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Page 1
The m6A/m1A/m5C-Related Methylation Modification Patterns and Immune Landscapes in Rheumatoid Arthritis and Osteoarthritis Revealed by Microarray and Single-Cell Transcriptome.
Zheng H, Aihaiti Y, Cai Y, Yuan Q, Yang M, Li Z, Xu K, Xu P. Zheng H, et al. J Inflamm Res. 2023 Nov 1;16:5001-5025. doi: 10.2147/JIR.S431076. eCollection 2023. J Inflamm Res. 2023. PMID: 37933335 Free PMC article.
Through WGCNA analysis, genes associated with cell pyroptosis or autophagy in OA and RA were identified, which were then combined with differentially expressed RNA modification-related genes to construct a PPI interaction network. Furthermore, hub genes were selected for c …
Through WGCNA analysis, genes associated with cell pyroptosis or autophagy in OA and RA were identified, which were then combined with diffe …
Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury.
Liu B, Ao S, Tan F, Ma W, Liu H, Liang H, Yang X, Chi X. Liu B, et al. Ann Transl Med. 2022 Jul;10(13):737. doi: 10.21037/atm-22-845. Ann Transl Med. 2022. PMID: 35957725 Free PMC article.
Correlation analyses of N6-adenosine methylation (m6A) RNA methylation regulators and hub genes and m6A modification analysis were performed. ...The mmu-miR-7212-5p-Hmox1 axis in ferroptosis and m6A RNA methylation regulators may have potential clinical signi …
Correlation analyses of N6-adenosine methylation (m6A) RNA methylation regulators and hub genes and m6A modification analysis …
Identification of hub biomarkers and exploring the roles of immunity, M6A, ferroptosis, or cuproptosis in rats with diabetic erectile dysfunction.
Wang Y, Zhang X, Chen Y, Zhu B, Xing Q. Wang Y, et al. Andrology. 2023 Feb;11(2):316-331. doi: 10.1111/andr.13265. Epub 2022 Aug 24. Andrology. 2023. PMID: 35975587 Free article.
The top 20 genes were selected based on the connectivity degrees in protein-protein interaction (PPI) network. Functional enrichment analysis was utilized to reveal DMED-related signaling pathways. ...Actually, DMED was markedly associated with m6A regulators and fe …
The top 20 genes were selected based on the connectivity degrees in protein-protein interaction (PPI) network. Functional enrichment …
Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4.
Chen CJ, Huang JY, Huang JQ, Deng JY, Shangguan XH, Chen AZ, Chen LT, Wu WH. Chen CJ, et al. Cell Cycle. 2023 Apr;22(8):986-1004. doi: 10.1080/15384101.2023.2170521. Epub 2023 Feb 10. Cell Cycle. 2023. PMID: 36762777 Free PMC article.
Subsequently, the string database and Cytoscape software were applied to construct protein-protein interaction (PPI) and DEM hub gene networks. Bioinformatics analysis and MeRIP were applied to predict and test METTL3-mediated m6A levels on mRNA of THRAP3, RBM25, an …
Subsequently, the string database and Cytoscape software were applied to construct protein-protein interaction (PPI) and DEM hub gene …
Construction of ceRNA and m6A-related lncRNA networks associated with anti-inflammation of AdipoAI.
Yu H, Wu H, Xie Q, Liu Z, Chen Z, Tu Q, Chen J, Fang F, Qiu W. Yu H, et al. Front Immunol. 2023 Jan 10;13:1051654. doi: 10.3389/fimmu.2022.1051654. eCollection 2022. Front Immunol. 2023. PMID: 36703959 Free PMC article.
Enrichment analyses were conducted on total mRNAs and DEmRNAs, including GSVA, ssGSEA, GO/KEGG, GSEA, and PPI analysis. Among all these processes, endocytosis was significantly enriched. A coexpression analysis was built based on DElncRNAs and DEmRNAs. Then, using TargetSc …
Enrichment analyses were conducted on total mRNAs and DEmRNAs, including GSVA, ssGSEA, GO/KEGG, GSEA, and PPI analysis. Among all the …
FunDMDeep-m6A: identification and prioritization of functional differential m6A methylation genes.
Zhang SY, Zhang SW, Fan XN, Zhang T, Meng J, Huang Y. Zhang SY, et al. Bioinformatics. 2019 Jul 15;35(14):i90-i98. doi: 10.1093/bioinformatics/btz316. Bioinformatics. 2019. PMID: 31510685 Free PMC article.
FunDMDeep-m6A includes, at the first step, DMDeep-m6A a novel method based on a deep learning model and a statistical test for identifying differential m6A methylation (DmM) sites from MeRIP-Seq data at a single-base resolution. ...These results demonstrate t …
FunDMDeep-m6A includes, at the first step, DMDeep-m6A a novel method based on a deep learning model and a statistical test for …
A comprehensive analysis of m6A/m7G/m5C/m1A-related gene expression and immune infiltration in liver ischemia-reperfusion injury by integrating bioinformatics and machine learning algorithms.
Meng Z, Li X, Lu S, Hua Y, Yin B, Qian B, Li Z, Zhou Y, Sergeeva I, Fu Y, Ma Y. Meng Z, et al. Eur J Med Res. 2024 Jun 13;29(1):326. doi: 10.1186/s40001-024-01928-y. Eur J Med Res. 2024. PMID: 38867322 Free PMC article.
Differentially expressed methylation-related genes (DEMRGs) were identified by overlapping DEG sets and 65 genes related to N6-methyladenosine (m6A), 7-methylguanine (m7G), 5-methylcytosine (m5C), and N1-methyladenosine (m1A). To evaluate the relationship between DEMRGs, a …
Differentially expressed methylation-related genes (DEMRGs) were identified by overlapping DEG sets and 65 genes related to N6-methyladenosi …
Expression and prognostic significance of m6A-related genes in TP53-mutant non-small-cell lung cancer.
Zhao Z, Wan J, Guo M, Wang Y, Yang Z, Zhou F, Li Z, Ming L. Zhao Z, et al. J Clin Lab Anal. 2022 Jan;36(1):e24118. doi: 10.1002/jcla.24118. Epub 2021 Nov 23. J Clin Lab Anal. 2022. PMID: 34812534 Free PMC article.
METHOD: First, we investigated 17 common m6A regulators' prognostic values in NSCLC. Then, after the establishment of risk signature, we explored the diagnostic value of m6A in TP53-mutant NSCLC. ...Finally, 338 differentially expression genes (DEGs) were found betw …
METHOD: First, we investigated 17 common m6A regulators' prognostic values in NSCLC. Then, after the establishment of risk signature, …
Identifying Prognostic Biomarkers Related to m6A Modification and Immune Infiltration in Renal Cell Carcinoma.
Ye J, Li P, Zhang H, Wu Q, Yang D. Ye J, et al. Genes (Basel). 2022 Nov 7;13(11):2059. doi: 10.3390/genes13112059. Genes (Basel). 2022. PMID: 36360294 Free PMC article.
METHODS: We identified hub genes through multi-dimensional screening, including DEGs, PPI analysis, LASSO regression, and random forest. Meanwhile, GO/KEGG enrichment, cMAP analysis, prognostic analysis, m6A prediction, and immune infiltration analysis were performe …
METHODS: We identified hub genes through multi-dimensional screening, including DEGs, PPI analysis, LASSO regression, and random fore …
Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype.
Gu C, Wu J, Zhang W, Yao Y, Yan W, Yuan Y, Wang W, Shang A. Gu C, et al. J Immunol Res. 2022 Jun 25;2022:7280977. doi: 10.1155/2022/7280977. eCollection 2022. J Immunol Res. 2022. PMID: 35795532 Free PMC article.
First, we used m6A regulators to examine m6A change in UC samples. These two patient groups were created by clustering three m6A gene expression datasets. These genes were then utilized to build an m6A gene network using WGCNA and PPI. These net …
First, we used m6A regulators to examine m6A change in UC samples. These two patient groups were created by clustering three …
92 results