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2002 1
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2006 4
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2013 2
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2015 8
2016 11
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2018 7
2019 7
2020 9
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Page 1
Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium.
Tentori CA, Zhao LP, Tinterri B, Strange KE, Zoldan K, Dimopoulos K, Feng X, Riva E, Lim B, Simoni Y, Murthy V, Hayes MJ, Poloni A, Padron E, Cardoso BA, Cross M, Winter S, Santaolalla A, Patel BA, Groarke EM, Wiseman DH, Jones K, Jamieson L, Manogaran C, Daver N, Gallur L, Ingram W, Ferrell PB, Sockel K, Dulphy N, Chapuis N, Kubasch AS, Olsnes AM, Kulasekararaj A, De Lavellade H, Kern W, Van Hemelrijck M, Bonnet D, Westers TM, Freeman S, Oelschlaegel U, Valcarcel D, Raddi MG, Grønbæk K, Fontenay M, Loghavi S, Santini V, Almeida AM, Irish JM, Sallman DA, Young NS, van de Loosdrecht AA, Adès L, Della Porta MG, Cargo C, Platzbecker U, Kordasti S; i4MDS consortium. Tentori CA, et al. Among authors: irish jm. Hemasphere. 2024 May 15;8(5):e64. doi: 10.1002/hem3.64. eCollection 2024 May. Hemasphere. 2024. PMID: 38756352 Free PMC article.
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes.
Thirman HL, Hayes MJ, Brown LE, Porco JA Jr, Irish JM. Thirman HL, et al. Among authors: irish jm. bioRxiv [Preprint]. 2024 May 3:2024.05.01.591362. doi: 10.1101/2024.05.01.591362. bioRxiv. 2024. PMID: 38826485 Free PMC article. Preprint.
Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution.
von Lersner AK, Fernandes F, Ozawa PMM, Jackson M, Masureel M, Ho H, Lima SM, Vagner T, Sung BH, Wehbe M, Franze K, Pua H, Wilson JT, Irish JM, Weaver AM, Di Vizio D, Zijlstra A. von Lersner AK, et al. Among authors: irish jm. ACS Nano. 2024 Apr 16;18(15):10464-10484. doi: 10.1021/acsnano.3c11561. Epub 2024 Apr 5. ACS Nano. 2024. PMID: 38578701 Free PMC article.
IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma.
Medina S, Brockman AA, Cross CE, Hayes MJ, Mobley BC, Mistry AM, Chotai S, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. Medina S, et al. Among authors: irish jm. bioRxiv [Preprint]. 2024 Mar 30:2024.03.29.587030. doi: 10.1101/2024.03.29.587030. bioRxiv. 2024. PMID: 38585888 Free PMC article. Preprint.
A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or acute myeloid leukemia refractory to hypomethylating agents.
Bewersdorf JP, Shallis RM, Sharon E, Park S, Ramaswamy R, Roe CE, Irish JM, Caldwell A, Wei W, Yacoub A, Madanat YF, Zeidner JF, Altman JK, Odenike O, Yerrabothala S, Kovacsovics T, Podoltsev NA, Halene S, Little RF, Piekarz R, Gore SD, Kim TK, Zeidan AM. Bewersdorf JP, et al. Among authors: irish jm. Ann Hematol. 2024 Jan;103(1):105-116. doi: 10.1007/s00277-023-05552-4. Epub 2023 Dec 1. Ann Hematol. 2024. PMID: 38036712 Clinical Trial.
Reply to Yasuma et al.
Norlander AE, Abney M, Cephus JY, Roe CE, Irish JM, Shelburne NJ, Newcomb DC, Hemnes AR, Peebles RS Jr. Norlander AE, et al. Among authors: irish jm. Am J Respir Crit Care Med. 2023 Dec 1;208(11):1249-1250. doi: 10.1164/rccm.202309-1622LE. Am J Respir Crit Care Med. 2023. PMID: 37774400 Free PMC article. No abstract available.
Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness.
Senosain MF, Zou Y, Patel K, Zhao S, Coullomb A, Rowe DJ, Lehman JM, Irish JM, Maldonado F, Kammer MN, Pancaldi V, Lopez CF. Senosain MF, et al. Among authors: irish jm. Cancer Res Commun. 2023 Jul 26;3(7):1350-1365. doi: 10.1158/2767-9764.CRC-22-0373. eCollection 2023 Jul. Cancer Res Commun. 2023. PMID: 37501683 Free PMC article.
Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence.
Geben LC, Brockman AA, Chalkley MBL, Sweet SR, Gallagher JE, Scheuing AL, Simerly RB, Ess KC, Irish JM, Ihrie RA. Geben LC, et al. Among authors: irish jm. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528513. doi: 10.1101/2023.02.14.528513. bioRxiv. 2023. PMID: 36824760 Free PMC article. Preprint.
Learning cell identity in immunology, neuroscience, and cancer.
Medina S, Ihrie RA, Irish JM. Medina S, et al. Among authors: irish jm. Semin Immunopathol. 2023 Jan;45(1):3-16. doi: 10.1007/s00281-022-00976-y. Epub 2022 Dec 19. Semin Immunopathol. 2023. PMID: 36534139 Free PMC article. Review.
Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.
Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker LM, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE Jr, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM. Kramer KJ, et al. Among authors: irish jm. Nat Commun. 2022 Jun 16;13(1):3466. doi: 10.1038/s41467-022-31142-5. Nat Commun. 2022. PMID: 35710908 Free PMC article.
Two New Neutrophil Subsets Define a Discriminating Sepsis Signature.
Meghraoui-Kheddar A, Chousterman BG, Guillou N, Barone SM, Granjeaud S, Vallet H, Corneau A, Guessous K, de Roquetaillade C, Boissonnas A, Irish JM, Combadière C. Meghraoui-Kheddar A, et al. Among authors: irish jm. Am J Respir Crit Care Med. 2022 Jan 1;205(1):46-59. doi: 10.1164/rccm.202104-1027OC. Am J Respir Crit Care Med. 2022. PMID: 34731593 Free article.
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant.
Yeh AC, Varelias A, Reddy A, Barone SM, Olver SD, Chilson K, Onstad LE, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman KB, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia MH, Irish JM, Lee SJ, Hill GR. Yeh AC, et al. Among authors: irish jm. Blood. 2021 Dec 30;138(26):2874-2885. doi: 10.1182/blood.2020009492. Blood. 2021. PMID: 34115118 Free PMC article.
Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma.
Le Gallou S, Lhomme F, Irish JM, Mingam A, Pangault C, Monvoisin C, Ferrant J, Azzaoui I, Rossille D, Bouabdallah K, Damaj G, Cartron G, Godmer P, Le Gouill S, Casasnovas RO, Molina TJ, Houot R, Lamy T, Tarte K, Fest T, Roussel M. Le Gallou S, et al. Among authors: irish jm. Front Immunol. 2021 Dec 16;12:755623. doi: 10.3389/fimmu.2021.755623. eCollection 2021. Front Immunol. 2021. PMID: 34975843 Free PMC article.
Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation.
Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB Jr, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR. Ramsey HE, et al. Among authors: irish jm. Target Oncol. 2021 Sep;16(5):663-674. doi: 10.1007/s11523-021-00830-5. Epub 2021 Jul 29. Target Oncol. 2021. PMID: 34324169 Free PMC article.
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS Jr, Irish JM, Newcomb DC, Rathmell JC. Healey DCC, et al. Among authors: irish jm. J Immunol. 2021 Mar 15;206(6):1127-1139. doi: 10.4049/jimmunol.2001029. Epub 2021 Feb 8. J Immunol. 2021. PMID: 33558372 Free PMC article.
A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research.
Chattopadhyay PK, Filby A, Jellison ER, Ferrari G, Green C, Cherian S, Irish J, Litwin V; other members of the ISAC COVID-19 Work Group. Chattopadhyay PK, et al. Among authors: irish j. Cytometry A. 2021 Jan;99(1):11-18. doi: 10.1002/cyto.a.24210. Epub 2020 Sep 8. Cytometry A. 2021. PMID: 32881296 Free PMC article. Review.
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.
Barone SM, Paul AGA, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM. Barone SM, et al. Among authors: irish jm. bioRxiv [Preprint]. 2020 Nov 4:2020.07.31.190454. doi: 10.1101/2020.07.31.190454. bioRxiv. 2020. Update in: Elife. 2021 Aug 05;10:e64653. doi: 10.7554/eLife.64653 PMID: 32766581 Free PMC article. Updated. Preprint.
CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation.
Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC. Beckermann KE, et al. Among authors: irish jm. JCI Insight. 2020 Aug 20;5(16):e138729. doi: 10.1172/jci.insight.138729. JCI Insight. 2020. PMID: 32814710 Free PMC article.
Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction.
Lim SP, Costantini B, Mian SA, Perez Abellan P, Gandhi S, Martinez Llordella M, Lozano JJ, Antunes Dos Reis R, Povoleri GAM, Mourikis TP, Abarrategi A, Ariza-McNaughton L, Heck S, Irish JM, Lombardi G, Marsh JCW, Bonnet D, Kordasti S, Mufti GJ. Lim SP, et al. Among authors: irish jm. Blood. 2020 Aug 13;136(7):885-897. doi: 10.1182/blood.2019001347. Blood. 2020. PMID: 32294156 Free PMC article.
Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells.
Leelatian N, Sinnaeve J, Mistry AM, Barone SM, Brockman AA, Diggins KE, Greenplate AR, Weaver KD, Thompson RC, Chambless LB, Mobley BC, Ihrie RA, Irish JM. Leelatian N, et al. Among authors: irish jm. Elife. 2020 Jun 23;9:e56879. doi: 10.7554/eLife.56879. Elife. 2020. PMID: 32573435 Free PMC article.
Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2019 Conference Workshops.
Czechowska K, Lannigan J, Aghaeepour N, Back JB, Begum J, Behbehani G, Bispo C, Bitoun D, Fernández AB, Boova ST, Brinkman RR, Ciccolella CO, Cotleur B, Davies D, Dela Cruz GV, Del Rio-Guerra R, Des Lauriers-Cox AM, Douagi I, Dumrese C, Bonilla Escobar DL, Estevam J, Ewald C, Fossum A, Gaudillière B, Green C, Groves C, Hall C, Haque Y, Hedrick MN, Hogg K, Hsieh EWY, Irish J, Lederer J, Leipold M, Lewis-Tuffin LJ, Litwin V, Lopez P, Nasdala I, Nedbal J, Ohlsson-Wilhelm BM, Price KM, Rahman AH, Rayanki R, Rieger AM, Robinson JP, Shapiro H, Sun YS, Tang VA, Tesfa L, Telford WG, Walker R, Welsh JA, Wheeler P, Tárnok A. Czechowska K, et al. Among authors: irish j. Cytometry A. 2019 Dec;95(12):1236-1274. doi: 10.1002/cyto.a.23941. Cytometry A. 2019. PMID: 31833655 Free article. No abstract available.
Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types.
Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM. Greenplate AR, et al. Among authors: irish jm. Cancer Immunol Res. 2019 Jan;7(1):86-99. doi: 10.1158/2326-6066.CIR-17-0692. Epub 2018 Nov 9. Cancer Immunol Res. 2019. PMID: 30413431 Free PMC article.
Machine learning reveals chronic graft-versus-host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies.
Gandelman JS, Byrne MT, Mistry AM, Polikowsky HG, Diggins KE, Chen H, Lee SJ, Arora M, Cutler C, Flowers M, Pidala J, Irish JM, Jagasia MH. Gandelman JS, et al. Among authors: irish jm. Haematologica. 2019 Jan;104(1):189-196. doi: 10.3324/haematol.2018.193441. Epub 2018 Sep 20. Haematologica. 2019. PMID: 30237265 Free PMC article. Clinical Trial.
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling.
Josefsson SE, Huse K, Kolstad A, Beiske K, Pende D, Steen CB, Inderberg EM, Lingjærde OC, Østenstad B, Smeland EB, Levy R, Irish JM, Myklebust JH. Josefsson SE, et al. Among authors: irish jm. Clin Cancer Res. 2018 Feb 15;24(4):870-881. doi: 10.1158/1078-0432.CCR-17-2337. Epub 2017 Dec 7. Clin Cancer Res. 2018. PMID: 29217528 Free PMC article.
Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies.
Greenplate A, Wang K, Tripathi RM, Palma N, Ali SM, Stephens PJ, Miller VA, Shyr Y, Guo Y, Reddy NM, Kozhaya L, Unutmaz D, Chen X, Irish JM, Davé UP. Greenplate A, et al. Among authors: irish jm. JCO Precis Oncol. 2018;2018:PO.17.00019. doi: 10.1200/PO.17.00019. Epub 2018 Feb 13. JCO Precis Oncol. 2018. PMID: 30079384 Free PMC article.
Regulatory myeloid cells: an underexplored continent in B-cell lymphomas.
Roussel M, Irish JM, Menard C, Lhomme F, Tarte K, Fest T. Roussel M, et al. Among authors: irish jm. Cancer Immunol Immunother. 2017 Aug;66(8):1103-1111. doi: 10.1007/s00262-017-2036-5. Epub 2017 Jul 8. Cancer Immunol Immunother. 2017. PMID: 28689360 Free PMC article. Review.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Siska PJ, et al. Among authors: irish jm. JCI Insight. 2017 Jun 15;2(12):e93411. doi: 10.1172/jci.insight.93411. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614802 Free PMC article.
Characterizing cell subsets using marker enrichment modeling.
Diggins KE, Greenplate AR, Leelatian N, Wogsland CE, Irish JM. Diggins KE, et al. Among authors: irish jm. Nat Methods. 2017 Mar;14(3):275-278. doi: 10.1038/nmeth.4149. Epub 2017 Jan 30. Nat Methods. 2017. PMID: 28135256 Free PMC article.
Single cell analysis of human tissues and solid tumors with mass cytometry.
Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM. Leelatian N, et al. Among authors: irish jm. Cytometry B Clin Cytom. 2017 Jan;92(1):68-78. doi: 10.1002/cyto.b.21481. Epub 2016 Oct 4. Cytometry B Clin Cytom. 2017. PMID: 27598832 Free PMC article.
Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.
Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ. Kordasti S, et al. Among authors: irish jm. Blood. 2016 Sep 1;128(9):1193-205. doi: 10.1182/blood-2016-03-703702. Epub 2016 Jun 8. Blood. 2016. PMID: 27281795 Free PMC article. Clinical Trial.
Systems immune monitoring in cancer therapy.
Greenplate AR, Johnson DB, Ferrell PB Jr, Irish JM. Greenplate AR, et al. Among authors: irish jm. Eur J Cancer. 2016 Jul;61:77-84. doi: 10.1016/j.ejca.2016.03.085. Epub 2016 May 4. Eur J Cancer. 2016. PMID: 27155446 Free PMC article. Review.
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.
Johnson DB, Estrada MV, Salgado R, Sanchez V, Doxie DB, Opalenik SR, Vilgelm AE, Feld E, Johnson AS, Greenplate AR, Sanders ME, Lovly CM, Frederick DT, Kelley MC, Richmond A, Irish JM, Shyr Y, Sullivan RJ, Puzanov I, Sosman JA, Balko JM. Johnson DB, et al. Among authors: irish jm. Nat Commun. 2016 Jan 29;7:10582. doi: 10.1038/ncomms10582. Nat Commun. 2016. PMID: 26822383 Free PMC article.
NetworkPainter: dynamic intracellular pathway animation in Cytobank.
Karr JR, Guturu H, Chen EY, Blair SL, Irish JM, Kotecha N, Covert MW. Karr JR, et al. Among authors: irish jm. BMC Bioinformatics. 2015 May 25;16:172. doi: 10.1186/s12859-015-0602-4. BMC Bioinformatics. 2015. PMID: 26003204 Free PMC article.
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Green MR, Kihira S, Liu CL, Nair RV, Salari R, Gentles AJ, Irish J, Stehr H, Vicente-Dueñas C, Romero-Camarero I, Sanchez-Garcia I, Plevritis SK, Arber DA, Batzoglou S, Levy R, Alizadeh AA. Green MR, et al. Among authors: irish j. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1116-25. doi: 10.1073/pnas.1501199112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713363 Free PMC article.
Beyond the age of cellular discovery.
Irish JM. Irish JM. Nat Immunol. 2014 Dec;15(12):1095-7. doi: 10.1038/ni.3034. Nat Immunol. 2014. PMID: 25396342
High-dimensional single-cell cancer biology.
Irish JM, Doxie DB. Irish JM, et al. Curr Top Microbiol Immunol. 2014;377:1-21. doi: 10.1007/82_2014_367. Curr Top Microbiol Immunol. 2014. PMID: 24671264 Free PMC article. Review.
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.
Myklebust JH, Irish JM, Brody J, Czerwinski DK, Houot R, Kohrt HE, Timmerman J, Said J, Green MR, Delabie J, Kolstad A, Alizadeh AA, Levy R. Myklebust JH, et al. Among authors: irish jm. Blood. 2013 Feb 21;121(8):1367-76. doi: 10.1182/blood-2012-04-421826. Epub 2013 Jan 7. Blood. 2013. PMID: 23297127 Free PMC article.
WebFlow: a software package for high-throughput analysis of flow cytometry data.
Hammer MM, Kotecha N, Irish JM, Nolan GP, Krutzik PO. Hammer MM, et al. Among authors: irish jm. Assay Drug Dev Technol. 2009 Feb;7(1):44-55. doi: 10.1089/adt.2008.174. Assay Drug Dev Technol. 2009. PMID: 19187010 Free PMC article.
However, these experiments generate thousands of data points per sample, each with multiple measured parameters, leading to data management and analysis challenges. We developed WebFlow (http://webflow.stanford.edu), a web server-based software package to manage, analyze, …
However, these experiments generate thousands of data points per sample, each with multiple measured parameters, leading to data management …