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Characterization of the Epidemiological Profile of Patients With Parkinson's Disease Who Were Hospitalized due to SARS-CoV-2 Infection: A Portrait of 4 Years of the Pandemic in Brazil.
Silva AEF, Costa PT, Mello LS, Marques LFA, Marson FAL. Silva AEF, et al. J Med Virol. 2025 Nov;97(11):e70670. doi: 10.1002/jmv.70670. J Med Virol. 2025. PMID: 41181863 Free PMC article.
Death was independently associated with advanced age, male sex, low vaccination coverage, and cardiovascular or chronic respiratory diseases. Age strongly predicted both Parkinson's diagnosis and mortality. Parkinson's patients had higher ICU admission rates …
Death was independently associated with advanced age, male sex, low vaccination coverage, and cardiovascular or chronic respiratory d …
Transcriptomic Analysis Reveals the Molecular Relationship Between Common Respiratory Infections and Parkinson's Disease.
Albeshri A, Bahieldin A, Ali HM. Albeshri A, et al. Curr Issues Mol Biol. 2025 Sep 7;47(9):727. doi: 10.3390/cimb47090727. Curr Issues Mol Biol. 2025. PMID: 41020849 Free PMC article.
Parkinson's disease (PD) is one of the most rapidly growing neurological disorders globally. ...Therefore, future studies should experimentally investigate the influence of age, vaccination status, infection type, and severity to clarify the role of RIs in PD's path …
Parkinson's disease (PD) is one of the most rapidly growing neurological disorders globally. ...Therefore, future studies should expe …
Long-term effects of influenza and Bacille Calmette-Guerin vaccination on systemic inflammation.
Debisarun PA, Röring RJ, Bulut Ö, Ten Doesschate T, van der Vaart TW, Kumar V, Lemmers H, Dijkstra H, Janssen AB, Veerman K, Ter Heine R, van Crevel R, Ten Oever J, Joosten LA, Bonten MJ, van Werkhoven CH, van de Wijgert JH, Netea MG. Debisarun PA, et al. Clin Transl Immunology. 2025 Sep 11;14(9):e70047. doi: 10.1002/cti2.70047. eCollection 2025. Clin Transl Immunology. 2025. PMID: 40949320 Free PMC article.
METHODS: Participants were randomised to BCG or placebo vaccination at the start of the Dutch SARS-CoV-2 epidemic in March/April 2020. They reported their influenza vaccination status for the most recent influenza season. ...RESULTS: Both BCG and quadr …
METHODS: Participants were randomised to BCG or placebo vaccination at the start of the Dutch SARS-CoV-2 epidemic in March/April 2020 …
Effectiveness, Usability, and Acceptability of ChatGPT With Retrieval-Augmented Generation (SIV-ChatGPT) in Increasing Seasonal Influenza Vaccination Uptake Among Older Adults: Quasi-Experimental Study.
Wang Z, Tsang TH, Yu FY, Fang Y, Chen S, Sun F, Mo PKH, Wong KC. Wang Z, et al. J Med Internet Res. 2025 Sep 8;27:e76849. doi: 10.2196/76849. J Med Internet Res. 2025. PMID: 40921067 Free PMC article.
BACKGROUND: Older adults are more vulnerable to severe consequences caused by seasonal influenza. Although seasonal influenza vaccination (SIV) is effective and free vaccines are available, the SIV uptake rate remained inadequate among people aged 65 years or …
BACKGROUND: Older adults are more vulnerable to severe consequences caused by seasonal influenza. Although seasonal influenza …
Geroscience: A Translational Review.
Kritchevsky SB, Cummings SR. Kritchevsky SB, et al. JAMA. 2025 Sep 23;334(12):1094-1102. doi: 10.1001/jama.2025.11289. JAMA. 2025. PMID: 40773213 Review.
IMPORTANCE: The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exponentially with age. ...A rapamycin analogue, everolimus, improved antibody titers to influenza vaccine in older adults. In hu …
IMPORTANCE: The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exp …
Effects of influenza vaccination on neurodegenerative and demyelinating disorders: a systematic review and meta-analysis.
Chen J, Zhou W, Cen M, Chen C, Cao K, Chen M, Qu R, Miao J, Qi J, Wu X, Zhang H, Feng Q, Dai A, Zhou J, Xu N, Hu X, Yang S. Chen J, et al. J Neurol. 2025 Jul 10;272(8):499. doi: 10.1007/s00415-025-13238-2. J Neurol. 2025. PMID: 40637899
BACKGROUND: Previous studies have highlighted potential associations between influenza vaccination (IV) and neurological outcomes, particularly neurodegenerative disorders (NDs) and demyelinating disorders (DDs). ...Elevated risks were primarily observed in e …
BACKGROUND: Previous studies have highlighted potential associations between influenza vaccination (IV) and neurological outco …
Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia.
Mutter P, Romem A. Mutter P, et al. Sci Rep. 2025 Jul 9;15(1):24702. doi: 10.1038/s41598-025-10633-7. Sci Rep. 2025. PMID: 40634642 Free PMC article.
This retrospective cohort study aimed to assess whether influenza vaccination reduces hospitalization rates and morbidity such as pneumonia incidence among older adults aged 80 years and above with severe dementia. ...There is a need for more tailored infl …
This retrospective cohort study aimed to assess whether influenza vaccination reduces hospitalization rates and morbidity such …
Influenza vaccination and risk of dementia: a systematic review and meta-analysis.
Yang WK, Shao SC, Liu CC, Chi CC. Yang WK, et al. Age Ageing. 2025 Jul 1;54(7):afaf169. doi: 10.1093/ageing/afaf169. Age Ageing. 2025. PMID: 40601364
BACKGROUND: The association between influenza vaccination and a reduction in dementia was unclear with inconsistent evidence. ...CONCLUSION: Influenza vaccination was associated with a decreasing risk of incident dementia in a dose-respon …
BACKGROUND: The association between influenza vaccination and a reduction in dementia was unclear with inconsistent evi …
Influenza vaccination in older people: a geriatrician's perspective.
Veronese N, Dominguez LJ, Ganci A, Speziale G, Mansueto P, Piro S, Basile G, Barbagallo M. Veronese N, et al. Aging Clin Exp Res. 2025 Jun 28;37(1):202. doi: 10.1007/s40520-025-03086-5. Aging Clin Exp Res. 2025. PMID: 40580272 Free PMC article. Review.
This review, informed by a geriatric conference in Enna, Sicily, examines the epidemiology of influenza in older populations, the impact of frailty on vaccination, and specific considerations for patients with dementia and diabetes. ...By addressing these gap …
This review, informed by a geriatric conference in Enna, Sicily, examines the epidemiology of influenza in older populations, the imp …
Influenza Vaccine Uptake and Associated Hospitalization Risk in Older Adults with or Without Dementia: Differences Between at Home-Living and Nursing Home Residents in Lombardy, Italy.
Blandi L, Signorelli C. Blandi L, et al. Vaccines (Basel). 2025 Apr 30;13(5):489. doi: 10.3390/vaccines13050489. Vaccines (Basel). 2025. PMID: 40432101 Free PMC article.
OBJECTIVE: Our population-based cohort study aims to compute the uptake of the influenza vaccine and the associated risk of hospitalization for respiratory diseases of infectious origin based on the residency setting and dementia status of people aged 65 or o …
OBJECTIVE: Our population-based cohort study aims to compute the uptake of the influenza vaccine and the associated risk of ho …
Battling Influenza in Elderly Patients: A Case of Severe Influenza A With Complications in a High-Risk Patient.
Ansari A, Taffaro A, McSween Z, Lu J, Huang A, Lazarescu R. Ansari A, et al. Cureus. 2025 Apr 15;17(4):e82303. doi: 10.7759/cureus.82303. eCollection 2025 Apr. Cureus. 2025. PMID: 40376338 Free PMC article.
This case report details an 80-year-old male with a history of hyperlipidemia, diabetes mellitus, and dementia who developed a severe influenza A infection complicated by sepsis and hypoxic respiratory failure. ...This case underscores the importance of early antivi …
This case report details an 80-year-old male with a history of hyperlipidemia, diabetes mellitus, and dementia who developed a severe …
Evidence on Protective Factors for Dementia and Cognitive Impairment in Older Adults: An Umbrella Review.
Sacchetti S, Locatelli G, Altomare D, Guaita A, Rolandi E. Sacchetti S, et al. Dement Geriatr Cogn Disord. 2025 Apr 3:1-15. doi: 10.1159/000545503. Online ahead of print. Dement Geriatr Cogn Disord. 2025. PMID: 40179847 Free article.
They showed that psychosocial factors (social engagement, purpose in life, life satisfaction, and cognitive reserve) and influenza vaccination protect against dementia. Evidence on antihypertensives is promising, while evidence on low-dose aspirin is promisin …
They showed that psychosocial factors (social engagement, purpose in life, life satisfaction, and cognitive reserve) and influenza …
The Effect of Influenza Vaccination on Hospitalization and Mortality Among People With Dementia.
Moses Appel A, Jensen-Dahm C, Munk Laursen T, Waldemar G, Janbek J. Moses Appel A, et al. J Am Geriatr Soc. 2025 May;73(5):1498-1505. doi: 10.1111/jgs.19392. Epub 2025 Mar 23. J Am Geriatr Soc. 2025. PMID: 40123175 Free PMC article.
The aim was to investigate the association between influenza vaccination and the rates of all-cause and influenza-related hospitalizations and deaths among older adults with dementia. ...Further exploration of the preventive potential of influenza …
The aim was to investigate the association between influenza vaccination and the rates of all-cause and influenza-relat …
Neurologic Complications of Influenza and Potential Protective Vaccine Effects.
Falsey AR. Falsey AR. Influenza Other Respir Viruses. 2025 Mar;19(3):e70071. doi: 10.1111/irv.70071. Influenza Other Respir Viruses. 2025. PMID: 40045906 Free PMC article. Review.
However, stroke and dementia are leading causes of death and disability worldwide, and there is increasing evidence linking these devasting illnesses with influenza. In addition, influenza vaccine has been associated with protective effects against str …
However, stroke and dementia are leading causes of death and disability worldwide, and there is increasing evidence linking these dev …
Dementia and influenza vaccination: Time trends and predictors of vaccine uptake among older adults.
Appel AM, Janbek J, Laursen TM, Gasse C, Waldemar G, Jensen-Dahm C. Appel AM, et al. Vaccine. 2025 Apr 2;51:126864. doi: 10.1016/j.vaccine.2025.126864. Epub 2025 Feb 16. Vaccine. 2025. PMID: 39961204 Free article.
The odds of vaccination in 2018/19 were lower for home-living people with dementia compared to home-living people without dementia (OR: 0.76; 95 % CI: 0.74-0.78). ...Home-living older adults with dementia were 24 % less likely to receive an influenz …
The odds of vaccination in 2018/19 were lower for home-living people with dementia compared to home-living people without d …
Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine.
Alfaro T, Froes F, Vicente C, Costa R, Gavina C, Baptista R, Maio A, da Cunha S, Neves JS, Leuschner P, Duque S, Pinto P. Alfaro T, et al. Pulmonology. 2025 Dec 31;31(1):2451456. doi: 10.1080/25310429.2025.2451456. Epub 2025 Jan 27. Pulmonology. 2025. PMID: 39869458 Free article. Review.
If it cannot be made available to this population, then the vaccine should be prioritised for individuals aged 75 years and those aged 50 years with risk factors. The vaccine should preferably be given between September and November and can be co-administered with t …
If it cannot be made available to this population, then the vaccine should be prioritised for individuals aged 75 years and those age …
Risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and COVID-19: A population-wide cohort in 2.6 million people in Wales.
Keene S, Abbasizanjani H, Torabi F, Knight R, Walker V, Raffetti E, Cezard G, Ip S, Sampri A, Bolton T, Denholm R, Khunti K, Akbari A, Quint J, Denaxas S, Sudlow C, Di Angelantonio E, Sterne JAC, Wood A, Whiteley WN; CVD-COVID-UK/COVID-IMPACT Consortium and the Longitudinal Health and Wellbeing COVID-19 National Core Study. Keene S, et al. Thromb Res. 2025 Jan;245:109213. doi: 10.1016/j.thromres.2024.109213. Epub 2024 Nov 19. Thromb Res. 2025. PMID: 39608301 Free article.
The corresponding aHRs after hospitalisation for pneumonia/influenza were: 5.42 (4.35-6.75), 3.87 (3.32-4.49), 1.96 (1.74-2.21), and 1.41 (1.30-1.53). ...The corresponding aHRs after hospitalisation for pneumonia/influenza were: 15.1 (10.3-22.0), 11.8 (9.23-15.1), 5 …
The corresponding aHRs after hospitalisation for pneumonia/influenza were: 5.42 (4.35-6.75), 3.87 (3.32-4.49), 1.96 (1.74-2.21), and …
Adeno-associated viral vectors deliver gene vaccines.
Wei L, Yu P, Wang H, Liu J. Wei L, et al. Eur J Med Chem. 2025 Jan 5;281:117010. doi: 10.1016/j.ejmech.2024.117010. Epub 2024 Oct 28. Eur J Med Chem. 2025. PMID: 39488197 Review.
We scrutinized AAVs, focusing on their virological properties, as well as bioengineering and chemical modifications to demonstrate their significant potential in gene vaccine delivery, and detailing the preparation of AAV particles. Additionally, we summarized the use of A …
We scrutinized AAVs, focusing on their virological properties, as well as bioengineering and chemical modifications to demonstrate their sig …
The efficacy of socially assistive robots in improving children's pain and negative affectivity during needle-based invasive treatment: A systematic review and meta-analysis.
Pan XY, Bi XY, Nong YN, Ye XC, Yan Y, Shang J, Zhou YM, Yao YZ. Pan XY, et al. BMC Pediatr. 2024 Oct 10;24(1):643. doi: 10.1186/s12887-024-05116-z. BMC Pediatr. 2024. PMID: 39390439 Free PMC article.
BACKGROUND: The ability of socially assistive robots (SARs) to treat dementia and Alzheimer's disease has been verified. Currently, to increase the range of their application, there is an increasing amount of interest in using SARs to relieve pain and negative emoti …
BACKGROUND: The ability of socially assistive robots (SARs) to treat dementia and Alzheimer's disease has been verified. Curre …
The effect of influenza vaccination on the rate of dementia amongst older adults.
Appel AM, Janbek J, Jensen-Dahm C, Laursen TM, Waldemar G. Appel AM, et al. Eur J Neurol. 2024 Dec;31(12):e16489. doi: 10.1111/ene.16489. Epub 2024 Oct 6. Eur J Neurol. 2024. PMID: 39370749 Free PMC article.
BACKGROUND AND PURPOSE: Previous studies have reported conflicting results regarding the association between influenza vaccination and dementia. This association was investigated in a nationwide register-based cohort study. ...DISCUSSION: Our results do not s …
BACKGROUND AND PURPOSE: Previous studies have reported conflicting results regarding the association between influenza vaccination …
Differential effects of social versus monetary incentives on inhibitory control under acute inflammation.
Alvarez GM, Jolink TA, West TN, Cardenas MN, Feldman MJ, Cohen JR, Muscatell KA. Alvarez GM, et al. Brain Behav Immun. 2025 Jan;123:950-964. doi: 10.1016/j.bbi.2024.09.010. Epub 2024 Sep 16. Brain Behav Immun. 2025. PMID: 39293694
While the impact of chronic, low-grade inflammation on cognitive functioning is documented in the context of neurodegenerative disease, less is known about the association between acute increases in inflammation and cognitive functioning in daily life. ...Using a within-pa …
While the impact of chronic, low-grade inflammation on cognitive functioning is documented in the context of neurodegenerative diseas …
The recombinant shingles vaccine is associated with lower risk of dementia.
Taquet M, Dercon Q, Todd JA, Harrison PJ. Taquet M, et al. Nat Med. 2024 Oct;30(10):2777-2781. doi: 10.1038/s41591-024-03201-5. Epub 2024 Jul 25. Nat Med. 2024. PMID: 39053634 Free PMC article.
We show that the recombinant vaccine is associated with a significantly lower risk of dementia in the 6 years post-vaccination. ...The recombinant shingles vaccine was also associated with lower risks of dementia than were two other vaccines com …
We show that the recombinant vaccine is associated with a significantly lower risk of dementia in the 6 years post-vaccinat …
Pneumococcal vaccination, but not influenza vaccination, is negatively associated with incident dementia among Japanese older adults: The JAGES 2013-2022 prospective cohort study.
Iwai-Saito K, Sato K, Fujii M, Kondo K. Iwai-Saito K, et al. Brain Behav Immun. 2024 Aug;120:452-463. doi: 10.1016/j.bbi.2024.06.020. Epub 2024 Jun 24. Brain Behav Immun. 2024. PMID: 38925416 Free article.
BACKGROUND: It is unclear whether inactivated influenza vaccination (IIV) or pneumococcal vaccination are associated with the risk of dementia; however, both types of vaccination are recommended for older adults. Studies have shown that the IIV …
BACKGROUND: It is unclear whether inactivated influenza vaccination (IIV) or pneumococcal vaccination are associated wi …
Prospective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases.
Zhao H, Zhou X, Fu K, Duan Y, Wen Q, Wang S, Zhan S. Zhao H, et al. NPJ Vaccines. 2024 Mar 2;9(1):51. doi: 10.1038/s41541-024-00841-z. NPJ Vaccines. 2024. PMID: 38431710 Free PMC article.
The effect of influenza vaccination (FluVac) on the risk of neurodegenerative diseases has not been well evaluated in prospective populations. ...However, Results of sensitivity analyses were consistent with the primary analyses. In conclusion, influenza …
The effect of influenza vaccination (FluVac) on the risk of neurodegenerative diseases has not been well evaluated in p …
Infection Control Policies and Practices in Residential Care Communities by Selected Organizational and Geographic Characteristics: United States, 2020.
Melekin A, Sengupta M. Melekin A, et al. Natl Health Stat Report. 2024 Feb;(200):1-8. Natl Health Stat Report. 2024. PMID: 38411549 Free article.
The largest differences were observed in the provision of annual influenza vaccination to residents and to all employees or contract staff by MSA status, bed size, and presence of a designated space for dementia care. A higher percentage of RCCs in non-MSAs ( …
The largest differences were observed in the provision of annual influenza vaccination to residents and to all employees or co …
COVID-19 and Influenza Vaccine Coadministration Among Older U.S. Adults.
Harris DA, Chachlani P, Hayes KN, McCarthy EP, Wen KJ, Deng Y, Zullo AR, Djibo DA, McMahill-Walraven CN, Smith-Ray RL, Gravenstein S, Mor V. Harris DA, et al. Am J Prev Med. 2024 Jul;67(1):67-78. doi: 10.1016/j.amepre.2024.02.013. Epub 2024 Feb 23. Am J Prev Med. 2024. PMID: 38401746 Free PMC article.
Investigations into COVID-19 and influenza vaccine coadministration are needed to describe compliance with newer recommendations and to identify potential gaps in the implementation of coadministration. ...This study included community-dwelling Medicare beneficiarie …
Investigations into COVID-19 and influenza vaccine coadministration are needed to describe compliance with newer recommendatio …
Vaccines and Dementia: Part II. Efficacy of BCG and Other Vaccines Against Dementia.
Greenblatt CL, Lathe R. Greenblatt CL, et al. J Alzheimers Dis. 2024;98(2):361-372. doi: 10.3233/JAD-231323. J Alzheimers Dis. 2024. PMID: 38393913 Free PMC article. Review.
There is growing awareness that infections may contribute to the development of senile dementia including Alzheimer's disease (AD), and that immunopotentiation is therefore a legitimate target in the management of diseases of the elderly including AD. ...We conclude …
There is growing awareness that infections may contribute to the development of senile dementia including Alzheimer's disease …
Pneumococcal Vaccination Lowers the Risk of Alzheimer's Disease: A Study Utilizing Data from the IBM MarketScan Database.
Huo X, Finkelstein J. Huo X, et al. Stud Health Technol Inform. 2024 Jan 25;310:961-965. doi: 10.3233/SHTI231107. Stud Health Technol Inform. 2024. PMID: 38269951
Previous studies demonstrated an association between influenza vaccination and the likelihood of developing Alzheimer's disease. This study was aimed at assessing whether pneumococcal vaccinations are associated with a lower risk of Alzheimer's disease …
Previous studies demonstrated an association between influenza vaccination and the likelihood of developing Alzheimer's …
Podcast: Influenza-Associated Complications and the Impact of Vaccination on Public Health.
Maggi S, Andrew MK, de Boer A. Maggi S, et al. Infect Dis Ther. 2024 Mar;13(3):413-420. doi: 10.1007/s40121-023-00885-z. Epub 2023 Nov 23. Infect Dis Ther. 2024. PMID: 37996695 Free PMC article.
Observational studies have identified beneficial effects of vaccination for cardioprotection as well as preventing dementia, but more evidence is required. In conclusion, influenza can cause a wide array of complications, which vaccination may help pre …
Observational studies have identified beneficial effects of vaccination for cardioprotection as well as preventing dementia, b …
Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge.
Cousins O, Schubert JJ, Chandra A, Veronese M, Valkimadi P, Creese B, Khan Z, Arathimos R, Hampshire A, Rosenzweig I, Ballard C, Corbett A, Aasland D, Velayudhan L, O'Neill M, Collier D, Awais R, Sander K, Årstad E, Howes O, Turkheimer F, Hodges A. Cousins O, et al. J Neuroinflammation. 2023 Nov 21;20(1):272. doi: 10.1186/s12974-023-02945-0. J Neuroinflammation. 2023. PMID: 37990275 Free PMC article.
BACKGROUND: Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer's disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer's disease. ...There were trends to suggest reduced microglia …
BACKGROUND: Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer's disease. The rs7593262 …
Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.
Ukraintseva S, Duan M, Simanek AM, Holmes R, Bagley O, Rajendrakumar AL, Yashkin AP, Akushevich I, Tropsha A, Whitson H, Yashin A, Arbeev K. Ukraintseva S, et al. J Alzheimers Dis. 2023;96(2):499-505. doi: 10.3233/JAD-230088. J Alzheimers Dis. 2023. PMID: 37807778 Free PMC article.
Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). ...Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of …
Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). ...Pneumoc …
The association of herpes zoster and influenza vaccinations with the risk of developing dementia: a population-based cohort study within the UK Clinical Practice Research Datalink.
Lophatananon A, Carr M, Mcmillan B, Dobson C, Itzhaki R, Parisi R, Ashcroft DM, Muir KR. Lophatananon A, et al. BMC Public Health. 2023 Oct 2;23(1):1903. doi: 10.1186/s12889-023-16768-4. BMC Public Health. 2023. PMID: 37784088 Free PMC article.
Influenza vaccination also was associated with a slightly reduced hazard of dementia risk (adjusted HR 0.96 with 95% CI: 0.94-0.97). CONCLUSION: Both zoster vaccine for prevention of shingles / herpes zoster and influenza vaccine to preve …
Influenza vaccination also was associated with a slightly reduced hazard of dementia risk (adjusted HR 0.96 with 95% CI …
Pleiotropic Effects of Influenza Vaccination.
Hjelholt AJ, Bergh C, Bhatt DL, Fröbert O, Kjolby MF. Hjelholt AJ, et al. Vaccines (Basel). 2023 Aug 25;11(9):1419. doi: 10.3390/vaccines11091419. Vaccines (Basel). 2023. PMID: 37766096 Free PMC article. Review.
The evolving nature of the influenza virus makes vaccination an important and efficacious strategy to reduce healthcare-related complications of influenza. ...In this review, we will discuss the possible nonspecific effects of influenza vaccination …
The evolving nature of the influenza virus makes vaccination an important and efficacious strategy to reduce healthcare-relate …
Acute cholangitis following mRNA COVID-19 vaccine booster in a patient receiving an anti-amyloid antibody for Alzheimer's disease: A case report.
Restifo LL, Erickson RP. Restifo LL, et al. SAGE Open Med Case Rep. 2023 Aug 30;11:2050313X231194507. doi: 10.1177/2050313X231194507. eCollection 2023. SAGE Open Med Case Rep. 2023. PMID: 37654545 Free PMC article.
A 77-year-old woman had 2 weeks of fever and flu-like symptoms starting several hours after receiving an mRNA booster for SARS-CoV-2 and the influenza vaccine, in separate shots. ...Medical history included APOE-epsilon4 carrier genotype, mild Alzheimer …
A 77-year-old woman had 2 weeks of fever and flu-like symptoms starting several hours after receiving an mRNA booster for SARS-CoV-2 …
Assessing the representativeness of cluster randomized trials: Evidence from two large pragmatic trials in United States nursing homes.
Joyce NR, Robertson SE, McCreedy E, Ogarek J, Davidson EH, Mor V, Gravenstein S, Dahabreh IJ. Joyce NR, et al. Clin Trials. 2023 Dec;20(6):613-623. doi: 10.1177/17407745231185055. Epub 2023 Jul 26. Clin Trials. 2023. PMID: 37493171 Free PMC article.
METHODS: We linked data from the high-dose influenza vaccine trial and the Music & Memory Pragmatic TRIal for Nursing Home Residents with ALzheimer's Disease (METRICaL) to nursing home assessments and Medicare fee-for-service claims. ...
METHODS: We linked data from the high-dose influenza vaccine trial and the Music & Memory Pragmatic TRIal for Nursing Home …
Vaccine uptake in caregivers family members and patients with dementia and relationship with severity of dementia and caregiver burden: a cross-sectional study.
Lucijanic J, Hanzevacki M, Bazdaric K, Jurin I, Lucijanic M. Lucijanic J, et al. Aging Clin Exp Res. 2023 Jul;35(7):1565-1569. doi: 10.1007/s40520-023-02443-6. Epub 2023 May 25. Aging Clin Exp Res. 2023. PMID: 37227580 Free PMC article.
We cross sectionally evaluated COVID-19 and seasonal flu vaccination rates among 94 dyads consisting of informal caregiver family member and non-institutionalized patient with dementia observed in family-medicine practice in Zagreb, Croatia. ...Caregiver and …
We cross sectionally evaluated COVID-19 and seasonal flu vaccination rates among 94 dyads consisting of informal caregiver fam …
Dementia, infections and vaccines: 30 years of controversy.
Ecarnot F, Boccardi V, Calcagno A, Franceschi C, Fülop T, Itzhaki RF, Michel JP, Panza F, Rainero I, Solfrizzi V, Ticinesi A, Veronese N, Maggi S. Ecarnot F, et al. Aging Clin Exp Res. 2023 Jun;35(6):1145-1160. doi: 10.1007/s40520-023-02409-8. Epub 2023 May 9. Aging Clin Exp Res. 2023. PMID: 37160649 Free PMC article. Review.
This paper reports the proceedings of a virtual meeting convened by the European Interdisciplinary Council on Ageing (EICA), to discuss the involvement of infectious disorders in the pathogenesis of dementia and neurological disorders leading to dementia. We recap h …
This paper reports the proceedings of a virtual meeting convened by the European Interdisciplinary Council on Ageing (EICA), to discuss the …
Association of Influenza Vaccination and Dementia Risk: A Meta-Analysis of Cohort Studies.
Sun H, Liu M, Liu J. Sun H, et al. J Alzheimers Dis. 2023;92(2):667-678. doi: 10.3233/JAD-221036. J Alzheimers Dis. 2023. PMID: 36744343
BACKGROUND: Dementia is a critical global public health problem. Previous cohort studies have found that influenza vaccination can decrease the risk of dementia. ...Pooled analysis of adjusted RRs found that influenza vaccination could re …
BACKGROUND: Dementia is a critical global public health problem. Previous cohort studies have found that influenza vaccinat …
Virus exposure and neurodegenerative disease risk across national biobanks.
Levine KS, Leonard HL, Blauwendraat C, Iwaki H, Johnson N, Bandres-Ciga S, Ferrucci L, Faghri F, Singleton AB, Nalls MA. Levine KS, et al. Neuron. 2023 Apr 5;111(7):1086-1093.e2. doi: 10.1016/j.neuron.2022.12.029. Epub 2023 Jan 19. Neuron. 2023. PMID: 36669485 Free PMC article.
The largest effect association was between viral encephalitis exposure and Alzheimer's disease. Influenza with pneumonia was significantly associated with five of the six neurodegenerative diseases studied. ...As vaccines are currently available for some of t …
The largest effect association was between viral encephalitis exposure and Alzheimer's disease. Influenza with pneumonia was s …
Unaltered T cell responses to common antigens in individuals with Parkinson's disease.
Williams GP, Muskat K, Frazier A, Xu Y, Mateus J, Grifoni A, da Silva Antunes R, Weiskopf D, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Sulzer D, Lindestam Arlehamn CS, Sette A. Williams GP, et al. J Neurol Sci. 2023 Jan 15;444:120510. doi: 10.1016/j.jns.2022.120510. Epub 2022 Nov 25. J Neurol Sci. 2023. PMID: 36495691 Free PMC article.
BACKGROUND AND OBJECTIVES: Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. ...These antigens encompassed both viral (coronavirus, rhinovirus, respiratory syncytial virus, influenza, cytomegalovirus) and bacte …
BACKGROUND AND OBJECTIVES: Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. …
Associations of influenza and pneumococcal vaccinations with burdens of older family caregivers: The Japan Gerontological Evaluation study (JAGES) cross-sectional study.
Iwai-Saito K, Sato K, Kondo K. Iwai-Saito K, et al. Vaccine. 2023 Jan 9;41(2):444-451. doi: 10.1016/j.vaccine.2022.11.047. Epub 2022 Dec 2. Vaccine. 2023. PMID: 36470685 Free article.
BACKGROUND: Influenza and pneumonia tend to be severe in older adults; thus, vaccination is necessary to prevent these illnesses. ...CONCLUSION: Our results suggest that the caregiving burden is a barrier to influenza vaccination but not to pneumococca …
BACKGROUND: Influenza and pneumonia tend to be severe in older adults; thus, vaccination is necessary to prevent these illness …
Antiviral Potential of Plants against COVID-19 during Outbreaks-An Update.
Jamal QMS. Jamal QMS. Int J Mol Sci. 2022 Nov 5;23(21):13564. doi: 10.3390/ijms232113564. Int J Mol Sci. 2022. PMID: 36362351 Free PMC article. Review.
Several human diseases are caused by viruses, including cancer, Type I diabetes, Alzheimer's disease, and hepatocellular carcinoma. In the past, people have suffered greatly from viral diseases such as polio, mumps, measles, dengue fever, SARS, MERS, AIDS, chikungunya feve …
Several human diseases are caused by viruses, including cancer, Type I diabetes, Alzheimer's disease, and hepatocellular carcinoma. I …
COVID-19 vaccine acceptance and hesitancy in patients with Parkinson's disease.
Zhou Y, Lin Z, Wan X, Liu J, Ding J, Zhang C, Ren K, Li D, Wu Y. Zhou Y, et al. Front Public Health. 2022 Oct 11;10:977940. doi: 10.3389/fpubh.2022.977940. eCollection 2022. Front Public Health. 2022. PMID: 36304248 Free PMC article.
BACKGROUND: As coronavirus disease 2019 (COVID-19) vaccination campaign underway, little is known about the vaccination coverage and the underlying barriers of the vaccination campaign in patients with Parkinson's disease (PD). ...COVID-19 vaccine …
BACKGROUND: As coronavirus disease 2019 (COVID-19) vaccination campaign underway, little is known about the vaccination covera …
Vaccination Reduces Risk of Alzheimer's Disease, Parkinson's Disease and Other Neurodegenerative Disorders.
Lehrer S, Rheinstein PH. Lehrer S, et al. Discov Med. 2022 Sep-Oct;34(172):97-101. Discov Med. 2022. PMID: 36281030 Free PMC article.
Neurodegeneration is an increasing problem of aging. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most frequent forms of age-related neurodegeneration. ...Unanswered question: Are the AD-risk-reducing effects of flu, pneumonia, and shingles v …
Neurodegeneration is an increasing problem of aging. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the most freque …
Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia.
Münch M, Goldbach R, Zumstein N, Vonmoos P, Scartezzini JL, Wirz-Justice A, Cajochen C. Münch M, et al. Brain Behav Immun Health. 2022 Sep 20;26:100515. doi: 10.1016/j.bbih.2022.100515. eCollection 2022 Dec. Brain Behav Immun Health. 2022. PMID: 36193044 Free PMC article.
Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual influenza …
Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. H …
[Progress in research of influenza vaccine and 23 valent pneumococcal polysaccharide vaccine immunization in patients with chronic obstructive pulmonary disease].
Sui HT, Guo Y, Yang ZN, Su JF, Shu X, Zhang Y, Wang HQ, Yang X. Sui HT, et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Sep 10;43(9):1508-1512. doi: 10.3760/cma.j.cn112338-20220328-00236. Zhonghua Liu Xing Bing Xue Za Zhi. 2022. PMID: 36117362 Review. Chinese.
A comprehensive review of the research of the effectiveness of influenza vaccine and 23 valent pneumococcal polysaccharide vaccine (PPV23) in patients with chronic obstructive pulmonary disease (COPD) both at home and abroad in recent years showed that inf …
A comprehensive review of the research of the effectiveness of influenza vaccine and 23 valent pneumococcal polysaccharide …
Influenza vaccination and dementia risk; an unanticipated benefit?
Ali E, Shaikh A. Ali E, et al. Ann Med Surg (Lond). 2022 Jul 19;80:104187. doi: 10.1016/j.amsu.2022.104187. eCollection 2022 Aug. Ann Med Surg (Lond). 2022. PMID: 36045777 Free PMC article.
Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, often associated with functional dependence and financial instability before progressing to complete degeneration of neural and motor skills …
Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, …
Assessing the impact of coronavirus disease 2019 on mortality: a population-based, matched case-control study.
Turjeman A, Wirtheim E, Poran I, Leibovici L. Turjeman A, et al. Clin Microbiol Infect. 2023 Jan;29(1):111.e1-111.e4. doi: 10.1016/j.cmi.2022.08.016. Epub 2022 Aug 27. Clin Microbiol Infect. 2023. PMID: 36031054 Free PMC article.
A multi-variate logistic analysis showed that COVID-19 (OR, 2.01; 95% CI, 1.07-3.77), low socio-economic status (OR, 1.36; 95% CI, 1.02-1.82), dementia (OR, 2.50; 95% CI, 2.10-3.01), smoking (OR, 1.35; 95% CI, 1.13-1.63) and an interaction variable of age >80 years and …
A multi-variate logistic analysis showed that COVID-19 (OR, 2.01; 95% CI, 1.07-3.77), low socio-economic status (OR, 1.36; 95% CI, 1.02-1.82 …
Risk of Alzheimer's Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching.
Bukhbinder AS, Ling Y, Hasan O, Jiang X, Kim Y, Phelps KN, Schmandt RE, Amran A, Coburn R, Ramesh S, Xiao Q, Schulz PE. Bukhbinder AS, et al. J Alzheimers Dis. 2022;88(3):1061-1074. doi: 10.3233/JAD-220361. J Alzheimers Dis. 2022. PMID: 35723106 Free PMC article.
BACKGROUND: Prior studies have found a reduced risk of dementia of any etiology following influenza vaccination in selected populations, including veterans and patients with serious chronic health conditions. However, the effect of influenza vaccina …
BACKGROUND: Prior studies have found a reduced risk of dementia of any etiology following influenza vaccination in sele …
COVID-19 mortality and its predictors in the elderly: A systematic review.
Dadras O, SeyedAlinaghi S, Karimi A, Shamsabadi A, Qaderi K, Ramezani M, Mirghaderi SP, Mahdiabadi S, Vahedi F, Saeidi S, Shojaei A, Mehrtak M, Azar SA, Mehraeen E, Voltarelli FA. Dadras O, et al. Health Sci Rep. 2022 May 23;5(3):e657. doi: 10.1002/hsr2.657. eCollection 2022 May. Health Sci Rep. 2022. Retraction in: Health Sci Rep. 2023 Jul 25;6(7):e1455. doi: 10.1002/hsr2.1455. PMID: 35620541 Free PMC article. Retracted. Review.
A review of articles revealed that increasing age, body mass index, a male gender, dementia, impairment or dependency in daily activities, presence of consolidations on chest X-ray, hypoxemic respiratory failure, and lower oxygen saturation at admission were risk factors f …
A review of articles revealed that increasing age, body mass index, a male gender, dementia, impairment or dependency in daily activi …
Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies.
Wu X, Yang H, He S, Xia T, Chen D, Zhou Y, Liu J, Liu M, Sun Z. Wu X, et al. Front Immunol. 2022 May 3;13:872542. doi: 10.3389/fimmu.2022.872542. eCollection 2022. Front Immunol. 2022. PMID: 35592323 Free PMC article.
All types of vaccination were associated with a trend toward reduced dementia risk, with rabies (HR=0.43), tetanus & diphtheria & pertussis (Tdap) (HR=0.69), herpes zoster (HR=0.69), influenza (HR=0.74), hepatitis A (HR=0.78), typhoid (HR=0.80), and h …
All types of vaccination were associated with a trend toward reduced dementia risk, with rabies (HR=0.43), tetanus & dipht …
COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism.
Smeyne RJ, Eells JB, Chatterjee D, Byrne M, Akula SM, Sriramula S, O'Rourke DP, Schmidt P. Smeyne RJ, et al. Mov Disord. 2022 Jul;37(7):1394-1404. doi: 10.1002/mds.29116. Epub 2022 Jun 9. Mov Disord. 2022. PMID: 35579496 Free PMC article.
BACKGROUND: Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses after seve …
BACKGROUND: Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnose …
Trends in Excess Winter Mortality (EWM) from 1900/01 to 2019/20-Evidence for a Complex System of Multiple Long-Term Trends.
Jones RP, Ponomarenko A. Jones RP, et al. Int J Environ Res Public Health. 2022 Mar 14;19(6):3407. doi: 10.3390/ijerph19063407. Int J Environ Res Public Health. 2022. PMID: 35329098 Free PMC article.
EWM has a good correlation with the number of estimated influenza deaths, but in this context influenza pandemics after the Spanish flu only had an EWM equivalent to that for seasonal influenza. ...Using data from 1980 onward the effect of influenza …
EWM has a good correlation with the number of estimated influenza deaths, but in this context influenza pandemics after the Sp …
Bullous pemphigoid after second dose of mRNA- (Pfizer-BioNTech) Covid-19 vaccine: A case report.
Alshammari F, Abuzied Y, Korairi A, Alajlan M, Alzomia M, AlSheef M. Alshammari F, et al. Ann Med Surg (Lond). 2022 Mar;75:103420. doi: 10.1016/j.amsu.2022.103420. Epub 2022 Mar 1. Ann Med Surg (Lond). 2022. PMID: 35251600 Free PMC article.
One case report reported a 78-year-old lady with diabetes and Alzheimer's disease who developed tense bullae on her face and torso after getting the second dosage of the Pfizer-BioNTech COVID-19 Vaccine. ...CONCLUSION: Although uncommon, several dermatological side …
One case report reported a 78-year-old lady with diabetes and Alzheimer's disease who developed tense bullae on her face and torso af …
Comparison of Complications after Coronavirus Disease and Seasonal Influenza, South Korea.
Lee H, Sung HK, Lee D, Choi Y, Lee JY, Lee JY, Oh MD. Lee H, et al. Emerg Infect Dis. 2022 Feb;28(2):347-353. doi: 10.3201/eid2802.211848. Emerg Infect Dis. 2022. PMID: 35076368 Free PMC article.
In most complications, COVID-19 patients had lower or similar relative risk compared with influenza patients; exceptions were hair loss, heart failure, mood disorder, and dementia. ...Overall, COVID-19 patients had fewer complications than influenza patients, …
In most complications, COVID-19 patients had lower or similar relative risk compared with influenza patients; exceptions were hair lo …
Influenza vaccination reduces dementia risk: A systematic review and meta-analysis.
Veronese N, Demurtas J, Smith L, Michel JP, Barbagallo M, Bolzetta F, Noale M, Maggi S. Veronese N, et al. Ageing Res Rev. 2022 Jan;73:101534. doi: 10.1016/j.arr.2021.101534. Epub 2021 Nov 30. Ageing Res Rev. 2022. PMID: 34861456
Animal models have indicated that influenza vaccination may prevent or delay the onset of dementia. However, the epidemiological evidence in human beings is still limited. ...Over a mean follow-up of 9 years, influenza vaccination mitigated the …
Animal models have indicated that influenza vaccination may prevent or delay the onset of dementia. However, the epidem …
Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer's Disease and Related Dementias.
Rivera-Hernandez M, Kumar A, Roy I, Fashaw-Walters S, Baldwin JA. Rivera-Hernandez M, et al. J Aging Health. 2022 Mar;34(2):283-296. doi: 10.1177/08982643211043319. Epub 2021 Oct 11. J Aging Health. 2022. PMID: 34634973 Free PMC article.
The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) received an antipsychotic medication; 3) experienced one/more falls with major injury; 4) were physically restrained; and 5) lost too much w …
The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) …
Dementia risk following influenza vaccination in a large veteran cohort.
Wiemken TL, Salas J, Hoft DF, Jacobs C, Morley JE, Scherrer JF. Wiemken TL, et al. Vaccine. 2021 Sep 15;39(39):5524-5531. doi: 10.1016/j.vaccine.2021.08.046. Epub 2021 Aug 20. Vaccine. 2021. PMID: 34420785
Competing risk models estimated the risk of dementia in those with influenza vaccination (n = 66,822) compared to those without vaccination (n = 56,925). ...After controlling for confounding, patients with influenza vaccination were signi …
Competing risk models estimated the risk of dementia in those with influenza vaccination (n = 66,822) compared to those …
Willingness to receive COVID-19 vaccination among adults with chronic diseases in the Kingdom of Saudi Arabia.
Al-Hanawi MK, Ahmad K, Haque R, Keramat SA. Al-Hanawi MK, et al. J Infect Public Health. 2021 Oct;14(10):1489-1496. doi: 10.1016/j.jiph.2021.08.002. Epub 2021 Aug 13. J Infect Public Health. 2021. PMID: 34417135 Free article.
Nevertheless, many people are hesitant to receive the COVID-19 vaccine due to fear of its side effects. The aim of this study was to identify the risk and protective factors of accepting COVID-19 vaccination among Saudi Arabian people with chronic diseases. ...RESUL …
Nevertheless, many people are hesitant to receive the COVID-19 vaccine due to fear of its side effects. The aim of this study was to …
Examining the barriers of influenza vaccine hesitancy in persons with dementia: a literature review.
Ashtarieh B, Grabkowski M, Bartfay E, Sun W. Ashtarieh B, et al. Aging Clin Exp Res. 2022 Feb;34(2):309-324. doi: 10.1007/s40520-021-01936-6. Epub 2021 Jul 28. Aging Clin Exp Res. 2022. PMID: 34319511 Free PMC article. Review.
Persons with dementia (PWD) face a serious threat to influenza on an annual basis, and vaccine hesitancy may further potentiate this risk. The purpose of this paper is to explore and understand the barriers PWD face in receiving the influenza vaccin …
Persons with dementia (PWD) face a serious threat to influenza on an annual basis, and vaccine hesitancy may further po …
Specific Treatment Exists for SARS-CoV-2 ARDS.
Kanwar B, Lee CJ, Lee JH. Kanwar B, et al. Vaccines (Basel). 2021 Jun 10;9(6):635. doi: 10.3390/vaccines9060635. Vaccines (Basel). 2021. PMID: 34200720 Free PMC article.
A pandemic of such a scale has not been seen since the 1918 influenza pandemic. Although the predominant clinical presentation is respiratory disease, neurological manifestations and sequelae are increasingly being recognized. ...The Sorokdo National Hospital reported a re …
A pandemic of such a scale has not been seen since the 1918 influenza pandemic. Although the predominant clinical presentation is res …
Could amantadine interfere with COVID-19 vaccines based on the LNP-mRNA platform?
Fedorowski JJ. Fedorowski JJ. Arch Med Sci. 2021 Mar 28;17(3):827-828. doi: 10.5114/aoms/134716. eCollection 2021. Arch Med Sci. 2021. PMID: 34025855 Free PMC article.
INTRODUCTION: Amantadine is a well-known medication with indications in neurology and infectious diseases. It is currently FDA approved for Parkinson's disease, drug-induced extrapyramidal symptoms, and influenza. METHODS: The article is the author's original resear …
INTRODUCTION: Amantadine is a well-known medication with indications in neurology and infectious diseases. It is currently FDA approved for …
Barriers to Vaccination Among People with Parkinson's Disease and Implications for COVID-19.
Phanhdone T, Drummond P, Meisel T, Friede N, Di Rocco A, Chodosh J, Fleisher J. Phanhdone T, et al. J Parkinsons Dis. 2021;11(3):1057-1065. doi: 10.3233/JPD-202497. J Parkinsons Dis. 2021. PMID: 33935103 Free PMC article.
BACKGROUND: Patients with Parkinson's disease (PD) are at higher risk of vaccine-preventable respiratory infections. ...In light of COVID-19, understanding barriers to vaccination in PD may inform strategies to increase vaccine uptake. OBJECTIVE: To id …
BACKGROUND: Patients with Parkinson's disease (PD) are at higher risk of vaccine-preventable respiratory infections. ...In lig …
Primary care physician volume and quality of care for older adults with dementia: a retrospective cohort study.
Lane NE, Ling V, Glazier RH, Stukel TA. Lane NE, et al. BMC Fam Pract. 2021 Mar 9;22(1):51. doi: 10.1186/s12875-021-01398-9. BMC Fam Pract. 2021. PMID: 33750310 Free PMC article.
Our objective was to determine whether people with dementia receive lower-quality care if their primary care physician sees many patients daily. ...Patients were 3% (95% CI: 0.4% to 6%, p = 0.02) less likely to receive influenza vaccination and 8% (95% CI: 4% …
Our objective was to determine whether people with dementia receive lower-quality care if their primary care physician sees many pati …
Exploring the Effect of Probiotics, Prebiotics, and Postbiotics in Strengthening Immune Activity in the Elderly.
Akatsu H. Akatsu H. Vaccines (Basel). 2021 Feb 8;9(2):136. doi: 10.3390/vaccines9020136. Vaccines (Basel). 2021. PMID: 33567790 Free PMC article. Review.
Vaccination is the easiest way to stimulate the immune system to confer protection from disease. However, the inefficacy of vaccination in the elderly, especially those under nutritional control such as individuals receiving artificial nutrition after cerebral infar …
Vaccination is the easiest way to stimulate the immune system to confer protection from disease. However, the inefficacy of vaccin …
Completion of the two-dose recombinant zoster vaccine series in adults 50 years and older.
Ackerson B, Qian L, Sy LS, Bruxvoort K, Wu J, Luo Y, Diaz-Decaro J, Talarico C, Tseng HF. Ackerson B, et al. Vaccine. 2021 Feb 5;39(6):926-932. doi: 10.1016/j.vaccine.2020.12.076. Epub 2021 Jan 11. Vaccine. 2021. PMID: 33441234
Characteristics including age, sex, race/ethnicity, Medicaid status, neighborhood level income and education, comorbidities, history of zoster, health care utilization before and after the first dose, receipt of influenza vaccine, vaccination month (supply sh …
Characteristics including age, sex, race/ethnicity, Medicaid status, neighborhood level income and education, comorbidities, history of zost …
Immunogenicity of The Influenza Vaccine in Multiple Sclerosis Patients: A Systematic Review and Meta-Analysis.
Nguyen J, Hardigan P, Kesselman MM, Demory Beckler M. Nguyen J, et al. Mult Scler Relat Disord. 2021 Feb;48:102698. doi: 10.1016/j.msard.2020.102698. Epub 2020 Dec 15. Mult Scler Relat Disord. 2021. PMID: 33385826
RESULTS: Across the various strains incorporated into the influenza vaccine analyzed in this paper, there was no statistical difference in immune response mounted against the influenza vaccine between healthy controls and multiple sclerosis patients. . …
RESULTS: Across the various strains incorporated into the influenza vaccine analyzed in this paper, there was no statistical d …
Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study.
Lee CY, Chang CC, Lin CS, Yeh CC, Hu CJ, Wu CZ, Chen TL, Liao CC. Lee CY, et al. J Clin Periodontol. 2020 Dec;47(12):1428-1436. doi: 10.1111/jcpe.13372. Epub 2020 Nov 11. J Clin Periodontol. 2020. PMID: 32991015
Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71-0.87), metformin (HR: 0.53, 95% CI: 0.44-0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61-0.74) were associated with a reduced risk of dementia, while diabetes, mental disor …
Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71-0.87), metformin (HR: 0.53, 95% CI: 0.44-0.62), and influen …
Physical health monitoring in dementia and associations with ethnicity: a descriptive study using electronic health records.
Bhanu C, Jones ME, Walters K, Petersen I, Manthorpe J, Raine R, Mukadam N, Cooper C. Bhanu C, et al. BJGP Open. 2020 Oct 27;4(4):bjgpopen20X101080. doi: 10.3399/bjgpopen20X101080. Print 2020 Oct. BJGP Open. 2020. PMID: 32967843 Free PMC article.
Using the Dementia : Good Care Planning framework and expert consensus, good care was defined as receiving, within 1 year: a dementia review; a blood pressure (BP) check (at least one); a GP consultation (at least one); a weight and/or body mass index (BMI) recordin …
Using the Dementia : Good Care Planning framework and expert consensus, good care was defined as receiving, within 1 year: a demen …
Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-beta accumulation and improves cognition in APP/PS1 mice.
Xing Z, Zuo Z, Hu D, Zheng X, Wang X, Yuan L, Zhou L, Qi F, Yao Z. Xing Z, et al. Brain Behav Immun. 2021 Jan;91:128-141. doi: 10.1016/j.bbi.2020.09.015. Epub 2020 Sep 19. Brain Behav Immun. 2021. PMID: 32956831
Similarly, independent studies have shown that boosting systemic immune system, by blocking PD-1 checkpoint pathway, modifies AD. Here we hypothesized that influenza vaccine would potentiate function of moderate dose anti-PD-1 and therefore combining them might allo …
Similarly, independent studies have shown that boosting systemic immune system, by blocking PD-1 checkpoint pathway, modifies AD. Here we hy …
Factors associated with influenza-like illness in care homes in Cheshire and Merseyside during the 2017-2018 influenza season.
Halloran NF, Harries AD, Ghebrehewet S, Cleary P. Halloran NF, et al. Public Health. 2020 Oct;187:89-96. doi: 10.1016/j.puhe.2020.07.005. Epub 2020 Sep 13. Public Health. 2020. PMID: 32937214
OBJECTIVES: The aim of the study was to identify care home characteristics associated with reported care home influenza outbreaks and factors associated with increased transmission of influenza-like illness (ILI) in care homes in Cheshire and Merseyside during the 2 …
OBJECTIVES: The aim of the study was to identify care home characteristics associated with reported care home influenza outbreaks and …
Evaluating the care provision of a community-based serious-illness care program via chart measures.
Kistler CE, Van Dongen MJ, Ernecoff NC, Daaleman TP, Hanson LC. Kistler CE, et al. BMC Geriatr. 2020 Sep 15;20(1):351. doi: 10.1186/s12877-020-01736-z. BMC Geriatr. 2020. PMID: 32933473 Free PMC article.
Patients were multi-morbid (53% 3 comorbidities), functionally impaired (45% had impairment in 2 activities of daily living) and 32% had dementia. During the study period, 31% of patients died. Chart review found high rates assessment of functional status (97%), falls (98% …
Patients were multi-morbid (53% 3 comorbidities), functionally impaired (45% had impairment in 2 activities of daily living) and 32% had …
The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network.
Caratozzolo S, Zucchelli A, Turla M, Cotelli MS, Fascendini S, Zanni M, Bianchetti A, Psy MP, Rozzini R, Boffelli S, Cappuccio M, Psy FG, Psy CV, Bellandi D, Caminati C, Gentile S, Psy EL, Di Fazio I, Psy MZ, Vezzadini G, Psy CF, Psy MC, Psy RT, Psy SP, Scalvini A, Di Cesare M, Psy MG, Falanga L, Medici N, Palamini N, Psy EZ, Psy EG, Bellelli G, Marengoni A, Trabucchi M, Padovani A; COVIDEM Network. Caratozzolo S, et al. Aging Clin Exp Res. 2020 Oct;32(10):2133-2140. doi: 10.1007/s40520-020-01676-z. Epub 2020 Sep 12. Aging Clin Exp Res. 2020. PMID: 32918696 Free PMC article.
Age, sex, education, clinical characteristics (including diagnosis of dementia) and flu vaccination history were obtained from previous medical records. Items regarding change in health status and outcome since the onset of the outbreak were collected. ...Non …
Age, sex, education, clinical characteristics (including diagnosis of dementia) and flu vaccination history were obtain …
Impact of Influenza Vaccination on Mortality in the Oldest Old: A Propensity Score-Matched Cohort Study.
Walzer P, Estève C, Barben J, Menu D, Cuenot C, Manckoundia P, Putot A. Walzer P, et al. Vaccines (Basel). 2020 Jul 3;8(3):356. doi: 10.3390/vaccines8030356. Vaccines (Basel). 2020. PMID: 32635210 Free PMC article.
Influenza remains a major cause of illness and death in geriatric populations. While the influenza vaccine has successfully reduced morbidity and mortality, its effectiveness is suspected to decrease with age. ...In conclusion, nearly a half of this ambulator …
Influenza remains a major cause of illness and death in geriatric populations. While the influenza vaccine has successf …
Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a.
Baudier RL, Zwezdaryk KJ, Czarny-Ratajczak M, Kodroff LH, Sullivan DE, Norton EB. Baudier RL, et al. J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2326-2332. doi: 10.1093/gerona/glaa165. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32609344 Free PMC article.
Aging is associated with a decline in immune function that is not fully understood including vaccine failure. Here we report transcriptomic analysis on B cells from naive or influenza-vaccinated mice of 3 ages: young (15-23 weeks), middle-aged (63-81 weeks), and old …
Aging is associated with a decline in immune function that is not fully understood including vaccine failure. Here we report transcri …
Effectiveness of Oseltamivir Prophylaxis in Influenza Outbreaks in Residential Aged Care.
Dronavalli M, Lord H, Alexander K, Boonwaat L, Pal N, Fletcher-Lartey SM. Dronavalli M, et al. J Epidemiol Glob Health. 2020 Jun;10(2):184-189. doi: 10.2991/jegh.k.200402.001. J Epidemiol Glob Health. 2020. PMID: 32538036 Free PMC article.
Influenza can spread rapidly through ACFs if precautionary measures are not taken. Along with influenza vaccination and precautionary hygiene measures, Oseltamivir Prophylaxis (OP) may be effective in reducing the attack rate of influenza by preventing …
Influenza can spread rapidly through ACFs if precautionary measures are not taken. Along with influenza vaccination and …
Comorbidities in the Elderly and Their Possible Influence on Vaccine Response.
Kwetkat A, Heppner HJ. Kwetkat A, et al. Interdiscip Top Gerontol Geriatr. 2020;43:73-85. doi: 10.1159/000504491. Epub 2020 Apr 9. Interdiscip Top Gerontol Geriatr. 2020. PMID: 32305984 Review.
The following chapter is focused on the impact of comorbidities on the effectiveness of vaccination in older persons. Relevant comorbidities are cardiovascular diseases like hypertension, coronary artery disease or congestive heart failure, which lead to reduction of va …
The following chapter is focused on the impact of comorbidities on the effectiveness of vaccination in older persons. Relevant comorb …
Influenza vaccination in early Alzheimer's disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells.
Yang Y, He Z, Xing Z, Zuo Z, Yuan L, Wu Y, Jiang M, Qi F, Yao Z. Yang Y, et al. J Neuroinflammation. 2020 Feb 19;17(1):65. doi: 10.1186/s12974-020-01741-4. J Neuroinflammation. 2020. PMID: 32075657 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. Our previous results demonstrated that inactivated influenza vaccine (IIV) facilitates hippocampal neurogenesis and blocks lipo …
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. O …
Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective.
Jakimovski D, Weinstock-Guttman B, Ramanathan M, Dwyer MG, Zivadinov R. Jakimovski D, et al. Vaccines (Basel). 2020 Jan 28;8(1):50. doi: 10.3390/vaccines8010050. Vaccines (Basel). 2020. PMID: 32012815 Free PMC article. Review.
In addition, the review specifically discusses the interactions between MS pathophysiology and vaccination for hepatitis B, influenza, human papillomavirus, diphtheria, pertussis, and tetanus (DTP), and Bacillus Calmette-Guerin (BCG). Data regarding potential intera …
In addition, the review specifically discusses the interactions between MS pathophysiology and vaccination for hepatitis B, influe …
Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study.
Luo CS, Chi CC, Fang YA, Liu JC, Lee KY. Luo CS, et al. J Investig Med. 2020 Apr;68(4):838-845. doi: 10.1136/jim-2019-001155. Epub 2020 Jan 14. J Investig Med. 2020. PMID: 31941664
This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patients with chronic obstructive pulmonary disease (COPD), who are expected to be more vulnerable to influenza infection. ...In conclusion, …
This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patient …
Use of prophylactic antivirals and care home characteristics associated with influenza in care homes with confirmed outbreaks.
Shah A, Harries AD, Cleary P, McGivern M, Ghebrehewet S. Shah A, et al. Public Health. 2019 Dec;177:48-56. doi: 10.1016/j.puhe.2019.07.018. Epub 2019 Sep 15. Public Health. 2019. PMID: 31533085
OBJECTIVES: To assess the association of antiviral prophylaxis and care home characteristics with the spread and severity of influenza-like illness in care homes with influenza outbreaks in North West England in the 2017/2018 influenza season. ...Consideratio …
OBJECTIVES: To assess the association of antiviral prophylaxis and care home characteristics with the spread and severity of influenza …
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Warren R, Domm W, Yee M, Campbell A, Malone J, Wright T, Mayer-Pröschel M, O'Reilly MA. Warren R, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L591-L601. doi: 10.1152/ajplung.00031.2019. Epub 2019 Sep 11. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31509427 Free PMC article.
Ataxia-telangiectasia (A-T), caused by mutations in the A-T mutated (ATM) gene, is a neurodegenerative disorder affecting 1 in 40,000-100,000 children. Recurrent respiratory infections are a common and challenging comorbidity, often leading to the development of bronchiect …
Ataxia-telangiectasia (A-T), caused by mutations in the A-T mutated (ATM) gene, is a neurodegenerative disorder affecting 1 in 40,000 …
Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection.
Bawage SS, Tiwari PM, Pillai S, Dennis VA, Singh SR. Bawage SS, et al. Viruses. 2019 Aug 11;11(8):739. doi: 10.3390/v11080739. Viruses. 2019. PMID: 31405261 Free PMC article.
Presently, minocycline is also known to show anti-viral activity against Influenza virus, Japanese encephalitis virus, Simian immunodeficiency virus, Human immunodeficiency virus and West Nile virus. Here, we investigate the effect of minocycline on Respiratory syncytial v …
Presently, minocycline is also known to show anti-viral activity against Influenza virus, Japanese encephalitis virus, Simian immunod …
National retrospective cohort study to identify age-specific fatality risks of comorbidities among hospitalised patients with influenza-like illness in Taiwan.
Weng TC, Chiu HR, Chen SY, Shih FY, King CC, Fang CC. Weng TC, et al. BMJ Open. 2019 Jun 24;9(6):e025276. doi: 10.1136/bmjopen-2018-025276. BMJ Open. 2019. PMID: 31239301 Free PMC article.
Severe liver diseases and hypothyroidism among elderly, and dementia/epilepsy among elderly and paediatrics were distinctively associated with likelihood of ILI-related fatality. ...These findings may help update guidelines for influenza vaccination and other …
Severe liver diseases and hypothyroidism among elderly, and dementia/epilepsy among elderly and paediatrics were distinctively associ …
Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival.
Hallberg P, Smedje H, Eriksson N, Kohnke H, Daniilidou M, Öhman I, Yue QY, Cavalli M, Wadelius C, Magnusson PKE, Landtblom AM, Wadelius M; Swedegene. Hallberg P, et al. EBioMedicine. 2019 Feb;40:595-604. doi: 10.1016/j.ebiom.2019.01.041. Epub 2019 Jan 30. EBioMedicine. 2019. PMID: 30711515 Free PMC article.
BACKGROUND: The incidence of narcolepsy rose sharply after the swine influenza A (H1N1) vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with excessive daytime sleepiness. ...Changes in regulation of GDNF have been associated with neu …
BACKGROUND: The incidence of narcolepsy rose sharply after the swine influenza A (H1N1) vaccination campaign with Pandemrix. N …
Effect of vaccination, comorbidities and age on mortality and severe disease associated with influenza during the season 2016-2017 in a Spanish tertiary hospital.
Gutiérrez-González E, Cantero-Escribano JM, Redondo-Bravo L, San Juan-Sanz I, Robustillo-Rodela A, Cendejas-Bueno E, Influenza Working Group. Gutiérrez-González E, et al. J Infect Public Health. 2019 Jul-Aug;12(4):486-491. doi: 10.1016/j.jiph.2018.11.011. Epub 2019 Jan 19. J Infect Public Health. 2019. PMID: 30670352 Free article.
The effect of influenza vaccine to prevent severe influenza or death was evaluated using multivariate logistic regression models. ...CONCLUSIONS: Age and dementia are significant independent risk factors for mortality associated with influenza a …
The effect of influenza vaccine to prevent severe influenza or death was evaluated using multivariate logistic regressi …
MELAS.
El-Hattab AW, Almannai M, Scaglia F. El-Hattab AW, et al. 2001 Feb 27 [updated 2018 Nov 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2001 Feb 27 [updated 2018 Nov 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301411 Free Books & Documents. Review.
Common clinical manifestations include stroke-like episodes, encephalopathy with seizures and/or dementia, muscle weakness and exercise intolerance, normal early psychomotor development, recurrent headaches, recurrent vomiting, hearing impairment, peripheral neuropathy, le …
Common clinical manifestations include stroke-like episodes, encephalopathy with seizures and/or dementia, muscle weakness and exerci …
Closing the medical mortality gap in patients with major psychiatric conditions.
de Silva PN. de Silva PN. Br J Hosp Med (Lond). 2018 Aug 2;79(8):444-448. doi: 10.12968/hmed.2018.79.8.444. Br J Hosp Med (Lond). 2018. PMID: 30070942
This article discusses options for closing the mortality gap between the general population and people with major psychiatric conditions such as psychosis, autism, learning disability and dementia. Most of the mortality (85%) involves physical disease, with most deaths occ …
This article discusses options for closing the mortality gap between the general population and people with major psychiatric conditions suc …
Design and Efficacy of Nanogels Formulations for Intranasal Administration.
Aderibigbe BA, Naki T. Aderibigbe BA, et al. Molecules. 2018 May 23;23(6):1241. doi: 10.3390/molecules23061241. Molecules. 2018. PMID: 29789506 Free PMC article. Review.
They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influe …
They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophren …
Putting research in place: an innovative approach to providing contextualized evidence synthesis for decision makers.
Bornstein S, Baker R, Navarro P, Mackey S, Speed D, Sullivan M. Bornstein S, et al. Syst Rev. 2017 Nov 2;6(1):218. doi: 10.1186/s13643-017-0606-4. Syst Rev. 2017. PMID: 29096710 Free PMC article.
RESULTS: CHRSP has published 25 syntheses on priority topics chosen by the provincial healthcare system, including: Clinical and cost-effectiveness: telehealth, rural renal dialysis, point-of-care testing; Community-based health services: helping seniors age in place, supporting …
RESULTS: CHRSP has published 25 syntheses on priority topics chosen by the provincial healthcare system, including: Clinical and cost-effect …
Markers of T Cell Senescence in Humans.
Xu W, Larbi A. Xu W, et al. Int J Mol Sci. 2017 Aug 10;18(8):1742. doi: 10.3390/ijms18081742. Int J Mol Sci. 2017. PMID: 28796199 Free PMC article. Review.
Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. ...The age-related effects on the immune system termed as "immunosene …
Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccin …
[Geriatric medicine].
Lajoso S, Launay CP, Poloni B, Büla C, Gold G, Lang PO. Lajoso S, et al. Rev Med Suisse. 2017 Jan 11;13(544-545):54-57. Rev Med Suisse. 2017. PMID: 28703537 Review. French.
The Framingham Heart Study reports the declining of the incidence of vascular dementia. The role played by microbleeds in cognitive deterioration was investigated and aducanumab showed encouraging effect in Alzheimer's disease. When vaccination against inf …
The Framingham Heart Study reports the declining of the incidence of vascular dementia. The role played by microbleeds in cognitive d …
Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis.
Sadasivan S, Sharp B, Schultz-Cherry S, Smeyne RJ. Sadasivan S, et al. NPJ Parkinsons Dis. 2017 May 23;3:18. doi: 10.1038/s41531-017-0019-z. eCollection 2017. NPJ Parkinsons Dis. 2017. PMID: 28649618 Free PMC article.
Central Nervous System inflammation has been implicated in neurodegenerative disorders including Parkinson's disease (Ransohoff, Science 353: 777-783, 2016; Kannarkat et al. ...Our observations also have important implications for public health, providing impetus fo …
Central Nervous System inflammation has been implicated in neurodegenerative disorders including Parkinson's disease (Ransohof …
Effect of dementia on receipt of influenza vaccine: a cohort study in French older adults using administrative data: 2007-2012.
Gallini A, Coley N, Andrieu S, Lapeyre-Mestre M, Gardette V. Gallini A, et al. Fundam Clin Pharmacol. 2017 Aug;31(4):471-480. doi: 10.1111/fcp.12281. Epub 2017 Apr 4. Fundam Clin Pharmacol. 2017. PMID: 28258589
Despite guidelines stating the vaccine benefit in this population, older adults with dementia may be less likely to receive influenza vaccine than cognitively intact older adults. But no study has yet reported on vaccine uptake in patients newly …
Despite guidelines stating the vaccine benefit in this population, older adults with dementia may be less likely to receive …
Influenza Vaccination Reduces Dementia Risk in Chronic Kidney Disease Patients: A Population-Based Cohort Study.
Liu JC, Hsu YP, Kao PF, Hao WR, Liu SH, Lin CF, Sung LC, Wu SY. Liu JC, et al. Medicine (Baltimore). 2016 Mar;95(9):e2868. doi: 10.1097/MD.0000000000002868. Medicine (Baltimore). 2016. PMID: 26945371 Free PMC article.
CKD, a manifestation of vascular diseases, is associated with a high risk of dementia. Here, we estimated the association between influenza vaccination and dementia risk in patients with CKD. ...Influenza vaccination exerts dose-response …
CKD, a manifestation of vascular diseases, is associated with a high risk of dementia. Here, we estimated the association between …
Differences in predictors of 5-year survival over a 10-year period in two cohorts of elderly nursing home residents in Sweden.
Sund Levander M, Milberg A, Rodhe N, Tingström P, Grodzinsky E. Sund Levander M, et al. Scand J Caring Sci. 2016 Dec;30(4):714-720. doi: 10.1111/scs.12284. Epub 2016 Feb 4. Scand J Caring Sci. 2016. PMID: 26842844 Free article.

RESULTS: In average, cohort 2007 survived 31 16 months and cohort 2000, 38 13 months, p < 0.001. Dementia, ageing and circulatory failure were more common as cause of death 2007, while stroke, chronic obstructive pulmonary disease (COPD) and pneumonia were less common,

…

RESULTS: In average, cohort 2007 survived 31 16 months and cohort 2000, 38 13 months, p < 0.001. Dementia, ageing and circulatory

…
Engineering humoral immunity as prophylaxis or therapy.
Deal CE, Balazs AB. Deal CE, et al. Curr Opin Immunol. 2015 Aug;35:113-22. doi: 10.1016/j.coi.2015.06.014. Epub 2015 Jul 14. Curr Opin Immunol. 2015. PMID: 26183209 Free PMC article. Review.
As such, it offers an alternative to immunogen-based vaccine design and a novel therapeutic intervention by enabling precise manipulation of humoral immunity. Success translating these approaches to patients may enable the development of effective prevention against previo …
As such, it offers an alternative to immunogen-based vaccine design and a novel therapeutic intervention by enabling precise manipula …
Immunosenescence: Implications for response to infection and vaccination in older people.
Pera A, Campos C, López N, Hassouneh F, Alonso C, Tarazona R, Solana R. Pera A, et al. Maturitas. 2015 Sep;82(1):50-5. doi: 10.1016/j.maturitas.2015.05.004. Epub 2015 May 18. Maturitas. 2015. PMID: 26044074 Review.
Population aging is associated to an increased frequency of age-related diseases including higher susceptibility to infections, cancer, cardiovascular and neurodegenerative diseases. Immunosenescence refers to the decline of the immune system associated to aging. ...Thus, …
Population aging is associated to an increased frequency of age-related diseases including higher susceptibility to infections, cancer, card …
A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-beta-amyloid antibody responses in mice with pre-existing virus specific memory.
Davtyan H, Ghochikyan A, Hovakimyan A, Davtyan A, Cadagan R, Marleau AM, Albrecht RA, García-Sastre A, Agadjanyan MG. Davtyan H, et al. J Neuroimmunol. 2014 Dec 15;277(1-2):77-84. doi: 10.1016/j.jneuroim.2014.10.002. Epub 2014 Oct 16. J Neuroimmunol. 2014. PMID: 25455094 Free PMC article.
Novel dual vaccine, WSN-Abeta(1-10), based on the recombinant influenza virus, expressing immunodominant B-cell epitope of beta-amyloid, simultaneously induced therapeutically potent anti-Abeta and anti-influenza antibodies. ...This inhibition is associated w …
Novel dual vaccine, WSN-Abeta(1-10), based on the recombinant influenza virus, expressing immunodominant B-cell epitope of bet …
CDC National Health Report: leading causes of morbidity and mortality and associated behavioral risk and protective factors--United States, 2005-2013.
Johnson NB, Hayes LD, Brown K, Hoo EC, Ethier KA; Centers for Disease Control and Prevention (CDC). Johnson NB, et al. MMWR Suppl. 2014 Oct 31;63(4):3-27. MMWR Suppl. 2014. PMID: 25356673
Data from the following CDC surveillance systems and surveys were used: Behavioral Risk Factor Surveillance System (BRFSS); Emerging Infections Program/Active Bacterial Core surveillance (EIP/ABCs); Foodborne Diseases Active Surveillance Network (FoodNet); Internet Panel Surveys: …
Data from the following CDC surveillance systems and surveys were used: Behavioral Risk Factor Surveillance System (BRFSS); Emerging Infecti …
Vaccination of Older Adults with Dementia Against Respiratory Infections.
Ridda I, Dastouri F, King C, Yin JK, Tashani M, Rashid H. Ridda I, et al. Infect Disord Drug Targets. 2014;14(2):133-9. doi: 10.2174/1871526514666140713153645. Infect Disord Drug Targets. 2014. PMID: 25019234 Review.
Most available data suggest that older adults with dementia are less likely to receive influenza or pneumococcal vaccine while a few studies indicate an increase in vaccination uptake but poor immunogenicity. Among dementia patients, community d …
Most available data suggest that older adults with dementia are less likely to receive influenza or pneumococcal vaccine …
Understanding gut microbiota in elderly's health will enable intervention through probiotics.
Pérez Martínez G, Bäuerl C, Collado MC. Pérez Martínez G, et al. Benef Microbes. 2014 Sep;5(3):235-46. doi: 10.3920/BM2013.0079. Benef Microbes. 2014. PMID: 24889891 Review.
The lifelong stimulation of innate and adaptive immune systems leads to immunosenescence and, as result, to a low ability to produce immunoglobulins against pathogens but also to a low-grade chronic inflammatory state (inflammaging) that is linked to most age-related health probl …
The lifelong stimulation of innate and adaptive immune systems leads to immunosenescence and, as result, to a low ability to produce immunog …
Age- and sex-related risk factors for influenza-associated mortality in the United States between 1997-2007.
Quandelacy TM, Viboud C, Charu V, Lipsitch M, Goldstein E. Quandelacy TM, et al. Am J Epidemiol. 2014 Jan 15;179(2):156-67. doi: 10.1093/aje/kwt235. Epub 2013 Nov 4. Am J Epidemiol. 2014. PMID: 24190951 Free PMC article.
In addition to respiratory and circulatory causes, mortality with underlying cancer, diabetes, renal disease, and Alzheimer disease had a contribution from influenza in adult age groups, whereas mortality with underlying septicemia had a contribution from influen …
In addition to respiratory and circulatory causes, mortality with underlying cancer, diabetes, renal disease, and Alzheimer disease h …
Improving the estimation of influenza-related mortality over a seasonal baseline.
Goldstein E, Viboud C, Charu V, Lipsitch M. Goldstein E, et al. Epidemiology. 2012 Nov;23(6):829-38. doi: 10.1097/EDE.0b013e31826c2dda. Epidemiology. 2012. PMID: 22992574 Free PMC article.
BACKGROUND: Existing methods for estimation of mortality attributable to influenza are limited by methodological and data uncertainty. We have used proxies for disease incidence of the three influenza cocirculating subtypes (A/H3N2, A/H1N1, and B) that combine data …
BACKGROUND: Existing methods for estimation of mortality attributable to influenza are limited by methodological and data uncertainty …
Impact of the demand for 'proxy assent' on recruitment to a randomised controlled trial of vaccination testing in care homes.
Whelan PJ, Walwyn R, Gaughran F, Macdonald A. Whelan PJ, et al. J Med Ethics. 2013 Jan;39(1):36-40. doi: 10.1136/medethics-2011-100119. Epub 2012 Sep 1. J Med Ethics. 2013. PMID: 22942376
In this paper, we describe the characteristics of a sample at different stages of the recruitment process of an influenza vaccine-based randomised control trial in elderly care home residents (the FEVER study). 62% (602/968) of potential subjects lacked capacity but …
In this paper, we describe the characteristics of a sample at different stages of the recruitment process of an influenza vaccine …
Factors associated with continued adherence to influenza vaccination in the elderly.
Martínez-Baz I, Aguilar I, Morán J, Albéniz E, Aldaz P, Castilla J. Martínez-Baz I, et al. Prev Med. 2012 Sep;55(3):246-50. doi: 10.1016/j.ypmed.2012.06.020. Epub 2012 Jun 30. Prev Med. 2012. PMID: 22759626
OBJECTIVE: We aimed to analyze the factors influencing continued adherence to influenza vaccination in elderly persons vaccinated in the preceding season. METHODS: Using a population-based vaccination registry, we evaluated the proportion of persons vaccinate …
OBJECTIVE: We aimed to analyze the factors influencing continued adherence to influenza vaccination in elderly persons vaccina …
Bullous pemphigoid triggered by swine flu vaccination: case report and review of vaccine triggered pemphigoid.
Walmsley N, Hampton P. Walmsley N, et al. J Dermatol Case Rep. 2011 Dec 12;5(4):74-6. doi: 10.3315/jdcr.2011.1081. J Dermatol Case Rep. 2011. PMID: 22408707 Free PMC article.
MAIN OBSERVATIONS: We report a case of atypical bullous pemphigoid which was strongly suspected to have been triggered by the swine flu vaccination. This is the first reported case of pemphigoid triggered by this vaccine. CONCLUSIONS: The use of the swine …
MAIN OBSERVATIONS: We report a case of atypical bullous pemphigoid which was strongly suspected to have been triggered by the swine flu …
The impact of dementia on influenza vaccination uptake in community and care home residents.
Shah SM, Carey IM, Harris T, DeWilde S, Cook DG. Shah SM, et al. Age Ageing. 2012 Jan;41(1):64-9. doi: 10.1093/ageing/afr135. Epub 2011 Nov 16. Age Ageing. 2012. PMID: 22089079
OBJECTIVE: To examine the effect of dementia diagnosis on flu vaccination uptake in community and care home residents in England and Wales. ...RESULTS: Age and sex standardised uptake of influenza vaccine was 74.7% (95% CI: 73.7-75.8%) in commun …
OBJECTIVE: To examine the effect of dementia diagnosis on flu vaccination uptake in community and care home residents i …
Recent publications in medical microbiology and immunology: a retrospective.
Doerr HW, Cinatl J. Doerr HW, et al. Med Microbiol Immunol. 2012 Feb;201(1):1-5. doi: 10.1007/s00430-011-0219-9. Epub 2011 Oct 29. Med Microbiol Immunol. 2012. PMID: 22033658 Review.
The review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine-based prevention of avian and swine-origin flu. Some new developments and concepts in diagnosis, (molecular) epidemiology, and th …
The review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine …
A comparative investigation of observational pain assessment tools for older adults with dementia.
Lints-Martindale AC, Hadjistavropoulos T, Lix LM, Thorpe L. Lints-Martindale AC, et al. Clin J Pain. 2012 Mar-Apr;28(3):226-37. doi: 10.1097/AJP.0b013e3182290d90. Clin J Pain. 2012. PMID: 21904200
OBJECTIVES: Pain assessment in patients with dementia and severe limitations in ability to communicate can be challenging. The American Geriatrics Society (AGS) encourages the incorporation of 6 behavioral domains (ie, facial expressions, verbalizations/vocalizations, body …
OBJECTIVES: Pain assessment in patients with dementia and severe limitations in ability to communicate can be challenging. The Americ …
Continuous use of antipsychotics and its association with mortality and hospitalization in institutionalized Chinese older adults: an 18-month prospective cohort study.
Chan TC, Luk JK, Shea YF, Lau KH, Chan FH, Yu GK, Chu LW. Chan TC, et al. Int Psychogeriatr. 2011 Dec;23(10):1640-8. doi: 10.1017/S104161021100175X. Epub 2011 Sep 9. Int Psychogeriatr. 2011. PMID: 21902863 Free article.
BACKGROUND: Previous meta-analyses have suggested that antipsychotics are associated with increased mortality in dementia patients with behavioral and psychological symptoms (BPSD). Subsequent observational studies, however, have produced conflicting results. ...Demographi …
BACKGROUND: Previous meta-analyses have suggested that antipsychotics are associated with increased mortality in dementia patients wi …
The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease.
Davtyan H, Ghochikyan A, Cadagan R, Zamarin D, Petrushina I, Movsesyan N, Martinez-Sobrido L, Albrecht RA, García-Sastre A, Agadjanyan MG. Davtyan H, et al. J Transl Med. 2011 Aug 1;9:127. doi: 10.1186/1479-5876-9-127. J Transl Med. 2011. PMID: 21806809 Free PMC article.
We attempt to improve vaccine efficacy by creating a novel chimeric flu vaccine expressing the small immunodominant B cell epitope of Abeta42. ...We demonstrated that this dual vaccine induced therapeutically potent anti-Abeta antibodies and anti-in …
We attempt to improve vaccine efficacy by creating a novel chimeric flu vaccine expressing the small immunodominant B c …
Rurality and nursing home quality: evidence from the 2004 National Nursing Home Survey.
Kang Y, Meng H, Miller NA. Kang Y, et al. Gerontologist. 2011 Dec;51(6):761-73. doi: 10.1093/geront/gnr065. Epub 2011 Jun 30. Gerontologist. 2011. PMID: 21719631
We used multilevel regression models to predict risk-adjusted rates of hospitalization, influenza and pneumococcal vaccination, and moderate to severe pain while controlling for resident and facility characteristics. ...Significant resident-level predictors included …
We used multilevel regression models to predict risk-adjusted rates of hospitalization, influenza and pneumococcal vaccination …
Seasonal influenza vaccination among homebound elderly receiving home-based primary care in New York City.
Banach DB, Ornstein K, Factor SH, Soriano TA. Banach DB, et al. J Community Health. 2012 Feb;37(1):10-4. doi: 10.1007/s10900-011-9409-z. J Community Health. 2012. PMID: 21533885 Free PMC article.
Seasonal influenza vaccination is recommended for all persons aged 50 years to reduce influenza related morbidity and mortality, but vaccination coverage among community-dwelling elderly remains low. ...This study assessed seasonal influenza …
Seasonal influenza vaccination is recommended for all persons aged 50 years to reduce influenza related morbidity and m …
Impact of a geriatric assessment clinic on organizational interventions in primary health-care facilities at a university hospital.
Boongird C, Thamakaison S, Krairit O. Boongird C, et al. Geriatr Gerontol Int. 2011 Apr;11(2):204-10. doi: 10.1111/j.1447-0594.2010.00671.x. Epub 2010 Dec 10. Geriatr Gerontol Int. 2011. PMID: 21143568
Eighty-seven percent were never given stool occult tests or an influenza vaccination. The three most common geriatric syndromes found were dementia/mild cognitive impairment (MCI) (60.4%), depression (29.9%) and gait problems (30.5%). ...
Eighty-seven percent were never given stool occult tests or an influenza vaccination. The three most common geriatric syndrome …
Pneumonia and influenza hospitalizations in elderly people with dementia.
Naumova EN, Parisi SM, Castronovo D, Pandita M, Wenger J, Minihan P. Naumova EN, et al. J Am Geriatr Soc. 2009 Dec;57(12):2192-9. doi: 10.1111/j.1532-5415.2009.02565.x. Epub 2009 Oct 26. J Am Geriatr Soc. 2009. PMID: 19874403
OBJECTIVES: To compare the demographic and geographic patterns of pneumonia and influenza (P&I) hospitalizations in older adults with dementia with those of the U.S. population and to examine the relationship between healthcare accessibility and P&I. ...RESU …
OBJECTIVES: To compare the demographic and geographic patterns of pneumonia and influenza (P&I) hospitalizations in older adults …
Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination.
Gallagher S, Phillips AC, Drayson MT, Carroll D. Gallagher S, et al. Psychosom Med. 2009 Apr;71(3):341-4. doi: 10.1097/PSY.0b013e31819d1910. Epub 2009 Mar 17. Psychosom Med. 2009. PMID: 19297308 Free article.
OBJECTIVE: Older spousal caregivers of dementia patients have been found to show a relatively poor antibody response to medical vaccination. ...They also provided a blood sample and were then vaccinated with the thymus-dependent trivalent influenza vaccine …
OBJECTIVE: Older spousal caregivers of dementia patients have been found to show a relatively poor antibody response to medical va …
Caregiving, repetitive thought, and immune response to vaccination in older adults.
Segerstrom SC, Schipper LJ, Greenberg RN. Segerstrom SC, et al. Brain Behav Immun. 2008 Jul;22(5):744-52. doi: 10.1016/j.bbi.2007.11.004. Epub 2007 Dec 31. Brain Behav Immun. 2008. PMID: 18166335 Free PMC article.
The present study tested the relationship of caregiving and two types of repetitive thought, negative (e.g., worry) and neutral (e.g., reflection), to pre- and post-influenza vaccine antibody and IL-6. Dementia caregivers (n=14) and controls (n=30) were inter …
The present study tested the relationship of caregiving and two types of repetitive thought, negative (e.g., worry) and neutral (e.g., refle …
[Studies of influenza vaccination among elderly nursing home residents].
Hayashi Y, Suzuki K, Tonegawa K. Hayashi Y, et al. Kansenshogaku Zasshi. 2007 Jul;81(4):408-13. doi: 10.11150/kansenshogakuzasshi1970.81.408. Kansenshogaku Zasshi. 2007. PMID: 17695795 Japanese.
We conducted a questionnaire survey of influenza vaccination among elderly nursing home residents, and investigated the actual condition and the view of vaccination of elderly people. ...In order to raise the rate of the vaccination in elderly nursing …
We conducted a questionnaire survey of influenza vaccination among elderly nursing home residents, and investigated the actual …
Risk factors for poor immune response to influenza vaccination in elderly people.
Bellei NC, Carraro E, Castelo A, Granato CF. Bellei NC, et al. Braz J Infect Dis. 2006 Aug;10(4):269-73. doi: 10.1590/s1413-86702006000400011. Braz J Infect Dis. 2006. PMID: 17293910
Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. ...Chemoprophylaxis in addition to vaccination for elderly presenting dementia should be considered, particularly fo …
Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its compl …
[Nosocomial influenza outbreak in a geriatrics department: Effectiveness of preventive measures].
Andrieu AG, Paute J, Glomot L, Jarlier V, Belmin J. Andrieu AG, et al. Presse Med. 2006 Oct;35(10 Pt 1):1419-26. doi: 10.1016/s0755-4982(06)74830-8. Presse Med. 2006. PMID: 17028529 Free article. French.
All cases met the definition of nosocomial infection. No deaths imputable to influenza occurred during the outbreak. The implementation of the nonpharmacologic measures aimed at preventing spread of the outbreak presented no particular difficulty, except for compliance wit …
All cases met the definition of nosocomial infection. No deaths imputable to influenza occurred during the outbreak. The implementati …
The psychometric quality and clinical usefulness of three pain assessment tools for elderly people with dementia.
Zwakhalen SM, Hamers JP, Berger MP. Zwakhalen SM, et al. Pain. 2006 Dec 15;126(1-3):210-20. doi: 10.1016/j.pain.2006.06.029. Epub 2006 Aug 4. Pain. 2006. PMID: 16890355
In view of the need for valid, reliable, and clinically useful scales to assess pain in elderly people with dementia, this study evaluated the psychometric properties of translated versions of the PAINAD, PACSLAC, and DOLOPLUS-2 scales. In an observational study design, tw …
In view of the need for valid, reliable, and clinically useful scales to assess pain in elderly people with dementia, this study eval …
Caregiver psychological distress as a barrier to influenza vaccination among community-dwelling elderly with dementia.
Thorpe JM, Sleath BL, Thorpe CT, Van Houtven CH, Blalock SJ, Landerman LR, Campbell WH, Clipp EC. Thorpe JM, et al. Med Care. 2006 Aug;44(8):713-21. doi: 10.1097/01.mlr.0000215905.36968.76. Med Care. 2006. PMID: 16862032
Vaccination was identified by examining Veteran Administration Outpatient Data Files for visits indicating influenza vaccine administration during the 1998 influenza vaccine season (September 1 to December 31). ...Furthermore, a number of factor …
Vaccination was identified by examining Veteran Administration Outpatient Data Files for visits indicating influenza vaccin …
What's new in clinical pharmacology and therapeutics.
Chawla PS, Kochar MS. Chawla PS, et al. WMJ. 2006 May;105(3):24-9. WMJ. 2006. PMID: 16749321 Review.
Lanthanum Carbonate is useful in treatment of hyperphosphatemia in patients with end stage renal disease. Flumist is an intranasal influenza vaccine. Eszopiclone is a new hypnotic that has fewer side effects. Memantine is in a new class of drugs useful in the treatm …
Lanthanum Carbonate is useful in treatment of hyperphosphatemia in patients with end stage renal disease. Flumist is an intranasal influe …
Limited literacy in older people and disparities in health and healthcare access.
Sudore RL, Mehta KM, Simonsick EM, Harris TB, Newman AB, Satterfield S, Rosano C, Rooks RN, Rubin SM, Ayonayon HN, Yaffe K. Sudore RL, et al. J Am Geriatr Soc. 2006 May;54(5):770-6. doi: 10.1111/j.1532-5415.2006.00691.x. J Am Geriatr Soc. 2006. PMID: 16696742
PARTICIPANTS: Two thousand five hundred twelve black and white community-dwelling older people who were well functioning at baseline (without functional difficulties or dementia). MEASUREMENTS: Participants' health literacy was assessed using the Rapid Estimate of Adult Li …
PARTICIPANTS: Two thousand five hundred twelve black and white community-dwelling older people who were well functioning at baseline (withou …
[Geriatrics].
Büla C. Büla C. Rev Med Suisse. 2006 Jan 4;2(47):19, 21-4. Rev Med Suisse. 2006. PMID: 16465940 French.
Several studies have shown that treatment of neuropsychiatric symptoms of dementia with psychotropic medication is modestly effective and could increase the risk of adverse events, including death. Influenza vaccination in long term care residents was shown t …
Several studies have shown that treatment of neuropsychiatric symptoms of dementia with psychotropic medication is modestly effective …
High levels of adamantane resistance among influenza A (H3N2) viruses and interim guidelines for use of antiviral agents--United States, 2005-06 influenza season.
Centers for Disease Control and Prevention (CDC). Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2006 Jan 20;55(2):44-6. MMWR Morb Mortal Wkly Rep. 2006. PMID: 16424859 Free article.
An estimated 200,000 persons are hospitalized each year and 36,000 persons die from complications of influenza in the United States. The cornerstone of influenza prevention is annual vaccination. ...The adamantanes are active against only influenza A v …
An estimated 200,000 persons are hospitalized each year and 36,000 persons die from complications of influenza in the United States. …
Virosome-based active immunization targets soluble amyloid species rather than plaques in a transgenic mouse model of Alzheimer's disease.
Zurbriggen R, Amacker M, Kammer AR, Westerfeld N, Borghgraef P, Van Leuven F, Van der Auwera I, Wera S. Zurbriggen R, et al. J Mol Neurosci. 2005;27(2):157-66. doi: 10.1385/JMN:27:2:157. J Mol Neurosci. 2005. PMID: 16186626
Active vaccination with amyloid peptides shows promise for the treatment and prevention of Alzheimer's disease (AD). Several studies in transgenic mouse models of AD have revealed the potency of vaccination to prevent or even clear amyloid plaques from mouse …
Active vaccination with amyloid peptides shows promise for the treatment and prevention of Alzheimer's disease (AD). Several s …
Giving the influenza jab: a review of the law.
Griffiths R. Griffiths R. Br J Community Nurs. 2004 Oct;9(10):442-5. doi: 10.12968/bjcn.2004.9.10.16120. Br J Community Nurs. 2004. PMID: 15577723 Review.
Relatives of five residents with advanced dementia did not want them to have the injection, mainly because they had heard that it would give the recipient the 'flu. An 85-year-old resident has complained that while she agreed to have a 'flu jab it now appears …
Relatives of five residents with advanced dementia did not want them to have the injection, mainly because they had heard that it wou …
Pneumonia in older residents of long-term care facilities.
Furman CD, Rayner AV, Tobin EP. Furman CD, et al. Am Fam Physician. 2004 Oct 15;70(8):1495-500. Am Fam Physician. 2004. PMID: 15526736 Free article.
Pneumonia is associated with significant mortality for up to two years. Dementia is related independently to the death rate within the first week after pneumonia, regardless of treatment. Prevention strategies include vaccination against S. pneumoniae and influen …
Pneumonia is associated with significant mortality for up to two years. Dementia is related independently to the death rate within th …
Rates of influenza vaccination in older adults and factors associated with vaccine use: a secondary analysis of the Canadian Study of Health and Aging.
Andrew MK, McNeil S, Merry H, Rockwood K. Andrew MK, et al. BMC Public Health. 2004 Aug 11;4:36. doi: 10.1186/1471-2458-4-36. BMC Public Health. 2004. PMID: 15306030 Free PMC article.
In Canada, vaccination rates remain suboptimal. We identified factors predictive of influenza vaccination, in order to determine which segments of the older adult population might be targeted to increase coverage in influenza vaccination program …
In Canada, vaccination rates remain suboptimal. We identified factors predictive of influenza vaccination, in order to …
[Diagnostic difficulties in Creutzfeldt-Jakob disease--case report].
Sienkiewicz-Jarosz H, Lipczyńska-Łojkowska W, Kulczyki J. Sienkiewicz-Jarosz H, et al. Neurol Neurochir Pol. 2003 Nov-Dec;37(6):1299-305. Neurol Neurochir Pol. 2003. PMID: 15174242 Polish.
Its main symptoms are rapidly progressing dementia, myoclonic jerks, visual disturbances, ataxia, and pyramidal and extrapyramidal signs. A case of sporadic form of the CJD is reported, with blurred vision as one of the first symptoms. This symptom occurred shortly after …
Its main symptoms are rapidly progressing dementia, myoclonic jerks, visual disturbances, ataxia, and pyramidal and extrapyramidal si …
[Measurement of the prevention policy in the hospital].
Grondin MA, Gerbaud L, Taillandier S, Jalenques I, Glanddier PY. Grondin MA, et al. Presse Med. 2004 Mar 27;33(6):373-7. doi: 10.1016/s0755-4982(04)98599-5. Presse Med. 2004. PMID: 15105778 French.
The criteria for prevention assessment were surveillance of blood pressure and glycaemia, screening of viral serologies for people having had blood transfusion or major surgery, surveillance of weight, check of tetanus vaccination, check of influenza vaccination …
The criteria for prevention assessment were surveillance of blood pressure and glycaemia, screening of viral serologies for people having ha …
Development and validation of a clinical prediction rule for hospitalization due to pneumonia or influenza or death during influenza epidemics among community-dwelling elderly persons.
Hak E, Wei F, Nordin J, Mullooly J, Poblete S, Nichol KL. Hak E, et al. J Infect Dis. 2004 Feb 1;189(3):450-8. doi: 10.1086/381165. Epub 2004 Jan 23. J Infect Dis. 2004. PMID: 14745702
BACKGROUND: Uncertainties among health care providers and patients about the risk of serious influenza-associated complications and the potential benefits of vaccination may contribute to unsatisfactorily low influenza vaccination rates. ...CONCLUSIONS …
BACKGROUND: Uncertainties among health care providers and patients about the risk of serious influenza-associated complications and t …
Emergence of amantadine-resistant influenza A viruses: epidemiological study.
Suzuki H, Saito R, Masuda H, Oshitani H, Sato M, Sato I. Suzuki H, et al. J Infect Chemother. 2003 Sep;9(3):195-200. doi: 10.1007/s10156-003-0262-6. J Infect Chemother. 2003. PMID: 14513385 Review.
At present, three licensed antiviral influenza agents are available in Japan: amantadine, zanamivir, and oseltamivir. These antiviral agents can be used for controlling and preventing influenza, but they are not a substitute for vaccination. Amantadine is an …
At present, three licensed antiviral influenza agents are available in Japan: amantadine, zanamivir, and oseltamivir. These antiviral …
Enhancement of antibody responses to influenza vaccination in the elderly following a cognitive-behavioural stress management intervention.
Vedhara K, Bennett PD, Clark S, Lightman SL, Shaw S, Perks P, Hunt MA, Philip JM, Tallon D, Murphy PJ, Jones RW, Wilcock GK, Shanks NM. Vedhara K, et al. Psychother Psychosom. 2003 Sep-Oct;72(5):245-52. doi: 10.1159/000071895. Psychother Psychosom. 2003. PMID: 12920328
At the end of the SMI or its equivalent time period, all participants received an influenza vaccination. IgG antibody titres to the vaccine were measured 0, 2, 4 and 6 weeks post-vaccine. ...CONCLUSIONS: The immune response to influenza vacci …
At the end of the SMI or its equivalent time period, all participants received an influenza vaccination. IgG antibody titres t …
Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly.
Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Nichol KL, et al. N Engl J Med. 2003 Apr 3;348(14):1322-32. doi: 10.1056/NEJMoa025028. N Engl J Med. 2003. PMID: 12672859 Free article.
BACKGROUND: Upper respiratory tract illnesses have been associated with an increased risk of ischemic heart disease and stroke. During two influenza seasons, we assessed the influence of vaccination against influenza on the risk of hospitalization for heart d …
BACKGROUND: Upper respiratory tract illnesses have been associated with an increased risk of ischemic heart disease and stroke. During two …
Chronic stress in nonelderly caregivers: psychological, endocrine and immune implications.
Vedhara K, McDermott MP, Evans TG, Treanor JJ, Plummer S, Tallon D, Cruttenden KA, Schifitto G. Vedhara K, et al. J Psychosom Res. 2002 Dec;53(6):1153-61. doi: 10.1016/s0022-3999(02)00343-4. J Psychosom Res. 2002. PMID: 12479999
OBJECTIVE: This investigation examined whether the immune dysregulation that characterises elderly informal caregivers (e.g., spousal caregivers of dementia patients) extends to a younger caregiver population, specifically spousal carers of patients with multiple sclerosis …
OBJECTIVE: This investigation examined whether the immune dysregulation that characterises elderly informal caregivers (e.g., spousal caregi …
Nursing home-acquired pneumonia.
Mylotte JM. Mylotte JM. Clin Infect Dis. 2002 Nov 15;35(10):1205-11. doi: 10.1086/344281. Epub 2002 Oct 28. Clin Infect Dis. 2002. PMID: 12410480 Review.
Clinical presentation of NHAP is said to be "atypical," but this may be confounded by dementia in the nursing home resident. A recent guideline has made recommendations regarding the minimal diagnostic workup when a resident has a suspected case of pneumonia. Until recentl …
Clinical presentation of NHAP is said to be "atypical," but this may be confounded by dementia in the nursing home resident. A recent …
[Neurological complication of influenza infections].
Brydak LB. Brydak LB. Przegl Epidemiol. 2002;56 Suppl 1:16-30. Przegl Epidemiol. 2002. PMID: 12194226 Review. Polish.
The most often occurring complications are pneumonia, bronchitis, bronchiolitis, myocarditis and otitis media. The other group is neurological post-influenza complications, including dementia, epileptic disorders, cerebrovascular disease, febrile convulsions, toxic …
The most often occurring complications are pneumonia, bronchitis, bronchiolitis, myocarditis and otitis media. The other group is neurologic …
Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals.
Weksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P. Weksler ME, et al. Exp Gerontol. 2002 Jul;37(7):943-8. doi: 10.1016/s0531-5565(02)00029-3. Exp Gerontol. 2002. PMID: 12086704
If anti-Abeta42 antibodies protect APP-transgenic mice, a model of Alzheimer's disease (AD), a high titer of anti-Abeta42 antibodies may protect humans from AD. ...The low titer of anti-Abeta42 antibodies in AD patients does not reflect the well-established, age-associated …
If anti-Abeta42 antibodies protect APP-transgenic mice, a model of Alzheimer's disease (AD), a high titer of anti-Abeta42 antibodies …
Past exposure to vaccines and subsequent risk of Alzheimer's disease.
Verreault R, Laurin D, Lindsay J, De Serres G. Verreault R, et al. CMAJ. 2001 Nov 27;165(11):1495-8. CMAJ. 2001. PMID: 11762573 Free PMC article.
RESULTS: Of the 4392 eligible subjects who were cognitively unimpaired and for whom vaccine information was available at baseline (in 1991-1992) and who completed follow-up 5 years later (in 1996-1997), 527 were diagnosed as having cognitive impairment or dementia o …
RESULTS: Of the 4392 eligible subjects who were cognitively unimpaired and for whom vaccine information was available at baseline (in …
[Efficacy and safety of influenza vaccination to elderly patients with neurological diseases].
Kaji M, Tsuru T, Oizumi K. Kaji M, et al. Kansenshogaku Zasshi. 2001 May;75(5):411-5. doi: 10.11150/kansenshogakuzasshi1970.75.411. Kansenshogaku Zasshi. 2001. PMID: 11424491 Clinical Trial. Japanese.
We vaccinated 105 elderly patients with neurological diseases (cerebrovascular disease, Parkinson disease etc.) and 134 people of a control group. Both groups were inoculated with influenza HA vaccine once. ...No severe side effects and adverse reactions were …
We vaccinated 105 elderly patients with neurological diseases (cerebrovascular disease, Parkinson disease etc.) and 134 people of a c …
Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine.
Glaser R, Sheridan J, Malarkey WB, MacCallum RC, Kiecolt-Glaser JK. Glaser R, et al. Psychosom Med. 2000 Nov-Dec;62(6):804-7. doi: 10.1097/00006842-200011000-00010. Psychosom Med. 2000. PMID: 11139000
Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can a …
Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell response …
Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with downregulation of B-lymphocyte GH mRNA.
Wu H, Wang J, Cacioppo JT, Glaser R, Kiecolt-Glaser JK, Malarkey WB. Wu H, et al. J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):M212-5. doi: 10.1093/gerona/54.4.m212. J Gerontol A Biol Sci Med Sci. 1999. PMID: 10219013
METHODS: We studied a population of female caregivers of patients with Alzheimer's dementia (AD) who suffered from the stress of caring for these patients. We utilized quantitative RT-PCR to determine GH mRNA levels in T- and B-cell populations from PBMC. ...CONCLUS …
METHODS: We studied a population of female caregivers of patients with Alzheimer's dementia (AD) who suffered from the stress …
Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination.
Vedhara K, Cox NK, Wilcock GK, Perks P, Hunt M, Anderson S, Lightman SL, Shanks NM. Vedhara K, et al. Lancet. 1999 Feb 20;353(9153):627-31. doi: 10.1016/S0140-6736(98)06098-X. Lancet. 1999. PMID: 10030328
BACKGROUND: There are many reports of psychological morbidity in spousal carers of patients with dementia. The consequences of this increased stress on the immune system are unclear. We investigated whether antibody responses to influenza vaccination differed …
BACKGROUND: There are many reports of psychological morbidity in spousal carers of patients with dementia. The consequences of this i …
Mortality associated with an influenza outbreak on a dementia care unit.
Brandeis GH, Berlowitz DR, Coughlin N. Brandeis GH, et al. Alzheimer Dis Assoc Disord. 1998 Sep;12(3):140-5. doi: 10.1097/00002093-199809000-00004. Alzheimer Dis Assoc Disord. 1998. PMID: 9772015
This retrospective cohort investigation was conducted on a dementia special care unit of a Department of Veterans Affairs facility, with more than 75% of residents clinically diagnosed with dementia of the Alzheimer type. ...Eight autopsies were performed, an …
This retrospective cohort investigation was conducted on a dementia special care unit of a Department of Veterans Affairs facility, w …
Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens.
Nichol KL, Wuorenma J, von Sternberg T. Nichol KL, et al. Arch Intern Med. 1998 Sep 14;158(16):1769-76. doi: 10.1001/archinte.158.16.1769. Arch Intern Med. 1998. PMID: 9738606 Clinical Trial.
Uncertainty about the benefits of influenza vaccination for healthy senior citizens may contribute to lower rates of utilization in this group. ...CONCLUSIONS: This study confirms that healthy senior citizens as well as senior citizens with underlying medical condit …
Uncertainty about the benefits of influenza vaccination for healthy senior citizens may contribute to lower rates of utilizati …
The influence of psychological stress on the immune response to vaccines.
Glaser R, Kiecolt-Glaser JK, Malarkey WB, Sheridan JF. Glaser R, et al. Ann N Y Acad Sci. 1998 May 1;840:649-55. doi: 10.1111/j.1749-6632.1998.tb09603.x. Ann N Y Acad Sci. 1998. PMID: 9629291
We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's disease (AD) patients and matched control subjects. Caregivers showed a poorer antibody response and virus-specific T-cell response followi …
We compared virus-specific antibody and T-cell responses to influenza virus vaccination in 32 caregivers of Alzheimer's …
Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults.
Malarkey WB, Wu H, Cacioppo JT, Malarkey KL, Poehlmann KM, Glaser R, Kiecolt-Glaser JK. Malarkey WB, et al. Endocrine. 1996 Aug;5(1):33-9. doi: 10.1007/BF02738653. Endocrine. 1996. PMID: 21153091
Acute and chronic stress can alter pituitary peptide secretion and might also influence neuroendocrine gene expression in human immune cells. We reasoned that, in Alzheimer caregivers, the chronic stress of caregiving would impact on the sympathetic-adrenal-medullary and h …
Acute and chronic stress can alter pituitary peptide secretion and might also influence neuroendocrine gene expression in human immune cells …
Chronic stress alters the immune response to influenza virus vaccine in older adults.
Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB, Sheridan J. Kiecolt-Glaser JK, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3043-7. doi: 10.1073/pnas.93.7.3043. Proc Natl Acad Sci U S A. 1996. PMID: 8610165 Free PMC article.
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and s …
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune r …
Epidemiology of parkinsonism: incidence, classification, and mortality.
Rajput AH, Offord KP, Beard CM, Kurland LT. Rajput AH, et al. Ann Neurol. 1984 Sep;16(3):278-82. doi: 10.1002/ana.410160303. Ann Neurol. 1984. PMID: 6333204
Incidences calculated for each calendar year (1967 through 1979) revealed no remarkable change following the 1976 swine flu vaccination program. There was no sex difference and the peak incidence occurred between ages 75 and 84 years. Idiopathic Parkinson's d …
Incidences calculated for each calendar year (1967 through 1979) revealed no remarkable change following the 1976 swine flu vaccin …