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Year Number of Results
2011 1
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2019 2
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11 results
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Minireview: structural insights into early folding events using continuous-flow time-resolved small-angle X-ray scattering.
Kathuria SV, Guo L, Graceffa R, Barrea R, Nobrega RP, Matthews CR, Irving TC, Bilsel O. Kathuria SV, et al. Among authors: nobrega rp. Biopolymers. 2011 Aug;95(8):550-8. doi: 10.1002/bip.21628. Epub 2011 Mar 25. Biopolymers. 2011. PMID: 21442608 Free PMC article. Review.
Small-angle X-ray scattering (SAXS) is a powerful method for obtaining quantitative structural information on the size and shape of proteins, and it is increasingly used in kinetic studies of folding and association reactions. In this minireview, we discuss recent developm …
Small-angle X-ray scattering (SAXS) is a powerful method for obtaining quantitative structural information on the size and shape of prote
Modulation of frustration in folding by sequence permutation.
Nobrega RP, Arora K, Kathuria SV, Graceffa R, Barrea RA, Guo L, Chakravarthy S, Bilsel O, Irving TC, Brooks CL 3rd, Matthews CR. Nobrega RP, et al. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10562-7. doi: 10.1073/pnas.1324230111. Epub 2014 Jul 7. Proc Natl Acad Sci U S A. 2014. PMID: 25002512 Free PMC article.
Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energy surface rough with local minima trapping frustrated species. ...Chemotaxis response regulator Y (CheY), a 129-amino acid bacterial prot
Folding of globular proteins can be envisioned as the contraction of a random coil unfolded state toward the native state on an energ …
Microsecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.
Kathuria SV, Kayatekin C, Barrea R, Kondrashkina E, Graceffa R, Guo L, Nobrega RP, Chakravarthy S, Matthews CR, Irving TC, Bilsel O. Kathuria SV, et al. Among authors: nobrega rp. J Mol Biol. 2014 May 1;426(9):1980-94. doi: 10.1016/j.jmb.2014.02.020. Epub 2014 Mar 4. J Mol Biol. 2014. PMID: 24607691 Free PMC article.
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein.
Basak S, Nobrega RP, Tavella D, Deveau LM, Koga N, Tatsumi-Koga R, Baker D, Massi F, Matthews CR. Basak S, et al. Among authors: nobrega rp. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6806-6811. doi: 10.1073/pnas.1818744116. Epub 2019 Mar 15. Proc Natl Acad Sci U S A. 2019. PMID: 30877249 Free PMC article.
The complex protection pattern for HDX corresponds closely with a pair of electrostatic networks on the surface and an extensive network of hydrophobic side chains in the interior of the protein. Mutational analysis showed that electrostatic and hydrophobic networks contri …
The complex protection pattern for HDX corresponds closely with a pair of electrostatic networks on the surface and an extensive network of …
Atomistic structural ensemble refinement reveals non-native structure stabilizes a sub-millisecond folding intermediate of CheY.
Shi J, Nobrega RP, Schwantes C, Kathuria SV, Bilsel O, Matthews CR, Lane TJ, Pande VS. Shi J, et al. Among authors: nobrega rp. Sci Rep. 2017 Mar 8;7:44116. doi: 10.1038/srep44116. Sci Rep. 2017. PMID: 28272524 Free PMC article.
The dynamics of globular proteins can be described in terms of transitions between a folded native state and less-populated intermediates, or excited states, which can play critical roles in both protein folding and function. ...This study demonstrates the paradigm …
The dynamics of globular proteins can be described in terms of transitions between a folded native state and less-populated intermedi …
Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies.
Yang R, Jain T, Lynaugh H, Nobrega RP, Lu X, Boland T, Burnina I, Sun T, Caffry I, Brown M, Zhi X, Lilov A, Xu Y. Yang R, et al. Among authors: nobrega rp. MAbs. 2017 May/Jun;9(4):646-653. doi: 10.1080/19420862.2017.1290753. Epub 2017 Feb 14. MAbs. 2017. PMID: 28281887 Free PMC article.
This high-throughput, middle-down approach allows detection of oxidation site(s) at the resolution of 3 distinct segments. The experimental oxidation data correlates well with theoretical predictions based on the solvent-accessible surface area of the methionine side-chain …
This high-throughput, middle-down approach allows detection of oxidation site(s) at the resolution of 3 distinct segments. The experi …
11 results