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Page 1
Spermine synthase.
Pegg AE, Michael AJ. Pegg AE, et al. Cell Mol Life Sci. 2010 Jan;67(1):113-21. doi: 10.1007/s00018-009-0165-5. Epub 2009 Oct 27. Cell Mol Life Sci. 2010. PMID: 19859664 Free PMC article. Review.
Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, …
Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermi …
Polyamine metabolism.
Seiler N. Seiler N. Digestion. 1990;46 Suppl 2:319-30. doi: 10.1159/000200405. Digestion. 1990. PMID: 2262065 Review.
In vertebrates, putrescine, the precursor of spermidine and spermine, is exclusively formed by decarboxylation of ornithine--as far as de novo synthesis is concerned. Spermidine and spermine synthase form spermidine from putrescine, and spermine from spermidine, by …
In vertebrates, putrescine, the precursor of spermidine and spermine, is exclusively formed by decarboxylation of ornithine--as far as de no …
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Wu H, et al. J Biol Chem. 2008 Jun 6;283(23):16135-46. doi: 10.1074/jbc.M710323200. Epub 2008 Mar 26. J Biol Chem. 2008. PMID: 18367445 Free PMC article.
The crystal structures of two ternary complexes of human spermine synthase (EC 2.5.1.22), one with 5'-methylthioadenosine and spermidine and the other with 5'-methylthioadenosine and spermine, have been solved. ...An analysis to trace possible evolutionary origins o …
The crystal structures of two ternary complexes of human spermine synthase (EC 2.5.1.22), one with 5'-methylthioadenosine and …
Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma.
Zhuo W, Xia H, Lan B, Chen Y, Wang X, Liu J. Zhuo W, et al. Front Immunol. 2024 Nov 25;15:1481331. doi: 10.3389/fimmu.2024.1481331. eCollection 2024. Front Immunol. 2024. PMID: 39654885 Free PMC article.
RESULTS: By conducting lasso regression analysis, we identified four independent prognostic genes: fatty acid binding protein 6 (FABP6), phosphoribosyl pyrophosphate amidotransferase (PPAT), spermine synthase (SMS), and dihydrodiol dehydrogenase (DHDH). Based on the …
RESULTS: By conducting lasso regression analysis, we identified four independent prognostic genes: fatty acid binding protein 6 (FABP6), pho …
Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers.
Fiori LM, Turecki G. Fiori LM, et al. Int J Neuropsychopharmacol. 2010 Jul;13(6):725-36. doi: 10.1017/S1461145709991167. Epub 2010 Jan 11. Int J Neuropsychopharmacol. 2010. PMID: 20059804 Free article.
Alterations in the levels of spermine synthase (SMS) and spermine oxidase (SMOX), two enzymes involved in polyamine metabolism, have previously been observed in brains of suicide completers. ...
Alterations in the levels of spermine synthase (SMS) and spermine oxidase (SMOX), two enzymes involved in polyamine metabolism …
Fatty acid metabolism affects hepatocellular carcinoma progression via the PPAR-γ signaling pathway and fatty acid β-oxidation.
Feng W, Liang J, Xu B, Huang L, Xu Q, Chen D, Lai J, Chen J. Feng W, et al. Int Immunopharmacol. 2024 Nov 15;141:112917. doi: 10.1016/j.intimp.2024.112917. Epub 2024 Aug 12. Int Immunopharmacol. 2024. PMID: 39137630
Among the four key prognostically related FAMGs, Spermine Synthase (SMS) was selected and validated as a potential oncogene affecting cell cycle, PPAR-gamma signaling pathway and fatty acid beta oxidation in HCC. ...
Among the four key prognostically related FAMGs, Spermine Synthase (SMS) was selected and validated as a potential oncogene af …
Rebalancing polyamine levels to treat Snyder-Robinson syndrome.
Gilmour SK. Gilmour SK. EMBO Mol Med. 2023 Nov 8;15(11):e18506. doi: 10.15252/emmm.202318506. Epub 2023 Sep 15. EMBO Mol Med. 2023. PMID: 37712293 Free PMC article.
Snyder-Robinson syndrome primarily affects the nervous system and skeletal tissues and is caused by loss-of-function mutations in the gene encoding spermine synthase (SMS), a polyamine biosynthesis enzyme. Affected males display a collection of clinical features inc …
Snyder-Robinson syndrome primarily affects the nervous system and skeletal tissues and is caused by loss-of-function mutations in the gene e …
Molecular Subtypes and Machine Learning-Based Predictive Models for Intracranial Aneurysm Rupture.
Zhong A, Wang F, Zhou Y, Ding N, Yang G, Chai X. Zhong A, et al. World Neurosurg. 2023 Nov;179:e166-e186. doi: 10.1016/j.wneu.2023.08.043. Epub 2023 Aug 18. World Neurosurg. 2023. PMID: 37597661
In subgroup I, specific genes were associated with inflammation and immunity, and weighted gene coexpression network analysis revealed that the black module genes were linked to IA rupture. We identified 4 hub genes (spermine synthase, macrophage receptor with colla …
In subgroup I, specific genes were associated with inflammation and immunity, and weighted gene coexpression network analysis revealed that …
Polyamines: from molecular biology to clinical applications.
Jänne J, Alhonen L, Leinonen P. Jänne J, et al. Ann Med. 1991 Aug;23(3):241-59. doi: 10.3109/07853899109148056. Ann Med. 1991. PMID: 1930914 Review.
Their biosynthesis is accomplished by a concerted action of four different enzymes: ornithine decarboxylase, adenosylmethionine decarboxylase, spermidine synthase and spermine synthase. Out of these four enzyme, the two decarboxylases represent unique mammalian enzy …
Their biosynthesis is accomplished by a concerted action of four different enzymes: ornithine decarboxylase, adenosylmethionine decarboxylas …
58 results