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2007 1
2008 2
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2011 4
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2013 5
2014 2
2015 2
2016 5
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2020 5
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Page 1
Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study.
Ashton PM, Chunga Chirambo A, Meiring JE, Patel PD, Mbewe M, Silungwe N, Chizani K, Banda H, Heyderman RS, Dyson ZA, MacPherson P, Henrion MYR; STRATAA Study Group; Holt KE, Gordon MA. Ashton PM, et al. Among authors: holt ke. Lancet Microbe. 2024 Mar;5(3):e226-e234. doi: 10.1016/S2666-5247(23)00327-0. Epub 2024 Feb 19. Lancet Microbe. 2024. PMID: 38387472 Free PMC article.
Between Oct 1, 2016, and Aug 31, 2019, of 177 typhoid fever cases confirmed by whole-genome sequencing, four (2%) were caused by S Typhi with QRDR mutations, compared with six (33%) of 18 cases between Sept 1 and Oct 31, 2019. ...INTERPRETATION: We postulate a causa …
Between Oct 1, 2016, and Aug 31, 2019, of 177 typhoid fever cases confirmed by whole-genome sequencing, four (2%) were caused by S …
Typhoid fever.
Meiring JE, Khanam F, Basnyat B, Charles RC, Crump JA, Debellut F, Holt KE, Kariuki S, Mugisha E, Neuzil KM, Parry CM, Pitzer VE, Pollard AJ, Qadri F, Gordon MA. Meiring JE, et al. Among authors: holt ke. Nat Rev Dis Primers. 2023 Dec 14;9(1):71. doi: 10.1038/s41572-023-00480-z. Nat Rev Dis Primers. 2023. PMID: 38097589 Review.
Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa and Asia. Typhoid primarily affects individuals ranging from infants through to young adults. ...
Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa a
Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes.
Carey ME, Dyson ZA, Ingle DJ, Amir A, Aworh MK, Chattaway MA, Chew KL, Crump JA, Feasey NA, Howden BP, Keddy KH, Maes M, Parry CM, Van Puyvelde S, Webb HE, Afolayan AO, Alexander AP, Anandan S, Andrews JR, Ashton PM, Basnyat B, Bavdekar A, Bogoch II, Clemens JD, da Silva KE, De A, de Ligt J, Diaz Guevara PL, Dolecek C, Dutta S, Ehlers MM, Francois Watkins L, Garrett DO, Godbole G, Gordon MA, Greenhill AR, Griffin C, Gupta M, Hendriksen RS, Heyderman RS, Hooda Y, Hormazabal JC, Ikhimiukor OO, Iqbal J, Jacob JJ, Jenkins C, Jinka DR, John J, Kang G, Kanteh A, Kapil A, Karkey A, Kariuki S, Kingsley RA, Koshy RM, Lauer AC, Levine MM, Lingegowda RK, Luby SP, Mackenzie GA, Mashe T, Msefula C, Mutreja A, Nagaraj G, Nagaraj S, Nair S, Naseri TK, Nimarota-Brown S, Njamkepo E, Okeke IN, Perumal SPB, Pollard AJ, Pragasam AK, Qadri F, Qamar FN, Rahman SIA, Rambocus SD, Rasko DA, Ray P, Robins-Browne R, Rongsen-Chandola T, Rutanga JP, Saha SK, Saha S, Saigal K, Sajib MSI, Seidman JC, Shakya J, Shamanna V, Shastri J, Shrestha R, Sia S, Sikorski MJ, Singh A, Smith AM, Tagg KA, Tamrakar D, Tanmoy AM, Thomas M, Thomas MS, Thomsen R, Thomson NR, Tupua S, Vaidya K, Valcanis M, Veeraraghavan B, Weill … See abstract for full author list ➔ Carey ME, et al. Among authors: holt ke. Elife. 2023 Sep 12;12:e85867. doi: 10.7554/eLife.85867. Elife. 2023. PMID: 37697804 Free PMC article.
BACKGROUND: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. ...Clinicians use antibi …
BACKGROUND: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggrega …
Unlocking the Potential of Genomic Data to Inform Typhoid Fever Control Policy: Supportive Resources for Genomic Data Generation, Analysis, and Visualization.
Carey ME, Dyson ZA, Argimón S, Cerdeira L, Yeats C, Aanensen D, Mboowa G, Baker S, Tessema SK, Smith AM, Okeke IN, Holt KE. Carey ME, et al. Among authors: holt ke. Open Forum Infect Dis. 2023 Jun 2;10(Suppl 1):S38-S46. doi: 10.1093/ofid/ofad044. eCollection 2023 May. Open Forum Infect Dis. 2023. PMID: 37274533 Free PMC article.
The global response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrated the value of timely and open sharing of genomic data with standardized metadata to facilitate monitoring of the emergence and spread of new variants. Here, we make the ca …
The global response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrated the value of timely and open s …
Linear plasmids in Klebsiella and other Enterobacteriaceae.
Hawkey J, Cottingham H, Tokolyi A, Wick RR, Judd LM, Cerdeira L, de Oliveira Garcia D, Wyres KL, Holt KE. Hawkey J, et al. Among authors: holt ke. Microb Genom. 2022 Apr;8(4):000807. doi: 10.1099/mgen.0.000807. Microb Genom. 2022. PMID: 35416146 Free PMC article.
To date, the only linear plasmids described in the family Enterobacteriaceae belong to Salmonella, first found in Salmonella enterica Typhi. Here, we describe a collection of 12 isolates of the Klebsiella pneumoniae species complex in which we identified linear plasmids. . …
To date, the only linear plasmids described in the family Enterobacteriaceae belong to Salmonella, first found in Salmonella enterica Typ
Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.
Dyson ZA, Malau E, Horwood PF, Ford R, Siba V, Yoannes M, Pomat W, Passey M, Judd LM, Ingle DJ, Williamson DA, Dougan G, Greenhill AR, Holt KE. Dyson ZA, et al. Among authors: holt ke. PLoS Negl Trop Dis. 2022 Mar 28;16(3):e0010306. doi: 10.1371/journal.pntd.0010306. eCollection 2022 Mar. PLoS Negl Trop Dis. 2022. PMID: 35344544 Free PMC article. Review.
BACKGROUND: Typhoid fever, a systemic infection caused by Salmonella enterica serovar Typhi, remains a considerable public health threat in impoverished regions within many low- and middle-income settings. ...Genotypic and phenotypic data demonstrated that the PNG S …
BACKGROUND: Typhoid fever, a systemic infection caused by Salmonella enterica serovar Typhi, remains a considerable public hea …
Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study.
Meiring JE, Shakya M, Khanam F, Voysey M, Phillips MT, Tonks S, Thindwa D, Darton TC, Dongol S, Karkey A, Zaman K, Baker S, Dolecek C, Dunstan SJ, Dougan G, Holt KE, Heyderman RS, Qadri F, Pitzer VE, Basnyat B, Gordon MA, Clemens J, Pollard AJ; STRATAA Study Group. Meiring JE, et al. Among authors: holt ke. Lancet Glob Health. 2021 Dec;9(12):e1688-e1696. doi: 10.1016/S2214-109X(21)00370-3. Lancet Glob Health. 2021. PMID: 34798028 Free PMC article.
Numerous data gaps exist concerning the epidemiology of Salmonella enterica serotype Typhi (S Typhi) and Salmonella enterica serotype Paratyphi (S Paratyphi), which are the causative agents of enteric fever. ...Multidrug resistance was observed in 44% S Typhi
Numerous data gaps exist concerning the epidemiology of Salmonella enterica serotype Typhi (S Typhi) and Salmonella enterica s …
Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.
Kariuki S, Dyson ZA, Mbae C, Ngetich R, Kavai SM, Wairimu C, Anyona S, Gitau N, Onsare RS, Ongandi B, Duchene S, Ali M, Clemens JD, Holt KE, Dougan G. Kariuki S, et al. Among authors: holt ke. Elife. 2021 Sep 13;10:e67852. doi: 10.7554/eLife.67852. Elife. 2021. PMID: 34515028 Free PMC article.
BACKGROUND: Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. ...RESULTS: 148 S. Typhi isolates from cases and 95 from controls (stool culture) were identified; a carriage …
BACKGROUND: Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to p …
Five Years of GenoTyphi: Updates to the Global Salmonella Typhi Genotyping Framework.
Dyson ZA, Holt KE. Dyson ZA, et al. Among authors: holt ke. J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S775-S780. doi: 10.1093/infdis/jiab414. J Infect Dis. 2021. PMID: 34453548 Free PMC article. Review.
In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have reveal …
In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nome …
A Bayesian approach for estimating typhoid fever incidence from large-scale facility-based passive surveillance data.
Phillips MT, Meiring JE, Voysey M, Warren JL, Baker S, Basnyat B, Clemens JD, Dolecek C, Dunstan SJ, Dougan G, Gordon MA, Thindwa D, Heyderman RS, Holt KE, Qadri F, Pollard AJ, Pitzer VE; STRATAA Study Group. Phillips MT, et al. Among authors: holt ke. Stat Med. 2021 Nov 20;40(26):5853-5870. doi: 10.1002/sim.9159. Epub 2021 Aug 24. Stat Med. 2021. PMID: 34428309 Free PMC article.
Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. ...Adjusted incidence rates were within or below the seroincidence rate limits of typhoid infection. Estimates of blood-culture-confirmed …
Decisions about typhoid fever prevention and control are based on estimates of typhoid incidence and their uncertainty. ...Adj …
50 results