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Did you mean ​Influence of NRF2 in skeletal muscle (71 results)?
Exercise-induced Nrf2 activation increases antioxidant defenses in skeletal muscles.
Powers SK, Lategan-Potgieter R, Goldstein E. Powers SK, et al. Free Radic Biol Med. 2024 Nov 1;224:470-478. doi: 10.1016/j.freeradbiomed.2024.07.041. Epub 2024 Aug 23. Free Radic Biol Med. 2024. PMID: 39181477 Review.
Following the discovery that exercise increases the production of reactive oxygen species in contracting skeletal muscles, evidence quickly emerged that endurance exercise training increases the abundance of key antioxidant enzymes in the trained muscles. ... …
Following the discovery that exercise increases the production of reactive oxygen species in contracting skeletal muscles, evi …
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness.
Galvan-Alvarez V, Gallego-Selles A, Martinez-Canton M, García-Gonzalez E, Gelabert-Rebato M, Ponce-Gonzalez JG, Larsen S, Morales-Alamo D, Losa-Reyna J, Perez-Suarez I, Dorado C, Perez-Valera M, Holmberg HC, Boushel R, de Pablos Velasco P, Helge JW, Martin-Rincon M, Calbet JAL. Galvan-Alvarez V, et al. Free Radic Biol Med. 2023 Nov 20;209(Pt 2):282-291. doi: 10.1016/j.freeradbiomed.2023.10.393. Epub 2023 Oct 17. Free Radic Biol Med. 2023. PMID: 37858747 Free article.
Ageing, a sedentary lifestyle, and obesity are associated with increased oxidative stress, while regular exercise is associated with an increased antioxidant capacity in trained skeletal muscles. Whether a higher aerobic fitness is associated with increased expressi …
Ageing, a sedentary lifestyle, and obesity are associated with increased oxidative stress, while regular exercise is associated with an incr …
Effects of environmental hypoxia on the goldfish skeletal muscle: Focus on oxidative status and mitochondrial dynamics.
Filice M, Caferro A, Gattuso A, Sperone E, Agnisola C, Faggio C, Cerra MC, Imbrogno S. Filice M, et al. J Contam Hydrol. 2024 Feb;261:104299. doi: 10.1016/j.jconhyd.2024.104299. Epub 2024 Jan 12. J Contam Hydrol. 2024. PMID: 38237486 Free article.
The skeletal muscle is a highly plastic tissue. Its ability to respond to external stimuli and challenges allows it to face the functional needs of the organism. ...Our results revealed novel aspects of the molecular mechanisms that in the goldfish skeletal …
The skeletal muscle is a highly plastic tissue. Its ability to respond to external stimuli and challenges allows it to face th …
Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.
Konopka AR, Laurin JL, Musci RV, Wolff CA, Reid JJ, Biela LM, Zhang Q, Peelor FF 3rd, Melby CL, Hamilton KL, Miller BF. Konopka AR, et al. Geroscience. 2017 Apr;39(2):175-186. doi: 10.1007/s11357-017-9968-8. Epub 2017 Mar 10. Geroscience. 2017. PMID: 28283797 Free PMC article. Clinical Trial.
CLA decreased oxidative stress and skeletal muscle oxidative damage with a trend to increase messenger RNA (mRNA) expression of a Nrf2 target, NAD(P)H dehydrogenase quinone 1 (NQO1). ...Overall, these data suggest that Protandim may enhance proteostatic mecha …
CLA decreased oxidative stress and skeletal muscle oxidative damage with a trend to increase messenger RNA (mRNA) expression o …
Research on the Anti-Fatigue Effects and Mechanisms of Arecoline in Sleep-Deprived Mice.
Wang D, Sun Y, Liu J, Sun J, Fan B, Lu C, Wang F. Wang D, et al. Nutrients. 2024 Aug 21;16(16):2783. doi: 10.3390/nu16162783. Nutrients. 2024. PMID: 39203919 Free PMC article.
Western blotting was employed to quantify the expression levels of nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), heme oxygenase 1 (HO-1), sequestosome-1 (p62), and NADPH quinone oxidoreductase 1 (NQO1) in the gastrocnemius …
Western blotting was employed to quantify the expression levels of nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-a …
Binge alcohol induces NRF2-related antioxidant response in the skeletal muscle of female mice.
Tice AL, Steiner JL. Tice AL, et al. Biochem Biophys Res Commun. 2024 Jun 25;714:149968. doi: 10.1016/j.bbrc.2024.149968. Epub 2024 Apr 20. Biochem Biophys Res Commun. 2024. PMID: 38657445
BACKGROUND: Chronic alcohol enhances oxidative stress, but the temporal response of antioxidant genes in skeletal muscle following a binge drinking episode remains unknown. METHODS: Experiment 1: C57BL/6Hsd female mice received an IP injection of saline (CON; n = 39 …
BACKGROUND: Chronic alcohol enhances oxidative stress, but the temporal response of antioxidant genes in skeletal muscle follo …
Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy.
Whitman SA, Long M, Wondrak GT, Zheng H, Zhang DD. Whitman SA, et al. Exp Cell Res. 2013 Oct 15;319(17):2673-83. doi: 10.1016/j.yexcr.2013.07.015. Epub 2013 Jul 27. Exp Cell Res. 2013. PMID: 23896025 Free PMC article.
The role of Nrf2 in disease prevention and treatment is well documented; however the specific role of Nrf2 in skeletal muscle is not well described. The current study investigated whether Nrf2 plays a protective role in an STZ-induced model of …
The role of Nrf2 in disease prevention and treatment is well documented; however the specific role of Nrf2 in skeletal …
TBBPA induces inflammation, apoptosis, and necrosis of skeletal muscle in mice through the ROS/Nrf2/TNF-alpha signaling pathway.
Zhang Q, Wang S, Wang F, Guo M, Xu S. Zhang Q, et al. Environ Pollut. 2023 Jan 15;317:120745. doi: 10.1016/j.envpol.2022.120745. Epub 2022 Nov 25. Environ Pollut. 2023. PMID: 36442820
However, the mechanism of TBBPA-induced skeletal muscle injury remains unclear. In this study, we constructed mouse skeletal muscle models (10, 20, and 40 mg/kg TBBPA) and mouse myoblasts (C2C12) cell models (2,4, and 8 mug/L TBBPA) at different concen …
However, the mechanism of TBBPA-induced skeletal muscle injury remains unclear. In this study, we constructed mouse skeleta …
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.
Wang S, Yang X, Liu K, Xiong D, Yalikun A, Hamiti Y, Yusufu A. Wang S, et al. J Transl Med. 2024 Nov 2;22(1):991. doi: 10.1186/s12967-024-05810-7. J Transl Med. 2024. PMID: 39487481 Free PMC article.
BACKGROUND: Muscle atrophy caused by denervation is common in neuromuscular diseases, leading to loss of muscle mass and function. ...The therapeutic potential of the NRF2-targeting drug Omaveloxolone was evaluated in the mouse model. RESULT: This research ex …
BACKGROUND: Muscle atrophy caused by denervation is common in neuromuscular diseases, leading to loss of muscle mass and funct …
Effect of Genistein Supplementation on Exercise-Induced Inflammation and Oxidative Stress in Mice Liver and Skeletal Muscle.
Wu C, Zhou S, Ma S, Suzuki K. Wu C, et al. Medicina (Kaunas). 2021 Sep 27;57(10):1028. doi: 10.3390/medicina57101028. Medicina (Kaunas). 2021. PMID: 34684067 Free PMC article.
Results: Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, liver interleukin (IL)-6, IL-1beta, superoxide dismutase 1 (SOD1), catalase (CAT), hemeoxygenase-1 (HO-1) gene expression levels and skeletal muscle IL-6, nuclear factor erythro …
Results: Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, liver interleukin (IL)-6, IL-1beta, superoxide dism …
72 results