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The molecular biology of NF2/Merlin on tumorigenesis and development.
Vlashi R, Sun F, Zheng C, Zhang X, Liu J, Chen G. Vlashi R, et al. FASEB J. 2024 Jul 15;38(13):e23809. doi: 10.1096/fj.202400019RR. FASEB J. 2024. PMID: 38967126 Review.
The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. ...This synthesis of current knowledge underscores the necessity for ongoing research to eluc …
The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tu …
European Association of Neuro-Oncology guideline on molecular testing of meningiomas for targeted therapy selection.
Sahm F, Bertero L, Brandner S, Capper D, Goldbrunner R, Jenkinson MD, Kalamarides M, Lamszus K, Albert NL, Mair MJ, Berghoff AS, Mawrin C, Wirsching HG, Maas SLN, Raleigh DR, Reifenberger G, Schweizer L, Suwala AK, Tabatabai G, Tabouret E, Short S, Wen PY, Weller M, Le Rhun E, Wesseling P, van den Bent M, Preusser M. Sahm F, et al. Neuro Oncol. 2025 May 15;27(4):869-883. doi: 10.1093/neuonc/noae253. Neuro Oncol. 2025. PMID: 39577862 Free PMC article. Review.
Here, we review the evidence for a predictive role of a wide range of molecular alterations and markers including NF2, AKT1, SMO, SMARCE1, PIK3CA, CDKN2A/B, CDK4/6, TERT, TRAF7, BAP1, KLF4,ARID1/2, SUFU, PD-L1, SSTR2A, PR/ER, mTOR, VEGF(R), PDGFR, as well as homologous rec …
Here, we review the evidence for a predictive role of a wide range of molecular alterations and markers including NF2, AKT1, SMO, SMA …
NF2-Related Schwannomatosis (NF2): Molecular Insights and Therapeutic Avenues.
Kim BH, Chung YH, Woo TG, Kang SM, Park S, Kim M, Park BJ. Kim BH, et al. Int J Mol Sci. 2024 Jun 14;25(12):6558. doi: 10.3390/ijms25126558. Int J Mol Sci. 2024. PMID: 38928264 Free PMC article. Review.
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, particularly bilateral vestibular schwannomas, meningiomas, and ependymomas. This review consolidates the current knowledge on NF2 synd …
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, pa …
Genomics of vestibular schwannoma.
Smith MJ, Messiaen LM, Evans DG. Smith MJ, et al. Handb Clin Neurol. 2025;212:59-67. doi: 10.1016/B978-0-12-824534-7.00023-8. Handb Clin Neurol. 2025. PMID: 41052866 Review.
The majority of vestibular schwannomas occur as solitary tumors in otherwise healthy individuals with no family history of vestibular schwannomas, while approximately 5% are associated with the tumor suppressor syndrome, NF2-related schwannomatosis. However, pathogenic var …
The majority of vestibular schwannomas occur as solitary tumors in otherwise healthy individuals with no family history of vestibular schwan …
Current molecular understanding of central nervous system schwannomas.
Tsuchiya T, Miyawaki S, Teranishi Y, Ohara K, Hirano Y, Ogawa S, Torazawa S, Sakai Y, Hongo H, Ono H, Saito N. Tsuchiya T, et al. Acta Neuropathol Commun. 2025 Feb 5;13(1):24. doi: 10.1186/s40478-025-01937-w. Acta Neuropathol Commun. 2025. PMID: 39910685 Free PMC article. Review.
The development of these tumors is primarily linked to mutations in the NF2 gene. Merlin, the protein encoded by NF2, is integral to several signaling pathways, including Ras/Raf/MEK/ERK, PI3K/Akt/mTORC1, Wnt/beta-catenin, and the Hippo pathway. ...In additio …
The development of these tumors is primarily linked to mutations in the NF2 gene. Merlin, the protein encoded by NF2, i …
Mesothelioma: molecular pathology and biomarkers.
Hung YP. Hung YP. Pathologie (Heidelb). 2024 Sep;45(5):316-323. doi: 10.1007/s00292-024-01344-3. Epub 2024 Aug 7. Pathologie (Heidelb). 2024. PMID: 39110166 Review. English.
Diffuse mesotheliomas are characterized by recurrent genomic alterations involving tumor suppressors and epigenetic regulators such as BAP1, CDKN2A, MTAP, and NF2. Depending on the differential diagnosis as informed by histologic assessment, one can apply the appropriate i …
Diffuse mesotheliomas are characterized by recurrent genomic alterations involving tumor suppressors and epigenetic regulators such as BAP1, …
NF2 is Essential for Human Endoderm Development.
Jeong M, Han D, Bhetariya P, Welling DB, Stojkovic M, Stankovic KM. Jeong M, et al. Adv Sci (Weinh). 2025 May;12(17):e2410909. doi: 10.1002/advs.202410909. Epub 2025 Feb 8. Adv Sci (Weinh). 2025. PMID: 39921490 Free PMC article.
Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers- ectoderm, mesoderm, and endoderm- which give rise to tissues and organs in the developing organism. The tumor suppressor gene NF2, moesin-ezrin-radixin like (MERLIN) tumor sup …
Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers- ectoderm, mesoderm, and endoderm- which give rise …
NF2-related schwannomatosis: A view from within the inner ear.
Brown ED, Nassar S, Jagger DJ. Brown ED, et al. Hear Res. 2025 May;460:109226. doi: 10.1016/j.heares.2025.109226. Epub 2025 Feb 28. Hear Res. 2025. PMID: 40049083 Free article. Review.
NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) is an autosomal dominant disorder associated with the growth of bilateral schwannomas on the cochleo-vestibular nerves and meningiomas. NF2-SWN is caused by pathogenic variation …
NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) is an autosomal dominant disorder associated …
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function.
Wang X, Zhu R, Yu P, Qi S, Zhong Z, Jin R, Wang Y, Gu Y, Ye D, Chen K, Shu Y, Wang Y, Yu FX. Wang X, et al. Sci Adv. 2025 Jan 24;11(4):eadp4765. doi: 10.1126/sciadv.adp4765. Epub 2025 Jan 22. Sci Adv. 2025. PMID: 39841844 Free PMC article.
NF2-related schwannomatosis, previously known as neurofibromatosis type 2, is a genetic disorder characterized by nerve tumors due to NF2 gene mutations. Mice with Nf2 deletion develop schwannomas slowly with low penetrance, hence inconvenient for prec …
NF2-related schwannomatosis, previously known as neurofibromatosis type 2, is a genetic disorder characterized by nerve tumors due to …
Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage.
Lee CJM, Autio MI, Zheng W, Song Y, Wang SC, Wong DCP, Xiao J, Zhu Y, Yusoff P, Yei X, Chock WK, Low BC, Sudol M, Foo RS. Lee CJM, et al. Circulation. 2024 Jun 18;149(25):1960-1979. doi: 10.1161/CIRCULATIONAHA.122.061335. Epub 2024 May 16. Circulation. 2024. PMID: 38752370 Free article.
After an independent secondary single guide ribonucleic acid validation of 25 candidates, we identified NF2 (neurofibromin 2), a moesin-ezrin-radixin like (MERLIN) tumor suppressor, as an upstream driver of early cardiomyocyte lineage specification. ...Sustai …
After an independent secondary single guide ribonucleic acid validation of 25 candidates, we identified NF2 (neurofibromin …
92 results