2021. PMID: 33411993 Free PMC article. Review.
Possible application of gene and cell therapies consists of long-term IOP control via increased aqueous humor drainage, including inhibition of fibrosis following filtration surgery, RGC neuroprotection and neuroregeneration, modification of ocular biomechanics for improved IOP t …
Possible application of gene and cell therapies consists of long-term IOP control via increased aqueous humor drainage, including inhibition …
Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma.
Tabak S, Schreiber-Avissar S, Beit-Yannai E. Tabak S, et al. Int J Mol Sci. 2021 Feb 28;22(5):2421. doi: 10.3390/ijms22052421. Int J Mol Sci. 2021. PMID: 33670885 Free PMC article. Review.
In addition, with regards to the elevated IOP in many POAG patients due to increased outflow resistance, Collagen type I degradation was stimulated by some miRNAs and prevented ECM deposition in TM cells. Mitochondrial dysfunction as a consequence of oxidative stress was s …
In addition, with regards to the elevated IOP in many POAG patients due to increased outflow resistance, Collagen type I degradation was sti …