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RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation.
Yan HHN, Lai JCW, Ho SL, Leung WK, Law WL, Lee JFY, Chan AKW, Tsui WY, Chan ASY, Lee BCH, Yue SSK, Man AHY, Clevers H, Yuen ST, Leung SY. Yan HHN, et al. Gut. 2017 Sep;66(9):1645-1656. doi: 10.1136/gutjnl-2016-311849. Epub 2016 Jun 21. Gut. 2017. PMID: 27329244
RESULTS: In one out of four serrated polyposis families, we identified a germline RNF43 mutation that displayed autosomal dominant cosegregation with the serrated polyposis phenotype, along with second-hit inactivation through loss of heterozygo …
RESULTS: In one out of four serrated polyposis families, we identified a germline RNF43 mutation that displayed …
Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.
Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC. Gala MK, et al. Gastroenterology. 2014 Feb;146(2):520-9. doi: 10.1053/j.gastro.2013.10.045. Gastroenterology. 2014. PMID: 24512911 Free PMC article.
BACKGROUND & AIMS: Little is known about the genetic factors that contribute to the development of sessile serrated adenomas (SSAs). SSAs contain somatic mutations in BRAF or KRAS early in development. ...Progression to serrated neoplasia
BACKGROUND & AIMS: Little is known about the genetic factors that contribute to the development of sessile serrated adenomas (SSA …