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Extracellular matrix produced by bone marrow stromal cells and by their derivative, SB623 cells, supports neural cell growth.
Aizman I, Tate CC, McGrogan M, Case CC. Aizman I, et al. J Neurosci Res. 2009 Nov 1;87(14):3198-206. doi: 10.1002/jnr.22146. J Neurosci Res. 2009. PMID: 19530164
In this study, we demonstrate in vitro that the ECM produced by MSC can support neural cell attachment and growth. We also compare the neurosupportive properties of MSC to the MSC derivative, SB623 cells, which is being deve …
In this study, we demonstrate in vitro that the ECM produced by MSC can support neural cell attachment and gr
Comparison of the neuropoietic activity of gene-modified versus parental mesenchymal stromal cells and the identification of soluble and extracellular matrix-related neuropoietic mediators.
Aizman I, Tirumalashetty BJ, McGrogan M, Case CC. Aizman I, et al. Stem Cell Res Ther. 2014 Feb 26;5(1):29. doi: 10.1186/scrt418. Stem Cell Res Ther. 2014. PMID: 24572070 Free PMC article.
This creates a new phenotype, which is effective in experimental stroke, exhibits immunosuppressive and angiogenic activity equal or superior to parental MSCs in vitro, and produces extracellular matrix (ECM) that is exceptionally supportive for neu
This creates a new phenotype, which is effective in experimental stroke, exhibits immunosuppressive and angiogenic activity equal or superio …