Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.
Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E.
Contat C, et al.
Elife. 2020 Jun 23;9:e53618. doi: 10.7554/eLife.53618.
Elife. 2020.
PMID: 32571479
Free PMC article.
In a genetically-engineered mouse model of lung adenocarcinoma, we show that the deletion of only one highly expressed glucose transporter, Glut1 or Glut3, in cancer cells does not impair tumor growth, whereas their combined loss diminishes tumor development. (18)F-FDG-PET …
In a genetically-engineered mouse model of lung adenocarcinoma, we show that the deletion of only one highly expressed glucose transporter, …