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2013 3
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14 results

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Probing the helical stability in a VEGF-mimetic peptide.
De Rosa L, Diana D, Di Stasi R, Romanelli A, Sciacca MFM, Milardi D, Isernia C, Fattorusso R, D'Andrea LD. De Rosa L, et al. Among authors: diana d. Bioorg Chem. 2021 Nov;116:105379. doi: 10.1016/j.bioorg.2021.105379. Epub 2021 Sep 21. Bioorg Chem. 2021. PMID: 34563997 Free article.
Ten peptides were, hence, synthesized and analyzed combining circular dichroism, calorimetry and NMR spectroscopy. We found that helical content and thermal stability of peptide QK changed when Leu10 was replaced. ...
Ten peptides were, hence, synthesized and analyzed combining circular dichroism, calorimetry and NMR spectroscopy. We found th …
Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution.
Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Cunsolo A, Gobbo M, Fattorusso R, Diana D, Stefanelli M, Tundo GR, Sbardella D, Coletta M, Fattorusso C. Persico M, et al. Among authors: diana d. Biomolecules. 2022 May 24;12(6):741. doi: 10.3390/biom12060741. Biomolecules. 2022. PMID: 35740865 Free PMC article.
Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. ...In particular, in order to evaluate how the introduction of a peptidic chain can affect the affinity and the interacting mechanism of porphyrins, we inves …
Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. ...In particular, in ord …
Cationic porphyrins are tunable gatekeepers of the 20S proteasome.
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R. Santoro AM, et al. Among authors: diana d. Chem Sci. 2016 Feb 1;7(2):1286-1297. doi: 10.1039/c5sc03312h. Epub 2015 Nov 9. Chem Sci. 2016. PMID: 29910886 Free PMC article.
In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine experimental (enzyme kinetics, UV stopped flow and NMR) and computational (bioinformatic analysis and docking studies) approaches to inspect prot …
In this light, and inspired by previous results evidencing the antiproteasome potential of cationic porphyrins, here we combine exper …
VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy.
Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD. Di Stasi R, et al. Among authors: diana d. Chemistry. 2018 Aug 6;24(44):11461-11466. doi: 10.1002/chem.201802117. Epub 2018 Jul 9. Chemistry. 2018. PMID: 29799174
To characterize the peptide bioactivity and its molecular recognition properties, a detailed picture of the interaction between peptide QK and VEGF receptors is reported. By combining NMR spectroscopy studies in solution on the purified receptor and in the presence …
To characterize the peptide bioactivity and its molecular recognition properties, a detailed picture of the interaction between peptide QK a …
Switching the N-Capping Region from all-L to all-D Amino Acids in a VEGF Mimetic Helical Peptide.
De Rosa L, Diana D, Capasso D, Stefania R, Di Stasi R, Fattorusso R, D'Andrea LD. De Rosa L, et al. Among authors: diana d. Molecules. 2022 Oct 17;27(20):6982. doi: 10.3390/molecules27206982. Molecules. 2022. PMID: 36296575 Free PMC article.
In this paper, we explored the effect of the chiral inversion of the N-capping sequence on QK folding, performing conformational analysis in solution by circular dichroism and NMR spectroscopy. The effect of such a modification on QK stability in serum and the proli …
In this paper, we explored the effect of the chiral inversion of the N-capping sequence on QK folding, performing conformational analysis in …
Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein.
Capasso D, Di Gaetano S, Celentano V, Diana D, Festa L, Di Stasi R, De Rosa L, Fattorusso R, D'Andrea LD. Capasso D, et al. Among authors: diana d. Mol Biosyst. 2017 Jul 25;13(8):1619-1629. doi: 10.1039/c7mb00190h. Mol Biosyst. 2017. PMID: 28685787
We found that residues 1617-1627 of the IQGAP1 protein show molecular features similar to those of the QK peptide sequence. The IQGAP1-derived synthetic peptide was analyzed by NMR spectroscopy and its biological activity was characterized in endothelial cells. ...
We found that residues 1617-1627 of the IQGAP1 protein show molecular features similar to those of the QK peptide sequence. The IQGAP1-deriv …
Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.
Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M. Carotenuto M, et al. Among authors: diana d. Sci Rep. 2013;3:1351. doi: 10.1038/srep01351. Sci Rep. 2013. PMID: 23448979 Free PMC article.
Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, we performed a conformational analysis of the h-Prune C-terminal to identify the amino acids involved in the interaction with Nm23-H1. ...
Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, we performed a …
Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States.
Santoro AM, D'Urso A, Cunsolo A, Milardi D, Purrello R, Sbardella D, Tundo GR, Diana D, Fattorusso R, Dato AD, Paladino A, Persico M, Coletta M, Fattorusso C. Santoro AM, et al. Among authors: diana d. Int J Mol Sci. 2020 Sep 29;21(19):7190. doi: 10.3390/ijms21197190. Int J Mol Sci. 2020. PMID: 33003385 Free PMC article.
The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structural "key code" present on the 20S proteasome alpha-rings and, by consequence, with its catalytic activity. ...
The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structu …
Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates.
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone EM, Fattorusso R. Diana D, et al. Chemistry. 2013 Sep 9;19(37):12217-20. doi: 10.1002/chem.201302168. Epub 2013 Aug 12. Chemistry. 2013. PMID: 23939913
This study shows that protein functions mediated by protein-protein interactions can be accurately followed in cell lysates by using fast NMR spectroscopy, which could be easily used for a very efficient NMR drug-discovery strategy....
This study shows that protein functions mediated by protein-protein interactions can be accurately followed in cell lysates by using fast …
14 results