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2016 1
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2024 10

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Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model.
Yang R, Wang X, Zheng W, Chen W, Gan W, Qin X, Huang J, Chen X, Zhou S. Yang R, et al. Int Wound J. 2023 Sep;20(7):2700-2717. doi: 10.1111/iwj.14144. Epub 2023 Mar 10. Int Wound J. 2023. PMID: 36896881 Free PMC article.
We constructed the m6A landscape and verified the corresponding genes using immunohistochemistry. ...PPI analysis elucidated six genes with significant differences between the two keloid sample groups. ...
We constructed the m6A landscape and verified the corresponding genes using immunohistochemistry. ...PPI analysis elucidated s …
Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury.
Liu B, Ao S, Tan F, Ma W, Liu H, Liang H, Yang X, Chi X. Liu B, et al. Ann Transl Med. 2022 Jul;10(13):737. doi: 10.21037/atm-22-845. Ann Transl Med. 2022. PMID: 35957725 Free PMC article.
The interaction network, targeted microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) of hub genes were predicted, and the critical miRNA-hub gene regulatory axis was verified using qPCR, Western blotting, malondialdehyde (MDA) determination and flow cytometry. Correlation analy …
The interaction network, targeted microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) of hub genes were predicted, and the critical miRNA-h …
Pulsatile Flow Increases METTL14-induced m6A modification and attenuates septic cardiomyopathy: an experimental study.
Zhu S, Wang K, Yu Z, Tang W, Zhang Y, Umar Shinge SA, Qiang Y, Liu H, Zeng J, Qiao K, Liu C, Li G. Zhu S, et al. Int J Surg. 2024 Mar 28;110(7):4103-15. doi: 10.1097/JS9.0000000000001402. Online ahead of print. Int J Surg. 2024. PMID: 38549224 Free PMC article.
Dot blot assay was applied to examine the m6A level, while qRT-PCR, Western blot, immunofluorescence, and immunohistochemistry were used to measure the expressions of related genes. ...The pulsatile flow mediates the METTL14-mediated m6A modification to zonula occlu …
Dot blot assay was applied to examine the m6A level, while qRT-PCR, Western blot, immunofluorescence, and immunohistochemistry were u …
FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes.
Zhang SY, Zhang SW, Fan XN, Zhang T, Meng J, Huang Y. Zhang SY, et al. Bioinformatics. 2019 Jul 15;35(14):i90-i98. doi: 10.1093/bioinformatics/btz316. Bioinformatics. 2019. PMID: 31510685 Free PMC article.
FunDMDeep-m6A includes, at the first step, DMDeep-m6A a novel method based on a deep learning model and a statistical test for identifying differential m6A methylation (DmM) sites from MeRIP-Seq data at a single-base resolution. ...These results demonstrate t …
FunDMDeep-m6A includes, at the first step, DMDeep-m6A a novel method based on a deep learning model and a statistical test for …
Construction of ceRNA and m6A-related lncRNA networks associated with anti-inflammation of AdipoAI.
Yu H, Wu H, Xie Q, Liu Z, Chen Z, Tu Q, Chen J, Fang F, Qiu W. Yu H, et al. Front Immunol. 2023 Jan 10;13:1051654. doi: 10.3389/fimmu.2022.1051654. eCollection 2022. Front Immunol. 2023. PMID: 36703959 Free PMC article.
Enrichment analyses were conducted on total mRNAs and DEmRNAs, including GSVA, ssGSEA, GO/KEGG, GSEA, and PPI analysis. Among all these processes, endocytosis was significantly enriched. ...Then, using TargetScan and miRwalk to predict related microRNAs of DElncRNAs and DE …
Enrichment analyses were conducted on total mRNAs and DEmRNAs, including GSVA, ssGSEA, GO/KEGG, GSEA, and PPI analysis. Among all the …
The m6A/m1A/m5C-Related Methylation Modification Patterns and Immune Landscapes in Rheumatoid Arthritis and Osteoarthritis Revealed by Microarray and Single-Cell Transcriptome.
Zheng H, Aihaiti Y, Cai Y, Yuan Q, Yang M, Li Z, Xu K, Xu P. Zheng H, et al. J Inflamm Res. 2023 Nov 1;16:5001-5025. doi: 10.2147/JIR.S431076. eCollection 2023. J Inflamm Res. 2023. PMID: 37933335 Free PMC article.
Through WGCNA analysis, genes associated with cell pyroptosis or autophagy in OA and RA were identified, which were then combined with differentially expressed RNA modification-related genes to construct a PPI interaction network. Furthermore, hub genes were selected for c …
Through WGCNA analysis, genes associated with cell pyroptosis or autophagy in OA and RA were identified, which were then combined with diffe …
Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis.
Zou J, Li Y, Liao N, Liu J, Zhang Q, Luo M, Xiao J, Chen Y, Wang M, Chen K, Zeng J, Mo Z. Zou J, et al. J Ovarian Res. 2022 Feb 28;15(1):30. doi: 10.1186/s13048-022-00962-w. J Ovarian Res. 2022. PMID: 35227296 Free PMC article.
MATERIALS AND METHODS: Multiple bioinformatic analyses, such as differential expression analysis, univariate Cox analysis, functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction, survival analysis, and immune infiltration analysi …
MATERIALS AND METHODS: Multiple bioinformatic analyses, such as differential expression analysis, univariate Cox analysis, functional and pa …
Expression and prognostic significance of m6A-related genes in TP53-mutant non-small-cell lung cancer.
Zhao Z, Wan J, Guo M, Wang Y, Yang Z, Zhou F, Li Z, Ming L. Zhao Z, et al. J Clin Lab Anal. 2022 Jan;36(1):e24118. doi: 10.1002/jcla.24118. Epub 2021 Nov 23. J Clin Lab Anal. 2022. PMID: 34812534 Free PMC article.
Finally, 338 differentially expression genes (DEGs) were found between high- and low-risk groups. GO enrichment analysis, PPI network, and GSEA enrichment analysis showed that m6A may affect the immune environment in extracellular and change the stability of mRNA. C …
Finally, 338 differentially expression genes (DEGs) were found between high- and low-risk groups. GO enrichment analysis, PPI network …
Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4.
Chen CJ, Huang JY, Huang JQ, Deng JY, Shangguan XH, Chen AZ, Chen LT, Wu WH. Chen CJ, et al. Cell Cycle. 2023 Apr;22(8):986-1004. doi: 10.1080/15384101.2023.2170521. Epub 2023 Feb 10. Cell Cycle. 2023. PMID: 36762777 Free PMC article.
Subsequently, the string database and Cytoscape software were applied to construct protein-protein interaction (PPI) and DEM hub gene networks. Bioinformatics analysis and MeRIP were applied to predict and test METTL3-mediated m6A levels on mRNA of THRAP3, RBM25, an …
Subsequently, the string database and Cytoscape software were applied to construct protein-protein interaction (PPI) and DEM hub gene …
Identifying Prognostic Biomarkers Related to m6A Modification and Immune Infiltration in Renal Cell Carcinoma.
Ye J, Li P, Zhang H, Wu Q, Yang D. Ye J, et al. Genes (Basel). 2022 Nov 7;13(11):2059. doi: 10.3390/genes13112059. Genes (Basel). 2022. PMID: 36360294 Free PMC article.
METHODS: We identified hub genes through multi-dimensional screening, including DEGs, PPI analysis, LASSO regression, and random forest. Meanwhile, GO/KEGG enrichment, cMAP analysis, prognostic analysis, m6A prediction, and immune infiltration analysis were performe …
METHODS: We identified hub genes through multi-dimensional screening, including DEGs, PPI analysis, LASSO regression, and random fore …
79 results