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Page 1
Pregabalin Improves Fibromyalgia-related Sleep Disturbance.
Roth T, Bhadra-Brown P, Pitman VW, Resnick EM. Roth T, et al. Clin J Pain. 2016 Apr;32(4):308-12. doi: 10.1097/AJP.0000000000000262. Clin J Pain. 2016. PMID: 26035523 Clinical Trial.
An exploratory correlation analysis of treatment effects found stage 1 sleep was negatively correlated with wake and sleep bout duration and positively with wake/sleep bout number; slow wave sleep (%total sleep time) was positively correlated with wake …
An exploratory correlation analysis of treatment effects found stage 1 sleep was negatively correlated with wake and sleep bout duration and …
Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome.
Garcia-Borreguero D, Patrick J, DuBrava S, Becker PM, Lankford A, Chen C, Miceli J, Knapp L, Allen RP. Garcia-Borreguero D, et al. Sleep. 2014 Apr 1;37(4):635-43. doi: 10.5665/sleep.3558. Sleep. 2014. PMID: 24899755 Free PMC article. Clinical Trial.

Pregabalin improved sleep maintenance, demonstrated by reductions in WASO (-27.1 min vs placebo [P < 0.0001]; -26.9 vs pramipexole) and number of awakenings after sleep onset (-2.7 vs placebo; -7.9 vs pramipexole [P < 0.0001]) by polysomnography, and an increase in subjecti

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Pregabalin improved sleep maintenance, demonstrated by reductions in WASO (-27.1 min vs placebo [P < 0.0001]; -26.9 vs pramipexole) and n

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Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Boyle J, Eriksson ME, Gribble L, Gouni R, Johnsen S, Coppini DV, Kerr D. Boyle J, et al. Diabetes Care. 2012 Dec;35(12):2451-8. doi: 10.2337/dc12-0656. Epub 2012 Sep 18. Diabetes Care. 2012. PMID: 22991449 Free PMC article. Clinical Trial.

For sleep, pregabalin improved sleep continuity (P < 0.001), whereas duloxetine increased wake and reduced total sleep time (P < 0.01 and P < 0.001). Despite negative effects on sleep, duloxetine enhanced central nervous system arousal and performance on se

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For sleep, pregabalin improved sleep continuity (P < 0.001), whereas duloxetine increased wake and reduced total sleep time

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Pregabalin increases slow-wave sleep and may improve attention in patients with partial epilepsy and insomnia.
Bazil CW, Dave J, Cole J, Stalvey J, Drake E. Bazil CW, et al. Epilepsy Behav. 2012 Apr;23(4):422-5. doi: 10.1016/j.yebeh.2012.02.005. Epub 2012 Mar 14. Epilepsy Behav. 2012. PMID: 22424859 Clinical Trial.
RESULTS: There was a significant increase in percentage of slow-wave sleep and a decrease in stage 1 sleep when subjects were taking pregabalin. ...CONCLUSION: Concurrent treatment with pregabalin improves sleep depth in patients with insomnia and epilepsy an …
RESULTS: There was a significant increase in percentage of slow-wave sleep and a decrease in stage 1 sleep when subjects were …
Exploratory polysomnographic evaluation of pregabalin on sleep disturbance in patients with epilepsy.
de Haas S, Otte A, de Weerd A, van Erp G, Cohen A, van Gerven J. de Haas S, et al. J Clin Sleep Med. 2007 Aug 15;3(5):473-8. J Clin Sleep Med. 2007. PMID: 17803010 Free PMC article. Clinical Trial.
RESULTS: Baseline PSGs showed sleep fragmentation. Mean sleep efficiency improved significantly in both treatment groups in the mean baseline to endpoint change; there was no significant between-group difference. ...
RESULTS: Baseline PSGs showed sleep fragmentation. Mean sleep efficiency improved significantly in both treatment groups in the mean …
A double-blind study in healthy volunteers to assess the effects on sleep of pregabalin compared with alprazolam and placebo.
Hindmarch I, Dawson J, Stanley N. Hindmarch I, et al. Sleep. 2005 Feb;28(2):187-93. doi: 10.1093/sleep/28.2.187. Sleep. 2005. PMID: 16171242 Clinical Trial.
Compared with placebo, pregabalin significantly increased slow-wave sleep both as a proportion of the total sleep period and the duration of stage 4 sleep. ...CONCLUSIONS: Pregabalin appears to have an effect on sleep and sleep architecture that distin …
Compared with placebo, pregabalin significantly increased slow-wave sleep both as a proportion of the total sleep …