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Year Number of Results
1965 1
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1992 2
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2003 14
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2005 30
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2011 28
2012 36
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2,062 results

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Page 1
Phage therapy: From biological mechanisms to future directions.
Strathdee SA, Hatfull GF, Mutalik VK, Schooley RT. Strathdee SA, et al. Cell. 2023 Jan 5;186(1):17-31. doi: 10.1016/j.cell.2022.11.017. Cell. 2023. PMID: 36608652 Free PMC article. Review.
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. ...Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review …
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria d …
Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles.
Furfaro LL, Payne MS, Chang BJ. Furfaro LL, et al. Front Cell Infect Microbiol. 2018 Oct 23;8:376. doi: 10.3389/fcimb.2018.00376. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30406049 Free PMC article. Review.
Increasing reports of antimicrobial resistance and limited new antibiotic discoveries and development have fuelled innovation in other research fields and led to a revitalization of bacteriophage (phage) studies in the Western world. Phage therapy mainly util …
Increasing reports of antimicrobial resistance and limited new antibiotic discoveries and development have fuelled innovation in other resea …
The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies.
Liu D, Van Belleghem JD, de Vries CR, Burgener E, Chen Q, Manasherob R, Aronson JR, Amanatullah DF, Tamma PD, Suh GA. Liu D, et al. Viruses. 2021 Jun 29;13(7):1268. doi: 10.3390/v13071268. Viruses. 2021. PMID: 34209836 Free PMC article. Review.
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades. ...Comprehensive and stand …
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) t …
Profiling the human intestinal environment under physiological conditions.
Shalon D, Culver RN, Grembi JA, Folz J, Treit PV, Shi H, Rosenberger FA, Dethlefsen L, Meng X, Yaffe E, Aranda-Díaz A, Geyer PE, Mueller-Reif JB, Spencer S, Patterson AD, Triadafilopoulos G, Holmes SP, Mann M, Fiehn O, Relman DA, Huang KC. Shalon D, et al. Nature. 2023 May;617(7961):581-591. doi: 10.1038/s41586-023-05989-7. Epub 2023 May 10. Nature. 2023. PMID: 37165188 Free PMC article.
Collection of 240 intestinal samples from 15 healthy individuals using the device and subsequent multi-omics analyses identified significant differences between bacteria, phages, host proteins and metabolites in the intestines versus stool. Certain microbial taxa were diff …
Collection of 240 intestinal samples from 15 healthy individuals using the device and subsequent multi-omics analyses identified significant …
Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.
Gordillo Altamirano F, Forsyth JH, Patwa R, Kostoulias X, Trim M, Subedi D, Archer SK, Morris FC, Oliveira C, Kielty L, Korneev D, O'Bryan MK, Lithgow TJ, Peleg AY, Barr JJ. Gordillo Altamirano F, et al. Nat Microbiol. 2021 Feb;6(2):157-161. doi: 10.1038/s41564-020-00830-7. Epub 2021 Jan 11. Nat Microbiol. 2021. PMID: 33432151
We characterized two bacteriophages, phiFG02 and phiCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. ...The phage-resistant strains were resensitized to human complement, b …
We characterized two bacteriophages, phiFG02 and phiCO01, against clinical isolates of Acinetobacter baumannii and established that t …
Safety of bacteriophage therapy in severe Staphylococcus aureus infection.
Petrovic Fabijan A, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR; Westmead Bacteriophage Therapy Team. Petrovic Fabijan A, et al. Nat Microbiol. 2020 Mar;5(3):465-472. doi: 10.1038/s41564-019-0634-z. Epub 2020 Feb 17. Nat Microbiol. 2020. PMID: 32066959 Clinical Trial.
In this single-arm non-comparative trial, 13 patients in an Australian hospital with severe Staphylococcus aureus infections were intravenously administered a good manufacturing practice-quality preparation of three Myoviridae bacteriophages (AB-SA01) as adjunctive therapy …
In this single-arm non-comparative trial, 13 patients in an Australian hospital with severe Staphylococcus aureus infections were intravenou …
Anti-phage defence through inhibition of virion assembly.
Patel PH, Taylor VL, Zhang C, Getz LJ, Fitzpatrick AD, Davidson AR, Maxwell KL. Patel PH, et al. Nat Commun. 2024 Feb 22;15(1):1644. doi: 10.1038/s41467-024-45892-x. Nat Commun. 2024. PMID: 38388474 Free PMC article.
Tab allows the invading phage replication cycle to proceed, but blocks assembly of the phage tail, thus preventing formation of infectious virions. While the infected cell dies through the activity of the replicating phage lysis proteins, there is no r …
Tab allows the invading phage replication cycle to proceed, but blocks assembly of the phage tail, thus preventing formation o …
Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan.
Johansen J, Atarashi K, Arai Y, Hirose N, Sørensen SJ, Vatanen T, Knip M, Honda K, Xavier RJ, Rasmussen S, Plichta DR. Johansen J, et al. Nat Microbiol. 2023 Jun;8(6):1064-1078. doi: 10.1038/s41564-023-01370-6. Epub 2023 May 15. Nat Microbiol. 2023. PMID: 37188814
A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and ba …
A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that i …
Engineered phage with antibacterial CRISPR-Cas selectively reduce E. coli burden in mice.
Gencay YE, Jasinskytė D, Robert C, Semsey S, Martínez V, Petersen AØ, Brunner K, de Santiago Torio A, Salazar A, Turcu IC, Eriksen MK, Koval L, Takos A, Pascal R, Schou TS, Bayer L, Bryde T, Johansen KC, Bak EG, Smrekar F, Doyle TB, Satlin MJ, Gram A, Carvalho J, Jessen L, Hallström B, Hink J, Damholt B, Troy A, Grove M, Clube J, Grøndahl C, Haaber JK, van der Helm E, Zdravkovic M, Sommer MOA. Gencay YE, et al. Nat Biotechnol. 2024 Feb;42(2):265-274. doi: 10.1038/s41587-023-01759-y. Epub 2023 May 4. Nat Biotechnol. 2024. PMID: 37142704 Free PMC article.
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy against a diverse range of clinically relevant Escherichia coli, we screened a library of 162 wild-type (WT) phages, identifying eight p …
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy agains …
2,062 results