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Evaluation of unlicensed and off-label antiepileptic drugs prescribed to children: Brazilian Regulatory Agency versus FDA.
Borges AP, Campos MS, Pereira LR. Borges AP, et al. Int J Clin Pharm. 2013 Jun;35(3):425-31. doi: 10.1007/s11096-013-9755-2. Epub 2013 Feb 21. Int J Clin Pharm. 2013. PMID: 23430533
The most used antiepileptic drugs were phenobarbital, phenytoin, carbamazepine, valproic acid and clonazepam. As expected, the number of pharmaceutical dosage form classified as unlicensed or off-label was high in both agencies, but distinct between the two. ...
The most used antiepileptic drugs were phenobarbital, phenytoin, carbamazepine, valproic acid and clonazepam. As expected, the number …
[Trigeminal neuralgia: drug therapy : The new German guideline].
Ruscheweyh R, Gierthmühlen J, Hedderich DM, Goßrau G, Leis S. Ruscheweyh R, et al. Schmerz. 2024 Aug;38(4):283-292. doi: 10.1007/s00482-024-00810-4. Epub 2024 Apr 30. Schmerz. 2024. PMID: 38689064 German.
The only active substances approved for the treatment of trigeminal neuralgia in Germany are carbamazepine and phenytoin, which is why off-label drugs often need to be used if there is no or insufficient effect or inacceptable side effects. ...
The only active substances approved for the treatment of trigeminal neuralgia in Germany are carbamazepine and phenytoin, which is wh …
Venlafaxine for neuropathic pain in adults.
Gallagher HC, Gallagher RM, Butler M, Buggy DJ, Henman MC. Gallagher HC, et al. Cochrane Database Syst Rev. 2015 Aug 23;2015(8):CD011091. doi: 10.1002/14651858.CD011091.pub2. Cochrane Database Syst Rev. 2015. PMID: 26298465 Free PMC article.
Comparators included placebo, imipramine, and carbamazepine and duration of treatment ranged from two to eight weeks. The risk of bias was considerable overall in the review, especially due to the small size of most studies and due to attrition bias. ...
Comparators included placebo, imipramine, and carbamazepine and duration of treatment ranged from two to eight weeks. The risk of bia …
Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1,300,000 older people.
Johnell K, Fastbom J. Johnell K, et al. Eur J Clin Pharmacol. 2011 Oct;67(10):1069-75. doi: 10.1007/s00228-011-1051-2. Epub 2011 Apr 28. Eur J Clin Pharmacol. 2011. PMID: 21533517
RESULTS: AEDs were used by 2% of the community-dwelling and 9% of the institutionalized elderly. The most commonly used AEDs were carbamazepine, gabapentin, pregabalin, valproic acid and lamotrigine. Institutionalization was strongly associated with AED use (OR(adjusted) = …
RESULTS: AEDs were used by 2% of the community-dwelling and 9% of the institutionalized elderly. The most commonly used AEDs were carbama …
Changes in anticonvulsant prescribing for Australian children: implications for Quality Use of Medicines.
Cohen SA, Lawson JA, Graudins LV, Pearson SA, Gazarian M. Cohen SA, et al. J Paediatr Child Health. 2012 Jun;48(6):490-5. doi: 10.1111/j.1440-1754.2011.02223.x. Epub 2011 Nov 3. J Paediatr Child Health. 2012. PMID: 22050665
Lamotrigine was the most frequently prescribed newer anticonvulsant (7.9-9.3 prescriptions/year). Carbamazepine prescriptions decreased by 38% and topiramate prescriptions increased by 19% over the 7-year study period; 3.6% of topiramate prescriptions were off-label (by ag …
Lamotrigine was the most frequently prescribed newer anticonvulsant (7.9-9.3 prescriptions/year). Carbamazepine prescriptions decreas …