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Year Number of Results
2016 2
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34 results

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Page 1
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1.
Booth C, Sevilla J, Almarza E, Kuo CY, Zubicaray J, Terrazas D, O'Toole G, Chitty-Lopez M, Choi G, Nicoletti E, Long-Boyle J, Fernandes A, Chetty K, De Oliveira S, Banuelos C, Xu-Bayford J, Bastone AL, John-Neek P, Jackson C, Moore TB, Gilmour K, Schambach A, Rothe M, Kasbekar S, Rao GR, Patel K, Shah G, Thrasher AJ, Bueren JA, Schwartz JD, Kohn DB. Booth C, et al. N Engl J Med. 2025 May 1;392(17):1698-1709. doi: 10.1056/NEJMoa2407376. N Engl J Med. 2025. PMID: 40305711 Clinical Trial.
Premature Loss of Deciduous Teeth as a Symptom of Systemic Disease: A Narrative Literature Review.
Spodzieja K, Olczak-Kowalczyk D. Spodzieja K, et al. Int J Environ Res Public Health. 2022 Mar 13;19(6):3386. doi: 10.3390/ijerph19063386. Int J Environ Res Public Health. 2022. PMID: 35329073 Free PMC article. Review.
RESULTS: In this study, 16 systemic diseases were linked to premature primary tooth loss in children: Papillon-Lefevre syndrome, mucocutaneous dyskeratosis, Coffin-Lowry syndrome, congenital adrenal hyperplasia, Langerhans cell histiocytosis, cherubism, hypophosphatasia, acatalas …
RESULTS: In this study, 16 systemic diseases were linked to premature primary tooth loss in children: Papillon-Lefevre syndrome, mucocutaneo …
Clinical and immunological characteristics of 69 leukocyte adhesion deficiency-I patients.
Fazlollahi MR, Hamidieh AA, Moradi L, Shokouhi Shoormati R, Sabetkish N, Esmaeili B, Badalzadeh M, Alizadeh Z, Shamlou S, Movahedi M, Mahloujirad M, Razaghian A, Arshi S, Gharagozlou M, Kalantari A, Bemanian MH, Safari M, Heidarzadeh Arani M, Nabavi M, Parvaneh N, Sadeghi-Shabestari M, Behfar M, Behniafard N, Sherkat R, Ahmadian Heris J, Shariat M, Radmehr R, Houshmand M, Kazemnejad A, Molitor A, Carapito R, Bahram S, Pourpak Z, Moin M. Fazlollahi MR, et al. Pediatr Allergy Immunol. 2023 Jul;34(7):e13990. doi: 10.1111/pai.13990. Pediatr Allergy Immunol. 2023. PMID: 37492921
Pediatric pyoderma gangrenosum associated with leukocyte adhesion deficiency type 1: A case report and review of the literature.
Smith KN, Welborn M, Monir RL, Motaparthi K, Schoch JJ. Smith KN, et al. Pediatr Dermatol. 2023 Nov-Dec;40(6):1086-1090. doi: 10.1111/pde.15292. Epub 2023 Mar 31. Pediatr Dermatol. 2023. PMID: 37002583 Review.
We report a unique case of pediatric pyoderma gangrenosum with a leukemoid reaction, secondary to an autosomal recessive leukocyte adhesion deficiency type 1....
We report a unique case of pediatric pyoderma gangrenosum with a leukemoid reaction, secondary to an autosomal recessive leukocyte …
Preclinical Evaluation of Foamy Virus Vector-Mediated Gene Addition in Human Hematopoietic Stem/Progenitor Cells for Correction of Leukocyte Adhesion Deficiency Type 1.
Smith RH, Bloomer H, Fink D, Keyvanfar K, Nasimuzzaman M, Sancheznieto F, Dutta R, Guenther Bui K, Alvarado LJ, Bauer TR Jr, Hickstein DD, Russell DW, Malik P, van der Loo JCM, Highfill SL, Kuhns DB, Pirooznia M, Larochelle A. Smith RH, et al. Hum Gene Ther. 2022 Dec;33(23-24):1293-1304. doi: 10.1089/hum.2022.065. Epub 2022 Nov 1. Hum Gene Ther. 2022. PMID: 36094106 Free PMC article.
We provide the first pre-clinical evidence of the therapeutic utility of a foamy virus vector (FVV) for the genetic correction of human leukocyte adhesion deficiency type 1 (LAD-1), an inherited primary immunodeficiency resulting from mutation o …
We provide the first pre-clinical evidence of the therapeutic utility of a foamy virus vector (FVV) for the genetic correction of human l …
Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey.
Yaz I, Ozbek B, Bildik HN, Tan C, Oskay Halacli S, Soyak Aytekin E, Esenboga S, Cekic S, Kilic SS, Keskin O, van Leeuwen K, Roos D, Cagdas D, Tezcan I. Yaz I, et al. Clin Exp Immunol. 2021 Oct;206(1):47-55. doi: 10.1111/cei.13645. Epub 2021 Aug 5. Clin Exp Immunol. 2021. PMID: 34310689 Free PMC article. Clinical Trial.
We present clinical and immunological features of 15 patients with leukocyte adhesion deficiency type 1 (LAD-1). Targeted next-generation sequencing was performed with either a primary immunodeficiency gene panel comprising 266 genes or a small …
We present clinical and immunological features of 15 patients with leukocyte adhesion deficiency type 1 ( …
The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells-Lessons Learned from Different Transgenic Mouse Models.
Klaus T, Wilson A, Fichter M, Bros M, Bopp T, Grabbe S. Klaus T, et al. Int J Mol Sci. 2023 Mar 28;24(7):6331. doi: 10.3390/ijms24076331. Int J Mol Sci. 2023. PMID: 37047302 Free PMC article. Review.
In humans, loss-of-function mutations in the common subunit CD18 result in leukocyte adhesion deficiency type-1 (LAD-1). Clinical symptoms vary depending on the extent of residual beta(2)-integrin function, and patients may experience leukocytos …
In humans, loss-of-function mutations in the common subunit CD18 result in leukocyte adhesion deficiency type- …
Mutation characterization and heterodimer analysis of patients with leukocyte adhesion deficiency: Including one novel mutation.
Teimourian S, De Boer M, Roos D, Isaian A, Moghanloo E, Lashkary S, Hassani B, Mollanoori H, Babaei V, Azarnezhad A. Teimourian S, et al. Immunol Lett. 2017 Jul;187:7-13. doi: 10.1016/j.imlet.2017.04.012. Epub 2017 Apr 23. Immunol Lett. 2017. PMID: 28445705
BACKGROUND AND AIM: Leukocyte adhesion deficiency type 1 (LAD-I) is a rare, autosomal recessive disorder of neutrophil migration, characterized by severe, recurrent bacterial infections, inadequate pus formation and impaired wound healing. ...
BACKGROUND AND AIM: Leukocyte adhesion deficiency type 1 (LAD-I) is a rare, autosomal recessive disorder …
Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1.
Levy-Mendelovich S, Rechavi E, Abuzaitoun O, Vernitsky H, Simon AJ, Lev A, Somech R. Levy-Mendelovich S, et al. Immunol Res. 2016 Apr;64(2):476-82. doi: 10.1007/s12026-015-8706-5. Immunol Res. 2016. PMID: 26434744
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive primary immunodeficiency, hallmarked by defective polymorphonuclear transmigration. ...
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive primary immunodeficiency, hallmark …
34 results