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Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
Cong M, Jing R. Cong M, et al. Biosci Rep. 2019 Nov 29;39(11):BSR20190291. doi: 10.1042/BSR20190291. Biosci Rep. 2019. PMID: 31652435 Free PMC article.
Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis. LncRNA tumor suppressor candidate 7 (TUSC-7) was shown to be a tumor suppressor in osteosarcoma. However, the regulation mechanism of TUSC-7 in osteosarcoma is unkno …
Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis. LncRNA tumor suppressor candidate 7 ( …
TACC3 protein regulates microtubule nucleation by affecting γ-tubulin ring complexes.
Singh P, Thomas GE, Gireesh KK, Manna TK. Singh P, et al. J Biol Chem. 2014 Nov 14;289(46):31719-31735. doi: 10.1074/jbc.M114.575100. Epub 2014 Sep 22. J Biol Chem. 2014. PMID: 25246530 Free PMC article.
Co-immunoprecipitation and sedimentation experiments revealed that TACC3 mediates interactions with proteins of both the gamma-tubulin ring complex (gamma-TuRC) and the gamma-tubulin small complex (gamma-TuSC). Interestingly, TACC3 depletion resulted in reduced levels of g …
Co-immunoprecipitation and sedimentation experiments revealed that TACC3 mediates interactions with proteins of both the gamma-tubulin ring …
Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions.
Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T. Ikeuchi Y, et al. Mol Cell. 2006 Jan 6;21(1):97-108. doi: 10.1016/j.molcel.2005.11.001. Mol Cell. 2006. PMID: 16387657 Free article.
The wobble bases of bacterial tRNAs responsible for NNR codons are modified to 5-methylaminomethyl-2-thiouridine (mnm5s2U). 2-thio modification of mnm5s2U is required for accurate decoding and essential for normal cell growth. We identified five genes yhhP, yheL, yheM, yhe …
The wobble bases of bacterial tRNAs responsible for NNR codons are modified to 5-methylaminomethyl-2-thiouridine (mnm5s2U). 2-thio modificat …
TUSC7 suppression of Notch activation through sponging MiR-146 recapitulated the asymmetric cell division in lung adenocarcinoma stem cells.
Huang G, Wang M, Li X, Wu J, Chen S, Du N, Li K, Wang J, Xu C, Ren H, Tang SC, Sun X. Huang G, et al. Life Sci. 2019 Sep 1;232:116630. doi: 10.1016/j.lfs.2019.116630. Epub 2019 Jul 4. Life Sci. 2019. PMID: 31279783
SIGNIFICANCE: TUSC-7 was proved to be one strong suppressive lnc-RNA in lung adenocarcinoma stem cells, functioning through inactivating NOTCH signaling, and the turbulence on division modes precisely pointed to the key mechanisms of stem cells' renewal. The decreas …
SIGNIFICANCE: TUSC-7 was proved to be one strong suppressive lnc-RNA in lung adenocarcinoma stem cells, functioning through in …
ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3.
Ren R, Du Y, Niu X, Zang R. Ren R, et al. J Cancer. 2021 Apr 17;12(11):3393-3406. doi: 10.7150/jca.51437. eCollection 2021. J Cancer. 2021. PMID: 33976749 Free PMC article.
Objective: Our purpose was to study the roles and molecular mechanisms of long non-coding RNA (lncRNA) ZFPM2 Antisense RNA 1 (ZFPM2-AS1) in thyroid cancer. ...Results: ZFPM2-AS1 and TUSC were both highly expressed and miR-515-5p was down-regulated in thyroid …
Objective: Our purpose was to study the roles and molecular mechanisms of long non-coding RNA (lncRNA) ZFPM2 Antisense RNA 1 ( …
Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
Hao L, Yun Y, Liang R, Yuan G. Hao L, et al. Clin Invest Med. 2020 Dec 27;43(4):E35-43. doi: 10.25011/cim.v43i4.34703. Clin Invest Med. 2020. PMID: 33370523
PURPOSE: Despite advances in our understanding of the roles of the long noncoding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) in cancer biology, which has been identified to act as a tumor suppressor by regulating cell proliferation, apoptosis, migration, invasion, c …
PURPOSE: Despite advances in our understanding of the roles of the long noncoding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) i …
{gamma}-Tubulin ring complexes regulate microtubule plus end dynamics.
Bouissou A, Vérollet C, Sousa A, Sampaio P, Wright M, Sunkel CE, Merdes A, Raynaud-Messina B. Bouissou A, et al. J Cell Biol. 2009 Nov 2;187(3):327-34. doi: 10.1083/jcb.200905060. Epub 2009 Oct 26. J Cell Biol. 2009. PMID: 19948476 Free PMC article.
In Drosophila melanogaster, it acts within two main complexes: the gamma-tubulin small complex (gamma-TuSC) and the gamma-tubulin ring complex (gamma-TuRC). Proteins specific of the gamma-TuRC, although nonessential for viability, are required for efficient mitotic progres …
In Drosophila melanogaster, it acts within two main complexes: the gamma-tubulin small complex (gamma-TuSC) and the gamma-tubulin rin …
Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex.
Numata T, Fukai S, Ikeuchi Y, Suzuki T, Nureki O. Numata T, et al. Structure. 2006 Feb;14(2):357-66. doi: 10.1016/j.str.2005.11.009. Structure. 2006. PMID: 16472754 Free article.
Structure-based sequence alignment suggested two putative active site Cys residues, Cys79 (in TusC) and Cys78 (in TusD), which are exposed on the hexameric complex. ...
Structure-based sequence alignment suggested two putative active site Cys residues, Cys79 (in TusC) and Cys78 (in TusD), which are ex …
tassel-less1 encodes a boron channel protein required for inflorescence development in maize.
Leonard A, Holloway B, Guo M, Rupe M, Yu G, Beatty M, Zastrow-Hayes G, Meeley R, Llaca V, Butler K, Stefani T, Jaqueth J, Li B. Leonard A, et al. Plant Cell Physiol. 2014 Jun;55(6):1044-54. doi: 10.1093/pcp/pcu036. Epub 2014 Mar 31. Plant Cell Physiol. 2014. PMID: 24685595
The ZmNIP3;1 gene is completely deleted in the tls1 mutant genome. Two Mutator-insertional TUSC alleles of ZmNIP3;1 exhibited tls1-like phenotypes, and allelism tests confirmed that the tls1 gene encodes ZmNIP3;1. Transgenic plants with an RNA interference (RNAi) co …
The ZmNIP3;1 gene is completely deleted in the tls1 mutant genome. Two Mutator-insertional TUSC alleles of ZmNIP3;1 exhibited tls1-li …
microRNA-378 promotes mesenchymal stem cell survival and vascularization under hypoxic-ischemic conditions in vitro.
Xing Y, Hou J, Guo T, Zheng S, Zhou C, Huang H, Chen Y, Sun K, Zhong T, Wang J, Li H, Wang T. Xing Y, et al. Stem Cell Res Ther. 2014 Nov 23;5(6):130. doi: 10.1186/scrt520. Stem Cell Res Ther. 2014. PMID: 25418617 Free PMC article.
In the miR-378 group, there was a decreased expression of tumor necrosis factor-alpha on protein level and a reduction of TUSC-2 under normoxic environment. Their expressions were both downregulated under hypoxic environment. ...
In the miR-378 group, there was a decreased expression of tumor necrosis factor-alpha on protein level and a reduction of TUSC-2 unde …