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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1983 1
1986 2
1987 29
1988 55
1989 44
1990 46
1991 38
1992 42
1993 42
1994 39
1995 55
1996 56
1997 69
1998 78
1999 76
2000 77
2001 87
2002 78
2003 69
2004 64
2005 101
2006 98
2007 87
2008 95
2009 96
2010 75
2011 107
2012 93
2013 90
2014 153
2015 173
2016 165
2017 163
2018 170
2019 170
2020 148
2021 141
2022 120
2023 134
2024 44

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3,273 results

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Page 1
An in vivo model of functional and vascularized human brain organoids.
Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. Mansour AA, et al. Nat Biotechnol. 2018 Jun;36(5):432-441. doi: 10.1038/nbt.4127. Epub 2018 Apr 16. Nat Biotechnol. 2018. PMID: 29658944 Free PMC article.
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease. To provide a vascularized and functional in vivo model of brain organoids, we es …
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity …
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, Panda S. Hatori M, et al. Cell Metab. 2012 Jun 6;15(6):848-60. doi: 10.1016/j.cmet.2012.04.019. Epub 2012 May 17. Cell Metab. 2012. PMID: 22608008 Free PMC article.
To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib …
To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib …
Interspecies Chimerism with Mammalian Pluripotent Stem Cells.
Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Wu J, et al. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. Cell. 2017. PMID: 28129541 Free PMC article.
Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evo …
Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment o …
Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.
Tan T, Wu J, Si C, Dai S, Zhang Y, Sun N, Zhang E, Shao H, Si W, Yang P, Wang H, Chen Z, Zhu R, Kang Y, Hernandez-Benitez R, Martinez Martinez L, Nuñez Delicado E, Berggren WT, Schwarz M, Ai Z, Li T, Rodriguez Esteban C, Ji W, Niu Y, Izpisua Belmonte JC. Tan T, et al. Cell. 2021 Apr 15;184(8):2020-2032.e14. doi: 10.1016/j.cell.2021.03.020. Cell. 2021. PMID: 33861963 Free article.
Studies using mouse and pig embryos suggest that hPSCs do not robustly contribute to chimera formation in species evolutionarily distant to humans. We studied the chimeric competency of human extended pluripotent stem cells (hEPSCs) in cynomolgus monkey …
Studies using mouse and pig embryos suggest that hPSCs do not robustly contribute to chimera formation in species evolutionari …
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, Liddle C, Auwerx J, Downes M, Panda S, Evans RM. Cho H, et al. Nature. 2012 Mar 29;485(7396):123-7. doi: 10.1038/nature11048. Nature. 2012. PMID: 22460952 Free PMC article.
As predicted by the cistromic analysis, dual depletion of Rev-erb-alpha and Rev-erb-beta function by creating double-knockout mice profoundly disrupted circadian expression of core circadian clock and lipid homeostatic gene networks. As a result, double-knockout mice …
As predicted by the cistromic analysis, dual depletion of Rev-erb-alpha and Rev-erb-beta function by creating double-knockout mice pr …
Conserved and divergent gene regulatory programs of the mammalian neocortex.
Zemke NR, Armand EJ, Wang W, Lee S, Zhou J, Li YE, Liu H, Tian W, Nery JR, Castanon RG, Bartlett A, Osteen JK, Li D, Zhuo X, Xu V, Chang L, Dong K, Indralingam HS, Rink JA, Xie Y, Miller M, Krienen FM, Zhang Q, Taskin N, Ting J, Feng G, McCarroll SA, Callaway EM, Wang T, Lein ES, Behrens MM, Ecker JR, Ren B. Zemke NR, et al. Nature. 2023 Dec;624(7991):390-402. doi: 10.1038/s41586-023-06819-6. Epub 2023 Dec 13. Nature. 2023. PMID: 38092918 Free PMC article.
Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles f …
Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse usi …
Acute Neuropixels recordings in the marmoset monkey.
Dotson NM, Davis ZW, Jendritza P, Reynolds JH. Dotson NM, et al. bioRxiv [Preprint]. 2023 Dec 15:2023.12.14.571771. doi: 10.1101/2023.12.14.571771. bioRxiv. 2023. PMID: 38168386 Free PMC article. Preprint.
High-density linear probes, like Neuropixels, provide an unprecedented opportunity to understand how neural populations within specific laminar compartments contribute to behavior. Marmoset monkeys, unlike macaque monkeys, have a lissencephalic (smooth …
High-density linear probes, like Neuropixels, provide an unprecedented opportunity to understand how neural populations within specific lami …
Revival of light signalling in the postmortem mouse and human retina.
Abbas F, Becker S, Jones BW, Mure LS, Panda S, Hanneken A, Vinberg F. Abbas F, et al. Nature. 2022 Jun;606(7913):351-357. doi: 10.1038/s41586-022-04709-x. Epub 2022 May 11. Nature. 2022. PMID: 35545677 Free PMC article.
We demonstrate the swift decline of neuronal signalling and identify conditions for reviving synchronous in vivo-like trans-synaptic transmission in postmortem mouse and human retina. ...Finally, we quantify the rate-limiting deactivation reaction of phototra …
We demonstrate the swift decline of neuronal signalling and identify conditions for reviving synchronous in vivo-like trans-sy …
Age-Related Learning and Working Memory Impairment in the Common Marmoset.
Glavis-Bloom C, Vanderlip CR, Reynolds JH. Glavis-Bloom C, et al. J Neurosci. 2022 Nov 23;42(47):8870-8880. doi: 10.1523/JNEUROSCI.0985-22.2022. Epub 2022 Oct 18. J Neurosci. 2022. PMID: 36257687 Free PMC article.
Ultimately, these barriers necessitate the development of novel aging models. As a nonhuman primate (NHP), the common marmoset (Callithrix jacchus) shares many features in common with humans and yet has a significantly shorter lifespan (10 years) than other …
Ultimately, these barriers necessitate the development of novel aging models. As a nonhuman primate (NHP), the common marmo …
A guide to the BRAIN Initiative Cell Census Network data ecosystem.
Hawrylycz M, Martone ME, Ascoli GA, Bjaalie JG, Dong HW, Ghosh SS, Gillis J, Hertzano R, Haynor DR, Hof PR, Kim Y, Lein E, Liu Y, Miller JA, Mitra PP, Mukamel E, Ng L, Osumi-Sutherland D, Peng H, Ray PL, Sanchez R, Regev A, Ropelewski A, Scheuermann RH, Tan SZK, Thompson CL, Tickle T, Tilgner H, Varghese M, Wester B, White O, Zeng H, Aevermann B, Allemang D, Ament S, Athey TL, Baker C, Baker KS, Baker PM, Bandrowski A, Banerjee S, Bishwakarma P, Carr A, Chen M, Choudhury R, Cool J, Creasy H, D'Orazi F, Degatano K, Dichter B, Ding SL, Dolbeare T, Ecker JR, Fang R, Fillion-Robin JC, Fliss TP, Gee J, Gillespie T, Gouwens N, Zhang GQ, Halchenko YO, Harris NL, Herb BR, Hintiryan H, Hood G, Horvath S, Huo B, Jarecka D, Jiang S, Khajouei F, Kiernan EA, Kir H, Kruse L, Lee C, Lelieveldt B, Li Y, Liu H, Liu L, Markuhar A, Mathews J, Mathews KL, Mezias C, Miller MI, Mollenkopf T, Mufti S, Mungall CJ, Orvis J, Puchades MA, Qu L, Receveur JP, Ren B, Sjoquist N, Staats B, Tward D, van Velthoven CTJ, Wang Q, Xie F, Xu H, Yao Z, Yun Z, Zhang YR, Zheng WJ, Zingg B. Hawrylycz M, et al. PLoS Biol. 2023 Jun 30;21(6):e3002133. doi: 10.1371/journal.pbio.3002133. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37390046 Free PMC article.
The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization. Emphasis of the BICCN is on the whole mous …
The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards deve …
3,273 results