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Year Number of Results
1787 1
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1849 1
1855 1
1857 1
1864 1
1866 2
1875 4
1881 1
1885 1
1889 1
1890 6
1891 7
1892 4
1893 1
1905 1
1914 1
1926 1
1928 1
1932 1
1934 1
1938 1
1941 1
1943 3
1945 22
1946 96
1947 176
1948 209
1949 124
1950 204
1951 239
1952 227
1953 223
1954 206
1955 207
1956 203
1957 233
1958 281
1959 260
1960 227
1961 294
1962 331
1963 411
1964 562
1965 698
1966 785
1967 967
1968 961
1969 1033
1970 921
1971 932
1972 931
1973 977
1974 1060
1975 883
1976 824
1977 786
1978 772
1979 858
1980 794
1981 902
1982 1012
1983 1060
1984 1235
1985 1466
1986 1514
1987 1431
1988 1528
1989 1580
1990 1731
1991 1913
1992 1972
1993 1974
1994 2325
1995 2209
1996 2448
1997 2615
1998 2943
1999 3604
2000 4710
2001 4833
2002 4724
2003 5270
2004 5969
2005 6809
2006 7082
2007 7588
2008 7582
2009 8518
2010 9916
2011 11275
2012 12140
2013 12643
2014 13464
2015 13582
2016 14301
2017 14907
2018 15418
2019 16572
2020 19049
2021 19995
2022 19701
2023 17822
2024 21947
2025 24515
2026 3671

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Exploring the underlying mechanisms of Hedyotis diffusa and Scutellaria Barbata herb pair on the prognosis and treatment efficacy of bladder cancer patients: an integrated approach of network pharmacology and bioinformatics analysis.
Liu Y, Duan L, Zhu M, Zhou Z, Zhao P, Zhan Y, Zhang X, Zhu Z. Liu Y, et al. BMC Complement Med Ther. 2026 Feb 13. doi: 10.1186/s12906-026-05279-5. Online ahead of print. BMC Complement Med Ther. 2026. PMID: 41689016 No abstract available.
Cross-kingdom miRNA delivery by Panax notoginseng-derived extracellular-like nanoparticles vesicles restores neuronal function after ischemic injury.
Yu Y, Tan N, Xu Z, Tan Z, Wang T, Liu H, Xu L, Lu D, Tang Y, Mai H. Yu Y, et al. J Nanobiotechnology. 2026 Feb 13. doi: 10.1186/s12951-026-04103-z. Online ahead of print. J Nanobiotechnology. 2026. PMID: 41688997
Blood-brain barrier (BBB) impermeability remains a major obstacle to the effective treatment of neurological disorders, particularly ischemic stroke. Here, we revealed that plant-derived extracellular vesicle-like nanoparticles (PEVs) offer a promising strategy to o …
Blood-brain barrier (BBB) impermeability remains a major obstacle to the effective treatment of neurological disorders, particularly …
Flavones and Aminoflavones Increase the Cytotoxicity of NK Cells in Human Non-Small Cell Lung Cancer.
Hsu PC, Chien CC, Cheng YJ, Chang CH, Shih TL. Hsu PC, et al. J Cell Mol Med. 2026 Feb;30(4):e71055. doi: 10.1111/jcmm.71055. J Cell Mol Med. 2026. PMID: 41688864
Moreover, aminoflavone 8 exhibited anti-tumour effects in a lung cancer xenograft mouse model. Combined therapy with aminoflavone 8 and NK-92MI cells had synergistic anti-tumour effects without liver or kidney toxicity. ...These findings suggest that aminoflavone 8 can pot …
Moreover, aminoflavone 8 exhibited anti-tumour effects in a lung cancer xenograft mouse model. Combined therapy with aminoflavone 8 a …
Unveiling the therapeutic potential of Farnesol against Parkinson's disease: insights from molecular Docking and animal studies.
Baishya HJ, Nargish J, Sola P. Baishya HJ, et al. Daru. 2026 Feb 14;34(1):14. doi: 10.1007/s40199-026-00592-3. Daru. 2026. PMID: 41688775
Nature offers a wealth of medicinal plants, among which Ocimum tenuiflorum stands out for its potential to treat various health issues. ...CONCLUSION: Farnesol exhibits significant neuroprotective effects in rotenone-induced PD models, suggesting its potential as a …
Nature offers a wealth of medicinal plants, among which Ocimum tenuiflorum stands out for its potential to treat various healt …
Bioactivity screening of endophytic fungi from Sterculia urens and GC-MS metabolites profiling of the potent isolate Chaetomium meridiolense.
Yadav G, Meena M, Sonigra P. Yadav G, et al. Sci Rep. 2026 Feb 13. doi: 10.1038/s41598-026-39125-y. Online ahead of print. Sci Rep. 2026. PMID: 41688594
Endophytic fungi associated with medicinal plants are recognized as promising sources of bioactive secondary metabolites. In this study, fungal endophytes were isolated from healthy leaves of Sterculia urens, an ethnomedicinal plant with documented therape …
Endophytic fungi associated with medicinal plants are recognized as promising sources of bioactive secondary metabolites. In t …
Phytochemical content, antioxidant and anti-inflammatory properties and wound healing effect of Chaiturus marrubiastrum: an in vitro and in vivo study.
Bulut S, Karakuyu NF, Sarman E, Sidal A, Kahraman A, Yilmaz MA, Cakir O. Bulut S, et al. Inflammopharmacology. 2026 Feb 14. doi: 10.1007/s10787-026-02132-6. Online ahead of print. Inflammopharmacology. 2026. PMID: 41688588
Medicinal plants have been traditionally used to treat wounds. The aim of this study was to investigate the antioxidant activity, wound healing effect and chemical content of the aerial parts of Chaiturus marrubiastrum (L.) ...Pressure wound model in rats was used t …
Medicinal plants have been traditionally used to treat wounds. The aim of this study was to investigate the antioxidant activi …
Cell-free systems for production of therapeutics.
Kaur S, Abdi G, Abbasi Tarighat M, Raja V, Bhat MA. Kaur S, et al. Prog Mol Biol Transl Sci. 2026;219:51-92. doi: 10.1016/bs.pmbts.2025.10.004. Epub 2025 Nov 27. Prog Mol Biol Transl Sci. 2026. PMID: 41688141 Review.
The development of the cell-free system (CFS) is transforming the manufacturing landscape of biomolecules with therapeutic value by providing a flexible and convenient alternative to cell-based expression systems. ...The emerging needs combining rapid, on-demand, and perso …
The development of the cell-free system (CFS) is transforming the manufacturing landscape of biomolecules with therapeutic value by p …
[Canine pyoderma: clinical presentation, diagnosis, and topical treatment - a review].
Juhasz A, Müller RS. Juhasz A, et al. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2026 Feb;54(1):6-22. doi: 10.1055/a-2768-1018. Epub 2026 Feb 13. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2026. PMID: 41688127 Review. German.
In light of increasing antibiotic resistance, particularly due to methicillin-resistant staphylococci, topical therapy is gaining importance. Numerous studies have now demonstrated the efficacy of topical treatments, especially for superficial pyodermas. ...However, …
In light of increasing antibiotic resistance, particularly due to methicillin-resistant staphylococci, topical therapy is gaining imp …
Biopolymer of zein/agarose hydrogels for efficient co-delivery of 5-fluorouracil/curcumin in human colorectal carcinoma treatment.
Pourmadadi M, Savari Z, Sadeghi M, Davoudi E, Biglari P, Ajalli N, Hashemipour M, Akbarzadeh S, Bahramian M, Mehrabi MG, Jazai FS. Pourmadadi M, et al. Int J Biol Macromol. 2026 Feb 11:150578. doi: 10.1016/j.ijbiomac.2026.150578. Online ahead of print. Int J Biol Macromol. 2026. PMID: 41687987
The co-delivery approach significantly mitigated the toxicity of free drugs to healthy cells, which further supports the potential of this system as option for cancer treatment. This project also explored the effect of combining herbal and chemical drugs …
The co-delivery approach significantly mitigated the toxicity of free drugs to healthy cells, which further supports the potential of …
Bioactive compounds from A. dahurica attenuate LPS-induced inflammation via dual inhibition of MAPK and NF-κB signaling pathways.
Zhang Y, Wu N, Yin X, Piao Y, Gao M, Piao J, Li X, Zhang C, Jin L. Zhang Y, et al. J Ethnopharmacol. 2026 Feb 11:121361. doi: 10.1016/j.jep.2026.121361. Online ahead of print. J Ethnopharmacol. 2026. PMID: 41687945
Benth. et Hook. f. ex Franch. et Sav. is a perennial, aromatic, herbaceous plant in the family Apiaceae, native to East Asia, and the roots are known as Bai Zhi (Angelicae Dahuricae Radix) in traditional Chinese medicine (TCM). ...Although pharmacological stu …
Benth. et Hook. f. ex Franch. et Sav. is a perennial, aromatic, herbaceous plant in the family Apiaceae, native to East Asia, and the …
Anti-inflammatory and analgesic activities of fingered citron (Citrus medica var. Sarcodactylus) fruit essential oil and its multi-target mechanism of action based on network pharmacology.
Zhu Y, Xia L, Guo H, Lin X, Ban J, Bai M, Hao W. Zhu Y, et al. Fitoterapia. 2026 Feb 11:107136. doi: 10.1016/j.fitote.2026.107136. Online ahead of print. Fitoterapia. 2026. PMID: 41687931
Sarcodactylus (Fingered Citron) fruit, providing experimental basis for its development as a plant-derived anti-inflammatory and analgesic drug. METHODS: The essential oil components were analyzed by steam distillation (SD) combined with gas chromatography-mass spectrometr …
Sarcodactylus (Fingered Citron) fruit, providing experimental basis for its development as a plant-derived anti-inflammatory and anal …
From nature to novelty: Enhancing rosmarinic acid's therapeutic potential through smart molecular design.
Leong KF, Chen Z, Coghi P. Leong KF, et al. Fitoterapia. 2026 Feb 11:107137. doi: 10.1016/j.fitote.2026.107137. Online ahead of print. Fitoterapia. 2026. PMID: 41687930 Review.
Rosmarinic acid (RA), a naturally occurring ester of caffeic acid and 3,4-dihydroxyphenyllactic acid, is widely distributed in medicinal plants of the Lamiaceae families. It has attracted considerable attention due to its broad spectrum of pharmacological properties …
Rosmarinic acid (RA), a naturally occurring ester of caffeic acid and 3,4-dihydroxyphenyllactic acid, is widely distributed in medicinal …
Ethyl gallate attenuates 5-flurouracil induced hepatic injury via MAPK/NF-κB downregulation in rats.
Priya MT, Sanjay S, Sharmila M, Karthick M, Harini KS, Langeswaran K, Ezhilarasan D. Priya MT, et al. Toxicol Appl Pharmacol. 2026 Feb 11:117756. doi: 10.1016/j.taap.2026.117756. Online ahead of print. Toxicol Appl Pharmacol. 2026. PMID: 41687884
Experimental studies have reported that 5-FU induces oxidative stress and inflammation. Ethyl gallate (EG), a plant-derived phytocompound, has been shown to possess antioxidant and anti-inflammatory properties. ...CONCLUSION: Our study demonstrates that EG and SIL treat …
Experimental studies have reported that 5-FU induces oxidative stress and inflammation. Ethyl gallate (EG), a plant-derived phytocomp …
STUDY OF THE BIOACTIVE COMPOUND COMPOSITION, ANTIMICROBIAL, AND CYTOTOXIC ACTIVITIES OF ENDEMIC PLANT SPECIES OF ADJARA-LAZETI.
Beridze D, Metreveli M, Meskhidze A, Meparishvili G, Bakuridze A, Jokhadze M, Berashvili D, Bakuridze L. Beridze D, et al. Georgian Med News. 2025 Dec;(369):138-152. Georgian Med News. 2025. PMID: 41687647
Dshorochensis, Amaracus rotundifolius, Rhododendron smirnovii, and Rhododendron ungernii. Methanolic leaf extracts were prepared and analyzed using GC-MS to identify bioactive constituents. Antimicrobial (specifically fungicidal) activity was evaluated in vitro agai …
Dshorochensis, Amaracus rotundifolius, Rhododendron smirnovii, and Rhododendron ungernii. Methanolic leaf extracts were prepared …
EXPLORING THE MECHANISM OF ACTION OF HEMP SEEDS (CANNABIS SATIVA L.) IN TREATING OSTEOPOROSIS USING NETWORK PHARMACOLOGY.
Wang Y, Xie Y, Yin C, Wu Q. Wang Y, et al. Georgian Med News. 2025 Dec;(369):38-43. Georgian Med News. 2025. PMID: 41687633
Notably, a subsequent analysis of the protein-protein interaction (PPI) network topology identified AKT1, TNF, and IL6 as pivotal targets within the therapeutic mechanism. In summary, the present study initially revealed the potential mechanism of OP treatment with …
Notably, a subsequent analysis of the protein-protein interaction (PPI) network topology identified AKT1, TNF, and IL6 as pivotal targets wi …
Communal to individual midwifery care: Cultural practices and the maternity journey of Sub-Saharan African women in New Zealand.
Fougang DC, Wepa D, Mpofu C. Fougang DC, et al. Midwifery. 2026 Feb 2;155:104725. doi: 10.1016/j.midw.2026.104725. Online ahead of print. Midwifery. 2026. PMID: 41687538
Participants described a repertoire of cultural practices, including herbal and dietary remedies, postpartum rituals, and newborn care customs. Herbal medicine was used to ease labour and promote physiological birth, while cultural nutrition supported …
Participants described a repertoire of cultural practices, including herbal and dietary remedies, postpartum rituals, and newb …
Dingxin recipe Ⅲ ameliorates atherosclerosis through stard4-mediated regulation of hepatic lipid metabolism.
Gu Y, Jin Y, Zhao H, Tang J, Li Z, Cheng S, Zhang Y, He P, Han Z, He J, Zhou F, Liu X, Jia Y. Gu Y, et al. Phytomedicine. 2026 Feb 6;153:157924. doi: 10.1016/j.phymed.2026.157924. Online ahead of print. Phytomedicine. 2026. PMID: 41687532
Dingxin Recipe III (DXRIII), a traditional Chinese herbal formula, has shown therapeutic effect for atherosclerosis, though its mechanisms remain unclear. ...METHODS: Male ApoE(-/-) mice were fed a high-fat diet for 12 weeks to induce atherosclerosis, followe …
Dingxin Recipe III (DXRIII), a traditional Chinese herbal formula, has shown therapeutic effect for atherosclerosis, th …
From biosensing to herbal discovery: A nanozyme cascade platform for acetylcholinesterase monitoring and inhibitor screening in synthetic and natural sources.
Cai S, Fan BW, Qin J, Pu CY, Qin YJ, Wu CT, Xu W, Li J. Cai S, et al. Talanta. 2026 Feb 9;304:129523. doi: 10.1016/j.talanta.2026.129523. Online ahead of print. Talanta. 2026. PMID: 41687295
Early diagnosis and therapeutic intervention for Alzheimer's disease (AD) necessitate advanced tools for detecting acetylcholinesterase (AChE) activity and screening AChE inhibitors (AChEIs). ...Innovatively, the platform was applied to screen AChE inhibitory activity in s …
Early diagnosis and therapeutic intervention for Alzheimer's disease (AD) necessitate advanced tools for detecting acetylcholinestera …
MdCNGC15B, a cyclic nucleotide-gated channel (CNGC) protein, positively regulates the tolerance to drought and salt stress in apple.
Guo XL, Li HL, Wu X, Wang TT, Guo YY, An JP, You CX. Guo XL, et al. J Plant Physiol. 2026 Feb 5;318:154722. doi: 10.1016/j.jplph.2026.154722. Online ahead of print. J Plant Physiol. 2026. PMID: 41687276
Abiotic stresses constrain plant growth and yield worldwide, with drought and salinity among the most severe limitations. ...This provides a new perspective for understanding the CNGC signaling mechanism in woody plants....
Abiotic stresses constrain plant growth and yield worldwide, with drought and salinity among the most severe limitations. ...This pro …
Metabolomics technology combined with O2PLS analysis reveals the active components of Paeoniae Radix Alba in preventing renal damage in rheumatoid arthritis.
Lv S, Lin J, Sun Y, Kang M, Li X, Song L, Li Y. Lv S, et al. J Pharm Biomed Anal. 2026 Feb 10;273:117403. doi: 10.1016/j.jpba.2026.117403. Online ahead of print. J Pharm Biomed Anal. 2026. PMID: 41687225
Paeoniae Radix Alba, known as BaiShao (BS) in Chinese, is a widely used herbal medicine for clinical RA treatment, yet its potential in preventing RA-associated renal damage and its underlying active ingredients remain elusive. ...Collectively, this st …
Paeoniae Radix Alba, known as BaiShao (BS) in Chinese, is a widely used herbal medicine for clinical RA treatment …
A novel thin layer chromatography based method for the quantification of quillaic acid saponins.
Bülow FE, Matkowski A, Weng A. Bülow FE, et al. J Pharm Biomed Anal. 2026 Feb 9;273:117409. doi: 10.1016/j.jpba.2026.117409. Online ahead of print. J Pharm Biomed Anal. 2026. PMID: 41687224
As plant derived molecules, their phytochemical analysis is key to ensure pharmaceutical quality. ...After validation, the method was applied to two plant species from Caryophyllaceae. To verify the plant's QA contents determined by TLC, a complementar …
As plant derived molecules, their phytochemical analysis is key to ensure pharmaceutical quality. ...After validation, the met …
Multifunctional natural herbal extracts Lamiophlomis rotata (Benth.) Kudo composite gel for infected wounds healing.
Yi X, Xiong S, Tuo W, Zhao J, Guo P, Yang Q, Zhang W, Tian Y, Du Y, Shu Y, Jia J, Li P, Zhu Y, Zhang C, Qu Y. Yi X, et al. Colloids Surf B Biointerfaces. 2026 Feb 3;262:115509. doi: 10.1016/j.colsurfb.2026.115509. Online ahead of print. Colloids Surf B Biointerfaces. 2026. PMID: 41687221
Wounds are susceptible to persistent infections and chronic inflammation, which can significantly impeding the healing process.Lamiophlomis rotata (Benth.) Kudo(LR), a traditional Tibetan medicine, is known for its efficacy in treating injuries, contusions, and skin ulcers …
Wounds are susceptible to persistent infections and chronic inflammation, which can significantly impeding the healing process.Lamiophlomis …
Transcriptomic profiling reveals the mechanisms underlying growth divergence in Apostichopus japonicus.
Chang S, Abulizi A, Huang X, Cong J, Sun Z, Wang Y. Chang S, et al. Comp Biochem Physiol Part D Genomics Proteomics. 2026 Feb 8;58:101777. doi: 10.1016/j.cbd.2026.101777. Online ahead of print. Comp Biochem Physiol Part D Genomics Proteomics. 2026. PMID: 41687134
Whereas SG individuals exhibited significant upregulation of genes associated with muscle and cytoskeletal structure, including ACTG1, MYHC, TITIN, and FLNB, reflecting compensatory or disordered activation rather than productive growth, as further supported by histological obser …
Whereas SG individuals exhibited significant upregulation of genes associated with muscle and cytoskeletal structure, including ACTG1, MYHC, …
Effects of matcha green tea on the pharmacokinetics of nadolol in rats.
Mashaqbeh ET, El-Elimat T, Alshogran OY, Hamzeh I, Obeidat ZM, Al Sharie AH, Hajji FE. Mashaqbeh ET, et al. PLoS One. 2026 Feb 13;21(2):e0342857. doi: 10.1371/journal.pone.0342857. eCollection 2026. PLoS One. 2026. PMID: 41686841
The concurrent use of herbal dietary supplements with prescription medications raises safety concerns due to the potential for clinically significant interactions. ...
The concurrent use of herbal dietary supplements with prescription medications raises safety concerns due to the potential for clinic …
Efficacy of Lajjabati (Mimosa pudica) and Daruchini (Cinnamomum verum) extracts on wound healing in rabbits.
Runa RA, Prodhan MAR, Akter S, Mustari A. Runa RA, et al. PLoS One. 2026 Feb 13;21(2):e0342449. doi: 10.1371/journal.pone.0342449. eCollection 2026. PLoS One. 2026. PMID: 41686781
Plant and herbal preparations are traditionally used in wound management to promote healing. The study aimed to explore the therapeutic efficacy of Lajjabati (Mimosa pudica) leaves and Daruchini (Cinnamomum verum) paste on wound healing and the histo-a …
Plant and herbal preparations are traditionally used in wound management to promote healing. The study aimed to explore …
Analysis of the antimicrobial activity of zinc oxide nanoparticles against drug-resistant bacteria and their applications in the disinfection process.
Alqaffaf D, Atoom AM, Abu Huwaij R, Abusalah MAHA, Alzubi BT, Al-Kaabneh A, Abusalah MAHA, Sughayer MA. Alqaffaf D, et al. PLoS One. 2026 Feb 13;21(2):e0340470. doi: 10.1371/journal.pone.0340470. eCollection 2026. PLoS One. 2026. PMID: 41686765
Future research could explore synergistic combinations with traditional antimicrobials to enhance efficacy against infections that are resistant to treatment....
Future research could explore synergistic combinations with traditional antimicrobials to enhance efficacy against infections that are resis …
Chestnut shell aqueous extract as a green efficient corrosion inhibitor for acid-cleaning carbon steel.
Zhou C, Zhou T. Zhou C, et al. PLoS One. 2026 Feb 13;21(2):e0340769. doi: 10.1371/journal.pone.0340769. eCollection 2026. PLoS One. 2026. PMID: 41686753
For the ECS sample itself, UV-visible absorption result reveals its pipi* transition of electrons similar to isoflavonoid; an orthogonal array with four factors is used to optimize the optimal combination of CS dosage, alcohol dosage, temperature, and pH for its preparation …
For the ECS sample itself, UV-visible absorption result reveals its pipi* transition of electrons similar to isoflavonoid; an orthogonal arr …
Super-barcoding of four Agrimonia species distributed in Korea based on complete plastid genomes and nuclear ribosomal DNAs.
Lee JJ, Kang JS, Kim YJ, Lee YS, Park JY, Jang W, Moon BC, Kim Y, Kim TY, Yang TJ. Lee JJ, et al. PLoS One. 2026 Feb 13;21(2):e0341151. doi: 10.1371/journal.pone.0341151. eCollection 2026. PLoS One. 2026. PMID: 41686737
The genus Agrimonia is widely distributed throughout temperate regions and includes species used in traditional medicine in Asia and Europe. However, their accurate identification is often challenging because the vegetative parts used, such as leaves and roots, are morphol …
The genus Agrimonia is widely distributed throughout temperate regions and includes species used in traditional medicine in Asia and …
A prokinetic agent DA-9701 formulated with Corydalis tuber and Pharbitidis semen improves nausea in migraine: A prospective observational study.
Son H, Lee S, Lee MJ, Kim M. Son H, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47623. doi: 10.1097/MD.0000000000047623. Medicine (Baltimore). 2026. PMID: 41686710
Although migraine prophylaxis is known to reduce nausea, the impact of nausea treatment on migraine headache frequency remains unclear. DA-9701, a prokinetic derived from Corydalis tuber and Pharbitidis semen, offers serotonin 5-HT1A/5-HT4 agonism and D2 antagonism, with a …
Although migraine prophylaxis is known to reduce nausea, the impact of nausea treatment on migraine headache frequency remains unclea …
Medication patterns and therapeutic strategies in Traditional Chinese Medicine for coronary heart disease: A text mining analysis of clinical literature.
Qu S, Pan L, Liang H, Zhu L, Chen Y, Cai S, Zhao X, Zhao H. Qu S, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47570. doi: 10.1097/MD.0000000000047570. Medicine (Baltimore). 2026. PMID: 41686613
This study employed scientific statistical methods to explore the medication rules of Chinese herbal medicines (CHMs) to treat CHD and provide a scientific and reliable theoretical basis for the improvement of patient symptoms. ...Summarize the prescribed med …
This study employed scientific statistical methods to explore the medication rules of Chinese herbal medicines (CHMs) t …
Insights into the potential mechanism of Beiqishen Jiangtang Granule in the treatment of type 2 diabetes nephropathy: A study based on network pharmacology, molecular docking, and biological validation.
Pan M, Wang P, Wang X, Wang Z, Zhang Z, Yang K, Liu W, Ma W, Liu X. Pan M, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47533. doi: 10.1097/MD.0000000000047533. Medicine (Baltimore). 2026. PMID: 41686594
Beiqishen Jiangtang Granule, derived from Huangqi Liu Yi Tang and Shengmai Yin, plays a significant role for the therapy of type 2 diabetes mellitus (T2DM). However, the underlying molecular therapeutic mechanisms remain unclear. This study uses an integrated …
Beiqishen Jiangtang Granule, derived from Huangqi Liu Yi Tang and Shengmai Yin, plays a significant role for the therapy of type 2 di …
Potential mechanisms of Si-Wu-Tang against esophageal squamous cell carcinoma: A machine learning pharmacological study.
Li X, Zhang C, Li J, Yuan J, Xing T, Yang H, Shi H. Li X, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47629. doi: 10.1097/MD.0000000000047629. Medicine (Baltimore). 2026. PMID: 41686584
This study revealed that SWT might exert its therapeutic effects on ESCC through multi-targets and multi-mechanisms....
This study revealed that SWT might exert its therapeutic effects on ESCC through multi-targets and multi-mechanisms....
Mechanism of traditional Chinese medicine in treating erectile dysfunction: A review.
Zhang R, Wang J, Xu P, Wang H, Pang K. Zhang R, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47652. doi: 10.1097/MD.0000000000047652. Medicine (Baltimore). 2026. PMID: 41686568 Review.
As people's lifestyles change and the aging of the population, the incidence of ED is increasing. traditional Chinese medicine (TCM) has long been a traditional clinical approach for treating ED in China and has been shown to be effective and safe. A large amount of …
As people's lifestyles change and the aging of the population, the incidence of ED is increasing. traditional Chinese medicine …
Exploration of pathogenesis and targeted drugs of postmenopausal osteoporosis by means of analysis based on reverse network pharmacology.
Wu D, Zhao W, Ni Y. Wu D, et al. Medicine (Baltimore). 2026 Feb 13;105(7):e47740. doi: 10.1097/MD.0000000000047740. Medicine (Baltimore). 2026. PMID: 41686547
This study aims to explore pathogenesis of postmenopausal osteoporosis and study of active compounds of traditional Chinese medicine (TCM) based on reverse network pharmacology and molecular docking. Targets of "osteoporosis" and "postmenopausal" were obtained from …
This study aims to explore pathogenesis of postmenopausal osteoporosis and study of active compounds of traditional Chinese medici …
A Comprehensive Review of Kombucha Fermentation and Probiotic Functional Mechanisms: Microbial Dynamics, Bioactive Compounds and Health Effects.
Senthilkumar K, Muthiah P. Senthilkumar K, et al. Probiotics Antimicrob Proteins. 2026 Feb 13. doi: 10.1007/s12602-026-10924-z. Online ahead of print. Probiotics Antimicrob Proteins. 2026. PMID: 41686420 Review.
The present study emphasizes, nutritional qualities of kombucha through different Komagataeibacter starter cultures and alternative substrates such as herbal infusions and fruit extracts. This review also highlights the role of AAB, LAB, and Yeast in the production …
The present study emphasizes, nutritional qualities of kombucha through different Komagataeibacter starter cultures and alternative substrat …
Effect of Spinacia oleracea on In Vitro Disintegration and Dissolution of Clopidogrel Bisulfate Tablets.
Sadaqa D, Naseef HA, Radwan A, Rabba AK, Muqedi RHM. Sadaqa D, et al. Pharmacol Res Perspect. 2026 Feb;14(1):e70223. doi: 10.1002/prp2.70223. Pharmacol Res Perspect. 2026. PMID: 41685910
Drug-food interactions may compromise therapeutic efficacy, particularly for life-saving medications such as anticoagulants. Changes in gastric fluid properties, including pH modification and surface film formation, can alter drug dissolution and release. ...
Drug-food interactions may compromise therapeutic efficacy, particularly for life-saving medications such as anticoagulants. Changes …
Electrochemical quantification of condensed tannins in extracts and herbal medicines using 3D-printed electrodes.
Petine DV, Prado DG, Marra MC, Rocha RG, Gravata Inoque NI, Martins MM, Crapnell RD, Banks CE, de Oliveira A, Munoz RAA, Sousa RMF. Petine DV, et al. Anal Methods. 2026 Feb 13. doi: 10.1039/d5ay02048d. Online ahead of print. Anal Methods. 2026. PMID: 41685748
Many herbal medicines contain bioactive polyphenolic compounds, such as flavonoids, tannins, phenolic acids, and lignans. ...Catechin was employed as an electrochemical probe for the indirect quantification of condensed tannins, expressed as catechin equivalents (CE …
Many herbal medicines contain bioactive polyphenolic compounds, such as flavonoids, tannins, phenolic acids, and lignans. ...C …
Phase 1 Trial of Withania somnifera Leaf Extract (RH324) in Advanced Non-Small Cell Lung Cancer Including [(18)F]FDG PET/CT as a Short-Term Metabolic Biomarker to Assess Efficacy: A Novel Model for Assessment of Complimentary Therapies in Early Phase Human Clinical Trials.
Heo JU, Rao S, Newton HB, Dowlati A, Muzic RF Jr, Kardan A. Heo JU, et al. Integr Cancer Ther. 2026 Jan-Dec;25:15347354251410182. doi: 10.1177/15347354251410182. Epub 2026 Feb 13. Integr Cancer Ther. 2026. PMID: 41685666 Clinical Trial.
This study focuses on RH324 (ReHeva Biosciences, Columbus, OH), a pharmaceutical-grade formulation derived from WS, which has received FDA allowance for clinical development as a botanical drug in the treatment of cancer. ...
This study focuses on RH324 (ReHeva Biosciences, Columbus, OH), a pharmaceutical-grade formulation derived from WS, which has receive …
Bio-Guided Isolation and Characterisation of Lanigeraflavone, a Novel Flavone From Kickxia lanigera (Desf.) Handel-Mazzetti: In Vitro and In Silico Antioxidant Proporties.
Gül F, Demirtaş İ, Başar Y, Altun M, Chi GF, Behçet L. Gül F, et al. Chem Biodivers. 2026 Feb;23(2):e03375. doi: 10.1002/cbdv.202503375. Chem Biodivers. 2026. PMID: 41685652
This study focuses on Kickxia lanigera (Def.) Hand.-Mazz., a plant that is traditionally used in Turkey and some other Middle Eastern countries to treat diabetes, kidney stones and venomous bites. The study aimed to determine the molecular basis of these traditional med …
This study focuses on Kickxia lanigera (Def.) Hand.-Mazz., a plant that is traditionally used in Turkey and some other Middle Eastern …
Cortex phellodendri Exerts Its Nephroprotective Effect via the Inhibition of the AGEs-RAGE Pathway.
Li A, Deng CF, Wu HZ, Zeng CY, Gao YX, Wang ZQ, Ma HY, Tang D. Li A, et al. Chem Biodivers. 2026 Feb;23(2):e02413. doi: 10.1002/cbdv.202502413. Chem Biodivers. 2026. PMID: 41685628
Diabetic nephropathy (DN) is a leading microvascular complication of diabetes, with limited effective treatments. Cortex phellodendri (CP), a traditional Chinese medicine known for its diverse chemical constituents, exhibits various pharmacological properties …
Diabetic nephropathy (DN) is a leading microvascular complication of diabetes, with limited effective treatments. Cortex phellodendri …
DoHY5/DoPIF5-DoPHT1 Module Mediates Red-Light Modulation of Phosphorus Homeostasis in Dendrobium officinale Kimura et Migo.
Tian L, Li Y, Sun X, Qin X, Yu H, Fan H, Liu L. Tian L, et al. J Agric Food Chem. 2026 Feb 13. doi: 10.1021/acs.jafc.5c15025. Online ahead of print. J Agric Food Chem. 2026. PMID: 41685622
Dendrobium officinale Kimura et Migo, a valuable medicinal orchid, thrives in mountainous environments, the specific habitat factors promoting polysaccharide accumulation in wild plants. ...
Dendrobium officinale Kimura et Migo, a valuable medicinal orchid, thrives in mountainous environments, the specific habitat factors …
Extraction, purification, structural elucidation, and immunomodulatory activity of Bletilla striata polysaccharides via the NF-κB signaling pathway.
Pang G, Zhou K, Gao D, Wang D, Xue J, Lu T, Chai H. Pang G, et al. Front Immunol. 2026 Jan 28;17:1749545. doi: 10.3389/fimmu.2026.1749545. eCollection 2026. Front Immunol. 2026. PMID: 41685332 Free PMC article.
INTRODUCTION: Bletilla striata is a traditional medicinal plant, and its polysaccharide components have been confirmed to possess immunomodulatory potential. However, most current studies focus on high-molecular-weight polysaccharides, while the immunomodulatory mec …
INTRODUCTION: Bletilla striata is a traditional medicinal plant, and its polysaccharide components have been confirmed to poss …
The stem of Schisandra chinensis and Schisandrin B alleviated DNCB-induced atopic dermatitis in mice by inhibiting the NF-κB pathway.
Ye C, Liu Y, Li Y, Li Z, Sui L, Cui J, Jiang Z, Li J, Song J, Liu J. Ye C, et al. Front Immunol. 2026 Jan 28;17:1725312. doi: 10.3389/fimmu.2026.1725312. eCollection 2026. Front Immunol. 2026. PMID: 41685331 Free PMC article.
The primary active component was identified through activity-guided assays employing hyaluronidase inhibition and HPLC. The therapeutic efficacy of SCSE and its constituent Schisandrin B (Sch B) was assessed in an AD mouse model. ...CONCLUSION: By simultaneously mitigating …
The primary active component was identified through activity-guided assays employing hyaluronidase inhibition and HPLC. The therapeutic …
Real-time PCR to target Hoodia in herbal supplements: a tool for conservation and trade regulation.
Fraiture MA, Gobbo A, Philipp P, Papazova N, Vanhee C, Roosens NHC. Fraiture MA, et al. Food Chem (Oxf). 2026 Jan 30;12:100367. doi: 10.1016/j.fochms.2026.100367. eCollection 2026 Jun. Food Chem (Oxf). 2026. PMID: 41685176 Free PMC article.
Plants belonging to the Hoodia genus are widely used as ingredients in herbal dietary supplements. ...Its applicability was verified by testing commercial herbal dietary supplements. This study provides enforcement laboratories with a validated molecular tool …
Plants belonging to the Hoodia genus are widely used as ingredients in herbal dietary supplements. ...Its applicability was ve …
Ethanolic extract of Commiphora myrrha gum-resin promotes therapeutic compound accumulation in Achillea fragrantissima under in vitro culture.
Khattab MS, Al Dayel MF, El Sherif F. Khattab MS, et al. Front Plant Sci. 2026 Jan 28;16:1714322. doi: 10.3389/fpls.2025.1714322. eCollection 2025. Front Plant Sci. 2026. PMID: 41685127 Free PMC article.
MATERIAL AND METHODS: Shoot-tip and root-segment explants were cultured on Murashi-ge and Skoog (MS) medium supplemented with filter-sterilized C. myrrha ethanolic extract at 0.5, 1.0, and 2.0 g.L(-1), alongside control treatment. Plant responses, including growth p …
MATERIAL AND METHODS: Shoot-tip and root-segment explants were cultured on Murashi-ge and Skoog (MS) medium supplemented with filter-sterili …
Altitude-mediated soil microbe-nutrient dynamics shape medicinal properties of Angelica sinensis.
Gong XF, Khan W, Yang L, Chen YK, Chen J, Zhang L, Zhang Y, Zhu Y, Wang ZY, Zhang BL, Xue LG. Gong XF, et al. Front Plant Sci. 2026 Jan 28;16:1703258. doi: 10.3389/fpls.2025.1703258. eCollection 2025. Front Plant Sci. 2026. PMID: 41685123 Free PMC article.
BACKGROUND: Rhizosphere microorganisms play a critical role in plant growth and medicinal quality, yet their altitudinal patterns and interactions with soil nutrients and bioactive compounds in Angelica sinensis (A. sinensis) remain poorly understood. ...These findi …
BACKGROUND: Rhizosphere microorganisms play a critical role in plant growth and medicinal quality, yet their altitudinal patte …
Ethanolic extract of Morinda citrifolia improves gut microbiota, intestinal morphology, and performance without adverse effects on hematological profiles in broiler chickens.
Paredes-López DM, Robles-Huaynate R, Perales-Camacho RA, Alania-Santiago CV, Aldava-Pardave U. Paredes-López DM, et al. Front Vet Sci. 2026 Jan 28;12:1686136. doi: 10.3389/fvets.2025.1686136. eCollection 2025. Front Vet Sci. 2026. PMID: 41684719 Free PMC article.
Therefore, there is a growing interest in alternative strategies, such as plant extracts and essential oils, to address this issue. The aim of this study was to evaluate the effect of Morinda citrifolia leaf ethanolic extract (MCEE) on the intestinal health and perf …
Therefore, there is a growing interest in alternative strategies, such as plant extracts and essential oils, to address this i …
Vernonia amygdalina as a hop substitute in red sorghum beer: Effects on fermentation performance and physicochemical properties.
Amisi AK, Luyeye N, Ngbolua JK, Matundu E, Kasereka G, Bwanganga JT. Amisi AK, et al. Curr Res Food Sci. 2026 Feb 2;12:101331. doi: 10.1016/j.crfs.2026.101331. eCollection 2026. Curr Res Food Sci. 2026. PMID: 41684706 Free PMC article.
The substitution of imported hops with locally available botanical alternatives offers a sustainable strategy for sorghum-based beer production. ...Higher substitution levels also increased color intensity, reflecting contributions of plant-derived pigments and poly …
The substitution of imported hops with locally available botanical alternatives offers a sustainable strategy for sorghum-based beer …
Activity of Biocidin® against microbial biofilms.
Mundanchira AV, Wong A, Klos-Maki K, Strand J, Marques CNH. Mundanchira AV, et al. Front Antibiot. 2026 Jan 28;4:1692653. doi: 10.3389/frabi.2025.1692653. eCollection 2025. Front Antibiot. 2026. PMID: 41684696 Free PMC article.
Resistance to antimicrobials is now widespread, and the search for alternative treatments, such as plant- or herbal-derived extracts, essential oils, and honey, is on the rise. ...Results from this work have implications for the use of Biocidin() as a …
Resistance to antimicrobials is now widespread, and the search for alternative treatments, such as plant- or herbal-der …
Antimicrobial Activity of Bee Pollen: Influence of Botanical Origin and Processing.
Lukman T, Smole Možina S. Lukman T, et al. Food Technol Biotechnol. 2026 Jan-Mar;64(1):67-80. doi: 10.17113/ftb.64.01.26.9421. Epub 2026 Feb 15. Food Technol Biotechnol. 2026. PMID: 41684680 Free PMC article.
Antimicrobial activity of bee pollen is influenced by natural factors such as the botanical and geographical origin, seasonal variation and beekeeping practices. The outcomes of in vitro testing also depend on choices related to extract preparation, solvent type, mi …
Antimicrobial activity of bee pollen is influenced by natural factors such as the botanical and geographical origin, seasonal variati …
Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway.
Fang X, Deng H, Li M, Gao X, He C, Liu H. Fang X, et al. Front Immunol. 2026 Jan 20;16:1730184. doi: 10.3389/fimmu.2025.1730184. eCollection 2025. Front Immunol. 2026. PMID: 41684537 Free PMC article.
The involvement of the Nox4/ROS/PI3K/Akt/PADI4 pathway was assessed. The therapeutic potential of Zuoqing Granule (ZQG), a clinically used traditional Chinese formulation, was evaluated both in vivo and in PMA-stimulated rat neutrophils in vitro. ...CONCLUSION: Our …
The involvement of the Nox4/ROS/PI3K/Akt/PADI4 pathway was assessed. The therapeutic potential of Zuoqing Granule (ZQG), a clinically …
Wedelolactone, a natural coumestan with multiple pharmacological effects.
Han S, Li M, Yang L, Zhuang X. Han S, et al. Front Pharmacol. 2026 Jan 28;16:1670032. doi: 10.3389/fphar.2025.1670032. eCollection 2025. Front Pharmacol. 2026. PMID: 41684521 Free PMC article. Review.
Natural products, especially those from medicinal plants, have been increasingly attractive to researchers. Wedelolactone (WL) is a natural coumestan that was first isolated from Wedelia Chinensis. ...This review integrates the recent progresses available on its pha …
Natural products, especially those from medicinal plants, have been increasingly attractive to researchers. Wedelolactone (WL) …
Troxerutin, a herbal metabolite with antidiabetic and antihypercholesterolemic potential, regulates metabolic gene activity in male diabetic rats.
Gul S, Naseem M, Sheikh IS, Ali HM, Rabbani I, Jamil T, Gul S, Chachar Z, Ullah S, Asif S, Ataya FS, Fouad D, Abass KS, Cai Y, Liu J, Huang F. Gul S, et al. Front Pharmacol. 2026 Jan 28;16:1687575. doi: 10.3389/fphar.2025.1687575. eCollection 2025. Front Pharmacol. 2026. PMID: 41684515 Free PMC article.
BACKGROUND/OBJECTIVE: This study evaluated the antidiabetic and antihypercholesterolemic potential of the botanical metabolite troxerutin (TRX) and compared it with that of metformin in high-fat diet-fed streptozotocin-induced diabetic male Wistar rats. ...CONCLUSION: Trox …
BACKGROUND/OBJECTIVE: This study evaluated the antidiabetic and antihypercholesterolemic potential of the botanical metabolite troxer …
Momordicine I Mediates Lipid-Lowering Effects of Momordica Charantia L. Triterpenoid Saponins via TFEB-Driven Lysosomal Biogenesis.
Bai J, Zhu Z, Pan B, Yang Z, Dai C, Huang S, Zhu Y, Zhao Y, Zhang N, Xiao X. Bai J, et al. J Food Sci. 2026 Feb;91(2):e70923. doi: 10.1111/1750-3841.70923. J Food Sci. 2026. PMID: 41684281
Results demonstrated that both BMSE and momordicine I significantly alleviated lipid accumulation in HepG2 cells and C. elegans, with momordicine I showing a relatively superior effect. Furthermore, treatment with BMSE and momordicine I promoted the formation of autophagos …
Results demonstrated that both BMSE and momordicine I significantly alleviated lipid accumulation in HepG2 cells and C. elegans, with momord …
Yiqi Daozhi Formula Reduces the M1 Polarization of Macrophages in Mice With Postoperative Ileus Through Mediating Glycolysis Metabolism.
Gang W, Xuan Z, Ye W, Chen Y, Jing Y, Tianle Z, Mingyue S, Yuewei T, Zhiwei J. Gang W, et al. Immun Inflamm Dis. 2026 Feb;14(2):e70353. doi: 10.1002/iid3.70353. Immun Inflamm Dis. 2026. PMID: 41684127
There is an urgent clinical need to search for treatment regimens that improve the therapeutic effect for POI. Current research indicates that Traditional Chinese Medicine (TCM) demonstrates significant efficacy in treating POI. Our research was conduc …
There is an urgent clinical need to search for treatment regimens that improve the therapeutic effect for POI. Current researc …
Molecular Mechanisms and Therapeutic Potentials of Triptolide in Autoimmune Diseases: Advances and Challenges.
Zhang J, Huang F, Xu Y, Xie J, Lei Y, Hu Z, Dai Y, Hou X. Zhang J, et al. Am J Chin Med. 2026;54(1):201-228. doi: 10.1142/S0192415X26500072. Epub 2026 Jan 22. Am J Chin Med. 2026. PMID: 41684091 Review.
The global incidence and prevalence of autoimmune diseases are increasing, and there is thus a need to develop novel, effective, and affordable therapeutic agents for autoimmune diseases. Triptolide (TP), a bioactive diterpenoid epoxide isolated from Tripterygium wilfordii …
The global incidence and prevalence of autoimmune diseases are increasing, and there is thus a need to develop novel, effective, and afforda …
Intestinal Protective Effects of a Pomegranate Peel Extract in In Vitro and Ex Vivo Studies.
Recinella L, Acquaviva A, Bruno A, Ciaramellano D, Centulio AP, Dovizio M, Milillo C, Mozzon M, Generali D, Genovesi G, Orlando G, Chiavaroli A, Ferrante C, Ballerini P, Brunetti L, Leone S. Recinella L, et al. Int J Mol Sci. 2026 Feb 6;27(3):1603. doi: 10.3390/ijms27031603. Int J Mol Sci. 2026. PMID: 41684022
Recovery of nutritional and bioactive molecules by pomegranate peel (PP) has found wide applications in food and pharmaceutical industries. We investigated protective effects of a PP extract (PPE) from Mediterranean (Mazara del Vallo, Italy) on intestinal inflammation by u …
Recovery of nutritional and bioactive molecules by pomegranate peel (PP) has found wide applications in food and pharmaceutical indus …
Molecular Mechanisms of Trichosanthes kirilowii in Response to Root-Knot Nematode Infection.
Zheng L, Wang H, Zhang Z, Gu J. Zheng L, et al. Int J Mol Sci. 2026 Feb 6;27(3):1594. doi: 10.3390/ijms27031594. Int J Mol Sci. 2026. PMID: 41684013
Root-knot nematode (RKN) infection poses a serious threat to the yield and quality of the perennial medicinal plant Trichosanthes kirilowii (T. kirilowii) in cultivation. However, its response mechanisms remain unclear. ...The results showed that RKN infection signi …
Root-knot nematode (RKN) infection poses a serious threat to the yield and quality of the perennial medicinal plant Trichosant …
Traditional Medicine Extracts of Gnidia sericocephala and Product Nkabinde in HIV-1 Latency Reversal: Insights from J-Lat Subtype B and J-Lat Subtype C Models.
Mngomezulu K, Khathi SP, Nkabinde SA, Nkabinde M, Ngcobo M, Gqaleni N. Mngomezulu K, et al. Int J Mol Sci. 2026 Feb 5;27(3):1581. doi: 10.3390/ijms27031581. Int J Mol Sci. 2026. PMID: 41684002
The persistence of latent HIV-1 reservoirs in individuals on antiretroviral therapy (ART) remains a major barrier to cure, necessitating strategies such as "shock and kill" using latency-reversing agents (LRAs). ...These findings demonstrate that G. sericocephala effective …
The persistence of latent HIV-1 reservoirs in individuals on antiretroviral therapy (ART) remains a major barrier to cure, necessitat …
In Vitro Bioactivity of Leaf Extract Fractions and Quercetin-3-O-Rhamnoside from Combretum elaeagnoides Against Staphylococcus Species Implicated in Causing Bovine Mastitis.
Erhabor RC, Dzoyem JP, Petzer IM, Abdalla MA, McGaw LJ. Erhabor RC, et al. Int J Mol Sci. 2026 Feb 5;27(3):1579. doi: 10.3390/ijms27031579. Int J Mol Sci. 2026. PMID: 41683998
In contrast, the CeAq, CeHx, and CeDCM fractions showed the best inhibitory activity against the 15-lipoxygenase enzyme (IC(50) = 3-4 g/mL). The extracts and fractions were non-cytotoxic to bovine dermis cells (LC(50) = 0.88-1 mg/mL). Combretum elaeagnoides extract and its …
In contrast, the CeAq, CeHx, and CeDCM fractions showed the best inhibitory activity against the 15-lipoxygenase enzyme (IC(50) = 3-4 g/mL). …
A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones from Nepeta cataria Leaves.
Kiatlertpongsa T, Nonkhwao S, Charoenrit J, Saetan J, Duangprom S, Songkoomkrong S, Amonruttanapun P, Janpan P, Sobhon P, Daduang S, Kornthong N. Kiatlertpongsa T, et al. Int J Mol Sci. 2026 Feb 5;27(3):1572. doi: 10.3390/ijms27031572. Int J Mol Sci. 2026. PMID: 41683995
The reliance on synthetic repellents such as N,N-diethyl-meta-toluamide (DEET) has raised health and environmental concerns, prompting the search for safer, plant-based alternatives. Catnip (Nepeta cataria L.), a rich source of iridoid monoterpenes, particularly nepetalact …
The reliance on synthetic repellents such as N,N-diethyl-meta-toluamide (DEET) has raised health and environmental concerns, prompting the s …
Isoflavone-Enriched Glycine tomentella Hayata Extract Attenuates Anxiety-like Behavior and Oxidative Stress in Mice via Radical Scavenging Activity.
Tsai MC, Lee MC, Ng MC, Lin YK, Lai PF, Liu HT. Tsai MC, et al. Int J Mol Sci. 2026 Feb 5;27(3):1560. doi: 10.3390/ijms27031560. Int J Mol Sci. 2026. PMID: 41683978
The root extract of Glycine tomentella Hayata (GTE), a traditional Chinese medicinal herb contains flavonoids, particularly, isoflavones. However, its neuroprotective effects against anxiety remain unclear. ...
The root extract of Glycine tomentella Hayata (GTE), a traditional Chinese medicinal herb contains flavonoids, particularly, i …
Chicory Extract Alleviates Anthracycline-Induced Cardiotoxicity by Inhibiting Mitochondrial Damage via the UCP2/NLRP3 Pathway.
Rao Y, Wang Y, Liu Y, Huang J, Ding X, Lin Z, Zhang B, Zhang X. Rao Y, et al. Int J Mol Sci. 2026 Feb 5;27(3):1557. doi: 10.3390/ijms27031557. Int J Mol Sci. 2026. PMID: 41683976
There were limited options available for the prevention and treatment of DIC. Chicory (Cichorium intybus L.) has demonstrated notable cardioprotective effects. ...Targeting UCP2 to regulate the NLRP3 pathway highlights chicory as a promising therapeutic strategy for …
There were limited options available for the prevention and treatment of DIC. Chicory (Cichorium intybus L.) has demonstrated notable …
Nephroprotective Effect of Methanolic Extract of Micromeria frivaldszkyana (Degen) Velen Against Acetaminophen Overdose in Rats.
Apostolova E, Kokova V, Dimov I, Choneva M, Delev D, Kostadinov I, Bivolarski I, Koleva M, Mladenova T, Todorov K, Bivolarska A. Apostolova E, et al. Int J Mol Sci. 2026 Feb 4;27(3):1547. doi: 10.3390/ijms27031547. Int J Mol Sci. 2026. PMID: 41683968
Micromeria frivaldszkyana (M. frivaldszkyana), an endemic plant to Bulgaria, has demonstrated significant antioxidant activity. This study represents the first evaluation of the nephroprotective effects of a methanolic extract of M. frivaldszkyana in an APAP-induced rat mo …
Micromeria frivaldszkyana (M. frivaldszkyana), an endemic plant to Bulgaria, has demonstrated significant antioxidant activity. This …
Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by Diospyros kaki Leaf Extract.
Jeon Y, Kwon H, Ahn HR, Huh G, Kim T, Park YT, Park HB, Jeong JH, Jo JH, Kim YJ, Jung SH. Jeon Y, et al. Int J Mol Sci. 2026 Feb 4;27(3):1544. doi: 10.3390/ijms27031544. Int J Mol Sci. 2026. PMID: 41683963
HTM cells were stimulated with LPA and treated with ethanol-based EEDK extracts. Expression of ECM/fibrosis-related genes (FN1, ACTA2, COL1A1, COL3A1, COL4A1, COL6A2, CCN2) and EMT markers (CDH2, VIM, SNAI1) was assessed, along with cell migration using a wound-healing ass …
HTM cells were stimulated with LPA and treated with ethanol-based EEDK extracts. Expression of ECM/fibrosis-related genes (FN1, ACTA2 …
Isolation and Characterization of 5-(1-Hydroxyethyl)-Dihydro-2-Furanone from Angiopteris evecta with Potent Anti-Inflammatory and Anti-Leukemic Activities.
Rueankham L, Viriyaadhammaa N, Yin W, Liu Y, Chiampanichayakul S, Rungrojsakul M, Katekunlaphan T, Okonogi S, Saiai A, Iwasaki A, Chick CN, Usuki T, Anuchapreeda S. Rueankham L, et al. Int J Mol Sci. 2026 Jan 30;27(3):1399. doi: 10.3390/ijms27031399. Int J Mol Sci. 2026. PMID: 41683821
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with poor prognosis, frequent relapse, and treatment-related toxicity. The discovery of novel anti-leukemic agents with improved selectivity remains an urgent clinical need. In this study, rhizomes of …
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with poor prognosis, frequent relapse, and treatment-related …
Anti-Adipogenic Effect of Secondary Metabolites Isolated from Tetracera loureiri on 3T3-L1 Adipocytes.
Lim SH, Park JH, Lee DH, Bang WY, Lee J, Sovann S, Masphal K, Kang JS, Seo DW, Oh JS. Lim SH, et al. Int J Mol Sci. 2026 Jan 29;27(3):1374. doi: 10.3390/ijms27031374. Int J Mol Sci. 2026. PMID: 41683798
A species of the genus Tetracera has been used as herbal medicine in traditional Indian Tetracera loureiri medicine. Tetracera loureiri, a plant from the Dilleniaceae family is considered one of the most valuable herbs in Thailand and is native to Sout …
A species of the genus Tetracera has been used as herbal medicine in traditional Indian Tetracera loureiri medicine. Te …
Special Issue "Recent Advances in Medicinal Plants and Natural Products".
Luís Â, Duarte AP. Luís Â, et al. Int J Mol Sci. 2026 Jan 29;27(3):1350. doi: 10.3390/ijms27031350. Int J Mol Sci. 2026. PMID: 41683772
Medicinal plants and natural products continue to represent a rich and rapidly evolving field in molecular sciences [...]....
Medicinal plants and natural products continue to represent a rich and rapidly evolving field in molecular sciences [...]....
Natural Bioactive Compounds Targeting FABP4 in Adipogenesis and Obesity: Evidence from In Vitro and In Vivo Studies.
Sobczyński J, Nowaczyński F, Smolińska K, Lachowicz-Radulska J, Serefko A, Szopa A. Sobczyński J, et al. Int J Mol Sci. 2026 Jan 28;27(3):1306. doi: 10.3390/ijms27031306. Int J Mol Sci. 2026. PMID: 41683732 Review.
Data from 3T3-L1/OP9 adipocytes, rodent studies, and selected alternative models indicate that many plant-derived extracts and phytochemicals (e.g., polyphenols, saponins, coumarins, terpenoids, and fermented products) down-regulate FABP4 at mRNA and/or protein leve …
Data from 3T3-L1/OP9 adipocytes, rodent studies, and selected alternative models indicate that many plant-derived extracts and …
Natural Neurobiological Active Compounds in Parkinson's Disease: Molecular Targets, Signaling Pathways, and Therapeutic Prospects.
Wu X, Zhang L, Luo S, Li Q, Wang J, Chen W, Zhou N, Zhou L, Li R, Xie Y, Chen Q, Guo P. Wu X, et al. Int J Mol Sci. 2026 Jan 28;27(3):1301. doi: 10.3390/ijms27031301. Int J Mol Sci. 2026. PMID: 41683726 Review.
Among the extensive relevant research, few have explored the precise pathogenic mechanisms underlying PD, and no curative treatment is available. Current pharmacological therapies mainly provide symptomatic relief by enhancing central dopaminergic function or modula …
Among the extensive relevant research, few have explored the precise pathogenic mechanisms underlying PD, and no curative treatment i …
Mechanisms of Antiproliferative Effects of Nobiletin, Scoparone, and Tangeretin Isolated from Citrus reticulata Peel Dichloromethane Extract in Acute Myeloid Leukemia Cells.
Russo C, Nahar L, Ismail FMD, Navarra M, Sarker SD. Russo C, et al. Int J Mol Sci. 2026 Jan 27;27(3):1256. doi: 10.3390/ijms27031256. Int J Mol Sci. 2026. PMID: 41683686
This mechanism was mediated by the modulation of BAX and BCL-2 genes in both AML cell lines. Notably, each treatment drove THP-1 and U937 cells into the sub-G0 phase, together with an increase in the cell population in the G1 phase of the cell cycle, both of which were det …
This mechanism was mediated by the modulation of BAX and BCL-2 genes in both AML cell lines. Notably, each treatment drove THP-1 and …
UHPLC-QTOF-MS Profiling of Chemical Constituents in POW9TM Cocktail with Antioxidant and Anti-Proliferative Potentials Against Vero, MCF-7 and MDA-MB-231 Cells.
Taworntawat C, Tonkittirattanakul P, Koonyosying P, Perrodin DD, Srichairatanakool S, Tipsuwan W. Taworntawat C, et al. Int J Mol Sci. 2026 Jan 27;27(3):1246. doi: 10.3390/ijms27031246. Int J Mol Sci. 2026. PMID: 41683673
Breast cancer remains one of the most prevalent and lethal malignancies affecting women worldwide, underscoring the need for safer and more effective therapeutic strategies. This study investigated the phytochemical composition, antioxidant activity, and antiproliferative …
Breast cancer remains one of the most prevalent and lethal malignancies affecting women worldwide, underscoring the need for safer and more …
The Role of Nut Sensitization in Pru p 3-Sensitized Patients: A XGBoost and Generalized Linear Model Application.
Gangemi S, Caristi G, Alessandrello C, Dimasi F, Nuccio F, Morabito M, Minciullo PL. Gangemi S, et al. Int J Mol Sci. 2026 Jan 26;27(3):1223. doi: 10.3390/ijms27031223. Int J Mol Sci. 2026. PMID: 41683649
As a panallergen, Pru p 3 shows high sequence homology with nsLTPs from other Rosaceae fruits but also from botanically unrelated sources, including nuts and pollens, leading to extensive cross-reactivity complicating diagnosis and management. ...
As a panallergen, Pru p 3 shows high sequence homology with nsLTPs from other Rosaceae fruits but also from botanically unrelated sou …
Green Synthesis of Silver Nanoparticles with Antibacterial, Anti-Inflammatory, and Antioxidant Activity Using Convolvulus arvensis.
Al-Audah SA, Alghamdi AI, Alsanie SI, Alabdalla NM, Alawdah A, Alenezi N, AlShammari A, Taha I, Albarrag A, Aldakeel S, Aldayel M. Al-Audah SA, et al. Int J Mol Sci. 2026 Jan 25;27(3):1210. doi: 10.3390/ijms27031210. Int J Mol Sci. 2026. PMID: 41683637
Due to the indiscriminate use of antimicrobial drugs in the treatment of infectious diseases, human pathogenic bacteria have developed resistance to many commercially available antibiotics. Medicinal plants such as Convolvulus arvensis represent a rene …
Due to the indiscriminate use of antimicrobial drugs in the treatment of infectious diseases, human pathogenic bacteria have d …
Evaluation of Polyphenol-Rich Lemon Peel Extract Use in a Zebrafish Model of Spinal Cord Injury: Morphology, Repair-Associated Markers, and Inflammatory Profile.
Sicari M, Pansera L, Mhalhel K, Aragona M, Galeano M, Colonna MR, Levanti M, Laurà R, Abbate F, Germanà A, Montalbano G. Sicari M, et al. Int J Mol Sci. 2026 Jan 25;27(3):1201. doi: 10.3390/ijms27031201. Int J Mol Sci. 2026. PMID: 41683629
To evaluate its potential effects, embryos were divided into six experimental groups: a baseline control group in which larvae were neither subjected to spinal cord injury nor treated (Ctrl Group); a group with larvae subjected to spinal cord injury at 3 dpf without treatment …
To evaluate its potential effects, embryos were divided into six experimental groups: a baseline control group in which larvae were neither …
From Elderflower to Bioactive Extracts: Phytochemical Characterization and Anti-Inflammatory Activity.
Koval M, Dresler S, Kowalik S, Schwarz B, Wawruszak A, Filipek A, Komar M, Jakschitz T, Beteinakis S, Bonn G, Koch W, Kukula-Koch W. Koval M, et al. Molecules. 2026 Feb 5;31(3):561. doi: 10.3390/molecules31030561. Molecules. 2026. PMID: 41683541
The anti-inflammatory potential was evaluated in TNFalpha-stimulated HaCaT NF-kappaB Luc reporter keratinocytes. Anhydrous ethanolic extracts demonstrated superior efficacy, significantly inhibiting NF-kappaB pathway activation at non-cytotoxic concentrations. ...These fin …
The anti-inflammatory potential was evaluated in TNFalpha-stimulated HaCaT NF-kappaB Luc reporter keratinocytes. Anhydrous ethanolic extr …
Linking Global Antioxidant Assays with Targeted HPLC Profiling of Prenylated Flavonoids in Humulus lupulus L. Extracts Obtained by Accelerated Solvent Extraction.
Haring N, Drábová B, Chňapek M. Haring N, et al. Molecules. 2026 Feb 5;31(3):562. doi: 10.3390/molecules31030562. Molecules. 2026. PMID: 41683539
This study evaluated the relationship between global antioxidant parameters and targeted profiling of prenylated flavonoids in hop extracts obtained under different ASE conditions. Total antioxidant capacity (TAC), total phenolic content (TPC), and concentrations of xantho …
This study evaluated the relationship between global antioxidant parameters and targeted profiling of prenylated flavonoids in hop extrac …
Exploring Castanea sativa Shells (CSSs) as a Source of AKR1B1 and AKR1B10 Inhibitors: From Extraction to Bioactivity Testing.
Piazza L, Tedeschi L, Felice F, Cecchettini A, Ceccherini E, Avanatti M, Suman AF, Balestri F, Rocchiccioli S, Signore G. Piazza L, et al. Molecules. 2026 Feb 5;31(3):563. doi: 10.3390/molecules31030563. Molecules. 2026. PMID: 41683538
The industrial chestnut food chain generates large amounts of this by-product, which represents both a waste disposal challenge and a potential source of promising biomolecules. Thermal treatments occurring during industrial processing, however, may affect both chemical co …
The industrial chestnut food chain generates large amounts of this by-product, which represents both a waste disposal challenge and a potent …
Selective Cytotoxic and Antiproliferative Effects of Extracts from Four Mexican Medicinal Plants in Human Cancer and Non-Cancerous Cell Lines.
Castañeda-Espinoza JD, Alvarez Soto YA, Marquina-Bahena S, Madariaga Sosa GA, Zagal Laguna KL, Guerrero-Alonso A, Salas-Vidal E, Furuzawa-Carballeda J, Uriostegui-Velarde JM, Mojica Cardoso C, Anzurez Jiménez AN, Carranza Valencia E, Ayala Calvillo E, Sánchez-Carranza JN. Castañeda-Espinoza JD, et al. Molecules. 2026 Feb 4;31(3):549. doi: 10.3390/molecules31030549. Molecules. 2026. PMID: 41683526
Background: Medicinal plants used in traditional Mexican medicine represent a valuable source of bioactive compounds with potential anticancer activity. ...Conclusions: These findings provide in vitro evidence of selective anticancer activity of Mexican me …
Background: Medicinal plants used in traditional Mexican medicine represent a valuable source of bioactive compounds wi …
Centella asiatica as a Model Biomass for Sustainable Production of Biochemicals via Green Extraction and Purification Technologies: A Comprehensive Field-to-Market Review.
Razzaq W, Mazzitelli JB, Fabiano Tixier AS, Vian MA. Razzaq W, et al. Molecules. 2026 Feb 2;31(3):526. doi: 10.3390/molecules31030526. Molecules. 2026. PMID: 41683503 Review.
Centella asiatica has emerged as a strategic biomass for the sustainable production of high-value biochemicals at the interface of traditional medicine and modern biotechnology. This review consolidates the current knowledge on its phytochemical diversity, emphasizing trit …
Centella asiatica has emerged as a strategic biomass for the sustainable production of high-value biochemicals at the interface of tradition …
Boosting the Sustainable Transformation of Cornus mas L. Stones Using a Hybrid Strategy Involving Microwave-Assisted Extraction.
Boyadzhieva SS, Tsvetanova FV, Coelho JAP, Staleva P, Kamenova-Nacheva M, Taneva S, Stateva RP. Boyadzhieva SS, et al. Molecules. 2026 Feb 2;31(3):525. doi: 10.3390/molecules31030525. Molecules. 2026. PMID: 41683502
The efficiency of the two routes was evaluated by comparing total polyphenol, flavonoid, and saponin content (TPC, TFC, TSC) and antioxidant activity (AA) of all obtained extracts, the fatty acid composition of MAE (route 1) and Soxhlet n-hexane extracts, and the me …
The efficiency of the two routes was evaluated by comparing total polyphenol, flavonoid, and saponin content (TPC, TFC, TSC) and antioxidant …
Screening of Tocopherol and Tocotrienol Diversity in Cornus Species Seeds Using a Sustainable Extraction Protocol.
Lazdiņa D, Mišina I, Dukurs K, Górnaś P. Lazdiņa D, et al. Molecules. 2026 Feb 2;31(3):519. doi: 10.3390/molecules31030519. Molecules. 2026. PMID: 41683496
Given the substantial number of samples included in this study, we applied a fast extraction protocol using an ethanol and ultrasound treatment and systematically compared its performance with that of a conventional alkaline saponification method. ...The applied sustainabl …
Given the substantial number of samples included in this study, we applied a fast extraction protocol using an ethanol and ultrasound tre …
Bioactive Potential and COX-2 Interaction of Ajuga iva (L.) Schreb. Hydroalcoholic Extract: Evidence from Experimental and Computational Studies.
Boutora Y, Boussekine S, Benslama O, Lekmine S, Mansouri N, Touzout N, Moussa H, Gacem R, Hfaiedh N, Nieto G. Boutora Y, et al. Molecules. 2026 Jan 31;31(3):496. doi: 10.3390/molecules31030496. Molecules. 2026. PMID: 41683475
The in silico docking results provide supportive, predictive molecular insights that may help rationalize the observed bioactivities and encourage further biochemical and mechanistic investigations into this traditionally used medicinal plant....
The in silico docking results provide supportive, predictive molecular insights that may help rationalize the observed bioactivities and enc …
Bioactivity-Guided Fractionation, Characterization, and Mechanistic Insights of Anticancer Agents from Simarouba glauca DC. Leaves.
Rudraswamy S, G V YD, Sheshanna SH, Doggalli N, Madhunapantula SV. Rudraswamy S, et al. Molecules. 2026 Jan 31;31(3):497. doi: 10.3390/molecules31030497. Molecules. 2026. PMID: 41683473
Although Simarouba glauca DC. has been recognized for its therapeutic properties, its anticancer effects against oral cancer have not been adequately investigated. ...Among all extracts, the S. glauca hexane extract (SGHE) exhibited the most potent anticancer activi …
Although Simarouba glauca DC. has been recognized for its therapeutic properties, its anticancer effects against oral cancer have not …
Optimization of Extraction and Antioxidant Activities of Resveratrol from Polygonum cuspidatum by Ultrasound-Assisted Natural Deep Eutectic Solvent Method.
Guo Y, Wan S, Gu Y, He T, Chen Z, Qu X, Quan J, Ma J, Hamid IAA. Guo Y, et al. Molecules. 2026 Jan 30;31(3):492. doi: 10.3390/molecules31030492. Molecules. 2026. PMID: 41683469
Polygonum cuspidatum, a traditional medicinal plant widely cultivated in Hubei Province, China, contains resveratrol, which has been shown to regulate lipoprotein metabolism, inhibit platelet aggregation, and aid in the prevention of arteriosclerosis and cardiovascu …
Polygonum cuspidatum, a traditional medicinal plant widely cultivated in Hubei Province, China, contains resveratrol, which ha …
Comparative Metabolomics Reveals Family-Genus-Specific Chemical Signatures and Potential Recognition Mechanisms in Cynomorium songaricum-Host Interactions.
Tang Y, Chen C, Zhang X, Zhou Y, Wang J. Tang Y, et al. Molecules. 2026 Jan 30;31(3):491. doi: 10.3390/molecules31030491. Molecules. 2026. PMID: 41683468
Cynomorium songaricum is an important medicinal holoparasitic plant in the arid regions of northwestern China. Its extremely low seed germination rate relies on chemical signals released from the rhizosphere of specific host plants. ...The unique chemical pro …
Cynomorium songaricum is an important medicinal holoparasitic plant in the arid regions of northwestern China. Its extremely l …
Polyphenols in Sugar Beet Leaves: Composition, Variability, and Valorization Opportunities.
Antczak-Chrobot A, Macierzyński J, Wojtczak M. Antczak-Chrobot A, et al. Molecules. 2026 Jan 30;31(3):489. doi: 10.3390/molecules31030489. Molecules. 2026. PMID: 41683466
Total polyphenols were quantified using vitexin as a reference standard, and the phenolic profile of methanolic extracts was characterized using complementary HPLC-DAD and LC-MS methods. The protein content in leaf blades ranged from 19% to 29% (dry weight) and was signifi …
Total polyphenols were quantified using vitexin as a reference standard, and the phenolic profile of methanolic extracts was characte …
Enhanced Antiplatelet Activity of Nitrated Fatty Acid Extracts from Phaseolus vulgaris L.
Rodríguez L, Montecino-Garrido HL, Lagos F, Carrasco B, Palomo I, Ormazabal P, Trostchansky A, Fuentes E. Rodríguez L, et al. Molecules. 2026 Jan 30;31(3):488. doi: 10.3390/molecules31030488. Molecules. 2026. PMID: 41683465
This study investigated whether Phaseolus vulgaris L. extracts can generate nitrated fatty acids under gastric-like conditions and evaluated their effects on human platelet function. ...Nitrated extracts markedly inhibited TRAP-6 induced aggregation (IC(50) 1.8 mg/m …
This study investigated whether Phaseolus vulgaris L. extracts can generate nitrated fatty acids under gastric-like conditions and ev …
12-epi-Turpelline, a Novel C20 Diterpene Alkaloid Isolated from Zanba Stir-Fried Tiebangchui.
He S, Yang L, Meng S, Feng N, Liu Y, Zhang Y, Chen D. He S, et al. Molecules. 2026 Jan 29;31(3):479. doi: 10.3390/molecules31030479. Molecules. 2026. PMID: 41683456
Aconitum pendulum Busch (Tiebangchui), a traditional Chinese medicinal herb, is recognized for its diverse pharmacological properties and for its significant toxicity. ...
Aconitum pendulum Busch (Tiebangchui), a traditional Chinese medicinal herb, is recognized for its diverse pharmacological pro …
Composition Study of Polyphyllin in Paris polyphylla by Ultrasound-Assisted Deep Eutectic Solvent Extraction Combined with UHPLC-MS/MS.
Guo J, Liu J, Li M, Tan Z, Lu H, Zhou Y. Guo J, et al. Molecules. 2026 Jan 29;31(3):473. doi: 10.3390/molecules31030473. Molecules. 2026. PMID: 41683450
Paris polyphylla (Chonglou), a medicinal herb documented in Shennong's Classic of Materia Medica and a key component of formulas such as Yunnan Baiyao, is a rare and endangered plant prized for its bioactive steroidal saponins, notably polyphyllin I (PPI) and II (PP …
Paris polyphylla (Chonglou), a medicinal herb documented in Shennong's Classic of Materia Medica and a key component of formulas such …
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