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The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
Reed R, Park K, Waddell B, Timbers TA, Li C, Baxi K, Giacomin RM, Leroux MR, Carvalho CE. Reed R, et al. Sci Rep. 2023 Jun 9;13(1):9410. doi: 10.1038/s41598-023-36430-8. Sci Rep. 2023. PMID: 37296204 Free PMC article.
We identify the centrosomal and microtubule-regulating transforming acidic coiled-coil protein, TACC/TAC-1, which also localizes to the basal body, as an SGO-1 binding protein. Genetic analyses indicate that TAC-1 activity must be maintained below a th …
We identify the centrosomal and microtubule-regulating transforming acidic coiled-coil protein, TACC/TAC-1, which also localiz …
CDKL kinase regulates the length of the ciliary proximal segment.
Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE, Leroux MR. Park K, et al. Curr Biol. 2021 Jun 7;31(11):2359-2373.e7. doi: 10.1016/j.cub.2021.03.068. Epub 2021 Apr 14. Curr Biol. 2021. PMID: 33857430 Free article.
Cilia are organelles found throughout most unicellular eukaryotes and different metazoan cell types. ...Here, we show that C. elegans CDKL-1, related to the human CDKL kinase family (CDKL1/CDKL2/CDKL3/CDKL4/CDKL5), specifically controls the length of the proximal segment, …
Cilia are organelles found throughout most unicellular eukaryotes and different metazoan cell types. ...Here, we show that C. elegans …
C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.
Barbelanne M, Lu Y, Kumar K, Zhang X, Li C, Park K, Warner A, Xu XZS, Shaham S, Leroux MR. Barbelanne M, et al. Among authors: park k. Sci Rep. 2024 Nov 16;14(1):28347. doi: 10.1038/s41598-024-79057-z. Sci Rep. 2024. PMID: 39550471 Free PMC article.
Primary (non-motile) cilia represent structurally and functionally diverse organelles whose roles as specialized cellular antenna are central to animal cell signaling pathways, sensory physiology and development. ...The nematode protein, PEF-1, depends on transition zone p …
Primary (non-motile) cilia represent structurally and functionally diverse organelles whose roles as specialized cellular antenna are …
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.
Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. Li C, et al. Among authors: park k. PLoS Biol. 2016 Mar 16;14(3):e1002416. doi: 10.1371/journal.pbio.1002416. eCollection 2016 Mar. PLoS Biol. 2016. PMID: 26982032 Free PMC article.
Cilia have a unique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins within the organelle. ...Consistent with a critical role in ciliary gate function, CEP-290 prevents inappropriate entry of m …
Cilia have a unique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compartmentalises sign …
IFT trains overcome an NPHP module barrier at the transition zone.
Park K, Leroux MR. Park K, et al. J Cell Biol. 2022 Jan 3;221(1):e202112015. doi: 10.1083/jcb.202112015. Epub 2021 Dec 10. J Cell Biol. 2022. PMID: 34889953 Free PMC article.
Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ an intraflagellar transport (IFT) system to form dynamic motile and signaling compartments. ...
Cilia harbor diffusion barriers for soluble and membrane proteins within their proximal-most transition zone (TZ) region and employ a …
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR. Canning P, et al. Among authors: park k. Cell Rep. 2018 Jan 23;22(4):885-894. doi: 10.1016/j.celrep.2017.12.083. Epub 2018 Jan 28. Cell Rep. 2018. PMID: 29420175 Free PMC article.
C. elegans CDKL-1, most closely related to CDKL1-4 and localized to neuronal cilia transition zones, modulates cilium length; this depends on its kinase activity and ?...Human CDKL5, linked to Rett syndrome, also localizes to cilia, and it impairs ciliogenesis when …
C. elegans CDKL-1, most closely related to CDKL1-4 and localized to neuronal cilia transition zones, modulates cilium length; this de …
EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling.
Loucks CM, Park K, Walker DS, McEwan AH, Timbers TA, Ardiel EL, Grundy LJ, Li C, Johnson JL, Kennedy J, Blacque OE, Schafer W, Rankin CH, Leroux MR. Loucks CM, et al. Among authors: park k. Elife. 2019 Feb 27;8:e37271. doi: 10.7554/eLife.37271. Elife. 2019. PMID: 30810526 Free PMC article.
Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, the roles of cilia in these neurons are poorly understood. To shed light into their functions, we studied EFHC1, an e …
Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular …
HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements.
Thakur A, Park K, Cullum R, Fuglerud BM, Khoshnoodi M, Drissler S, Stephan TL, Lotto J, Kim D, Gonzalez FJ, Hoodless PA. Thakur A, et al. Among authors: park k. Commun Biol. 2024 Jan 31;7(1):144. doi: 10.1038/s42003-024-05835-0. Commun Biol. 2024. PMID: 38297077 Free PMC article.
Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver functions, primarily through binding to enhancers. In mammalian cells, active and primed enhancers are marked by monomethylation of his …
Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver …
13 results