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219 results

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Page 1
Pharmacologic treatment of delirium symptoms: A systematic review.
Sadlonova M, Duque L, Smith D, Madva EN, Amonoo HL, Vogelsang J, Staton SC, von Arnim CAF, Huffman JC, Celano CM. Sadlonova M, et al. Gen Hosp Psychiatry. 2022 Nov-Dec;79:60-75. doi: 10.1016/j.genhosppsych.2022.10.010. Epub 2022 Oct 21. Gen Hosp Psychiatry. 2022. PMID: 36375344
Despite somewhat mixed findings and a relative lack of high-quality trials, it appears that antipsychotic medications (e.g., haloperidol, olanzapine, risperidone, or quetiapine) and dexmedetomidine have the potential to improve delirium outcomes. CONCLUSIONS: Pharma …
Despite somewhat mixed findings and a relative lack of high-quality trials, it appears that antipsychotic medications (e.g., haloperidol …
Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms.
Sadlonova M, Beach SR, Funk MC, Rosen JH, Ramirez Gamero AF, Karlson RA, Huffman JC, Celano CM. Sadlonova M, et al. J Intensive Care Med. 2025 Apr;40(4):355-371. doi: 10.1177/08850666231222470. Epub 2023 Dec 21. J Intensive Care Med. 2025. PMID: 38130132 Review.
BackgroundPatients experiencing significant agitation or perceptual disturbances related to delirium in an intensive care setting may benefit from short-term treatment with an antipsychotic medication. ...In intensive care settings, we re …
BackgroundPatients experiencing significant agitation or perceptual disturbances related to delirium in an intensive care …
Haloperidol for the Treatment of Delirium in ICU Patients.
Andersen-Ranberg NC, Poulsen LM, Perner A, Wetterslev J, Estrup S, Hästbacka J, Morgan M, Citerio G, Caballero J, Lange T, Kjær MN, Ebdrup BH, Engstrøm J, Olsen MH, Oxenbøll Collet M, Mortensen CB, Weber SO, Andreasen AS, Bestle MH, Uslu B, Scharling Pedersen H, Gramstrup Nielsen L, Toft Boesen HC, Jensen JV, Nebrich L, La Cour K, Laigaard J, Haurum C, Olesen MW, Overgaard-Steensen C, Westergaard B, Brand B, Kingo Vesterlund G, Thornberg Kyhnauv P, Mikkelsen VS, Hyttel-Sørensen S, de Haas I, Aagaard SR, Nielsen LO, Eriksen AS, Rasmussen BS, Brix H, Hildebrandt T, Schønemann-Lund M, Fjeldsøe-Nielsen H, Kuivalainen AM, Mathiesen O; AID-ICU Trial Group. Andersen-Ranberg NC, et al. N Engl J Med. 2022 Dec 29;387(26):2425-2435. doi: 10.1056/NEJMoa2211868. Epub 2022 Oct 26. N Engl J Med. 2022. PMID: 36286254 Clinical Trial.
BACKGROUND: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited. ...Haloperidol or placebo was administered in the ICU for as long as delirium …
BACKGROUND: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU) …
Acute encephalopathy in the ICU: a practical approach.
Kurtz P, van den Boogaard M, Girard TD, Hermann B. Kurtz P, et al. Curr Opin Crit Care. 2024 Apr 1;30(2):106-120. doi: 10.1097/MCC.0000000000001144. Epub 2024 Feb 9. Curr Opin Crit Care. 2024. PMID: 38441156 Review.
In comatose patients, the roles of continuous EEG monitoring and neuroimaging have grown for the early detection of secondary brain injury and treatment of reversible causes. SUMMARY: Evidence-based pharmacologic treatments for delirium are limited. Dexmedetomidine …
In comatose patients, the roles of continuous EEG monitoring and neuroimaging have grown for the early detection of secondary brain injury a …
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness.
Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW; MIND-USA Investigators. Girard TD, et al. N Engl J Med. 2018 Dec 27;379(26):2506-2516. doi: 10.1056/NEJMoa1808217. Epub 2018 Oct 22. N Engl J Med. 2018. PMID: 30346242 Free PMC article. Clinical Trial.
BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU). METHODS: In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute respiratory f …
BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive …
Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium: Randomized Controlled Trial.
Zakhary T, Ahmed I, Luttfi I, Montasser M. Zakhary T, et al. Neurocrit Care. 2024 Oct;41(2):550-557. doi: 10.1007/s12028-024-01948-w. Epub 2024 Apr 1. Neurocrit Care. 2024. PMID: 38561588 Free PMC article. Clinical Trial.
BACKGROUND: In the population of patients in the intensive care unit (ICU), most studies compared the use of atypical antipsychotics, such as quetiapine, with the use of traditional haloperidol in patients with delirium of various forms and etio …
BACKGROUND: In the population of patients in the intensive care unit (ICU), most studies compared the use of atypical a …
Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses.
Cheng SL, Hsu TW, Kao YC, Yu CL, Thompson T, Carvalho AF, Stubbs B, Tseng PT, Hsu CW, Yang FC, Tu YK, Liang CS. Cheng SL, et al. Crit Care. 2025 Mar 20;29(1):126. doi: 10.1186/s13054-025-05342-6. Crit Care. 2025. PMID: 40114217 Free PMC article. Review.
BACKGROUND: Although haloperidol is commonly used to treat or prevent delirium in intensive care unit (ICU) patients, the evidence remains inconclusive. ...CONCLUSION: Our study supported the use of haloperidol for delirium trea …
BACKGROUND: Although haloperidol is commonly used to treat or prevent delirium in intensive care unit (ICU …
Antipsychotic Medications for Delirium Treatment in the Pediatric Intensive Care Unit: A Systematic Review.
Cavagnero F, Salerno A, Rizzolli CM, Marchetto L, Stritoni V, Tosoni A, Tessari A, Amigoni A, Daverio M. Cavagnero F, et al. Paediatr Drugs. 2025 Nov;27(6):707-722. doi: 10.1007/s40272-025-00716-3. Epub 2025 Sep 4. Paediatr Drugs. 2025. PMID: 40906237
BACKGROUND AND OBJECTIVES: Pediatric delirium (PD) is a common but underdiagnosed condition in pediatric intensive care units (PICUs), affecting 17-66% of patients. ...The limited sample size, the only modest quality of the studies, and the lack of rep …
BACKGROUND AND OBJECTIVES: Pediatric delirium (PD) is a common but underdiagnosed condition in pediatric intensive care …
Aripiprazole and delirium.
Alao AO, Moskowitz L. Alao AO, et al. Ann Clin Psychiatry. 2006 Oct-Dec;18(4):267-9. doi: 10.1080/10401230600948506. Ann Clin Psychiatry. 2006. PMID: 17162627
In addition, it is associated with a higher morbidity, mortality or longer hospitalization. Traditionally, haloperidol has been used to treat delirium-associated agitation. However, atypical antipsychotics are being increasingly used to treat delirium. ...CON …
In addition, it is associated with a higher morbidity, mortality or longer hospitalization. Traditionally, haloperidol has been used …
Interventions for preventing intensive care unit delirium in adults.
Herling SF, Greve IE, Vasilevskis EE, Egerod I, Bekker Mortensen C, Møller AM, Svenningsen H, Thomsen T. Herling SF, et al. Cochrane Database Syst Rev. 2018 Nov 23;11(11):CD009783. doi: 10.1002/14651858.CD009783.pub2. Cochrane Database Syst Rev. 2018. PMID: 30484283 Free PMC article.
Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer …
Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profound …
219 results