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MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.
Ogawa Y, Morikawa S, Okano H, Mabuchi Y, Suzuki S, Yaguchi T, Sato Y, Mukai S, Yaguchi S, Inaba T, Okamoto S, Kawakami Y, Tsubota K, Matsuzaki Y, Shimmura S. Ogawa Y, et al. Elife. 2016 Jan 26;5:e09394. doi: 10.7554/eLife.09394. Elife. 2016. PMID: 26809474 Free PMC article.
Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pat
Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC
Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.
Mukai S, Ogawa Y, Saya H, Kawakami Y, Tsubota K. Mukai S, et al. PLoS One. 2018 Oct 11;13(10):e0203742. doi: 10.1371/journal.pone.0203742. eCollection 2018. PLoS One. 2018. PMID: 30307955 Free PMC article.
Chronic graft-versus-host disease (cGVHD) is a marked complication of hematopoietic stem cell transplantation, and multiple organs can be affected by cGVHD-induced inflammation and fibrosis. ...To investigate the effectiveness of tranilast for cGVHD, we used an M
Chronic graft-versus-host disease (cGVHD) is a marked complication of hematopoietic stem cell transplantation, and multiple organs ca …