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Page 1
Amantadine and memantine: a comprehensive review for acquired brain injury.
Ma HM, Zafonte RD. Ma HM, et al. Brain Inj. 2020 Feb 23;34(3):299-315. doi: 10.1080/02699052.2020.1723697. Epub 2020 Feb 20. Brain Inj. 2020. PMID: 32078407 Review.
This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both amantadine and memantine are commonly used in the acute rehabilitation setting follow …
This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been tr …
Ethical Considerations of Off-Label Prescribing in Disruptive Mood Dysregulation Disorder.
Maiyuran H, Saylor C, Appel J, Rice TR. Maiyuran H, et al. J Clin Ethics. 2024 Winter;35(4):288-295. doi: 10.1086/732212. J Clin Ethics. 2024. PMID: 39540642
A case history of a 12-year-old girl with DMDD who was treated with amantadine with good response illustrates these ethical considerations within a clinical context. There are significant benefits of off-label uses of medications in the treatment of DMDD. The promising pot …
A case history of a 12-year-old girl with DMDD who was treated with amantadine with good response illustrates these ethical considera …
Non-dopaminergic treatments for motor control in Parkinson's disease.
Fox SH. Fox SH. Drugs. 2013 Sep;73(13):1405-15. doi: 10.1007/s40265-013-0105-4. Drugs. 2013. PMID: 23917951 Review.
To reduce levodopa-induced dyskinesia, drugs that target overactive glutamatergic neurotransmission can be used, and include the non-selective N-methyl D-aspartate antagonist amantadine. More recently, selective metabotropic glutamate receptor (mGluR5) antagonists are bein …
To reduce levodopa-induced dyskinesia, drugs that target overactive glutamatergic neurotransmission can be used, and include the non-selecti …
Efficacy of off-label augmentation in unipolar depression: A systematic review of the evidence.
Kleeblatt J, Betzler F, Kilarski LL, Bschor T, Köhler S. Kleeblatt J, et al. Eur Neuropsychopharmacol. 2017 May;27(5):423-441. doi: 10.1016/j.euroneuro.2017.03.003. Epub 2017 Mar 17. Eur Neuropsychopharmacol. 2017. PMID: 28318897
For the six drugs dexamethasone, mecamylamine, riluzole, amantadine, pramipexole and yohimbine clear proof of efficacy was not possible due to low levels of evidence, small sample sizes or discordant results. ...
For the six drugs dexamethasone, mecamylamine, riluzole, amantadine, pramipexole and yohimbine clear proof of efficacy was not possib …
Amantadine-induced livedo reticularis in a child treated off label for neurobehavioral disorders.
Helmandollar KJ, Hoverson KR, Meyerle JH. Helmandollar KJ, et al. Cutis. 2018 Sep;102(3):E8-E9. Cutis. 2018. PMID: 30372725
We report the case of an 8-year-old boy who was taking amantadine off label for multiple childhood neurobehavioral disorders and subsequently developed livedo reticularis. Although this side effect is well-described in adult patients taking amantadine for Parkinson …
We report the case of an 8-year-old boy who was taking amantadine off label for multiple childhood neurobehavioral disorders and subs …
Open, uncontrolled, nonrandomized, 9-month, off-label use of bupropion to treat fatigue in a single patient with multiple sclerosis.
Siniscalchi A, Gallelli L, Tolotta GA, Loiacono D, De Sarro G. Siniscalchi A, et al. Clin Ther. 2010 Nov;32(12):2030-4. doi: 10.1016/j.clinthera.2010.10.012. Clin Ther. 2010. PMID: 21118738
The Beck Depression Inventory scale excluded an association between depression and fatigue (score of 8; possible range, 0-24); both the Pittsburgh Sleep Quality Index (score of 4; possible range, 0-21) and the Epworth Sleepiness Scale (score of 6; possible range, 0-24) excluded n …
The Beck Depression Inventory scale excluded an association between depression and fatigue (score of 8; possible range, 0-24); both the Pitt …