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464 results

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Page 1
Polycystic kidney disease.
Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters DJM, Torres VE. Bergmann C, et al. Nat Rev Dis Primers. 2018 Dec 6;4(1):50. doi: 10.1038/s41572-018-0047-y. Nat Rev Dis Primers. 2018. PMID: 30523303 Free PMC article. Review.
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main for …
Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney …
Autosomal Dominant Polycystic Kidney Disease: A Review.
Chebib FT, Hanna C, Harris PC, Torres VE, Dahl NK. Chebib FT, et al. JAMA. 2025 May 20;333(19):1708-1719. doi: 10.1001/jama.2025.0310. JAMA. 2025. PMID: 40126492 Review.
IMPORTANCE: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and is the most common inherited kidney disorder worldwide. ...Approximately 50% of individuals with ADPKD require kidney …
IMPORTANCE: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney …
Polycystic kidney disease.
Harris PC, Torres VE. Harris PC, et al. Annu Rev Med. 2009;60:321-37. doi: 10.1146/annurev.med.60.101707.125712. Annu Rev Med. 2009. PMID: 18947299 Free PMC article. Review.
The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. ...The disease phenotype is highly variable, ranging from neonatal death to later presentation with minim …
The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and c …
Autosomal dominant polycystic kidney disease.
Torres VE, Harris PC, Pirson Y. Torres VE, et al. Lancet. 2007 Apr 14;369(9569):1287-1301. doi: 10.1016/S0140-6736(07)60601-1. Lancet. 2007. PMID: 17434405 Review.
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. ...
Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. ...
Polycystic Kidney Disease Diet: What is Known and What is Safe.
Chebib FT, Nowak KL, Chonchol MB, Bing K, Ghanem A, Rahbari-Oskoui FF, Dahl NK, Mrug M. Chebib FT, et al. Clin J Am Soc Nephrol. 2024 May 1;19(5):664-682. doi: 10.2215/CJN.0000000000000326. Epub 2023 Sep 20. Clin J Am Soc Nephrol. 2024. PMID: 37729939 Free PMC article. Review.
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by kidney cyst formation and progressive kidney function loss. ...
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by kidney cyst formation and p …
Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases.
Cornec-Le Gall E, Torres VE, Harris PC. Cornec-Le Gall E, et al. J Am Soc Nephrol. 2018 Jan;29(1):13-23. doi: 10.1681/ASN.2017050483. Epub 2017 Oct 16. J Am Soc Nephrol. 2018. PMID: 29038287 Free PMC article. Review.
Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between two groups of inherited disorders, autosomal dominant polycystic kidney diseases (ADPKD), a significant cause of ESRD, and autosomal dominant polycystic liv …
Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between two groups of inherited disorders, autosomal …
Tolvaptan in patients with autosomal dominant polycystic kidney disease.
Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS; TEMPO 3:4 Trial Investigators. Torres VE, et al. N Engl J Med. 2012 Dec 20;367(25):2407-18. doi: 10.1056/NEJMoa1205511. Epub 2012 Nov 3. N Engl J Med. 2012. PMID: 23121377 Free PMC article. Clinical Trial.
BACKGROUND: The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure. ...The primary outcome was the annual rate of change in the total kidney volume. Sequential secondary end po …
BACKGROUND: The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, an …
Genetic Spectrum of Polycystic Kidney and Liver Diseases and the Resulting Phenotypes.
Yang H, Sieben CJ, Schauer RS, Harris PC. Yang H, et al. Adv Kidney Dis Health. 2023 Sep;30(5):397-406. doi: 10.1053/j.akdh.2023.04.004. Adv Kidney Dis Health. 2023. PMID: 38097330 Free PMC article. Review.
Polycystic kidney diseases are a group of monogenically inherited disorders characterized by cyst development in the kidney with defects in primary cilia function central to pathogenesis. Autosomal dominant polycystic kidney disease (ADPK …
Polycystic kidney diseases are a group of monogenically inherited disorders characterized by cyst development in the …
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE. Chebib FT, et al. J Am Soc Nephrol. 2018 Oct;29(10):2458-2470. doi: 10.1681/ASN.2018060590. Epub 2018 Sep 18. J Am Soc Nephrol. 2018. PMID: 30228150 Free PMC article. Review.
In the past, the treatment of autosomal dominant polycystic kidney disease (ADPKD) has been limited to the management of its symptoms and complications. Recently, the US Food and Drug Administration (FDA) approved tolvaptan as the first drug treatment to slow kid …
In the past, the treatment of autosomal dominant polycystic kidney disease (ADPKD) has been limited to the management of its s …
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O; REPRISE Trial Investigators. Torres VE, et al. N Engl J Med. 2017 Nov 16;377(20):1930-1942. doi: 10.1056/NEJMoa1710030. Epub 2017 Nov 4. N Engl J Med. 2017. PMID: 29105594 Free article. Clinical Trial.
BACKGROUND: In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, 60 ml per minute), the vasopressin V(2)-receptor antagonist tolvaptan slowed the growth in total kidney volume a …
BACKGROUND: In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated c …
464 results