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Year Number of Results
1998 1
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Page 1
Wnt pathway activation by ADP-ribosylation.
Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y. Yang E, et al. Among authors: ahmed y. Nat Commun. 2016 May 3;7:11430. doi: 10.1038/ncomms11430. Nat Commun. 2016. PMID: 27138857 Free PMC article.
Wnt/beta-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer. ...
Wnt/beta-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer. ...
Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.
Tian A, Benchabane H, Ahmed Y. Tian A, et al. Among authors: ahmed y. J Dev Biol. 2018 Mar 28;6(2):8. doi: 10.3390/jdb6020008. J Dev Biol. 2018. PMID: 29615557 Free PMC article. Review.
In mammals, the Wnt/beta-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the …
In mammals, the Wnt/beta-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wn …
The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E. Ng VH, et al. Among authors: ahmed y. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z. Nat Commun. 2023. PMID: 37798301 Free PMC article.
Corrigendum to "The protective effect of thymoquinone or/and thymol against monosodium glutamate-induced attention-deficit/hyperactivity disorder (ADHD)-like behavior in rats: Modulation of Nrf2/HO-1, TLR4/NF-kappaB/NLRP3/caspase-1 and Wnt/beta-Catenin signaling pathways in rat model" [Biomed. Pharmacother. 155 (2022) 113799].
Abu-Elfotuh K, Abdel-Sattar SA, Abbas AN, Mahran YF, Alshanwani AR, Hamdan AME, Atwa AM, Reda E, Ahmed YM, Zaghlool SS, El-Din MN. Abu-Elfotuh K, et al. Among authors: ahmed ym. Biomed Pharmacother. 2023 Jun;162:114735. doi: 10.1016/j.biopha.2023.114735. Epub 2023 Apr 21. Biomed Pharmacother. 2023. PMID: 37088669 Free article. No abstract available.
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y. Spencer ZT, et al. Among authors: ahmed y. Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0. Nat Commun. 2023. PMID: 37798281 Free PMC article.
Usp46 inactivation in Wingless-responding cells destabilizes Arrow, reduces cytoplasmic accumulation of the transcriptional coactivator Armadillo/beta-catenin, and attenuates or abolishes Wingless target gene activation, which prevents the concentration-dependent regulatio …
Usp46 inactivation in Wingless-responding cells destabilizes Arrow, reduces cytoplasmic accumulation of the transcriptional coactivator Arma …
Nuclear Regulation of Wnt/beta-Catenin Signaling: It's a Complex Situation.
Anthony CC, Robbins DJ, Ahmed Y, Lee E. Anthony CC, et al. Among authors: ahmed y. Genes (Basel). 2020 Aug 4;11(8):886. doi: 10.3390/genes11080886. Genes (Basel). 2020. PMID: 32759724 Free PMC article. Review.
Of the myriad of signaling events that have been ascribed to cellular activation by Wnt ligands, the canonical Wnt/beta-catenin pathway has been the most studied and best understood. Misregulation of Wnt/beta-catenin signaling has been implicated in developmental de …
Of the myriad of signaling events that have been ascribed to cellular activation by Wnt ligands, the canonical Wnt/beta-catenin pathw …
Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries.
Tian A, Benchabane H, Wang Z, Ahmed Y. Tian A, et al. Among authors: ahmed y. PLoS Genet. 2016 Feb 4;12(2):e1005822. doi: 10.1371/journal.pgen.1005822. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26845150 Free PMC article.
Intestinal stem cell (ISC) self-renewal and proliferation are directed by Wnt/beta-catenin signaling in mammals, whereas aberrant Wnt pathway activation in ISCs triggers the development of human colorectal carcinoma. ...
Intestinal stem cell (ISC) self-renewal and proliferation are directed by Wnt/beta-catenin signaling in mammals, whereas aberrant Wnt …
Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.
Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y. Takacs CM, et al. Among authors: ahmed y. Science. 2008 Jan 18;319(5861):333-6. doi: 10.1126/science.1151232. Science. 2008. PMID: 18202290
The Apc amino terminus is important for its activating function, whereas the beta-catenin binding sites are dispensable. Apc likely promotes Wingless transduction through down-regulation of Axin, a negative regulator of Wingless signaling. ...
The Apc amino terminus is important for its activating function, whereas the beta-catenin binding sites are dispensable. Apc likely p …
Wnt signalosomes: What we know that we do not know.
Hartmann H, Siddiqui GS, Bryant J, Robbins DJ, Weiss VL, Ahmed Y, Lee E. Hartmann H, et al. Among authors: ahmed y. Bioessays. 2025 Feb;47(2):e2400110. doi: 10.1002/bies.202400110. Epub 2024 Nov 9. Bioessays. 2025. PMID: 39520379 Free PMC article. Review.
Signaling through the Wnt/beta-catenin pathway is relayed through three multiprotein complexes: (1) the membrane-associated signalosome, which includes the activated Wnt receptors, (2) the cytoplasmic destruction complex that regulates turnover of the transcriptional coact …
Signaling through the Wnt/beta-catenin pathway is relayed through three multiprotein complexes: (1) the membrane-associated signaloso …
31 results