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Candida spp. in Human Intestinal Health and Disease: More than a Gut Feeling.
Kreulen IAM, de Jonge WJ, van den Wijngaard RM, van Thiel IAM. Kreulen IAM, et al. Among authors: van den wijngaard rm. Mycopathologia. 2023 Dec;188(6):845-862. doi: 10.1007/s11046-023-00743-z. Epub 2023 Jun 9. Mycopathologia. 2023. PMID: 37294505 Free PMC article. Review.
Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain.
van Thiel I, de Jonge W, van den Wijngaard R. van Thiel I, et al. Among authors: van den wijngaard r. Gut Microbes. 2023 Jan-Dec;15(1):2168992. doi: 10.1080/19490976.2023.2168992. Gut Microbes. 2023. PMID: 36723172 Free PMC article. Review.
In this review, we discuss the available clinical and preclinical IBS mycobiome data, and speculate how these recent findings may relate to earlier observations in IBS. By surveying literature from the broader mycobiome research field, we identified questions open t …
In this review, we discuss the available clinical and preclinical IBS mycobiome data, and speculate how these recent findings may rel …
Genetic and phenotypic diversity of fecal Candida albicans strains in irritable bowel syndrome.
van Thiel IAM, Stavrou AA, de Jong A, Theelen B, Davids M, Hakvoort TBM, Admiraal-van den Berg I, Weert ICM, de Kruijs MAMH, Vu D, Moissl-Eichinger C, Heinsbroek SEM, Jonkers DMAE, Hagen F, Boekhout T, de Jonge WJ, van den Wijngaard RM. van Thiel IAM, et al. Among authors: van den wijngaard rm. Sci Rep. 2022 Mar 30;12(1):5391. doi: 10.1038/s41598-022-09436-x. Sci Rep. 2022. PMID: 35354908 Free PMC article.
Visceral hypersensitivity is thought to be responsible for pain complaints in a subset of patients. In an IBS-like animal model, visceral hypersensitivity was triggered by intestinal fungi, and lower mycobiota alpha-diversity in IBS patients was accomp …
Visceral hypersensitivity is thought to be responsible for pain complaints in a subset of patients. In an IBS-like animal mode …
Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel.
van Thiel IAM, de Jonge WJ, Chiu IM, van den Wijngaard RM. van Thiel IAM, et al. Among authors: van den wijngaard rm. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 1;318(6):G1034-G1041. doi: 10.1152/ajpgi.00196.2019. Epub 2020 Apr 20. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32308040 Free PMC article.
Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). ...In this paper, we review current knowledge on t …
Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently …
Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms.
Botschuijver S, van Diest SA, van Thiel IAM, Saia RS, Strik AS, Yu Z, Maria-Ferreira D, Welting O, Keszthelyi D, Jennings G, Heinsbroek SEM, Elferink RPO, Schuren FHJ, de Jonge WJ, van den Wijngaard RM. Botschuijver S, et al. Among authors: van den wijngaard rm. Sci Rep. 2019 Aug 29;9(1):12530. doi: 10.1038/s41598-019-49096-y. Sci Rep. 2019. PMID: 31467355 Free PMC article.
We anticipated that miltefosine may act on different mechanistic levels of fungal-induced abdominal pain and may be repurposed to IBS. In the IBS-like rat model of maternal separation we assessed the visceromotor response to colonic distension as indirect readout fo …
We anticipated that miltefosine may act on different mechanistic levels of fungal-induced abdominal pain and may be repurposed to IBS …
Reversal of visceral hypersensitivity in rat by Menthacarin® , a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation.
Botschuijver S, Welting O, Levin E, Maria-Ferreira D, Koch E, Montijn RC, Seppen J, Hakvoort TBM, Schuren FHJ, de Jonge WJ, van den Wijngaard RM. Botschuijver S, et al. Among authors: van den wijngaard rm. Neurogastroenterol Motil. 2018 Jun;30(6):e13299. doi: 10.1111/nmo.13299. Epub 2018 Jan 31. Neurogastroenterol Motil. 2018. PMID: 29383802
This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. ...Therefore, Menthacarin() may be a safe and effective treatment option that should be tested for IBS....
This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. ...Therefore, Menthacarin() may be …
Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats.
Botschuijver S, Roeselers G, Levin E, Jonkers DM, Welting O, Heinsbroek SEM, de Weerd HH, Boekhout T, Fornai M, Masclee AA, Schuren FHJ, de Jonge WJ, Seppen J, van den Wijngaard RM. Botschuijver S, et al. Among authors: van den wijngaard rm. Gastroenterology. 2017 Oct;153(4):1026-1039. doi: 10.1053/j.gastro.2017.06.004. Epub 2017 Jun 15. Gastroenterology. 2017. PMID: 28624575
BACKGROUND & AIMS: Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). ...The intestinal fungi might therefore be manipulated for treatment of IBS-related visceral hypersensitivity....
BACKGROUND & AIMS: Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). ...The intestinal fungi mig …
Absence of diurnal variation in visceromotor response to colorectal distention in normal Long Evans rats.
Botschuijver S, Yu Z, Welting O, Cailotto C, Kalsbeek A, van den Wijngaard R. Botschuijver S, et al. Among authors: van den wijngaard r. F1000Res. 2016 Jan 22;5:98. doi: 10.12688/f1000research.7238.1. eCollection 2016. F1000Res. 2016. PMID: 26925229 Free PMC article.
BACKGROUND: Enhanced colorectal sensitivity (i.e. visceral hypersensitivity) is thought to be a pathophysiological mechanism in irritable bowel syndrome (IBS). ...Prior to investigating altered rhythmicity in relation to visceral hypersensitivity in a rat mod …
BACKGROUND: Enhanced colorectal sensitivity (i.e. visceral hypersensitivity) is thought to be a pathophysiological mechanism in irrit …
Dietary Marine n-3 PUFAs Do Not Affect Stress-Induced Visceral Hypersensitivity in a Rat Maternal Separation Model.
van Diest SA, van den Elsen LW, Klok AJ, Welting O, Hilbers FW, van de Heijning BJ, Gaemers IC, Boeckxstaens GE, Werner MF, Willemsen LE, de Jonge WJ, van den Wijngaard RM. van Diest SA, et al. Among authors: van den wijngaard rm. J Nutr. 2015 May;145(5):915-22. doi: 10.3945/jn.114.201731. Epub 2015 Feb 25. J Nutr. 2015. PMID: 25716554 Free article.
BACKGROUND: Although never evaluated for efficacy, n-3 (omega-3) long-chain polyunsaturated fatty acids (LCPUFAs) are commercially offered as treatment for irritable bowel syndrome (IBS). OBJECTIVE: This study was designed to investigate, in a mast cell-dependent model for …
BACKGROUND: Although never evaluated for efficacy, n-3 (omega-3) long-chain polyunsaturated fatty acids (LCPUFAs) are commercially offered a …
Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations.
van den Wijngaard RM, Stanisor OI, van Diest SA, Welting O, Wouters MM, Cailotto C, de Jonge WJ, Boeckxstaens GE. van den Wijngaard RM, et al. Neurogastroenterol Motil. 2013 Dec;25(12):e780-90. doi: 10.1111/nmo.12202. Epub 2013 Aug 21. Neurogastroenterol Motil. 2013. PMID: 23965154
BACKGROUND: In irritable bowel syndrome (IBS), familial clustering and transfer across generations may largely depend on environmental factors but this is difficult to establish in the human setting. ...Thus, MS is a suitable model to evaluate environmental triggers releva …
BACKGROUND: In irritable bowel syndrome (IBS), familial clustering and transfer across generations may largely depend on environmenta …
25 results