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Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors.
Bantounas I, Ranjzad P, Tengku F, Silajdžić E, Forster D, Asselin MC, Lewis P, Lennon R, Plagge A, Wang Q, Woolf AS, Kimber SJ. Bantounas I, et al. Stem Cell Reports. 2018 Mar 13;10(3):766-779. doi: 10.1016/j.stemcr.2018.01.008. Epub 2018 Feb 8. Stem Cell Reports. 2018. PMID: 29429961 Free PMC article.
Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development and disease. ...They expressed nephron and collecting duct lineage marker genes, several of which are mutated in human kidney disease. ...
Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development and disease. ...The
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.
Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, Lian MM, Liu M, Aizawa E, Rodriguez Esteban C, Yong KSM, Chen Q, Campistol JM, Fang M, Khor CC, Foo JN, Izpisua Belmonte JC, Xia Y. Low JH, et al. Cell Stem Cell. 2019 Sep 5;25(3):373-387.e9. doi: 10.1016/j.stem.2019.06.009. Epub 2019 Jul 11. Cell Stem Cell. 2019. PMID: 31303547 Free PMC article.
Human pluripotent stem cell-derived kidney organoids recapitulate developmental processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and functionality, have greatly hampered their application. .
Human pluripotent stem cell-derived kidney organoids recapitulate developmental processes and tiss
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