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Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review.
Urits I, Peck J, Orhurhu MS, Wolf J, Patel R, Orhurhu V, Kaye AD, Viswanath O. Urits I, et al. Curr Pain Headache Rep. 2019 Jul 29;23(9):66. doi: 10.1007/s11916-019-0803-z. Curr Pain Headache Rep. 2019. PMID: 31359175 Review.
RECENT FINDINGS: The most commonly used antidepressants for chronic pain are tricyclic antidepressants (TCAs), though selective serotonin or noradrenaline reuptake inhibitors and other atypical antidepressants have been shown to be effective at treating chronic pain. In addition …
RECENT FINDINGS: The most commonly used antidepressants for chronic pain are tricyclic antidepressants (TCAs), though selective serotonin or …
Efficacy and safety of established and off-label ADHD drug therapies for cognitive impairment or attention-deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force.
Miskowiak KW, Obel ZK, Guglielmo R, Bonnin CDM, Bowie CR, Balanzá-Martínez V, Burdick KE, Carvalho AF, Dols A, Douglas K, Gallagher P, Kessing LV, Lafer B, Lewandowski KE, López-Jaramillo C, Martinez-Aran A, McIntyre RS, Porter RJ, Purdon SE, Schaffer A, Stokes PRA, Sumiyoshi T, Torres IJ, Van Rheenen TE, Yatham LN, Young AH, Vieta E, Hasler G. Miskowiak KW, et al. Bipolar Disord. 2024 May;26(3):216-239. doi: 10.1111/bdi.13414. Epub 2024 Mar 3. Bipolar Disord. 2024. PMID: 38433530
RESULTS: Seventeen studies were identified (N = 2136), investigating armodafinil (k = 4, N = 1581), methylphenidate (k = 4, N = 84), bupropion (k = 4, n = 249), clonidine (k = 1, n = 70), lisdexamphetamine (k = 1, n = 25), mixed amphetamine salts (k = 1, n = 30), or modafi …
RESULTS: Seventeen studies were identified (N = 2136), investigating armodafinil (k = 4, N = 1581), methylphenidate (k = 4, N = 84), bupr …
Open, uncontrolled, nonrandomized, 9-month, off-label use of bupropion to treat fatigue in a single patient with multiple sclerosis.
Siniscalchi A, Gallelli L, Tolotta GA, Loiacono D, De Sarro G. Siniscalchi A, et al. Clin Ther. 2010 Nov;32(12):2030-4. doi: 10.1016/j.clinthera.2010.10.012. Clin Ther. 2010. PMID: 21118738
The discontinuation and reinitiation of bupropion confirmed the effectiveness of bupropion for improving chronic fatigue in this patient. ...CONCLUSION: This patient with relapsing-remitting MS experienced improvements in chronic fatigue (as measured by FSS) after t …
The discontinuation and reinitiation of bupropion confirmed the effectiveness of bupropion for improving chronic fatigue in th …
Bupropion for attention deficit hyperactivity disorder (ADHD) in adults.
Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C. Verbeeck W, et al. Cochrane Database Syst Rev. 2017 Oct 2;10(10):CD009504. doi: 10.1002/14651858.CD009504.pub2. Cochrane Database Syst Rev. 2017. PMID: 28965364 Free PMC article.
AUTHORS' CONCLUSIONS: The findings of this review, which compared bupropion to placebo for adult ADHD, indicate a possible benefit of bupropion. We found low-quality evidence that bupropion decreased the severity of ADHD symptoms and moderately increased the …
AUTHORS' CONCLUSIONS: The findings of this review, which compared bupropion to placebo for adult ADHD, indicate a possible benefit of …