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2024 7
2025 182
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219 results

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Page 1
Early-Onset Gastrointestinal Cancers: A Review.
Jayakrishnan T, Ng K. Jayakrishnan T, et al. JAMA. 2025 Oct 21;334(15):1373-1385. doi: 10.1001/jama.2025.10218. JAMA. 2025. PMID: 40674064 Review.
Nonmodifiable risk factors include family history, hereditary syndromes (eg, Lynch syndrome), and inflammatory bowel disease for patients with early-onset CRC. Approximately 15% to 30% of early-onset GI cancers have pathogenic germline variants in genes such as DNA …
Nonmodifiable risk factors include family history, hereditary syndromes (eg, Lynch syndrome), and inflammatory bowel disease f …
Epidemiology, pathogenesis, biology and evolving management of MSI-H/dMMR cancers.
Ambrosini M, Manca P, Nasca V, Sciortino C, Ghelardi F, Seligmann JF, Taieb J, Pietrantonio F. Ambrosini M, et al. Nat Rev Clin Oncol. 2025 Jun;22(6):385-407. doi: 10.1038/s41571-025-01015-z. Epub 2025 Apr 3. Nat Rev Clin Oncol. 2025. PMID: 40181086 Review.
In a minority of patients, MSI-H/dMMR cancers result from an inherited pathogenic variant in the context of Lynch syndrome, which has important implications for familial genetic screening. Whether these hereditary cancers have a different biology and clinical behavi …
In a minority of patients, MSI-H/dMMR cancers result from an inherited pathogenic variant in the context of Lynch syndrome, wh …
Therapeutic targeting of mismatch repair-deficient cancers.
Johannet P, Rousseau B, Aghajanian C, Foote MB, Diaz LA Jr. Johannet P, et al. Nat Rev Clin Oncol. 2025 Oct;22(10):734-759. doi: 10.1038/s41571-025-01054-6. Epub 2025 Jul 10. Nat Rev Clin Oncol. 2025. PMID: 40640471 Review.
MMRd is associated with hereditary cancer syndromes such as Lynch syndrome and constitutional MMRd as well as with sporadic tumour development across a variety of tissues. ...
MMRd is associated with hereditary cancer syndromes such as Lynch syndrome and constitutional MMRd as well as with sporadic tu …
Comprehensive genetic and epigenetic characterization of Lynch-like syndrome patients.
Pirini F, Calzari L, Tedaldi G, Tebaldi M, Zampiga V, Cangini I, Danesi R, Ravegnani M, Arcangeli V, Passardi A, Petracci E, Bravaccini S, Marisi G, Viel A, Barana D, Pedroni M, Roncucci L, Calistri D, Gentilini D. Pirini F, et al. Int J Cancer. 2025 Aug 15;157(4):788-799. doi: 10.1002/ijc.35451. Epub 2025 Apr 21. Int J Cancer. 2025. PMID: 40259440 Free PMC article.
Lynch-like syndrome (LLS) presents very similar clinicopathological characteristics to Lynch syndrome (LS) but the mechanism for cancer predisposition remains unknown. The present study aims to investigate the causal mechanism of LLS by a comprehensive genetic and e …
Lynch-like syndrome (LLS) presents very similar clinicopathological characteristics to Lynch syndrome (LS) but the mechanism f …
Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategies.
Gómez-Molina R, Martínez R, Suárez M, Peña-Cabia A, Calderón MC, Mateo J. Gómez-Molina R, et al. Oncol Res. 2025 Jun 26;33(7):1531-1545. doi: 10.32604/or.2025.063951. eCollection 2025. Oncol Res. 2025. PMID: 40612862 Free PMC article. Review.
Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated with a higher risk of colorectal cancer (CRC) and other cancers. ...
Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated wi …
Gene-Specific Detection Rate of Adenomas and Advanced Adenomas in Lynch Syndrome.
Sánchez A, Castillo-Iturra J, Roos VH, Dueñas N, Pineda M, Moreno L, Rodríguez-Alonso L, Ramon Y Cajal T, Llort G, Piñol V, Lopez Fernandez A, Salces I, Picó MD, Rivas L, Bujanda L, Garzon M, Pizarro A, Martinez de Castro E, Lopez-Arias MJ, Poves C, Garau C, Rodriguez-Alcalde D, Herraiz M, Alvarez-Urrutia C, Dacal A, Carrillo-Palau M, Cid L, Ponce M, Barreiro-Alonso E, Saperas E, Aguirre E, Bastiaansen B, Ocaña T, Carballal S, Rivero-Sanchez L, Ortiz O, Daca-Alvarez M, Prat-Galito R, Bessa X, Cubiella J, Jover R, Rodríguez-Moranta F, Balmaña J, Brunet J, Castells A, Capellá G, Ladabaum U, Dekker E, Moreira L, Pellisé M, Balaguer F. Sánchez A, et al. Gastroenterology. 2025 Sep;169(4):663-675. doi: 10.1053/j.gastro.2025.03.042. Epub 2025 Apr 30. Gastroenterology. 2025. PMID: 40315961
BACKGROUND & AIMS: Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting and removing adenomas. The existence of gene-specific differences in adenoma detection has been proposed yet remains insufficiently explore …
BACKGROUND & AIMS: Colonoscopy is expected to reduce colorectal cancer (CRC) incidence in Lynch syndrome (LS) by detecting …
Uveal Melanoma and the Lynch Syndrome Tumor Spectrum.
Le Ven A, Villy MC, Silveira AB, Houy A, Masliah-Planchon J, Warcoin M, Le Mentec M, Simaga F, De Pauw A, Buecher B, Gauthier-Villars M, Verrier T, Merchadou K, Renault V, Vincent-Salomon A, Sauge J, El Zein S, Dubois d'Enghien C, Piperno-Neumann S, Matet A, Malaise D, Cassoux N, Lumbroso-Le Rouic L, Stoppa-Lyonnet D, Stern MH, Rodrigues M, Golmard L, Colas C. Le Ven A, et al. JAMA Ophthalmol. 2025 Aug 1;143(8):661-668. doi: 10.1001/jamaophthalmol.2025.1779. JAMA Ophthalmol. 2025. PMID: 40531527
Among them, 21 were found in clinically relevant genes, with an enrichment in the mismatch repair (MMR) genes, involved in Lynch syndrome, a frequent predisposition to colon and endometrial cancers. This finding suggested MMR germline PVs could also predispose to UM …
Among them, 21 were found in clinically relevant genes, with an enrichment in the mismatch repair (MMR) genes, involved in Lynch s …
219 results