Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1985 1
1986 1
1988 1
1989 2
1990 1
1994 2
1997 1
1998 1
1999 1
2001 1
2002 2
2003 1
2004 1
2005 1
2006 3
2007 1
2008 7
2009 10
2010 5
2011 5
2012 4
2013 4
2015 2
2017 1
2018 5
2019 2
2020 2
2021 2
2022 1
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

68 results

Results by year

Filters applied: . Clear all
Page 1
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.
Kyuma T, Kizaki H, Ryuno H, Sekimizu K, Kaito C. Kyuma T, et al. Biochimie. 2015 Dec;119:166-74. doi: 10.1016/j.biochi.2015.10.027. Epub 2015 Nov 3. Biochimie. 2015. PMID: 26545800
We previously reported that the rRNA methyltransferases RsmI and RsmH, which are responsible for cytidine dimethylation at position 1402 of 16S rRNA in the decoding center of the ribosome, contribute to Staphylococcus aureus virulence. Here we evaluated other …
We previously reported that the rRNA methyltransferases RsmI and RsmH, which are responsible for cytidine dimethylation at pos …
Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea.
Knüppel R, Trahan C, Kern M, Wagner A, Grünberger F, Hausner W, Quax TEF, Albers SV, Oeffinger M, Ferreira-Cerca S. Knüppel R, et al. Nucleic Acids Res. 2021 Feb 22;49(3):1662-1687. doi: 10.1093/nar/gkaa1268. Nucleic Acids Res. 2021. PMID: 33434266 Free PMC article.
In addition, our study reveals an unexpected KsgA/Dim1-dependent variability of rRNA modifications within the archaeal phylum. Combining structure-based functional studies across evolutionary divergent organisms, we provide evidence on how rRNA structure sequ …
In addition, our study reveals an unexpected KsgA/Dim1-dependent variability of rRNA modifications within the archaeal phylum. …
Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance.
Park AK, Kim H, Jin HJ. Park AK, et al. FEMS Microbiol Lett. 2010 Aug 1;309(2):151-62. doi: 10.1111/j.1574-6968.2010.02031.x. Epub 2010 Jun 8. FEMS Microbiol Lett. 2010. PMID: 20618865
It has long been speculated that erm and ksgA are related evolutionarily due to their sequence similarity and analogous catalytic reactions. ...On the other hand, the phylogenetic analysis cannot support the commonly assumed phylogenetic relationships between erm and ks
It has long been speculated that erm and ksgA are related evolutionarily due to their sequence similarity and analogous catalytic rea …
Dissection of 16S rRNA methyltransferase (KsgA) function in Escherichia coli.
Inoue K, Basu S, Inouye M. Inoue K, et al. J Bacteriol. 2007 Dec;189(23):8510-8. doi: 10.1128/JB.01259-07. Epub 2007 Sep 21. J Bacteriol. 2007. PMID: 17890303 Free PMC article.
A 16S rRNA methyltransferase, KsgA, identified originally in Escherichia coli is highly conserved in all living cells, from bacteria to humans. KsgA orthologs in eukaryotes possess functions in addition to their rRNA methyltransferase act …
A 16S rRNA methyltransferase, KsgA, identified originally in Escherichia coli is highly conserved in all living cells, …
KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion.
Sun J, Kinman LF, Jahagirdar D, Ortega J, Davis JH. Sun J, et al. Nat Struct Mol Biol. 2023 Oct;30(10):1468-1480. doi: 10.1038/s41594-023-01078-5. Epub 2023 Aug 31. Nat Struct Mol Biol. 2023. PMID: 37653244 Free PMC article.
Ribosome assembly is orchestrated by many assembly factors, including ribosomal RNA methyltransferases, whose precise role is poorly understood. Here, we leverage the power of cryo-EM and machine learning to discover that the E. coli methyltransferase KsgA pe …
Ribosome assembly is orchestrated by many assembly factors, including ribosomal RNA methyltransferases, whose precise role is poorly …
Dimethyl adenosine transferase (KsgA) contributes to cell-envelope fitness in Salmonella Enteritidis.
Chiok KL, Paul NC, Adekanmbi EO, Srivastava SK, Shah DH. Chiok KL, et al. Microbiol Res. 2018 Nov;216:108-119. doi: 10.1016/j.micres.2018.08.009. Epub 2018 Aug 23. Microbiol Res. 2018. PMID: 30269850 Free PMC article.
The cell-envelope fitness defects were alleviated by expression of wild-type KsgA (WT-ksgA) but not by its catalytically inactive form (ksgAE66A), suggesting that the dimethyl transferase activity of KsgA is important for cell-envelope fitness in S. ...Enteri …
The cell-envelope fitness defects were alleviated by expression of wild-type KsgA (WT-ksgA) but not by its catalytically inact …
KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli.
Zhang-Akiyama QM, Morinaga H, Kikuchi M, Yonekura S, Sugiyama H, Yamamoto K, Yonei S. Zhang-Akiyama QM, et al. Nucleic Acids Res. 2009 Apr;37(7):2116-25. doi: 10.1093/nar/gkp057. Epub 2009 Feb 17. Nucleic Acids Res. 2009. PMID: 19223326 Free PMC article.
The protein was subsequently purified from the E. coli mutM nth nei mutant and was identified as KsgA, a 16S rRNA adenine methyltransferase. Recombinant KsgA also formed the trapped complex with 5-foU/C- and thymine glycol (Tg)/C-containing oligonucleo …
The protein was subsequently purified from the E. coli mutM nth nei mutant and was identified as KsgA, a 16S rRNA adenine m
Structural basis of successive adenosine modifications by the conserved ribosomal methyltransferase KsgA.
Stephan NC, Ries AB, Boehringer D, Ban N. Stephan NC, et al. Nucleic Acids Res. 2021 Jun 21;49(11):6389-6398. doi: 10.1093/nar/gkab430. Nucleic Acids Res. 2021. PMID: 34086932 Free PMC article.
Here we present the cryo-EM structure of Escherichia coli KsgA bound to an E. coli 30S at a resolution of 3.1 A. The high-resolution structure reveals how KsgA recognizes immature rRNA and binds helix 45 in a conformation where one of the substrate nucleotide …
Here we present the cryo-EM structure of Escherichia coli KsgA bound to an E. coli 30S at a resolution of 3.1 A. The high-resolution …
Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases.
Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP. Pulicherla N, et al. J Mol Biol. 2009 Sep 4;391(5):884-93. doi: 10.1016/j.jmb.2009.06.015. Epub 2009 Jun 9. J Mol Biol. 2009. PMID: 19520088 Free PMC article.
The enzymes of the KsgA/Dim1 family are universally distributed throughout all phylogeny; however, structural and functional differences are known to exist. ...Previous work showed that eukaryotic and archaeal Dim1 were able to robustly complement for KsgA in E. col …
The enzymes of the KsgA/Dim1 family are universally distributed throughout all phylogeny; however, structural and functional differen …
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase.
Tu C, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X. Tu C, et al. Structure. 2009 Mar 11;17(3):374-85. doi: 10.1016/j.str.2009.01.010. Structure. 2009. PMID: 19278652 Free PMC article.
Among methyltransferases, KsgA and the reaction it catalyzes are conserved throughout evolution. However, the specifics of substrate recognition by the enzyme remain unknown. Here we report structures of Aquifex aeolicus KsgA, in its ligand-free form, in comp …
Among methyltransferases, KsgA and the reaction it catalyzes are conserved throughout evolution. However, the specifics of sub …
68 results