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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 32
2009 55
2010 55
2011 49
2012 55
2013 69
2014 110
2015 121
2016 120
2017 101
2018 93
2019 91
2020 95
2021 91
2022 69
2023 75
2024 22

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1,126 results

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Page 1
Risk and safety of probiotics.
Doron S, Snydman DR. Doron S, et al. Clin Infect Dis. 2015 May 15;60 Suppl 2(Suppl 2):S129-34. doi: 10.1093/cid/civ085. Clin Infect Dis. 2015. PMID: 25922398 Free PMC article. Review.
Critics point out that the preponderance of evidence, including the long history of safe probiotic use as well as data from clinical trials, and animal and in vitro studies all support the assumption that probiotics are generally safe for most populations. ...
Critics point out that the preponderance of evidence, including the long history of safe probiotic use as well as data from clinical trials, …
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. Roper J, et al. Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Nat Biotechnol. 2017. PMID: 28459449 Free PMC article.
In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germline mutant mice. ...Apcdelta/delta;Kras(G12D/+);Trp53delta/delta (AKP) mouse colon organoids and human CRC organoids engraft in …
In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germli …
Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Buckley ST, Bækdal TA, Vegge A, Maarbjerg SJ, Pyke C, Ahnfelt-Rønne J, Madsen KG, Schéele SG, Alanentalo T, Kirk RK, Pedersen BL, Skyggebjerg RB, Benie AJ, Strauss HM, Wahlund PO, Bjerregaard S, Farkas E, Fekete C, Søndergaard FL, Borregaard J, Hartoft-Nielsen ML, Knudsen LB. Buckley ST, et al. Sci Transl Med. 2018 Nov 14;10(467):eaar7047. doi: 10.1126/scitranslmed.aar7047. Sci Transl Med. 2018. PMID: 30429357 Clinical Trial.
In contrast to intestinal absorption usually seen with small molecules, clinical and preclinical dog studies revealed that absorption of semaglutide takes place in the stomach, is confined to an area in close proximity to the tablet surface, and requires coformulation with …
In contrast to intestinal absorption usually seen with small molecules, clinical and preclinical dog studies revealed that absorption …
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses.
Muendlein HI, Connolly WM, Cameron J, Jetton D, Magri Z, Smirnova I, Vannier E, Li X, Martinot AJ, Batorsky R, Poltorak A. Muendlein HI, et al. Sci Immunol. 2022 Dec 23;7(78):eadd0665. doi: 10.1126/sciimmunol.add0665. Epub 2022 Dec 23. Sci Immunol. 2022. PMID: 36563168 Free PMC article.
We present evidence of a role for the TRIFosome downstream of TNF-R1, independent of TLR3 or TLR4 engagement. Specifically, TNF-induced cell death and inflammation in murine macrophages were driven by the TLR4 adaptor TRIF and the LPS co-receptor CD14, highlighting an impo …
We present evidence of a role for the TRIFosome downstream of TNF-R1, independent of TLR3 or TLR4 engagement. Specifically, TNF-induced cell …
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Jackstadt R, van Hooff SR, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, Roper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ. Jackstadt R, et al. Cancer Cell. 2019 Sep 16;36(3):319-336.e7. doi: 10.1016/j.ccell.2019.08.003. Cancer Cell. 2019. PMID: 31526760 Free PMC article.
The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastas …
The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NO …
JNK and cardiometabolic dysfunction.
Craige SM, Chen K, Blanton RM, Keaney JF Jr, Kant S. Craige SM, et al. Biosci Rep. 2019 Jul 18;39(7):BSR20190267. doi: 10.1042/BSR20190267. Print 2019 Jul 31. Biosci Rep. 2019. PMID: 31270248 Free PMC article. Review.
The c-Jun N-terminal Kinases (JNKs) are a family of stress signaling kinases that have been recently indicated in CMS. The purpose of this review is to examine the in vivo implications of JNK as a potential therapeutic target for CMS. ...
The c-Jun N-terminal Kinases (JNKs) are a family of stress signaling kinases that have been recently indicated in CMS. The purpose of this r …
Intestinal organoid/enteroid-based models for Cryptosporidium.
Bhalchandra S, Lamisere H, Ward H. Bhalchandra S, et al. Curr Opin Microbiol. 2020 Dec;58:124-129. doi: 10.1016/j.mib.2020.10.002. Epub 2020 Oct 25. Curr Opin Microbiol. 2020. PMID: 33113480 Free PMC article. Review.
These systems will lead to a better understanding of the mechanisms of host-parasite interactions in vivo....
These systems will lead to a better understanding of the mechanisms of host-parasite interactions in vivo....
Progress and challenges in experimental models for pheochromocytoma and paraganglioma.
Tischler AS, Favier J. Tischler AS, et al. Endocr Relat Cancer. 2023 Apr 4;30(5):e220405. doi: 10.1530/ERC-22-0405. Print 2023 May 1. Endocr Relat Cancer. 2023. PMID: 36810302
While there are no human cell line or xenograft models that faithfully recapitulate the genotype or phenotype of these tumors, the past decade has shown progress in development and utilization of animal models, including a mouse and a rat model for SDH-defici …
While there are no human cell line or xenograft models that faithfully recapitulate the genotype or phenotype of these tumors, the past deca …
Interaction of extraembryonic microglia and neonatal brain development.
Sharma R, Mei A, Mathew V, Kashpur O, Wallingford MC. Sharma R, et al. Exp Neurol. 2022 May;351:113986. doi: 10.1016/j.expneurol.2022.113986. Epub 2022 Jan 19. Exp Neurol. 2022. PMID: 35065053 Review.
The YS is the first site of hematopoiesis in development. Uniquely, microglial pregenital cells in the mouse derive from an early myeloid branch of the hematopoietic lineage in the YS. ...Abnormal microglial function has been linked to neurodevelopmental and neurodegenerat …
The YS is the first site of hematopoiesis in development. Uniquely, microglial pregenital cells in the mouse derive from an early mye …
1,126 results